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Mon Jul 12 16:44:16 2004

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS
CURRENT BIOLOGY
12 (20): 1748-1755 OCT 15 2002
and the citing papers

Nodes: 81
Authors: 232, Journals: 39, Outer References: 2449
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
#LCRNCRNodes / Authors / DateLCSGCS
10371 2002 CURRENT BIOLOGY 12(20):1748-1755
Rada C; Williams GT; Nilsen H; Barnes DE; Lindahl T; Neuberger MS
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
8080
21332 2003 ALLERGOLOGIE 26(10):440-445
Luger E; Radbruch A
Regulation der IgE-expression
00
342173 2003 ANNUAL REVIEW OF GENETICS 37():31-66
Rattray AJ; Strathern JN
Error-prone DNA polymerases: When making a mistake is the only way to get ahead
00
422034 2003 BIOCHIMIE 85(11):1053-1071
Fortini P; Pascucci B; Parlanti E; D'Errico M; Simonelli V; Dogliotti E
The base excision repair: mechanisms and its relevance for cancer susceptibility
00
54405 2003 CANCER RESEARCH 63(14):3894-3898
Smit LA; Bende RJ; Aten J; Guikema JEJ; Aarts WM; van Noesel CJM
Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype
01
61646 2003 CURRENT OPINION IN IMMUNOLOGY 15(2):190-198
Kenter AL
Class-switch recombination: after the dawn of AID
68
71617 2003 CURRENT OPINION IN RHEUMATOLOGY 15(4):422-429
Gulino AV; Notarangelo LD
Hyper IgM syndromes
02
811028 2003 DNA REPAIR 2(2):135-149
Kunkel TA; Pavlov YI; Bebenek K
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates
922
91309 2003 DNA REPAIR 2(5):623-627
Diaz M; Storb U
A novel cytidine dearninase AIDS in the delivery of error-prone polymerases to immunoglobulin genes
11
1057410 2003 DNA REPAIR 2(10):1075-1085
Jansen JG; de Wind N
Biological functions of translesion synthesis proteins in vertebrates
01
#LCRNCRNodes / Authors / DateLCSGCS
11116511 2003 DNA REPAIR 2(11):1163-1174
Yu KF; Lieber MR
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
01
12105112 2003 EMBO JOURNAL 22(21):5893-5903
Schrader CE; Bradley SP; Vardo J; Mochegova SN; Flanagan E; Stavnezer J
Mutations occur in the Ig S mu region but rarely in S gamma regions prior to class switch recombination
33
13116213 2003 ENVIRONMENTAL MICROBIOLOGY 5(10):814-827
Kivisaar M
Stationary phase mutagenesis: mechanisms that accelerate adaptation of microbial populations under environmental stress
04
1435714 2003 EUROPEAN JOURNAL OF IMMUNOLOGY 33(8):2069-2073
Durandy A
Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation
01
1513315 2003 EUROPEAN JOURNAL OF IMMUNOLOGY 33(8):2108-2113
Delpy L; Le Bert M; Cogne M; Khamlichi AA
Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes
00
1611916 2003 GENES CHROMOSOMES & CANCER 38(1):32-39
Bemark M; Neuberger MS
By-products of immunoglobulin somatic hypermutation
00
1743917 2003 IMMUNITY 19(2):235-242
Michael N; Shen HM; Longerich S; Kim N; Longacre A; Storb U
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
24
1835218 2003 IMMUNITY 19(4):515-524
Min IM; Schrader CE; Vardo J; Luby TM; D'Avirro N; Stavnezer J; Selsing E
The S mu tandem repeat region is critical for Ig isotype switching in the absence of Msh2
23
19219819 2003 IMMUNOLOGICAL REVIEWS 194(1):77-95
Mills KD; Ferguson DO; Alt FW
The role of DNA breaks in genomic instability and tumorigenesis
112
2013020 2003 INTERNATIONAL IMMUNOLOGY 15(4):477-481
Longacre A; Sun TH; Goldsby RE; Preston BD; Storb U
Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading
11
#LCRNCRNodes / Authors / DateLCSGCS
2111821 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19583-19586
Petersen-Mahrt SK; Neuberger MS
In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1)
49
2248322 2003 JOURNAL OF CLINICAL IMMUNOLOGY 23(4):235-246
Wu XP; Feng JL; Komori A; Kim EC; Zan H; Casali P
Immunoglobulin somatic hypermutation: Double-strand DNA breaks, AID and error-prone DNA repair
01
2382123 2003 JOURNAL OF CLINICAL INVESTIGATION 112(1):19-22
Manis JP; Alt FW
Novel antibody switching defects in human patients
11
2413624 2003 JOURNAL OF CLINICAL INVESTIGATION 112(1):136-142
Imai K; Catalan N; Plebani A; Marodi L; Ozden S; Kumaki S; Nagendran V; Wood P; Glastre C; Sarrot-Reynauld F; Hermine O; Forveille M; Revy P; Fischer A; Durandy A
Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination
811
2512125 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(10):1291-1296
Dickerson SK; Market E; Besmer E; Papavasiliou EN
AID mediates hypermutation by deaminating single stranded DNA
2940
2613126 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(10):1377-1383
Schrader CE; Vardo J; Stavnezer J
Mlh1 can function in antibody class switch recombination independently of Msh2
910
2768927 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(12):1767-1778
Reina-San-Martin B; Difilippantonio S; Hanitsch L; Masilamani RF; Nussenzweig A; Nussenzweig MC
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
815
2824328 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(4):635-643
McDonald JP; Frank EG; Plosky BS; Rogozin IB; Masutani C; Hanaoka F; Woodgate R; Gearhart PJ
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation
410
2985029 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(8):1171-1178
Martin A; Li ZQ; Lin DP; Bardwell PD; Iglesias-Ussel MD; Edelmann W; Scharff MD
Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination
22
3013430 2003 JOURNAL OF IMMUNOLOGY 170(4):1620-1624
Bardwell PD; Martin A; Wong E; Li ZQ; Edelmann W; Scharff MD
Cutting edge: The G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination
55
#LCRNCRNodes / Authors / DateLCSGCS
3135231 2003 JOURNAL OF IMMUNOLOGY 170(11):5558-5562
Winter DB; Phung QH; Zeng XM; Seeberg E; Barnes DE; Lindahl T; Gearhart PJ
Normal somatic hypermutation 8-hydroxyguanine-DNA of Ig genes in the absence of glycosylase
00
3254232 2003 JOURNAL OF IMMUNOLOGY 171(5):2504-2509
Catalan N; Selz F; Imai K; Revy P; Fischer A; Durandy A
The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region
33
3356633 2003 JOURNAL OF IMMUNOLOGY 171(12):6556-6564
Cook AJL; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ
Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
23
3411634 2003 M S-MEDECINE SCIENCES 19(2):139-141
Catalan N; Imai K; Revy P; Fischer A; Durandy A
Activation-induced cytidine deaminase: a mysterious enzyme
00
3584535 2003 MOLECULAR CELL 12(2):501-508
Barreto V; Reina-San-Martin B; Ramiro AR; McBride KM; Nussenzweig MC
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
77
3613436 2003 MOLECULAR IMMUNOLOGY 39(16):1025-1034
Boursier L; Su W; Spencer J
Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments
01
3752437 2003 MOLECULAR IMMUNOLOGY 40(5):261-268
Diaz M; Ray M; Wheeler LJ; Verkoczy LK; Mathews CK
Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool
12
38114438 2003 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 531(1-2):231-251
Slupphaug G; Kavli B; Krokan HE
The interacting pathways for prevention and repair of oxidative DNA damage
01
39216939 2003 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 544(1):65-85
Rogozin IB; Pavlov YI
Theoretical analysis of mutation hotspots and their DNA sequence context specificity
15
4013140 2003 NATURE 422(6933):726-730
Chaudhuri J; Tian M; Khuong C; Chua K; Pinaud E; Alt FW
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
4065
#LCRNCRNodes / Authors / DateLCSGCS
4152741 2003 NATURE 424(6944):103-107
Pham P; Bransteitter R; Petruska J; Goodman MF
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
1930
4251242 2003 NATURE IMMUNOLOGY 4(5):429-430
Fugmann SD; Schatz DG
RNA AIDs DNA
36
4315843 2003 NATURE IMMUNOLOGY 4(5):435-441
Shinkura R; Tian M; Smith M; Chua K; Fujiwara Y; Alt FW
The influence of transcriptional orientation on endogenous switch region function
1621
4415844 2003 NATURE IMMUNOLOGY 4(5):452-456
Ramiro AR; Stavropoulos P; Jankovic M; Nussenzweig MC
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
3248
45710745 2003 NATURE IMMUNOLOGY 4(7):631-638
Reynaud CA; Aoufouchi S; Faili A; Weill JC
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
510
4694746 2003 NATURE IMMUNOLOGY 4(9):843-848
Ta VT; Nagaoka H; Catalan N; Durandy A; Fischer A; Imai K; Nonoyama S; Tashiro J; Ikegawa M; Ito S; Kinoshita K; Muramatsu M; Honjo T
AID mutant analyses indicate requirement for class-switch-specific cofactors
1116
4791247 2003 NATURE IMMUNOLOGY 4(10):945-946
Li ZQ; Woo CJ; Scharff MD
Mutations in AID and UNG extend the function of AID
22
4894748 2003 NATURE IMMUNOLOGY 4(10):1023-1028
Imai K; Slupphaug G; Lee WI; Revy P; Nonoyama S; Catalan N; Yel L; Forveille M; Kavli B; Krokan HE; Ochs HD; Fischer A; Durandy A
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
1518
49912949 2003 NATURE REVIEWS IMMUNOLOGY 3(12):962-972
de Villartay JP; Fischer A; Durandy A
The mechanisms of immune diversification and their disorders
00
5051750 2003 ONCOGENE 22(35):5379-5380
Gearhart PJ
B cells pay a price
00
#LCRNCRNodes / Authors / DateLCSGCS
5113551 2003 ONCOGENE 22(35):5381-5386
Nilsen H; Stamp G; Andersen S; Hrivnak G; Krokan HE; Lindahl T; Barnes DE
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
33
52215852 2003 PHARMACOLOGY & THERAPEUTICS 100(2):157-170
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Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response
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5313353 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(5):2634-2638
Doi T; Kinoshita K; Ikegawa M; Muramatsu M; Honjo T
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
1522
5412754 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(7):4102-4107
Bransteitter R; Pham P; Scharff MD; Goodman MF
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
3853
5556255 2003 TRENDS IN BIOCHEMICAL SCIENCES 28(6):305-312
Neuberger MS; Harris RS; Di Noia J; Petersen-Mahrt SK
Immunity through DNA deamination
310
561322456 2004 ADVANCES IN IMMUNOLOGY, VOL 82 82():295-330
Durandy A; Revy P; Fischer A
Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (hyper-IgM syndromes)
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57115957 2004 BLOOD 103(10):3828-3836
Khamlichi AA; Glaudet F; Oruc Z; Denis V; Le Bert M; Cogne M
Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat
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5874358 2004 CURRENT OPINION IN IMMUNOLOGY 16(2):241-245
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The regulation of somatic hypermutation
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5962959 2004 DNA REPAIR 3(1):85-89
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DNA-cytosine deaminases: from antibody maturation to antiviral defense
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6012760 2004 DNA REPAIR 3(2):163-169
Sandigursky M; Sandigursky S; Sonati P; Daly MJ; Franklin WA
Multiple uracil-DNA glycosylase activities in Deinococcus radiodurans
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6123361 2004 DNA REPAIR 3(5):505-513
Fischer JA; Muller-Weeks S; Caradonna S
Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycle
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6211462 2004 EUROPEAN JOURNAL OF IMMUNOLOGY 34(2):504-508
Di Noia JM; Neuberger MS
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination
11
63178763 2004 GENES & DEVELOPMENT 18(1):1-11
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The generation of antibody diversity through somatic hypermutation and class switch recombination
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Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
12
6882768 2004 INTERNATIONAL IMMUNOLOGY 16(4):549-557
Rush JS; Fugmann SD; Schatz DG
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination
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Delineation of the role of the Mre11 complex in class switch recombination
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Mapping of a functional recombination motif that defines Isotype specificity for mu ->gamma 3 switch recombination implicates NF-kappa B p50 as the isotype-specific switching factor
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Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions
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72106972 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(9):1235-1244
McBride KM; Barreto V; Ramiro AR; Stavropoulos P; Nussenzweig MC
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
00
7372973 2004 JOURNAL OF IMMUNOLOGY 172(6):3382-3384
Rogozin IB; Diaz M
Cutting edge: DGYW/WRCH is a better predictor of mutability at G : C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
00
74149674 2004 JOURNAL OF IMMUNOLOGY 172(10):5815-5821
Wang CL; Wabl M
DNA acrobats of the Ig class switch
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Cascalho M
Advantages and disadvantages of cytidine deamination
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7695776 2004 JOURNAL OF MOLECULAR BIOLOGY 337(3):585-596
Beale RCL; Petersen-Mahrt SK; Watt IN; Harris RS; Rada C; Neuberger MS
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: Correlation with mutation spectra in vivo
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77717177 2004 JOURNAL OF MOLECULAR MEDICINE-JMM 82(5):280-297
Krokan HE; Kavli B; Slupphaug G
Novel aspects of macromolecular repair and relationship to human disease
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781010278 2004 NATURE IMMUNOLOGY 5(1):23-30
Fischer A
Human primary immunodeficiency diseases: a perspective
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7993779 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(7):1975-1980
Ito S; Nagaoka H; Shinkura R; Begum N; Muramatsu M; Nakata M; Honjo T
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
44
8023480 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(21):8108-8113
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Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappa B activation pathways
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8185481 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(21):8114-8119
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