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Mon Jul 12 16:38:10 2004

AID mutates E-coli suggesting a DNA deamination mechanism for antibody diversification
Petersen-Mahrt SK, Harris RS, Neuberger MS
NATURE
418 (6893): 99-103 JUL 4 2002
and the citing papers.

Nodes: 127
Authors: 390, Journals: 57, Outer References: 3338
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
#LCRNCRNodes / Authors / DateLCSGCS
11691 2002 AIDS 16():S17-S23
Gummuluru S; Emerman M
Advances in HIV molecular biology
00
22372 2002 CURRENT BIOLOGY 12(20):1748-1755
Rada C; Williams GT; Nilsen H; Barnes DE; Lindahl T; Neuberger MS
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
6480
31173 2002 CURRENT BIOLOGY 12(21):R725-R727
Storb U; Stavnezer J
Immunoglobulin genes: Generating diversity with AID and UNG
019
42114 2002 MOLECULAR CELL 10(5):962-963
Kunkel TA; Diaz M
Enzymatic cytosine deamination: Friend AND foe
12
52295 2002 MOLECULAR CELL 10(5):1247-1253
Harris RS; Petersen-Mahrt SK; Neuberger MS
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
3248
60296 2002 NATURE 418(6893):99-103
Petersen-Mahrt SK; Harris RS; Neuberger MS
AID mutates E-coli suggesting a DNA deamination mechanism for antibody diversification
126126
72137 2002 NATURE 419(6902):29-+
Gearhart PJ
Immunology - The roots of antibody diversity
48
81218 2002 NATURE 419(6902):43-48
Di Noia J; Neuberger MS
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
5772
91299 2002 NATURE 419(6910):944-947
Faili A; Aoufouchi S; Flatter E; Gueranger Q; Reynaud CA; Weill JC
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota
2845
1011310 2002 NATURE IMMUNOLOGY 3(9):800-801
Honjo T
Does AID need another aid?
24
#LCRNCRNodes / Authors / DateLCSGCS
112211 2002 NATURE REVIEWS IMMUNOLOGY 2(8):539-539
Bell J
Deamination unlocks diversity
00
12111712 2002 NATURE REVIEWS IMMUNOLOGY 2(8):605-614
Martin A; Scharff MD
Aid and mismatch repair in antibody diversification
1523
13110713 2002 NATURE REVIEWS IMMUNOLOGY 2(9):688-698
Flajnik MF
Comparative analyses of immunoglobulin genes: Surprises and portents
214
141214 2002 NATURE REVIEWS MOLECULAR CELL BIOLOGY 3(8):552-552
Bell J
Antibody responses - Deamination unlocks diversity
00
15211115 2002 ONCOGENE 21(58):8935-8948
Krokan HE; Drablos F; Slupphaug G
Uracil in DNA - occurrence, consequences and repair
512
1623516 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(19):12304-12308
Martin A; Scharff MD
Somatic hypermutation of the AID transgene in B and non-B cells
1215
1712717 2002 TRENDS IN GENETICS 18(11):541-543
Stavnezer J; Bradley SP
Does activation-induced deaminase initiate antibody diversification by DNA deamination?
22
1823318 2003 ALLERGOLOGIE 26(10):440-445
Luger E; Radbruch A
Regulation der IgE-expression
00
19128319 2003 ANNUAL REVIEW OF IMMUNOLOGY 21():579-628
Gould HJ; Sutton BJ; Beavil AJ; Beavil RL; McCloskey N; Coker HA; Fear D; Smurthwaite L
The biology of IgE and the basis of allergic disease
08
2023620 2003 BLOOD 101(9):3574-3580
Greeve J; Philipsen A; Krause K; Klapper W; Heidom K; Castle BE; Janda J; Marcu KB; Parwaresch R
Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas
24
#LCRNCRNodes / Authors / DateLCSGCS
2122521 2003 BLOOD 101(10):4029-4032
Oppezzo P; Vuillier F; Vasconcelos Y; Dumas G; Magnac C; Payelle-Brogard B; Pritsch O; Dighiero G
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
310
2214422 2003 BLOOD 101(12):4903-4908
McCarthy H; Wierda WG; Barron LL; Cromwell CC; Wang J; Coombes KR; Rangel R; Elenitoba-Johnson KSJ; Keating MJ; Abruzzo LV
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia
210
2374623 2003 BLOOD 102(9):3333-3339
Albesiano E; Messmer BT; Damle RN; Allen SL; Rai KR; Chiorazzi N
Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone
04
2433024 2003 CANCER CELL 3(2):105-110
Kunkel TA
Considering the cancer consequences of altered DNA polymerase function
01
25104025 2003 CANCER RESEARCH 63(14):3894-3898
Smit LA; Bende RJ; Aten J; Guikema JEJ; Aarts WM; van Noesel CJM
Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype
01
2642026 2003 CELL 114(3):281-283
Goff SP
Death by deamination: A novel host restriction system for HIV-1
23
2722427 2003 CHEMICAL PHYSICS LETTERS 381(5-6):660-665
Kedzierski P; Sokalski WA; Cheng HS; Mitchell J; Leszczynski J
DFT study of the reaction proceeding in the cytidine deaminase
01
28119128 2003 CHEMICAL REVIEWS 103(7):2729-2759
Stivers JT; Jiang YL
A mechanistic perspective on the chemistry of DNA repair glycosylases
06
2956429 2003 CURRENT OPINION IN IMMUNOLOGY 15(2):190-198
Kenter AL
Class-switch recombination: after the dawn of AID
68
3016130 2003 CURRENT OPINION IN IMMUNOLOGY 15(3):354-361
McHeyzer-Williams MG
B cells as effectors
01
#LCRNCRNodes / Authors / DateLCSGCS
3136131 2003 CURRENT OPINION IN RHEUMATOLOGY 15(4):422-429
Gulino AV; Notarangelo LD
Hyper IgM syndromes
02
32510232 2003 DNA REPAIR 2(2):135-149
Kunkel TA; Pavlov YI; Bebenek K
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates
922
3323033 2003 DNA REPAIR 2(5):623-627
Diaz M; Storb U
A novel cytidine dearninase AIDS in the delivery of error-prone polymerases to immunoglobulin genes
11
3426134 2003 EMBO JOURNAL 22(7):1654-1664
Simpson LJ; Sale JE
Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line
29
35155135 2003 EMBO JOURNAL 22(21):5893-5903
Schrader CE; Bradley SP; Vardo J; Mochegova SN; Flanagan E; Stavnezer J
Mutations occur in the Ig S mu region but rarely in S gamma regions prior to class switch recombination
33
36516236 2003 ENVIRONMENTAL MICROBIOLOGY 5(10):814-827
Kivisaar M
Stationary phase mutagenesis: mechanisms that accelerate adaptation of microbial populations under environmental stress
04
3765737 2003 EUROPEAN JOURNAL OF IMMUNOLOGY 33(8):2069-2073
Durandy A
Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation
01
3831938 2003 GENES CHROMOSOMES & CANCER 38(1):32-39
Bemark M; Neuberger MS
By-products of immunoglobulin somatic hypermutation
00
3913139 2003 GENES TO CELLS 8(12):941-950
Kamiya H; Iida E; Murata-Kamiya N; Yamamoto Y; Miki T; Harashima H
Suppression of spontaneous and hydrogen peroxide-induced mutations by a MutT-type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein
00
4075240 2003 IMMUNITY 19(4):515-524
Min IM; Schrader CE; Vardo J; Luby TM; D'Avirro N; Stavnezer J; Selsing E
The S mu tandem repeat region is critical for Ig isotype switching in the absence of Msh2
23
#LCRNCRNodes / Authors / DateLCSGCS
4133441 2003 IMMUNOLOGY LETTERS 86(3):265-270
Shimizu T; Shinkai Y; Ogi T; Ohmori H; Azuma T
The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene
01
4212642 2003 JOURNAL OF BACTERIOLOGY 185(15):4626-4629
Kim M; Huang T; Miller JH
Competition between MutY and mismatch repair at A center dot C mispairs in vivo
01
4314843 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(3):1395-1398
Blanc V; Davidson NO
C-to-U RNA editing: Mechanisms leading to genetic diversity
37
4441844 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19583-19586
Petersen-Mahrt SK; Neuberger MS
In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1)
59
4568345 2003 JOURNAL OF CLINICAL IMMUNOLOGY 23(4):235-246
Wu XP; Feng JL; Komori A; Kim EC; Zan H; Casali P
Immunoglobulin somatic hypermutation: Double-strand DNA breaks, AID and error-prone DNA repair
01
46102146 2003 JOURNAL OF CLINICAL INVESTIGATION 112(1):19-22
Manis JP; Alt FW
Novel antibody switching defects in human patients
11
4743647 2003 JOURNAL OF CLINICAL INVESTIGATION 112(1):136-142
Imai K; Catalan N; Plebani A; Marodi L; Ozden S; Kumaki S; Nagendran V; Wood P; Glastre C; Sarrot-Reynauld F; Hermine O; Forveille M; Revy P; Fischer A; Durandy A
Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination
711
4843248 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(9):1173-1181
Okazaki I; Hiai H; Kakazu N; Yamada S; Muramatsu M; Kinoshita K; Honjo T
Constitutive expression of AID leads to tumorigenesis
1116
4942149 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(10):1291-1296
Dickerson SK; Market E; Besmer E; Papavasiliou EN
AID mediates hypermutation by deaminating single stranded DNA
3340
5023150 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(10):1377-1383
Schrader CE; Vardo J; Stavnezer J
Mlh1 can function in antibody class switch recombination independently of Msh2
710
#LCRNCRNodes / Authors / DateLCSGCS
5198951 2003 JOURNAL OF EXPERIMENTAL MEDICINE 197(12):1767-1778
Reina-San-Martin B; Difilippantonio S; Hanitsch L; Masilamani RF; Nussenzweig A; Nussenzweig MC
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
815
5254352 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(4):635-643
McDonald JP; Frank EG; Plosky BS; Rogozin IB; Masutani C; Hanaoka F; Woodgate R; Gearhart PJ
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation
410
53105053 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(8):1171-1178
Martin A; Li ZQ; Lin DP; Bardwell PD; Iglesias-Ussel MD; Edelmann W; Scharff MD
Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination
22
5414954 2003 JOURNAL OF IMMUNOLOGY 170(7):3707-3716
Pan-Hammarstrom Q; Dai SJ; Zhao YF; van Dijk-Hard IF; Gatti RA; Borresen-Dale AL; Hammarstrom L
ATM is not required in somatic hypermutation of V-H, but is involved in the introduction of mutations in the switch mu region
78
5545255 2003 JOURNAL OF IMMUNOLOGY 170(11):5558-5562
Winter DB; Phung QH; Zeng XM; Seeberg E; Barnes DE; Lindahl T; Gearhart PJ
Normal somatic hypermutation 8-hydroxyguanine-DNA of Ig genes in the absence of glycosylase
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5684256 2003 JOURNAL OF IMMUNOLOGY 171(5):2504-2509
Catalan N; Selz F; Imai K; Revy P; Fischer A; Durandy A
The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region
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5723457 2003 JOURNAL OF IMMUNOLOGY 171(10):5602-5610
Coker HA; Durham SR; Gould HJ
Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
02
5886658 2003 JOURNAL OF IMMUNOLOGY 171(12):6556-6564
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Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
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59111459 2003 JOURNAL OF LEUKOCYTE BIOLOGY 73(3):323-332
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Activation-induced cytidine deaminase: a mysterious enzyme
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61124561 2003 MOLECULAR CELL 12(2):501-508
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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
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Diaz M; Ray M; Wheeler LJ; Verkoczy LK; Mathews CK
Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool
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6414864 2003 MOLECULAR IMMUNOLOGY 40(5):287-295
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Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism
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Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion
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The interacting pathways for prevention and repair of oxidative DNA damage
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Theoretical analysis of mutation hotspots and their DNA sequence context specificity
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Chaudhuri J; Tian M; Khuong C; Chua K; Pinaud E; Alt FW
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
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Zhang H; Yang B; Pomerantz RJ; Zhang CM; Arunachalam SC; Gao L
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
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Pham P; Bransteitter R; Petruska J; Goodman MF
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
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7145871 2003 NATURE IMMUNOLOGY 4(5):435-441
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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
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E-proteins directly regulate expression of activation-induced deaminase in mature B cells
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Reynaud CA; Aoufouchi S; Faili A; Weill JC
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
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75134775 2003 NATURE IMMUNOLOGY 4(9):843-848
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AID mutant analyses indicate requirement for class-switch-specific cofactors
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Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
1018
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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
1419
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B cells pay a price
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Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
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3853
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RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
34
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Immunity through DNA deamination
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Cloning and expression of the AID gene in the channel catfish
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Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycle
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Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination
11
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1012187101 2004 GENES & DEVELOPMENT 18(1):1-11
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The generation of antibody diversity through somatic hypermutation and class switch recombination
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Developing a genetic system in Deinococcus radiodurans for analyzing mutations
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Transcription-coupled mutagenesis by the DNA deaminase AID
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104168104 2004 IMMUNITY 20(2):133-144
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T cell-independent somatic hypermutation in murine B cells with an immature phenotype
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The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes
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Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
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DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
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Delineation of the role of the Mre11 complex in class switch recombination
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53BP1 is required for class switch recombination
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1121856112 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(7):917-924
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Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions
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1131469113 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(9):1235-1244
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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
00
114138114 2004 JOURNAL OF IMMUNOLOGY 172(1):340-348
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Partitioning of rearranged Ig genes by mutation analysis demonstrates D-D fusion and V gene replacement in the expressed human repertoire
01
1151029115 2004 JOURNAL OF IMMUNOLOGY 172(6):3382-3384
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Cutting edge: DGYW/WRCH is a better predictor of mutability at G : C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
00
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DNA acrobats of the Ig class switch
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Cascalho M
Advantages and disadvantages of cytidine deamination
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Analysis of strand biased 'G'center dot C hypermutation in human immunoglobulin V-lambda gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase
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Human primary immunodeficiency diseases: a perspective
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#LCRNCRNodes / Authors / DateLCSGCS
121636121 2004 NATURE STRUCTURAL & MOLECULAR BIOLOGY 11(5):435-442
Yu Q; Konig R; Pillai S; Chiles K; Kearney M; Palmer S; Richman D; Coffin JM; Landau NR
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
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1221159122 2004 NUCLEIC ACIDS RESEARCH 32(8):2421-2429
Suspene R; Sommer P; Henry M; Ferris S; Guetard D; Pochet S; Chester A; Navaratnam N; Wain-Hobson S; Vartanian JP
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase
00
1231637123 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(7):1975-1980
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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
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124430124 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(11):3927-3932
Schrofelbauer R; Chen D; Landau NR
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)
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125236125 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(12):4262-4267
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Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes
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1261242126 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(19):7352-7356
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Genome-wide somatic hypermutation
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1271554127 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(21):8114-8119
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The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1
00

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