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Thu Nov 17 15:20:09 2005

BRCT repeats as phosphopeptide-binding modules involved in protein targeting
Manke IA, Lowery DM, Nguyen A, Yaffe MB
SCIENCE 302 (5645): 636-639 OCT 24 2003
and the citing papers

Nodes: 102, Authors: 379, Journals: 54, Outer References: 3891, Words: 447
Collection span: 2003 - 2005
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
11102 2003 OCT 24 SCIENCE 302 (5645): 579-580
Caldecott KW
The BRCT domain: Signaling with friends?
79
20223 2003 OCT 24 SCIENCE 302 (5645): 636-639
Manke IA; Lowery DM; Nguyen A; Yaffe MB
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
101101
3131 2003 DEC [15] NATURE REVIEWS MOLECULAR CELL BIOLOGY 4 (12): 910-910
Wilson N
Signal transduction - A new family
00
411813 2004 FEB [15] CELL CYCLE 3 (2): 179-181
Meetei AR; Yan ZJ; Wang W
FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination
215
513429 2004 FEB 25 EMBO JOURNAL 23 (4): 908-918
den Elzen NR; O'Connell MJ
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
18
614830 2004 MAR 10 EMBO JOURNAL 23 (5): 1188-1197
Rouse J
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
27
7114532 2004 MAR 15 GENES & DEVELOPMENT 18 (6): 602-616
Peterson CL; Cote J
Cellular machineries for chromosomal DNA repair
236
815533 2004 MAR 15 GENES & DEVELOPMENT 18 (6): 673-686
Liu K; Luo YH; Lin FT; Lin WC
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
214
914541 2004 MAY 1 JOURNAL OF IMMUNOLOGY 172 (9): 5478-5488
Repasky JAE; Corbett E; Boboila C; Schatz DG
Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination
01
1023847 2004 MAY 7 MOLECULAR CELL 14 (3): 405-412
Shiozaki EN; Gu LC; Yan N; Shi YG
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: Implications for signaling
1012
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1123614 2004 MAY [15] CELL CYCLE 3 (5): 529-533
den Elzen N; Kosoy A; Christopoulos H; O'Connell MJ
Resisting arrest - Recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1
02
1214034 2004 MAY 15 GENES & DEVELOPMENT 18 (10): 1154-1164
Furuya K; Poitelea M; Guo L; Caspari T; Carr AM
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BCRT domains of Rad4(TOPBP1)
37
1313460 2004 MAY [15] TRENDS IN BIOCHEMICAL SCIENCES 29 (5): 227-232
Berwick DC; Tavare JM
Identifying protein kinase substrates: hunting for the organ-grinder's monkeys
04
1414431 2004 JUN 1 FEBS LETTERS 567 (1): 74-79
Castagnoli L; Costantini A; Dall'armi C; Gonfloni S; Montecchi-Palazzi L; et al.
Selectivity and promiscuity in the interaction network mediated by protein recognition modules
06
1521109 2004 JUN [15] CANCER BIOLOGY & THERAPY 3 (6): 521-527
Scully R; Xie AY; Nagaraju G
Molecular functions of BRCA1 in the DNA damage response
13
1629810 2004 JUN [15] CANCER BIOLOGY & THERAPY 3 (6): 528-533
Lane TF
BRCA1 and transcription
00
1713911 2004 JUN 15 CANCER RESEARCH 64 (12): 4148-4154
Gilmore PM; McCabe N; Quinn JE; Kennedy RD; Gorski JJ; et al.
BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3
02
1816516 2004 JUN [15] CURRENT OPINION IN CELL BIOLOGY 16 (3): 328-334
Lisby M; Rothstein R
DNA damage checkpoint and repair centers
213
1915718 2004 JUN [15] CURRENT OPINION IN GENETICS & DEVELOPMENT 14 (3): 292-300
Cobb JA; Shimada K; Gasser SM
Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response
09
2014435 2004 JUN [15] GENES TO CELLS 9 (6): 523-531
Ohashi E; Murakumo Y; Kanjo N; Akagi J; Masutani C; et al.
Interaction of hREV1 with three human Y-family DNA polymerases
219
#LCRNCRNode / Date / Journal / AuthorLCSGCS
2116549 2004 JUN [15] MOLECULAR GENETICS AND GENOMICS 271 (5): 603-615
Pierstorff E; Kane CM
Genetic interactions between an RNA polymerase II phosphatase and centromeric elements in Saccharomyces cerevisiae
00
2213655 2004 JUN [15] NATURE STRUCTURAL & MOLECULAR BIOLOGY 11 (6): 512-518
Clapperton JA; Manke IA; Lowery DM; Ho T; Haire LF; et al.
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
1317
2313656 2004 JUN [15] NATURE STRUCTURAL & MOLECULAR BIOLOGY 11 (6): 519-525
Williams RS; Lee MS; Hau DD; Glover JNM
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
1114
2411234 2004 [JUN 30] ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE 33: 225-244
Yaffe MB; Smerdon SJ
The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function
04
25222719 2004 [JUN 30] CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 63 63: 1-35
Ward I; Chen JJ
Early events in the DNA damage response
01
26112228 2004 [JUN 30] DNA REPAIR AND REPLICATION 69: 101-135
Wang JYJ; Cho SK
Coordination of repair, checkpoint, and cell death responses to DNA damage
00
2714842 2004 JUL 9 JOURNAL OF MOLECULAR BIOLOGY 340 (3): 469-475
Sturdy A; Naseem R; Webb M
Purification and characterisation of a soluble N-terminal fragment of the breast cancer susceptibility protein BRCA1
12
2819144 2004 JUL [15] MOLECULAR AND CELLULAR BIOLOGY 24 (14): 6215-6230
Nakamura TM; Du LL; Redon C; Russell P
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
318
2955258 2004 JUL [15] STRUCTURE 12 (7): 1137-1146
Botuyan MVE; Nomine Y; Yu XC; Juranic N; Macura S; et al.
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains
67
3012637 2004 AUG 13 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34091-34094
Xu XZ; Lee J; Stern DF
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
18
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3118620 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 845-854
Stracker TH; Theunissen JWF; Morales M; Petrini JHJ
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together
018
3215621 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 855-861
Kobayashi J; Antoccia A; Tauchi H; Matsuura S; Komatsu K
NBS1 and its functional role in the DNA damage response
15
33111222 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 889-900
Kurz EU; Lees-Miller SP
DNA damage-induced activation of ATM and ATM-dependent signaling pathways
023
34110323 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 901-908
Shechter D; Costanzo V; Gautier J
Regulation of DNA replication by ATR: signaling in response to DNA intermediates
09
3519824 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 909-918
Burma S; Chen DJ
Role of DNA-PK in the cellular response to DNA double-strand breaks
015
3615625 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 945-952
Mochan TA; Venere M; DiTullio RA; Halazonetis TD
53BP1, an activator of ATM in response to DNA damage
27
3714326 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 953-957
Stuck M; Jackson SP
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
25
3814127 2004 AUG-SEP [AUG 15] DNA REPAIR 3 (8-9): 1063-1069
Wang XZ; D'Andrea AD
The interplay of Fanconi anemia proteins in the DNA damage response
112
3917836 2004 AUG [15] IMMUNOLOGICAL REVIEWS 200: 156-164
McElhinny SAN; Ramsden DA
Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair
05
4016945 2004 AUG [15] MOLECULAR AND CELLULAR BIOLOGY 24 (16): 6947-6956
Moisan A; Larochelle C; Guillemette B; Gaudreau L
BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels
14
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4115051 2004 AUG [15] NATURE BIOTECHNOLOGY 22 (8): 993-1000
Nguyen A; Rothman DM; Stehn J; Imperiali B; Yaffe MB
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function
08
4216738 2004 SEP 3 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37282-37290
Wang YG; Nnakwe C; Lane WS; Modesti M; Frank KM
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase
02
4324139 2004 SEP 10 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (37): 38409-38414
Du LL; Moser BA; Russell P
Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2
12
4434559 2004 SEP [15] STRUCTURE 12 (9): 1551-1562
Charier G; Couprie J; Alpha-Bazin B; Meyer V; Quemeneur E; et al.
The tudor tandem of 53BP1: A new structural motif involved in DNA and RG-rich peptide binding
110
4515757 2004 SEP 16 ONCOGENE 23 (42): 7116-7124
Maiorana A; Tu XA; Cheng GJ; Baserga R
Role of pescadillo in the transformation and immortalization of mammalian cells
04
4618512 2004 SEP 17 CELL 118 (6): 699-713
Lisby M; Barlow JH; Burgess RC; Rothstein R
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
150
471595 2004 OCT 5 BIOCHEMISTRY 43 (39): 12648-12659
Feng H; Parker JM; Lu J; Cao WG
Effects of deletion and site-directed mutations on Ligation steps of NAD(+)-dependent DNA ligase: A biochemical analysis of BRCA1 C-terminal domain
01
48112515 2004 OCT [15] CHROMOSOMA 113 (4): 157-166
Assenmacher N; Hopfner KP
MRE11/RAD50/NBS1: complex activities
03
4911452 2004 OCT [15] NATURE CELL BIOLOGY 6 (10): 916-917
Ashworth A
Refocusing on BRCA1
01
50111353 2004 OCT [15] NATURE REVIEWS MOLECULAR CELL BIOLOGY 5 (10): 792-804
Bartek J; Lukas C; Lukas J
Checking on DNA damage in S phase
123
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5154046 2004 NOV [15] MOLECULAR AND CELLULAR BIOLOGY 24 (21): 9478-9486
Yu XC; Chen JJ
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
34
5266661 2004 NOV [15] TRENDS IN BIOCHEMICAL SCIENCES 29 (11): 579-585
Glover JNM; Williams RS; Lee MS
Interactions between BRCT repeats and phosphoproteins: tangled up in two
35
532238 2004 NOV 18 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1675 (1-3): 192-197
Myre MA; O'Day DH
Dictyostelium nucleomorphin is a member of the BRCT domain family of cell cycle checkpoint proteins
02
5449650 2004 NOV 18 NATURE 432 (7015): 316-323
Kastan MB; Bartek J
Cell-cycle checkpoints and cancer
136
5524717 2004 DEC [15] CURRENT OPINION IN CELL BIOLOGY 16 (6): 629-633
McGowan CH; Russell P
The DNA damage response: sensing and signaling
03
5623743 2004 DEC [15] JOURNAL OF RADIATION RESEARCH 45 (4): 473-478
Kobayashi J
Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain
01
5725754 2004 DEC [15] NATURE REVIEWS MOLECULAR CELL BIOLOGY 5 (12): 1038-1043
Ramadan K; Shevelev I; Hubscher U
The DNA-polymerase-X family: controllers of DNA quality?
03
5824648 2004 DEC 22 MOLECULAR CELL 16 (6): 979-990
Downs JA; Allard S; Jobin-Robitaille O; Javaheri A; Auger A; et al.
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
225
595736 2004 DEC 28 BIOCHEMISTRY 43 (51): 15983-15995
Gaiser OJ; Ball LJ; Schmieder P; Leitner D; Strauss H; et al.
Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1
00
602527 2004 DEC 28 BIOCHEMISTRY 43 (51): 16505-16514
Mani RS; Karimi-Busheri F; Fanta M; Caldecott KW; Cass CE; et al.
Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA
01
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Jowsey PA; Doherty AJ; Rouse J
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation
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6245690 2005 JAN 14 JOURNAL OF MOLECULAR BIOLOGY 345 (2): 275-287
Mark WY; Liao JCC; Lu Y; Ayed A; Laister R; et al.
Characterization of segments from the central region of BRCA1: An intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?
14
6336774 2005 JAN [15] CELL CYCLE 4 (1): 80-86
Fei PW; Yin JH; Wang WD
New advances in the DNA damage response network of Fanconi anemia and BRCA proteins - FAAP95 replaces BRCA2 as the true FANCB protein
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6428492 2005 JAN [15] JOURNAL OF VIROLOGY 79 (1): 569-580
Jurvansuu J; Raj K; Stasiak A; Beard P
Viral transport of DNA damage that mimics a stalled replication fork
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6514093 2005 JAN [15] MOLECULAR AND CELLULAR BIOLOGY 25 (2): 779-788
Adams DJ; van der Weyden L; Gergely FV; Arends MJ; Ng BL; et al.
BRCTx is a novel, highly conserved RAD18-interacting protein
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Joughin BA; Tidor B; Yaffe MB
A computational method for the analysis and prediction of protein: phosphopeptide-binding sites
02
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Li L; Zou L
Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells
00
6835379 2005 FEB 25 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6993-7001
Au WWY; Henderson BR
The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
11
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Abbott KL; Archambault J; Xiao H; Nguyen BD; Roeder RG; et al.
Interactions of the HIV-1 tat and RAP74 proteins with the RNA polymerase IICTD phosphatase FCP1
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Monti S; Savage KJ; Kutok JL; Feuerhake F; Kurtin P; et al.
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
71111598 2005 MAR 3 ONCOGENE 24 (10): 1653-1662
Yang XJ
Multisite protein modi. cation and intramolecular signaling
04
7214580 2005 MAR 4 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 8172-8179
Lo KWH; Kan HM; Chan LN; Xu WG; Wang KP; et al.
The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation
00
7314177 2005 MAR [15] GENETICS 169 (3): 1451-1460
Holway AH; Hung C; Michael WM
Systematic, RNA-hiterference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans
00
7415576 2005 MAR 21 FEBS LETTERS 579 (8): 1808-1814
Pawson T; Linding R
Synthetic modular systems - reverse engineering of signal transduction
00
7555669 2005 APR 1 BIOPHYSICAL CHEMISTRY 114 (1): 1-12
Pyrpassopoulos S; Ladopoulou A; Vlassi M; Papanikolau Y; Vorgias CE; et al.
Thermal denaturation of the BRCT tandem repeat region of human tumour suppressor gene product BRCA1
00
7639367 2005 APR [15] BIOESSAYS 27 (4): 397-407
Traven A; Heierhorst J
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
01
7714281 2005 APR 15 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (15): 14709-14715
Chen BPC; Chan DW; Kobayashi J; Burma S; Asaithamby A; et al.
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
01
7827188 2005 MAY 1 JOURNAL OF CELL SCIENCE 118 (9): 2043-2055
Pryde F; Khalili S; Robertson K; Selfridge J; Ritchie AM; et al.
53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin
00
7915799 2005 MAY 26 ONCOGENE 24 (23): 3726-3736
Feki A; Jefford CE; Berardi P; Wu JY; Cartier L; et al.
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
00
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Hassa PO; Hottiger MO
An epigenetic code for DNA damage repair pathways?
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
8125475 2005 JUN [15] CURRENT OPINION IN GENETICS & DEVELOPMENT 15 (3): 241-248
Ponting C; Jackson AP
Evolution of primary microcephaly genes and the enlargement of primate brains
01
8225796 2005 [JUN 30] NUCLEIC ACIDS RESEARCH 33 (1): 356-365
Jansen JG; Tsaalbi-Shtylik A; Langerak P; Calleja F; Meijers CM; et al.
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis
12
8334497 2005 [JUN 30] NUCLEIC ACIDS RESEARCH 33 (4): 1280-1289
Ross AL; Simpson LJ; Sale JE
Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1
00
84415266 2005 JUL [15] BIOCHIMIE 87 (7): 579-589
Lisby M; Rothstein R
Localization of checkpoint and repair proteins in eukaryotes
00
8513378 2005 JUL [15] GYNECOLOGIC ONCOLOGY 98 (1): 68-76
He QY; Zhou Y; Wong E; Ehlen TG; Auersperg N; et al.
Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies
00
8613495 2005 JUL [15] NATURE STRUCTURAL & MOLECULAR BIOLOGY 12 (7): 589-593
Lou ZK; Minter-Dykhouse K; Chen JJ
BRCA1 participates in DNA decatenation
11
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Salgado J; Zabalegui N; Garcia-Amigot F; Gil MC; Gonzalez MS; et al.
Structure-based assessment of BRCA1 and BRCA2 mutations in a small Spanish population
00
8864886 2005 JUL 18 JOURNAL OF CELL BIOLOGY 170 (2): 201-211
Bekker-Jensen S; Lukas C; Melander F; Bartek J; Lukas J
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
00
8924282 2005 AUG 12 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (32): 29374-29380
Zeng L; Hu YY; Li BJ
Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression
00
9021371 2005 AUG [15] CANCER CELL 8 (2): 95-97
Ashworth A
Oh what a tangled web it weaves: BRCA1 and DNA decatenation
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
9114187 2005 AUG 15 JOURNAL OF CELL BIOLOGY 170 (4): 571-582
Yuce O; Piekny A; Glotzer M
An ECT2-centralspindlin complex regulates the localization and function of RhoA
00
9264464 2005 AUG 23 BIOCHEMISTRY 44 (33): 10941-10946
Varma AK; Brown RS; Birrane G; Ladias JAA
Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex
00
9315373 2005 AUG 26 CELL 122 (4): 579-591
Zinkel SS; Hurov KE; Ong C; Abtahl FM; Gross A; et al.
A role for proapoptotic BID in the DNA-damage response
03
9434983 2005 AUG 26 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (34): 30206-30213
Beernink PT; Hwang M; Ramirez M; Murphy MB; Doyle SA; et al.
Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein
00
9515184 2005 SEP 2 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (35): 30984-30993
Keilhack H; David FS; McGregor M; Cantley LC; Neel BG
Diverse biochemical properties of Shp2 mutants
00
9657072 2005 SEP 8 CANCER LETTERS 227 (1): 1-7
Billack B; Monteiro ANA
BRCA1 in breast and ovarian cancer predisposition
00
9739568 2005 SEP [15] BIOESSAYS 27 (9): 884-893
Henderson BR
Regulation of BRICA1, BRCA2 and BARD1 intracellular trafficking
00
98245391 2005 SEP-OCT [SEP 15] JOURNAL OF MOLECULAR RECOGNITION 18 (5): 343-384
Uversky VN; Oldfield CJ; Dunker AK
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
00
9962894 2005 SEP [15] NATURE GENETICS 37 (9): 953-957
Bridge WL; Vandenberg CJ; Franklin RJ; Hiom K
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
01
10062385 2005 SEP 16 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (37): 32053-32056
Lee MS; Edwards RA; Thede GL; Glover JNM
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail
00

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