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ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML
SCIENCE 295:(5556)858-861 FEB 1 2002
and the citing papers

Nodes: 199
Authors: 610, Journals: 112, Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
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#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
101134101 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20235-20239
Wright G; Higgin JJ; Raines RT; Steenbergen C; Murphy E
Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes
23
102159102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(25):22316-22324
Del Toro R; Levitsky KL; Lopez-Barneo J; Chiara MD
Induction of T-type calcium channel gene expression by chronic hypoxia
05
103430103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780
Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
820
104436104 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(34):31895-31901
Naranjo-Suarez S; Castellanos MC; Alvarez-Tejado M; Vara A; Landazuri MO; del Peso L
Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation
02
105158105 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33384-33391
Kodama T; Shimizu N; Yoshikawa N; Makino Y; Ouchida R; Okamoto K; Hisada T; Nakamura H; Morimoto C; Tanaka H
Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression
00
106163106 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(38):35878-35888
Lees MJ; Peet DJ; Whitelaw ML
Defining the role for XAP2 in stabilization of the dioxin receptor
02
107351107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304
Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT
The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
03
108442108 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326
Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
922
109149109 2003 JOURNAL OF CELL SCIENCE 116(11):2247-2260
Turcotte S; Desrosiers RR; Beliveau R
HIF-1 alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
25
1101797110 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049
Masson N; Ratcliffe PJ
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels
28
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
111150111 2003 JOURNAL OF CLINICAL INVESTIGATION 111(5):571-574
Soberman RJ
The expanding network of redox signaling: new observations, complexities, and perspectives
08
112675112 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783
Safran M; Kaelin WG
HIF hydroxylation and the mammalian oxygen-sensing pathway
123
113170113 2003 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26(9):832-837
Jelkmann W
Erythropoietin
00
114146114 2003 JOURNAL OF IMMUNOLOGY 171(12):6534-6540
Makino Y; Nakamura H; Ikeda E; Ohnuma K; Yamauchi K; Yabe Y; Poellinger L; Okada Y; Morimoto C; Tanaka H
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
00
115118115 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(16):4710-4711
Kinzie SD; Thevis M; Ngo K; Whitelegge J; Loo JA; Abu-Omar MM
Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron
02
1162107116 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(26):7828-7842
Mehn MP; Fujisawa K; Hegg EL; Que L
Oxygen activation by nonheme iron(II) complexes: alpha-keto carboxylate versus carboxylate
110
11711104117 2003 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14(11):2712-2722
Maxwell P
HIF-1: An oxygen response system with special relevance to the kidney
22
118142118 2003 MOLECULAR AND CELLULAR BIOLOGY 23(1):359-369
Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS
Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia
624
119449119 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971
Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha
514
120241120 2003 MOLECULAR AND CELLULAR BIOLOGY 23(19):6739-6749
Tomita S; Ueno M; Sakamoto M; Kitahama Y; Ueki M; Maekawa N; Sakamoto H; Gassmann M; Kageyama R; Ueda N; Gonzalez FJ; Takahama Y
Defective brain development in mice lacking the Hif-1 alpha gene in neural cells
34
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1215111121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374
Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC
Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation
16
122235122 2003 MOLECULAR BIOLOGY OF THE CELL 14(6):2216-2225
Zhou J; Schmid T; Brune B
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 alpha through a nuclear factor-kappa B-dependent pathway
34
123659123 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481
Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B
Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases
613
124374124 2003 MOLECULAR CANCER THERAPEUTICS 2(3):235-243
Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation
412
125234125 2003 MOLECULAR PHARMACOLOGY 64(6):1485-1493
Davidson T; Salnikow K; Costa M
Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel
00
126856126 2003 MOLECULES AND CELLS 16(1):1-12
Freeman RS; Hasbani DM; Lipscomb EA; Straub JA; Xie L
SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
01
1278115127 2003 NATURE MEDICINE 9(6):677-684
Pugh CW; Ratcliffe PJ
Regulation of angiogenesis by hypoxia: role of the HIF system
1066
12811107128 2003 NATURE REVIEWS CANCER 3(10):721-732
Semenza GL
Targeting HIF-1 for cancer therapy
647
12911116129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811
Giaccia A; Siim BG; Johnson RS
HIF-1 as a target for drug development
215
130848130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512
Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ
Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2
26
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
131140131 2003 NEOPLASMA 50(1):13-21
Chrastina A; Pastorekova S; Pastorek J
Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by I-125-labeled M75 monoclonal antibody
02
132155132 2003 PLACENTA 24(2-3):199-208
Rajakumar A; Doty K; Daftary A; Harger G; Conrad KP
Impaired oxygen-dependent reduction of HIF-1 alpha and -2 alpha proteins in pre-eclamptic placentae
47
133457133 2003 PLACENTA 24(10):941-950
Schaffer L; Scheid A; Spielmann P; Breymann C; Zimmermann R; Meuli M; Gassmann M; Marti HH; Wenger RH
Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation
12
134121134 2003 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 17(5):371-376
Hirota J; Satomi Y; Yoshikawa K; Takao T
epsilon-N,N,N-Trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry
02
135297135 2003 REDOX REPORT 8(6):325-340
Land SC
Oxygen-sensing pathways and the development of mammalian gas exchange
00
136214136 2003 SCIENTIST 17(8):34-35
Russo E
Discovering HIF regulation
00
137456137 2003 SEIKAGAKU 75(7):577-587
Tomita T; Saito MI
Recent progress in biochemical studies of hemoprotein
00
138278138 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89
Pugh CW; Ratcliffe PJ
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis
321
139282139 2003 STRAHLENTHERAPIE UND ONKOLOGIE 179(12):801-811
Vordermark D; Brown JM
Endogenous markers of tumor hypoxia - Predictors of clinical radiation resistance?
02
140153140 2003 THROMBOSIS AND HAEMOSTASIS 89(4):666-673
Kietzmann T; Jungermann K; Gorlach A
Regulation of the hypoxia-dependent plasminogen activator inhibitor I expression by MAP kinases
04
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
141272141 2003 TOR-TARGET OF RAPAMYCIN 279:299-319
Abraham RT
MTOR as a positive regulator of tumor cell responses to hypoxia
00
142255142 2003 TRENDS IN ENDOCRINOLOGY AND METABOLISM 14(10):453-459
Baysal BE
On the association of succinate dehydrogenase mutations with hereditary paraganglioma
01
1434152143 2004 AMERICAN JOURNAL OF NEPHROLOGY 24(1):1-13
Maynard MA; Ohh M
von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer
00
144462144 2004 AMERICAN JOURNAL OF PATHOLOGY 164(6):1875-1882
Michiels C
Physiological and pathological responses to hypoxia
00
14518268145 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(4):R608-R623
Hopfl G; Ogunshola O; Gassmann M
HIFs and tumors - causes and consequences
04
1468165146 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(6):R977-R988
Fandrey J
Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
00
147238147 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 287(3):R600-R607
Ma Y; Freitag P; Zhou J; Brune B; Frede S; Fandrey J
Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1
00
148354148 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 286(2):F338-F348
Turcotte S; Desrosiers RR; Beliveau R
Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma
00
149489149 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 287(1):F1-F6
Sufan RI; Jewett MAS; Ohh M
The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma
00
1504131150 2004 ANTIOXIDANTS & REDOX SIGNALING 6(1):155-167
Asikainen TM; White CW
Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: Implications for antioxidant therapy
01
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1516135151 2004 ARTHRITIS AND RHEUMATISM 50(1):10-23
Distler JHW; Wenger RH; Gassmann M; Kurowska M; Hirth A; Gay S; Distler O
Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis
01
152271152 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 316(4):969-977
Haddad JJ
Oxygen sensing and oxidant/redox-related pathways
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153338153 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317(1):84-91
Takahashi R; Kobayashi C; Kondo Y; Nakatani Y; Kudo I; Kunimoto M; Imura N; Hara S
Subcellular localization and regulation of hypoxia-inducible factor-2 alpha in vascular endothelial cells
00
154121154 2004 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1691(1):17-22
Daly EB; Wind T; Jiang XM; Sun L; Hogg PJ
Secretion of phosphoglycerate kinase from tumour cells is controlled by oxygen-sensing hydroxylases
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155984155 2004 BIOESSAYS 26(3):262-269
Bardos JI; Athcroft M
Hypoxia-inducible factor-1 and oncogenic signalling
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1562190156 2004 BIOLOGICAL CHEMISTRY 385(3-4):223-230
Metzen E; Ratcliffe PJ
HIF hydroxylation and cellular oxygen sensing
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157237157 2004 BIOLOGICAL CHEMISTRY 385(3-4):231-237
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Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures
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158134158 2004 CANCER RESEARCH 64(2):456-462
Datta K; Li JP; Bhattacharya R; Gasparian L; Wang EF; Mukhopadhyay D
Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer
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159151159 2004 CANCER RESEARCH 64(5):1765-1772
Mizukami Y; Li JN; Zhang XB; Zimmer MA; Iliopoulos O; Chung DC
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
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1604114160 2004 CARDIOVASCULAR RESEARCH 62(1):43-52
Martinez-Ruiz A; Lamas S
S-nitrosylation: a potential new paradigm in signal transduction
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161840161 2004 CELL CYCLE 3(2):156-159
Maxwell PH
HIF-1's relationship to oxygen - Simple yet sophisticated
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Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates
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Fe(II)/alpha-ketoglutarate-dependent hydroxylases and related enzymes
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164845164 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14(1):81-85
Poellinger L; Johnson RS
HIF-1 and hypoxic response: the plot thickens
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16521144165 2004 CURRENT PHARMACEUTICAL DESIGN 10(8):821-833
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Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer
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Targeting hypoxia tolerance in cancer
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Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions
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1682111168 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13(7):829-839
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Targeting hypoxia-inducible factor-1 for therapy and prevention
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1701143170 2004 FASEB JOURNAL 18(6)
Kageyama Y; Koshiji M; To KKW; Tian YM; Ratcliffe PJ; Huang LE
Leu-574 of human HIF-1a is a molecular determinant of prolyl hydroxylation
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171544171 2004 FASEB JOURNAL 18(10)
Warnecke C; Zaborowska Z; Kurreck J; Erdmann VA; Frei U; Wiesener M; Eckardt KU
Differentiating the functional role of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2 alpha target gene in Hep3B and Kelly cells
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172248172 2004 FASEB JOURNAL 18(10)
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Persistent induction of HIF-1 alpha and -2 alpha in cardiomyocytes and stromal cells of ischemic myocardium
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173391173 2004 FEBS LETTERS 569(1-3):1-6
Kinnula VL; Paakko P; Soini Y
Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung
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1741278174 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(6):718-744
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Superoxide dismutases in malignant cells and human tumors
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175152175 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(10):1279-1288
Goyal P; Weissmann N; Grimminger F; Hegel C; Bader L; Rose F; Fink L; Ghofrani HA; Schermuly RT; Schmidt HHHW; Seeger W; Hanze J
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species
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176165176 2004 INTERNATIONAL JOURNAL OF CANCER 111(1):43-50
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Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
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177152177 2004 JOURNAL OF APPLIED PHYSIOLOGY 96(3):1173-1177
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Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2 - Regulation by competition between intrinsically unstructured ligands for non-identical binding sites
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179931179 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904
Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
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180541180 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):13506-13513
Zhou J; Schmid T; Frank R; Brune B
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1 alpha from pVHL-independent degradation
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1811035181 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14391-14397
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1821042182 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501
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Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors
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184774184 2004 JOURNAL OF PHARMACOLOGICAL SCIENCES 94(3):221-232
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Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools
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185340185 2004 MOLECULAR CANCER RESEARCH 2(1):43-52
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1865168186 2004 NATURE REVIEWS CANCER 4(5):381-393
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Searching for the hereditary causes of renal-cell carcinoma
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18722108187 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5(5):343-354
Schofield CJ; Ratcliffe PJ
Oxygen sensing by HIF hydroxylases
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Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity
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190127190 2004 OXYGEN SENSING 381:133-+
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Perceived hyperoxia: Oxygen-regulated signal transduction pathways in the heart
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191427191 2004 OXYGEN SENSING 381:305-320
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Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing
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192334192 2004 OXYGEN SENSING 381:467-487
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Oxygen-dependent asparagine hydroxylation
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Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: Activation of hypoxia-inducible factor 1 alpha
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Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of beta 2 integrin gene expression
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196327196 2004 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 141(2):115-123
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Effects of iron-chelators on ion-channels and HIF-1 alpha in the carotid body
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Mukhopadhyay D; Datta K
Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors
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Walmsley SR; Sheares KKK; Sobolewski A; Morrell NW; Chilvers ER
New insights into oxygen sensing at a cellular level
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Zhao JH; Chen HB; Davidson T; Kluz T; Zhang QW; Costa M
Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway
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