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ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML SCIENCE 295:(5556)858-861 FEB 1 2002 and the citing papers |
Nodes: 199
Authors: 610,
Journals: 112,
Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
Page 2: 1 (1) 2 (101)
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
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101 | 1 | 34 | 101 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20235-20239 Wright G; Higgin JJ; Raines RT; Steenbergen C; Murphy E Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes | 2 | 3 |
102 | 1 | 59 | 102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(25):22316-22324 Del Toro R; Levitsky KL; Lopez-Barneo J; Chiara MD Induction of T-type calcium channel gene expression by chronic hypoxia | 0 | 5 |
103 | 4 | 30 | 103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780 Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor | 8 | 20 |
104 | 4 | 36 | 104 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(34):31895-31901 Naranjo-Suarez S; Castellanos MC; Alvarez-Tejado M; Vara A; Landazuri MO; del Peso L Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation | 0 | 2 |
105 | 1 | 58 | 105 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33384-33391 Kodama T; Shimizu N; Yoshikawa N; Makino Y; Ouchida R; Okamoto K; Hisada T; Nakamura H; Morimoto C; Tanaka H Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression | 0 | 0 |
106 | 1 | 63 | 106 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(38):35878-35888 Lees MJ; Peet DJ; Whitelaw ML Defining the role for XAP2 in stabilization of the dioxin receptor | 0 | 2 |
107 | 3 | 51 | 107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304 Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia | 0 | 3 |
108 | 4 | 42 | 108 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326 Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing | 9 | 22 |
109 | 1 | 49 | 109 2003 JOURNAL OF CELL SCIENCE 116(11):2247-2260 Turcotte S; Desrosiers RR; Beliveau R HIF-1 alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma | 2 | 5 |
110 | 17 | 97 | 110 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049 Masson N; Ratcliffe PJ HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels | 2 | 8 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
111 | 1 | 50 | 111 2003 JOURNAL OF CLINICAL INVESTIGATION 111(5):571-574 Soberman RJ The expanding network of redox signaling: new observations, complexities, and perspectives | 0 | 8 |
112 | 6 | 75 | 112 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783 Safran M; Kaelin WG HIF hydroxylation and the mammalian oxygen-sensing pathway | 1 | 23 |
113 | 1 | 70 | 113 2003 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26(9):832-837 Jelkmann W Erythropoietin | 0 | 0 |
114 | 1 | 46 | 114 2003 JOURNAL OF IMMUNOLOGY 171(12):6534-6540 Makino Y; Nakamura H; Ikeda E; Ohnuma K; Yamauchi K; Yabe Y; Poellinger L; Okada Y; Morimoto C; Tanaka H Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells | 0 | 0 |
115 | 1 | 18 | 115 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(16):4710-4711 Kinzie SD; Thevis M; Ngo K; Whitelegge J; Loo JA; Abu-Omar MM Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron | 0 | 2 |
116 | 2 | 107 | 116 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(26):7828-7842 Mehn MP; Fujisawa K; Hegg EL; Que L Oxygen activation by nonheme iron(II) complexes: alpha-keto carboxylate versus carboxylate | 1 | 10 |
117 | 11 | 104 | 117 2003 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14(11):2712-2722 Maxwell P HIF-1: An oxygen response system with special relevance to the kidney | 2 | 2 |
118 | 1 | 42 | 118 2003 MOLECULAR AND CELLULAR BIOLOGY 23(1):359-369 Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia | 6 | 24 |
119 | 4 | 49 | 119 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971 Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha | 5 | 14 |
120 | 2 | 41 | 120 2003 MOLECULAR AND CELLULAR BIOLOGY 23(19):6739-6749 Tomita S; Ueno M; Sakamoto M; Kitahama Y; Ueki M; Maekawa N; Sakamoto H; Gassmann M; Kageyama R; Ueda N; Gonzalez FJ; Takahama Y Defective brain development in mice lacking the Hif-1 alpha gene in neural cells | 3 | 4 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
121 | 5 | 111 | 121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
122 | 2 | 35 | 122 2003 MOLECULAR BIOLOGY OF THE CELL 14(6):2216-2225 Zhou J; Schmid T; Brune B Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 alpha through a nuclear factor-kappa B-dependent pathway | 3 | 4 |
123 | 6 | 59 | 123 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481 Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases | 6 | 13 |
124 | 3 | 74 | 124 2003 MOLECULAR CANCER THERAPEUTICS 2(3):235-243 Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation | 4 | 12 |
125 | 2 | 34 | 125 2003 MOLECULAR PHARMACOLOGY 64(6):1485-1493 Davidson T; Salnikow K; Costa M Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel | 0 | 0 |
126 | 8 | 56 | 126 2003 MOLECULES AND CELLS 16(1):1-12 Freeman RS; Hasbani DM; Lipscomb EA; Straub JA; Xie L SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases | 0 | 1 |
127 | 8 | 115 | 127 2003 NATURE MEDICINE 9(6):677-684 Pugh CW; Ratcliffe PJ Regulation of angiogenesis by hypoxia: role of the HIF system | 10 | 66 |
128 | 11 | 107 | 128 2003 NATURE REVIEWS CANCER 3(10):721-732 Semenza GL Targeting HIF-1 for cancer therapy | 6 | 47 |
129 | 11 | 116 | 129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 2 | 15 |
130 | 8 | 48 | 130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 2 | 6 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
131 | 1 | 40 | 131 2003 NEOPLASMA 50(1):13-21 Chrastina A; Pastorekova S; Pastorek J Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by I-125-labeled M75 monoclonal antibody | 0 | 2 |
132 | 1 | 55 | 132 2003 PLACENTA 24(2-3):199-208 Rajakumar A; Doty K; Daftary A; Harger G; Conrad KP Impaired oxygen-dependent reduction of HIF-1 alpha and -2 alpha proteins in pre-eclamptic placentae | 4 | 7 |
133 | 4 | 57 | 133 2003 PLACENTA 24(10):941-950 Schaffer L; Scheid A; Spielmann P; Breymann C; Zimmermann R; Meuli M; Gassmann M; Marti HH; Wenger RH Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation | 1 | 2 |
134 | 1 | 21 | 134 2003 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 17(5):371-376 Hirota J; Satomi Y; Yoshikawa K; Takao T epsilon-N,N,N-Trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry | 0 | 2 |
135 | 2 | 97 | 135 2003 REDOX REPORT 8(6):325-340 Land SC Oxygen-sensing pathways and the development of mammalian gas exchange | 0 | 0 |
136 | 2 | 14 | 136 2003 SCIENTIST 17(8):34-35 Russo E Discovering HIF regulation | 0 | 0 |
137 | 4 | 56 | 137 2003 SEIKAGAKU 75(7):577-587 Tomita T; Saito MI Recent progress in biochemical studies of hemoprotein | 0 | 0 |
138 | 2 | 78 | 138 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89 Pugh CW; Ratcliffe PJ The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis | 3 | 21 |
139 | 2 | 82 | 139 2003 STRAHLENTHERAPIE UND ONKOLOGIE 179(12):801-811 Vordermark D; Brown JM Endogenous markers of tumor hypoxia - Predictors of clinical radiation resistance? | 0 | 2 |
140 | 1 | 53 | 140 2003 THROMBOSIS AND HAEMOSTASIS 89(4):666-673 Kietzmann T; Jungermann K; Gorlach A Regulation of the hypoxia-dependent plasminogen activator inhibitor I expression by MAP kinases | 0 | 4 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
141 | 2 | 72 | 141 2003 TOR-TARGET OF RAPAMYCIN 279:299-319 Abraham RT MTOR as a positive regulator of tumor cell responses to hypoxia | 0 | 0 |
142 | 2 | 55 | 142 2003 TRENDS IN ENDOCRINOLOGY AND METABOLISM 14(10):453-459 Baysal BE On the association of succinate dehydrogenase mutations with hereditary paraganglioma | 0 | 1 |
143 | 4 | 152 | 143 2004 AMERICAN JOURNAL OF NEPHROLOGY 24(1):1-13 Maynard MA; Ohh M von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer | 0 | 0 |
144 | 4 | 62 | 144 2004 AMERICAN JOURNAL OF PATHOLOGY 164(6):1875-1882 Michiels C Physiological and pathological responses to hypoxia | 0 | 0 |
145 | 18 | 268 | 145 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(4):R608-R623 Hopfl G; Ogunshola O; Gassmann M HIFs and tumors - causes and consequences | 0 | 4 |
146 | 8 | 165 | 146 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(6):R977-R988 Fandrey J Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression | 0 | 0 |
147 | 2 | 38 | 147 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 287(3):R600-R607 Ma Y; Freitag P; Zhou J; Brune B; Frede S; Fandrey J Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1 | 0 | 0 |
148 | 3 | 54 | 148 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 286(2):F338-F348 Turcotte S; Desrosiers RR; Beliveau R Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma | 0 | 0 |
149 | 4 | 89 | 149 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 287(1):F1-F6 Sufan RI; Jewett MAS; Ohh M The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma | 0 | 0 |
150 | 4 | 131 | 150 2004 ANTIOXIDANTS & REDOX SIGNALING 6(1):155-167 Asikainen TM; White CW Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: Implications for antioxidant therapy | 0 | 1 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
151 | 6 | 135 | 151 2004 ARTHRITIS AND RHEUMATISM 50(1):10-23 Distler JHW; Wenger RH; Gassmann M; Kurowska M; Hirth A; Gay S; Distler O Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis | 0 | 1 |
152 | 2 | 71 | 152 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 316(4):969-977 Haddad JJ Oxygen sensing and oxidant/redox-related pathways | 0 | 0 |
153 | 3 | 38 | 153 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317(1):84-91 Takahashi R; Kobayashi C; Kondo Y; Nakatani Y; Kudo I; Kunimoto M; Imura N; Hara S Subcellular localization and regulation of hypoxia-inducible factor-2 alpha in vascular endothelial cells | 0 | 0 |
154 | 1 | 21 | 154 2004 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1691(1):17-22 Daly EB; Wind T; Jiang XM; Sun L; Hogg PJ Secretion of phosphoglycerate kinase from tumour cells is controlled by oxygen-sensing hydroxylases | 0 | 0 |
155 | 9 | 84 | 155 2004 BIOESSAYS 26(3):262-269 Bardos JI; Athcroft M Hypoxia-inducible factor-1 and oncogenic signalling | 0 | 0 |
156 | 21 | 90 | 156 2004 BIOLOGICAL CHEMISTRY 385(3-4):223-230 Metzen E; Ratcliffe PJ HIF hydroxylation and cellular oxygen sensing | 0 | 0 |
157 | 2 | 37 | 157 2004 BIOLOGICAL CHEMISTRY 385(3-4):231-237 Berchner-Pfannschmidt U; Wotzlaw C; Merten E; Acker H; Fandrey J Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures | 0 | 0 |
158 | 1 | 34 | 158 2004 CANCER RESEARCH 64(2):456-462 Datta K; Li JP; Bhattacharya R; Gasparian L; Wang EF; Mukhopadhyay D Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer | 1 | 2 |
159 | 1 | 51 | 159 2004 CANCER RESEARCH 64(5):1765-1772 Mizukami Y; Li JN; Zhang XB; Zimmer MA; Iliopoulos O; Chung DC Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer | 0 | 0 |
160 | 4 | 114 | 160 2004 CARDIOVASCULAR RESEARCH 62(1):43-52 Martinez-Ruiz A; Lamas S S-nitrosylation: a potential new paradigm in signal transduction | 0 | 1 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
161 | 8 | 40 | 161 2004 CELL CYCLE 3(2):156-159 Maxwell PH HIF-1's relationship to oxygen - Simple yet sophisticated | 0 | 1 |
162 | 4 | 513 | 162 2004 CHEMICAL REVIEWS 104(2):939-986 Costas M; Mehn MP; Jensen MP; Que L Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates | 0 | 5 |
163 | 8 | 340 | 163 2004 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 39(1):21-68 Hausinger RP Fe(II)/alpha-ketoglutarate-dependent hydroxylases and related enzymes | 0 | 0 |
164 | 8 | 45 | 164 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14(1):81-85 Poellinger L; Johnson RS HIF-1 and hypoxic response: the plot thickens | 0 | 0 |
165 | 21 | 144 | 165 2004 CURRENT PHARMACEUTICAL DESIGN 10(8):821-833 Hewitson KS; McNeill LA; Schofield CJ Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer | 0 | 1 |
166 | 7 | 174 | 166 2004 DRUG RESISTANCE UPDATES 7(1):25-40 Wouters BG; van den Beucken T; Magagnin MG; Lambin P; Koumenis C Targeting hypoxia tolerance in cancer | 0 | 0 |
167 | 10 | 123 | 167 2004 EXPERIMENTAL AND MOLECULAR MEDICINE 36(1):1-12 Lee JW; Bae SH; Jeong JW; Kim SH; Kim KW Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions | 0 | 0 |
168 | 2 | 111 | 168 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13(7):829-839 Rebar EJ Development of proangiogenic engineered transcription factors for the treatment of cardiovascular disease | 0 | 0 |
169 | 24 | 185 | 169 2004 EXPERT OPINION ON THERAPEUTIC PATENTS 14(7):951-966 Zhong H Targeting hypoxia-inducible factor-1 for therapy and prevention | 0 | 0 |
170 | 11 | 43 | 170 2004 FASEB JOURNAL 18(6) Kageyama Y; Koshiji M; To KKW; Tian YM; Ratcliffe PJ; Huang LE Leu-574 of human HIF-1a is a molecular determinant of prolyl hydroxylation | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
171 | 5 | 44 | 171 2004 FASEB JOURNAL 18(10) Warnecke C; Zaborowska Z; Kurreck J; Erdmann VA; Frei U; Wiesener M; Eckardt KU Differentiating the functional role of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2 alpha target gene in Hep3B and Kelly cells | 0 | 0 |
172 | 2 | 48 | 172 2004 FASEB JOURNAL 18(10) Jurgensen JS; Rosenberger C; Wiesener MS; Warnecke C; Horstrup JH; Grafe M; Philipp S; Griethe W; Maxwell PH; Frei U; Bachmann S; Willenbrock R; Eckardt KU Persistent induction of HIF-1 alpha and -2 alpha in cardiomyocytes and stromal cells of ischemic myocardium | 0 | 0 |
173 | 3 | 91 | 173 2004 FEBS LETTERS 569(1-3):1-6 Kinnula VL; Paakko P; Soini Y Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung | 0 | 0 |
174 | 1 | 278 | 174 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(6):718-744 Kinnula VL; Crapo JD Superoxide dismutases in malignant cells and human tumors | 1 | 3 |
175 | 1 | 52 | 175 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(10):1279-1288 Goyal P; Weissmann N; Grimminger F; Hegel C; Bader L; Rose F; Fink L; Ghofrani HA; Schermuly RT; Schmidt HHHW; Seeger W; Hanze J Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species | 0 | 0 |
176 | 1 | 65 | 176 2004 INTERNATIONAL JOURNAL OF CANCER 111(1):43-50 Swinson DEB; Jones JL; Cox G; Richardson D; Harris AL; O'Byrne KJ Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways | 0 | 0 |
177 | 1 | 52 | 177 2004 JOURNAL OF APPLIED PHYSIOLOGY 96(3):1173-1177 Semenza GL O-2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1 | 1 | 1 |
178 | 5 | 32 | 178 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(4):3042-3049 De Guzman RN; Martinez-Yamout MA; Dyson HJ; Wright PE Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2 - Regulation by competition between intrinsically unstructured ligands for non-identical binding sites | 0 | 0 |
179 | 9 | 31 | 179 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904 Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | 1 | 1 |
180 | 5 | 41 | 180 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):13506-13513 Zhou J; Schmid T; Frank R; Brune B PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1 alpha from pVHL-independent degradation | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
181 | 10 | 35 | 181 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14391-14397 Linke S; Stojkoski C; Kewley RJ; Booker GW; Whitelaw ML; Peet DJ Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor | 2 | 2 |
182 | 10 | 42 | 182 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501 Aprelikova O; Chandramouli GVR; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors | 0 | 0 |
183 | 3 | 88 | 183 2004 JOURNAL OF NEUROSURGERY 100(3):488-497 Jensen RL; Gillespie D; House P; Layfield L; Shelton C Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1 alpha expression | 0 | 0 |
184 | 7 | 74 | 184 2004 JOURNAL OF PHARMACOLOGICAL SCIENCES 94(3):221-232 Park JW; Chun YS; Kim NS Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools | 0 | 0 |
185 | 3 | 40 | 185 2004 MOLECULAR CANCER RESEARCH 2(1):43-52 Qi H; Gervais ML; Li W; DeCaprio JA; Challis JRG; Ohh M Molecular cloning and characterization of the von Hippel-Lindau-like protein | 0 | 0 |
186 | 5 | 168 | 186 2004 NATURE REVIEWS CANCER 4(5):381-393 Pavlovich CP; Schmidt LS Searching for the hereditary causes of renal-cell carcinoma | 0 | 0 |
187 | 22 | 108 | 187 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5(5):343-354 Schofield CJ; Ratcliffe PJ Oxygen sensing by HIF hydroxylases | 0 | 0 |
188 | 14 | 190 | 188 2004 NATURE REVIEWS NEUROSCIENCE 5(6):437-448 Sharp FR; Bernaudin M HIf1 and oxygen sensing in the brain | 0 | 0 |
189 | 2 | 23 | 189 2004 ONCOGENE 23(13):2315-2323 Lewis MD; Roberts BJ Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity | 0 | 0 |
190 | 1 | 27 | 190 2004 OXYGEN SENSING 381:133-+ Roy S; Khanna S; Sen CK Perceived hyperoxia: Oxygen-regulated signal transduction pathways in the heart | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
191 | 4 | 27 | 191 2004 OXYGEN SENSING 381:305-320 Masson N; Ratcliffe PJ Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing | 0 | 0 |
192 | 3 | 34 | 192 2004 OXYGEN SENSING 381:467-487 Peet DJ; Lando D; Whelan DA; Whitelaw ML; Gorman JJ Oxygen-dependent asparagine hydroxylation | 0 | 0 |
193 | 1 | 45 | 193 2004 PEDIATRIC RESEARCH 55(3):385-394 Wang XH; Deng JX; Boyle DW; Zhong J; Lee WH Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: Activation of hypoxia-inducible factor 1 alpha | 0 | 0 |
194 | 1 | 40 | 194 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(12):4302-4307 Liu Q; Berchner-Pfannschmidt U; Moller U; Brecht M; Wotzlaw C; Acker H; Jungermann K; Kietzmann T A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression | 2 | 2 |
195 | 2 | 58 | 195 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(28):10440-10445 Kong TQ; Eltzschig HK; Karhausen J; Colgan SP; Shelley CS Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of beta 2 integrin gene expression | 0 | 0 |
196 | 3 | 27 | 196 2004 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 141(2):115-123 Roy A; Li JQ; Baby SM; Mokashi A; Buerk DG; Lahiri S Effects of iron-chelators on ion-channels and HIF-1 alpha in the carotid body | 0 | 0 |
197 | 2 | 107 | 197 2004 SEMINARS IN CANCER BIOLOGY 14(2):123-130 Mukhopadhyay D; Datta K Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors | 0 | 0 |
198 | 1 | 22 | 198 2004 THORAX 59(2):90-92 Walmsley SR; Sheares KKK; Sobolewski A; Morrell NW; Chilvers ER New insights into oxygen sensing at a cellular level | 0 | 0 |
199 | 1 | 16 | 199 2004 TOXICOLOGY AND APPLIED PHARMACOLOGY 196(3):404-409 Zhao JH; Chen HB; Davidson T; Kluz T; Zhang QW; Costa M Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway | 0 | 0 |
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