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Fri Jan 13 11:29:13 2006

EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M
SCIENCE 304 (5676): 1497-1500 JUN 4 2004
and the citing papers

Nodes: 555, Authors: 2608, Journals: 174, Outer References: 17084, Words: 1428
Collection span: 2004 - 2006
View: Overview. Sorted by year, source, volume, issue, page. Page 1 of 6: [  1  2  3  4  5  6 ]

#LCRNCRNode / Date / Journal / AuthorLCSGCS
1181 2004 AMERICAN FAMILY PHYSICIAN 70 (9): 1637-+
Collins F
Genomics and the family physician: Realizing the potential
01
22392 2004 ANNALES DE PATHOLOGIE 24 (5): 416-426
Penault-Llorca F; Sobourin JC
The pathologist and EGFR in 2004: I like you, so don't I
00
31153 2004 ANNALS OF ONCOLOGY 15: 81-83
Giaccone G
Twenty-five years of treating advanced NSCLC: what have we achieved?
00
411444 2004 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1705 (1): 53-66
Cummings J; Ward TH; Ranson M; Dive C
Apoptosis pathway-targeted drugs - from the bench to the clinic
12
51415 2004 BREAST CANCER RESEARCH 6 (5): 204-210
Lin NU; Winer EP
New targets for therapy in breast cancer - Small molecule tyrosine kinase inhibitors
13
61256 2004 BRITISH JOURNAL OF CANCER 91: S1-S2
Camus P
Interstitial lung disease in patients with non-small-cell lung cancer: causes, mechanisms and management - Introduction
00
71447 2004 BRITISH JOURNAL OF CANCER 91 (7): 1301-1307
Swinson DEB; Cox G; O'Byrne KJ
Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer
33
81298 2004 CANCER 101 (7): 1632-1638
Shah L; Walter KL; Borczuk AC; Kawut SM; Sonett JR; et al.
Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma
15
91869 2004 CANCER 101 (8): 1733-1744
Gridelli C; Massarelli E; Maione P; Rossi A; Herbst RS; et al.
Potential role of molecularly targeted therapy in the management of advanced nonsmall cell lung carcinoma in the elderly
01
1011210 2004 CANCER BIOLOGY & THERAPY 3 (9): 911-915
Mihich E
Cancer therapeutics - Personal experiences and future perspectives
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1116311 2004 CANCER CELL 6 (3): 209-214
Ishizawar R; Parsons SJ
c-Src and cooperating partners in human cancer
313
1216312 2004 CANCER CELL 6 (4): 321-326
Abbruzzese JL; Lippman SM
The convergence of cancer prevention and therapy in early-phase clinical drug development
18
1337613 2004 CANCER CELL 6 (5): 433-438
Weir B; Zhao XJ; Meyerson M
Somatic alterations in the human cancer genome
23
1412214 2004 CANCER RESEARCH 64 (20): 7241-7244
Tracy S; Mukohara T; Hansen M; Meyerson M; Johnson BE; et al.
Gefitinib induces apoptosis in the EGFR(L858R) non-small-cell lung cancer cell line H3255
2629
1514515 2004 CANCER RESEARCH 64 (23): 8723-8730
Chen YL; Law PY; Loh HH
Inhibition of Akt/protein kinase B signaling by naltrindole in small cell lung cancer cells
03
1612016 2004 CANCER RESEARCH 64 (24): 8816-8820
Bentires-Alj M; Paez JG; David FS; Keilhack H; Halmos B; et al.
Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia
114
1722917 2004 CANCER RESEARCH 64 (24): 8919-8923
Kosaka T; Yatabe Y; Endoh H; Kuwano H; Takahashi T; et al.
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
4851
1813218 2004 CANCER RESEARCH 64 (24): 9093-9100
Reyzer ML; Caldwell RL; Dugger TC; Forbes JT; Ritter CA; et al.
Early changes in protein expression detected by mass spectrometry predict tumor response to molecular therapeutics
14
1921519 2004 CANCER RESEARCH 64 (24): 9101-9104
Arao T; Fukumoto H; Takeda M; Tamura T; Saijo N; et al.
Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474
810
2011020 2004 CELL CYCLE 3 (7): 833-835
Druker BJ
Imatinib: Paradigm or anomaly?
45
#LCRNCRNode / Date / Journal / AuthorLCSGCS
2128321 2004 CELL CYCLE 3 (8): 1035-1042
Blagosklonny MV
Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
24
2213222 2004 CELL CYCLE 3 (10): 1221-1224
Samuels Y; Velculescu VE
Oncogenic mutations of PIK3CA in human cancers
28
232823 2004 CELL CYCLE 3 (12): 1496-1497
Settleman J
Inhibition of mutant EGF receptors by Gefitinib - Targeting an Achilles' heel of lung cancer
34
2412424 2004 CLINICAL CANCER RESEARCH 10 (19): 6522-6527
Messersmith WA; Laheru DA; Senzer NN; Donehower RC; Grouleff P; et al.
Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): Early termination due to increased toxicities
26
2513625 2004 CLINICAL CANCER RESEARCH 10 (21): 7311-7317
Kim YH; Ishii G; Goto K; Nagai K; Tsuta K; et al.
Dominant papillary subtype is a significant predictor of the response to gefitinib in adenocarcinoma of the lung
23
2613726 2004 CLINICAL CANCER RESEARCH 10 (22): 7547-7554
Petty WJ; Dragnev KH; Memoli VA; Ma Y; Desai NB; et al.
Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers
28
2714827 2004 CLINICAL CANCER RESEARCH 10 (22): 7764-7774
Kalish LH; Kwong RA; Cole IE; Gallagher RM; Sutherland RL; et al.
Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines
24
2812528 2004 CLINICAL CANCER RESEARCH 10 (24): 8195-8203
Huang SF; Liu HP; Li LH; Ku YC; Fu YN; et al.
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
3739
2914129 2004 CLINICAL CANCER RESEARCH 10 (24): 8351-8356
Thomas GV; Horvath S; Smith BL; Crosby K; Lebel LA; et al.
Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer
00
3013030 2004 CLINICAL CANCER RESEARCH 10 (24): 8594-8602
Schiff BA; McMurphy AB; Jasser SA; Younes MN; Doan D; et al.
Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer
04
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3113831 2004 CLINICAL CANCER RESEARCH 10 (24): 8613-8619
Onn A; Isobe T; Wu WJ; Itasaka S; Shintani T; et al.
Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer
00
32110932 2004 CURRENT MOLECULAR MEDICINE 4 (8): 855-868
Dharmawardana PG; Giubellino A; Bottaro DP
Hereditary papillary renal carcinoma type I
02
3317733 2004 CURRENT OPINION IN CELL BIOLOGY 16 (6): 670-678
Senderowicz AM
Targeting cell cycle and apoptosis for the treatment of human malignancies
03
3417834 2004 CURRENT OPINION IN CHEMICAL BIOLOGY 8 (4): 432-441
Mazitschek R; Giannis A
Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases
14
3513135 2004 CURRENT OPINION IN ONCOLOGY 16 (6): 536-541
Loi S; Buyse M; Sotiriou C; Cardoso F
Challenges in breast cancer clinical trial design in the postgenomic era
00
3618536 2004 DRUG DEVELOPMENT RESEARCH 62 (2): 86-96
Hakonarsson H; Stefansson K
Role of pharmacogenomics in drug development
02
3717937 2004 DRUG DISCOVERY TODAY 9 (14): 610-618
Savage SA; Chanock SJ
Using germ-line genetic variation to investigate and treat cancer
01
3815638 2004 DRUG DISCOVERY TODAY 9 (18): 795-802
Desany B; Zhang ZM
Bioinformatics and cancer target discovery
01
3918439 2004 DRUG RESISTANCE UPDATES 7 (4-5): 245-255
Alaoui-Jamali MA; Dupre I; Qiang H
Prediction of drug sensitivity and drug resistance in cancer by transcriptional and proteomic profiling
01
4048840 2004 DRUGS 64 (21): 2475-2492
Frampton JE; Easthope SE
Gefitinib - A review of its use in the management of advanced non-small-cell lung cancer
05
#LCRNCRNode / Date / Journal / AuthorLCSGCS
41124441 2004 ENDOCRINE-RELATED CANCER 11 (4): 659-687
Carter P; Smith L; Ryan M
Identification and validation of cell surface antigens for antibody targeting in oncology
00
42113542 2004 ENDOCRINE-RELATED CANCER 11 (4): 689-708
Harari PM
Epidermal growth factor receptor inhibition strategies in oncology
212
43115243 2004 EUROPEAN JOURNAL OF PHARMACOLOGY 500 (1-3): 267-280
Nebert DW; Vesell ES
Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
213
4419944 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13 (12): 1569-1577
Zhang H; Yee D
The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
03
4519245 2004 EXPERT OPINION ON PHARMACOTHERAPY 5 (7): 1621-1633
Humblet Y
Cetuximab: an IgG(1) monoclonal antibody for the treatment of epidermal growth factor receptor-expressing tumours
12
4623446 2004 HUMAN MOLECULAR GENETICS 13 (24): 3029-3043
Kakiuchi S; Daigo Y; Ishikawa N; Furukawa C; Tsunoda T; et al.
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839)
25
4712747 2004 JOURNAL OF CHROMATOGRAPHY A 1053 (1-2): 279-290
Marko-Varga GA; Fehniger TE
Microscale protein expression profiling during disease evolvement
05
4812248 2004 JOURNAL OF CLINICAL ONCOLOGY 22 (16): 3209-3211
Dubinett SM; Elashoff D; Meyerson M
Assessing prognosis in non-small-cell lung cancer: Avenues to a more complete picture?
00
4914449 2004 JOURNAL OF CLINICAL ONCOLOGY 22 (16): 3238-3247
Perez-Soler R; Chachoua A; Hammond LA; Rowinsky EK; Huberman M; et al.
Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
4257
5014350 2004 JOURNAL OF CLINICAL ONCOLOGY 22 (20): 4031-4034
Oliveira AM; Fletcher CDM
Molecular prognostication for soft tissue sarcomas: Are we ready yet?
03
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5111951 2004 JOURNAL OF CLINICAL ONCOLOGY 22 (22): 4442-4445
Ratain MJ; Eckhardt SG
Phase II studies of modern drugs directed against new targets: If you are fazed, too, then resist RECIST
12
5214252 2004 JOURNAL OF CLINICAL ONCOLOGY 22 (23): 4725-4729
Shuch B; Mikhail M; Satagopan J; Lee P; Yee H; et al.
Racial disparity of epidermal growth factor receptor expression in prostate cancer
12
5321953 2004 JOURNAL OF THE NATIONAL CANCER INSTITUTE 96 (15): 1117-1119
Pao W; Miller VA; Venkatraman E; Kris MG
Predicting sensitivity of non-small-cell lung cancer to gefitinib: Is there a role for P-akt?
69
5414954 2004 JOURNAL OF THE NATIONAL CANCER INSTITUTE 96 (15): 1133-1141
Cappuzzo F; Magrini E; Ceresoli GL; Bartolini S; Rossi E; et al.
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
4563
5511255 2004 M S-MEDECINE SCIENCES 20 (8-9): 750-751
Besse B; Le Chevalier T; Soria JC
Selection of patients responsive to lressa((R))
00
5617456 2004 MOLECULAR CANCER THERAPEUTICS 3 (10): 1335-1342
Britten CD
Targeting ErbB receptor signaling: A pan-ErbB approach to cancer
55
571757 2004 NATURE 430 (6995): 30-30
Stratton MR; Futreal PA
Cancer - Understanding the target
23
581858 2004 NATURE 431 (7008): 525-526
Stephens P; Hunter C; Bignell G; Edkins S; Davies H; et al.
Intragenic ERBB2 kinase mutations in tumours
4553
5933159 2004 NATURE 432 (7015): 294-297
Sawyers C
Targeted cancer therapy
818
6029860 2004 NATURE 432 (7015): 298-306
Massague J
G1 cell-cycle control and cancer
134
#LCRNCRNode / Date / Journal / AuthorLCSGCS
6111161 2004 NATURE BIOTECHNOLOGY 22 (10): 1215-1217
Hood L; Perlmutter RM
The impact of systems approaches on biological problems in drug discovery
110
621262 2004 NATURE MEDICINE 10 (8): 764-764
Katsnelson A
Experts call for smarter approach to targeted therapies
01
63111863 2004 NATURE MEDICINE 10 (8): 789-799
Vogelstein B; Kinzler KW
Cancer genes and the pathways they control
13118
6422664 2004 NATURE MEDICINE 10 (12): 1289-1291
Evans BJ; Flockhart DA; Meslin EM
Creating incentives for genomic research to improve targeting of therapies
00
6518565 2004 NATURE REVIEWS CANCER 4 (9): 718-727
Dibb NJ; Dilworth SM; Mol CD
Opinion - Switching on kinases: oncogenic activation of BRAF and the PDGFR family
616
6613766 2004 NATURE REVIEWS CANCER 4 (10): 820-828
von Eschenbach AC
A vision for the National Cancer Program in the United States
29
6738867 2004 NATURE REVIEWS CANCER 4 (12): 956-965
Herbst RS; Fukuoka M; Baselga J
Timeline - Gefitinib - a novel targeted approach to treating cancer
1018
6817168 2004 NATURE REVIEWS DRUG DISCOVERY 3 (9): 739-748
Weinshilboum R; Wang LW
Pharmacogenomics: Bench to bedside
015
6918469 2004 NATURE REVIEWS DRUG DISCOVERY 3 (9): 749-761
Koch WH
Technology platforms for pharmacogenomic diagnostic assays
18
7011070 2004 NATURE REVIEWS DRUG DISCOVERY 3 (9): 763-769
Lesko LJ; Woodcock J
Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective
318
#LCRNCRNode / Date / Journal / AuthorLCSGCS
7139271 2004 NATURE REVIEWS DRUG DISCOVERY 3 (12): 1001-1010
Daub H; Specht K; Ullrich A
Strategies to overcome resistance to targeted protein kinase inhibitors
724
72111872 2004 NATURE REVIEWS DRUG DISCOVERY 3 (12): 1011-1022
Yingling JM; Blanchard KL; Sawyer JS
Development of TGF-beta signalling inhibitors for cancer therapy
013
7316573 2004 NATURE REVIEWS GENETICS 5 (9): 645-656
Roses AD
Pharmacogenetics and drug development: The path to safer and more effective drugs
121
74110174 2004 NATURE REVIEWS NEUROSCIENCE 5 (10): 782-792
Mischel PS; Cloughesy TF; Nelson SF
DNA-microarray analysis of brain cancer: Molecular classification for therapy
111
7511475 2004 NEW ENGLAND JOURNAL OF MEDICINE 351 (5): 501-505
Roberts TG; Chabner BA
Sounding board: Beyond fast track for drug approvals
23
761276 2004 NEW ENGLAND JOURNAL OF MEDICINE 351 (12): 1260-1260
Rich JN; Rasheed BKA; Yan H
EGFR mutations and sensitivity to gefitinib
44
771577 2004 NEW ENGLAND JOURNAL OF MEDICINE 351 (27): 2883-2883
Barber TD; Vogelstein B; Kinzler KW; Velculescu VE
Somatic mutations of EGFR in colorectal cancers and glioblastomas
2025
7817678 2004 NUCLEIC ACIDS RESEARCH 32 (19): Art. No. e148
Pincas H; Pingle MR; Huang JM; Lao KQ; Paty PB; et al.
High sensitivity EndoV mutation scanning through real-time ligase proofreading
00
7926279 2004 ONCOGENE 23 (51): 8392-8400
Willingham AT; Deveraux QL; Hampton GM; Aza-Blanc P
RNAi and HTS: exploring cancer by systematic loss-of-function
15
8011580 2004 ONCOLOGIST 9 (4): 357-360
Druker BJ
Molecularly targeted Therapy: Have the floodgates opened?
13
#LCRNCRNode / Date / Journal / AuthorLCSGCS
8111881 2004 PHARMACOGENOMICS 5 (8): 1167-1173
Campbell DA; Carmichael J; Chopra R
Molecular pathology in oncology - the AstraZeneca perspective
11
8212982 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (36): 13306-13311
Pao W; Miller V; Zakowski M; Doherty J; Politi K; et al.
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
184209
8317483 2004 RADIOTHERAPY AND ONCOLOGY 72 (3): 257-266
Baumann M; Krause M
Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results
216
843984 2004 RESPIROLOGY 9 (4): 426-427
Fong KM; Bowman R
A molecular chink in the lung cancer armour
00
851385 2004 SCHIZOPHRENIA RESEARCH 72 (1): 75-77
Scolnick E
Program to improve cognitive functioning in patients with schizophrenia: reflections
02
861686 2004 SCIENCE 304 (5676): 1458-+
Minna JD; Gazdar AF; Sprang SR; Herz J
Cancer - A bull's eye for targeted lung cancer therapy
1417
8702687 2004 SCIENCE 304 (5676): 1497-1500
Paez JG; Janne PA; Lee JC; Tracy S; Greulich H; et al.
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
554555
8811988 2004 SCIENCE 305 (5687): 1163-1167
Sordella R; Bell DW; Haber DA; Settleman J
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
107132
891889 2004 SCIENTIST 18 (15): 26-27
May M
Pharmacogenomics lurches forward - Small battles push toward making personalized medicine a reality
00
9016690 2004 SEMINARS IN ONCOLOGY 31 (5): 6-13
Yarden Y; Baselga J; Miles D
Molecular approach to breast cancer treatment
04
#LCRNCRNode / Date / Journal / AuthorLCSGCS
9112891 2004 SEMINARS IN ONCOLOGY 31 (6): 27-31
Govindan R; Garfield DH
Treatment approaches in patients with advanced non-small cell lung cancer and poor performance status
00
9233492 2004 TRENDS IN MOLECULAR MEDICINE 10 (10): 481-486
Gazdar AF; Shigematsu H; Herz J; Minna JD
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
1620
9316993 2004 TRENDS IN PHARMACOLOGICAL SCIENCES 25 (9): 457-464
Petros WP; Evans WE
Pharmacogenomics in cancer therapy: is host genome variability important?
02
9412794 2004 XENOBIOTICA 34 (10): 901-915
McKillop D; Partridge EA; Hutchison M; Rhead SA; Parry AC; et al.
Pharmacokinetics of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat and dog
13
9515595 2005 ACTA HISTOCHEMICA ET CYTOCHEMICA 38 (3): 209-216
Tani Y; Hatanaka Y; Hashizume K
Development of precise pharmocodiagnostic (PharmDx) tests for molecular targeted therapies
00
9611596 2005 ACTA ONCOLOGICA 44 (7): 717-722
Hotta K; Ueoka H; Kiura K; Tabata M; Ogino A; et al.
Safety and efficacy of gefitinib treatment in elderly patients with non-small-cell lung cancer: Okayama Lung Cancer Study Group experience
00
9721997 2005 ADVANCES IN ANATOMIC PATHOLOGY 12 (2): 47-52
Chang KL; Lau SK
EGFR mutations in non-small cell lung carcinomas may predict response to gefitinib - Extension of an emerging paradigm
00
98119098 2005 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 21 (4): 321-339
Jalving M; Koornstra JJ; De Jong S; De Vries EGE; Kleibeuker JH
Review article: the potential of combinational regimen with non-steroidal anti-inflammatory drugs in the chemoprevention of colorectal cancer
00
9921899 2005 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 124 (1): 20-23
Le LH; Chetty R; Moore MJ
Epidermal growth factor receptor expression in anal canal carcinoma
00
1003125100 2005 AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 13 (12): 1027-1040
Gershenfeld HK; Philibert RA; Boehm GW
Looking forward in geriatric anxiety and depression - Implications of basic science for the future
01

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