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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK GENES & DEVELOPMENT 16 (12): 1466-1471 JUN 15 2002 and the citing papers |
Nodes: 99
Authors: 344,
Journals: 63,
Outer References: 3157
Collection span: 2002 - 2004
View: Overview. Sorted by first author.
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
---|---|---|---|---|---|
1 | 2 | 68 | 96 2004 OXYGEN SENSING 381:488-510 Acker H; Huckstorf C; Sauer H; Streller T; Wartenberg M Deciphering the oxygen sensing pathway by microscopy | 0 | 0 |
2 | 6 | 42 | 87 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501 Aprelikova O; Chandramouli GVR; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors | 0 | 0 |
3 | 5 | 96 | 4 2002 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 67:133-142 Arbeit JM Quiescent hypervascularity mediated by Gain of HIF-1 alpha function | 0 | 0 |
4 | 5 | 84 | 70 2004 BIOESSAYS 26(3):262-269 Bardos JI; Athcroft M Hypoxia-inducible factor-1 and oncogenic signalling | 0 | 0 |
5 | 4 | 49 | 26 2003 EMBO JOURNAL 22(16):4082-4090 Berra E; Benizri E; Ginouves A; Volmat V; Roux D; Pouyssegur J HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 alpha in normoxia | 10 | 25 |
6 | 2 | 69 | 28 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):791-798 Bilton RL; Booker GW The subtle side to hypoxia inducible factor (HIF alpha) regulation | 3 | 11 |
7 | 6 | 62 | 23 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(6):650-656 Binley K; Kan O; White J; Naylor S Exploiting the hypoxia response | 0 | 1 |
8 | 1 | 260 | 19 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(7):1376-1393 Bracken CP; Whitelaw ML; Peet DJ The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses | 2 | 4 |
9 | 1 | 128 | 32 2003 FRONTIERS IN BIOSCIENCE 8:D100-D116 Brat DJ; Kaur B; Van Meir EG Genetic modulation of hypoxia induced gene expression and angiogenesis: Relevance to brain tumors | 0 | 5 |
10 | 11 | 89 | 33 2003 GENES & DEVELOPMENT 17(21):2614-2623 Bruick RK Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor | 2 | 12 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
11 | 1 | 21 | 17 2003 BREAST CANCER RESEARCH 5(6):R223-R230 Cayre A; Rossignol F; Clottes E; Penault-Llorca F aHIF but not HIF-1 alpha transcript is a poor prognostic marker in human breast cancer | 0 | 1 |
12 | 4 | 128 | 75 2004 CARDIOVASCULAR RESEARCH 61(3):437-447 Chi NC; Karliner JS Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors | 0 | 1 |
13 | 2 | 99 | 35 2003 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 36(1):120-127 Choi KS; Bae MK; Jeong JW; Moon HE; Kim KW Hypoxia-induced angiogenesis during carcinogenesis | 0 | 6 |
14 | 3 | 21 | 72 2004 BMC CELL BIOLOGY 5 Cikala M; Alexandrova O; David CN; Proschel M; Stiening B; Cramer P; Bottger A The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity | 0 | 0 |
15 | 3 | 20 | 45 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(40):38183-38187 D'Angelo G; Duplan E; Boyer N; Vigne P; Frelin C Hypoxia up-regulates prolyl hydroxylase activity - A feedback mechansim that limits HIF-1 responses during reoxygenation | 0 | 6 |
16 | 7 | 32 | 69 2004 BIOCHEMICAL JOURNAL 380:419-424 Dalgard CL; Lu HS; Mohyeldin A; Verma A Endogenous 2-oxoacids differentially regulate expression of oxygen sensors | 0 | 0 |
17 | 1 | 42 | 11 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356 Dann CE; Bruick RK; Deisenhofer J Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 15 | 27 |
18 | 3 | 133 | 68 2004 ANTIOXIDANTS & REDOX SIGNALING 6(4):777-791 Dimova EY; Samoylenko A; Kietzmann T Oxidative stress and hypoxia: Implications for plasminogen activator inhibitor-1 expression | 0 | 1 |
19 | 1 | 29 | 36 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(3):1802-1806 Elkins JM; Hewitson KS; McNeill LA; Seibel JF; Schlemminger I; Pugh CW; Ratcliffe PJ; Schofield CJ Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha | 16 | 25 |
20 | 7 | 165 | 66 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(6):R977-R988 Fandrey J Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
21 | 1 | 352 | 63 2003 REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 146 146:159-216 Fluck M; Hoppeler H Molecular basis of skeletal muscle plasticity-from gene to form and function | 0 | 8 |
22 | 5 | 48 | 59 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 1 | 6 |
23 | 4 | 116 | 58 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 3 | 15 |
24 | 1 | 59 | 65 2003 THROMBOSIS AND HAEMOSTASIS 89(5):926-935 Gorlach A; Berchner-Pfannschmidt U; Wotzlaw C; Cool RH; Fandrey J; Acker H; Jungermann K; Kietzmann T Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1 | 2 | 6 |
25 | 1 | 111 | 9 2002 MASS SPECTROMETRY REVIEWS 21(3):183-216 Gorman JJ; Wallis TP; Pitt JJ Protein disulfide bond determination by mass spectrometry | 0 | 8 |
26 | 1 | 49 | 34 2003 HEARING RESEARCH 183(1-2):73-83 Gross J; Rheinlander C; Fuchs J; Mazurek B; Machulik A; Andreeva N; Kietzmann T Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats | 0 | 0 |
27 | 5 | 146 | 21 2003 CURRENT MEDICINAL CHEMISTRY 10(12):1005-1019 Hanauske-Abel HM; Popowicz AM The HAG mechanism: A molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases | 0 | 0 |
28 | 2 | 32 | 47 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40337-40342 Hanson ES; Rawlins ML; Leibold EA Oxygen and iron regulation of iron regulatory protein 2 | 3 | 9 |
29 | 7 | 71 | 14 2003 BIOCHEMICAL SOCIETY TRANSACTIONS 31:510-515 Hewitson KS; McNeill LA; Elkins JM; Schofield CJ The role of iron and 2-oxoglutarate oxygenases in signalling | 2 | 4 |
30 | 17 | 144 | 76 2004 CURRENT PHARMACEUTICAL DESIGN 10(8):821-833 Hewitson KS; McNeill LA; Schofield CJ Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer | 0 | 1 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
31 | 3 | 66 | 48 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(50):50771-50780 Hon T; Dodd A; Dirmeier R; Gorman N; Sinclair PR; Zhang L; Poyton RO A mechanism of oxygen sensing in yeast - Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity | 0 | 0 |
32 | 3 | 111 | 54 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
33 | 2 | 46 | 7 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):39792-39800 Huang JH; Zhao Q; Mooney SM; Lee FS Sequence determinants in hypoxia-inducible factor-1 alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3 | 21 | 39 |
34 | 3 | 79 | 40 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19575-19578 Huang LE; Bunn HF Hypoxia-inducible factor and its biomedical relevance | 10 | 21 |
35 | 1 | 53 | 8 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755 Huang LE; Pete EA; Schau M; Milligan J; Gu J Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 3 | 7 |
36 | 1 | 49 | 3 2002 CELL 111(5):709-720 Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 19 | 43 |
37 | 1 | 41 | 5 2002 GENES & DEVELOPMENT 16(12):1441-1445 Kaelin WG How oxygen makes its presence felt | 7 | 31 |
38 | 7 | 43 | 80 2004 FASEB JOURNAL 18(6) Kageyama Y; Koshiji M; To KKW; Tian YM; Ratcliffe PJ; Huang LE Leu-574 of human HIF-1a is a molecular determinant of prolyl hydroxylation | 0 | 0 |
39 | 2 | 47 | 83 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(4):2550-2558 Kasuno K; Takabuchi S; Fukuda K; Kizaka-Kondoh S; Yodoi J; Adachi T; Semenza GL; Hirota K Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling | 1 | 2 |
40 | 1 | 104 | 82 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36(2):189-204 Kewley RJ; Whitelaw ML; Chapman-Smith A The mammalian basic helix-loop-helix/PAS family of transcriptional regulators | 0 | 3 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
41 | 2 | 60 | 22 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):55-60 Kim W; Kaelin WG The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer | 2 | 11 |
42 | 1 | 22 | 18 2003 CANCER RESEARCH 63(8):1764-1768 Knowles HJ; Raval RR; Harris AL; Ratcliffe PJ Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells | 5 | 15 |
43 | 1 | 58 | 43 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33384-33391 Kodama T; Shimizu N; Yoshikawa N; Makino Y; Ouchida R; Okamoto K; Hisada T; Nakamura H; Morimoto C; Tanaka H Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression | 0 | 0 |
44 | 7 | 31 | 85 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904 Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | 1 | 1 |
45 | 4 | 53 | 74 2004 CANCER CELL 6(1):33-43 Kung AL; Zabludoff SD; France DS; Freedman SJ; Tanner EA; Vieira A; Cornell-Kennon S; Lee J; Wang BQ; Wang JM; Memmert K; Naegeli HU; Petersen F; Eck MJ; Bair KW; Wood AW; Livingston DM Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway | 0 | 0 |
46 | 3 | 121 | 27 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):781-790 Lando D; Gorman JJ; Whitelaw ML; Peet DJ Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation | 7 | 16 |
47 | 0 | 34 | 6 2002 GENES & DEVELOPMENT 16(12):1466-1471 Lando D; Peet DJ; Gorman JJ; Whelan DA; Whitelaw ML; Bruick RK FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor | 98 | 98 |
48 | 1 | 39 | 38 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):7558-7563 Lee C; Kim SJ; Jeong DG; Lee SM; Ryu SE Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | 11 | 14 |
49 | 8 | 123 | 77 2004 EXPERIMENTAL AND MOLECULAR MEDICINE 36(1):1-12 Lee JW; Bae SH; Jeong JW; Kim SH; Kim KW Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions | 0 | 0 |
50 | 1 | 63 | 44 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(38):35878-35888 Lees MJ; Peet DJ; Whitelaw ML Defining the role for XAP2 in stabilization of the dioxin receptor | 0 | 2 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
51 | 3 | 69 | 98 2004 SEMINARS IN RADIATION ONCOLOGY 14(3):207-214 Leo C; Giaccia AJ; Denko NC The hypoxic tumor microenvironment and gene expression | 0 | 0 |
52 | 1 | 23 | 93 2004 ONCOGENE 23(13):2315-2323 Lewis MD; Roberts BJ Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity | 0 | 0 |
53 | 1 | 52 | 25 2003 EMBO JOURNAL 22(8):1857-1867 Li ZB; Wang DK; Na X; Schoen SR; Messing EM; Wu G The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1 alpha transcriptional activity | 2 | 5 |
54 | 8 | 35 | 86 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14391-14397 Linke S; Stojkoski C; Kewley RJ; Booker GW; Whitelaw ML; Peet DJ Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor | 2 | 2 |
55 | 1 | 40 | 97 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(12):4302-4307 Liu Q; Berchner-Pfannschmidt U; Moller U; Brecht M; Wotzlaw C; Acker H; Jungermann K; Kietzmann T A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression | 1 | 2 |
56 | 5 | 57 | 84 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(10):9504-9511 Martin-Puig S; Temes E; Olmos G; Jones DR; Aragones J; Landazuri MO Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms | 1 | 1 |
57 | 7 | 97 | 50 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049 Masson N; Ratcliffe PJ HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels | 3 | 8 |
58 | 2 | 27 | 94 2004 OXYGEN SENSING 381:305-320 Masson N; Ratcliffe PJ Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing | 0 | 0 |
59 | 6 | 104 | 52 2003 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14(11):2712-2722 Maxwell P HIF-1: An oxygen response system with special relevance to the kidney | 1 | 2 |
60 | 6 | 100 | 73 2004 CANCER BIOLOGY & THERAPY 3(1):29-35 Maxwell P; Salnikow K HIF-1 - An oxygen and metal responsive transcription factor | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
61 | 2 | 62 | 24 2003 CURRENT PHARMACEUTICAL DESIGN 9(7):531-541 Mazure NM; Brahimi-Horn MC; Pouyssegur J Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis | 1 | 12 |
62 | 1 | 31 | 1 2002 BIOCHEMICAL JOURNAL 367:571-575 McNeill LA; Hewitson KS; Claridge TD; Seibel JF; Horsfall LE; Schofield CJ Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 | 18 | 22 |
63 | 2 | 26 | 60 2003 PHARMACOLOGY 69(2):74-78 Meissner U; Allabauer I; Repp R; Rascher W; Dotsch J Inducible expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha) as a tool for studying HIF-1 alpha-dependent gene regulation during normoxia in vitro | 0 | 0 |
64 | 2 | 42 | 49 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326 Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing | 9 | 22 |
65 | 18 | 90 | 71 2004 BIOLOGICAL CHEMISTRY 385(3-4):223-230 Metzen E; Ratcliffe PJ HIF hydroxylation and cellular oxygen sensing | 0 | 0 |
66 | 2 | 59 | 55 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481 Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases | 7 | 13 |
67 | 3 | 29 | 16 2003 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(16):2677-2680 Mole DR; Schlemminger I; McNeill LA; Hewitson KS; Pugh CW; Ratcliffe PJ; Schofield CJ 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase | 2 | 3 |
68 | 1 | 36 | 30 2003 FASEB JOURNAL 17(15) Moon EJ; Jeong CH; Jeong JW; Kim KR; Yu DY; Murakami S; Kim CW; Kim KW Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1 alpha | 0 | 0 |
69 | 1 | 32 | 88 2004 JOURNAL OF CLINICAL PATHOLOGY 57(7):706-711 Morris MR; Maina EN; Morgan NV; Gentle D; Astuti D; Moch H; Kishida T; Yao M; Schraml P; Richards FM; Latif F; Maher ER Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma | 0 | 0 |
70 | 2 | 36 | 42 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(34):31895-31901 Naranjo-Suarez S; Castellanos MC; Alvarez-Tejado M; Vara A; Landazuri MO; del Peso L Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation | 0 | 2 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
71 | 3 | 74 | 89 2004 JOURNAL OF PHARMACOLOGICAL SCIENCES 94(3):221-232 Park JW; Chun YS; Kim NS Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools | 0 | 0 |
72 | 2 | 49 | 53 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971 Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha | 3 | 14 |
73 | 3 | 34 | 95 2004 OXYGEN SENSING 381:467-487 Peet DJ; Lando D; Whelan DA; Whitelaw ML; Gorman JJ Oxygen-dependent asparagine hydroxylation | 0 | 0 |
74 | 2 | 37 | 37 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):6816-6823 Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor gene product | 2 | 8 |
75 | 2 | 37 | 78 2004 EXPERIMENTAL CELL RESEARCH 295(2):340-349 Piret JP; Lecocq C; Toffoli S; Ninane N; Raes M; Michiels C Hypoxia and CoCl2 protect HepG2 cells against serum deprivation-and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1 | 0 | 0 |
76 | 5 | 109 | 13 2003 ANNALS OF MEDICINE 35(6):380-390 Pugh CW Oxygen sensing in cancer | 0 | 0 |
77 | 3 | 115 | 56 2003 NATURE MEDICINE 9(6):677-684 Pugh CW; Ratcliffe PJ Regulation of angiogenesis by hypoxia: role of the HIF system | 8 | 66 |
78 | 1 | 78 | 64 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89 Pugh CW; Ratcliffe PJ The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis | 0 | 21 |
79 | 1 | 55 | 61 2003 PLACENTA 24(2-3):199-208 Rajakumar A; Doty K; Daftary A; Harger G; Conrad KP Impaired oxygen-dependent reduction of HIF-1 alpha and -2 alpha proteins in pre-eclamptic placentae | 4 | 7 |
80 | 1 | 49 | 2 2002 BLOOD PURIFICATION 20(5):445-450 Ratcliffe PJ From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway | 1 | 6 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
81 | 1 | 75 | 51 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783 Safran M; Kaelin WG HIF hydroxylation and the mammalian oxygen-sensing pathway | 4 | 23 |
82 | 3 | 40 | 99 2004 TOXICOLOGY AND APPLIED PHARMACOLOGY 196(2):258-265 Salnikow K; Li XM; Lippmann M Effect of nickel and iron co-exposure on human lung cells | 0 | 0 |
83 | 1 | 55 | 39 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14013-14019 Sang NL; Stiehl DP; Bohensky J; Leshchinsky I; Srinivas V; Caro J MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 | 7 | 20 |
84 | 2 | 57 | 62 2003 PLACENTA 24(10):941-950 Schaffer L; Scheid A; Spielmann P; Breymann C; Zimmermann R; Meuli M; Gassmann M; Marti HH; Wenger RH Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation | 1 | 2 |
85 | 1 | 105 | 20 2003 CRITICAL CARE MEDICINE 31(12):S651-S657 Scharte M; Fink MP Red blood cell physiology in critical illness | 0 | 0 |
86 | 1 | 25 | 15 2003 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(8):1451-1454 Schlemminger I; Mole DR; McNeill LA; Dhanda A; Hewitson KS; Tian YM; Ratcliffe PJ; Pugh CW; Schofield CJ Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases | 3 | 4 |
87 | 18 | 108 | 91 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5(5):343-354 Schofield CJ; Ratcliffe PJ Oxygen sensing by HIF hydroxylases | 0 | 0 |
88 | 1 | 38 | 10 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572 Semenza GL Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 1 | 5 |
89 | 3 | 107 | 57 2003 NATURE REVIEWS CANCER 3(10):721-732 Semenza GL Targeting HIF-1 for cancer therapy | 7 | 47 |
90 | 8 | 190 | 92 2004 NATURE REVIEWS NEUROSCIENCE 5(6):437-448 Sharp FR; Bernaudin M HIf1 and oxygen sensing in the brain | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
91 | 2 | 89 | 67 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 287(1):F1-F6 Sufan RI; Jewett MAS; Ohh M The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma | 0 | 0 |
92 | 4 | 64 | 90 2004 MOLECULAR BIOLOGY 38(1):47-57 Turpaev KT; Litvinov DY Redox-dependent regulation of the expression of nitric oxide-inducible genes | 0 | 0 |
93 | 1 | 45 | 29 2003 FASEB JOURNAL 17(6) Warnecke C; Griethe W; Weidemann A; Jurgensen JS; Willam C; Bachmann S; Ivashchenko Y; Wagner I; Frei U; Wiesener M; Eckardt KU Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors | 0 | 0 |
94 | 4 | 44 | 81 2004 FASEB JOURNAL 18(10) Warnecke C; Zaborowska Z; Kurreck J; Erdmann VA; Frei U; Wiesener M; Eckardt KU Differentiating the functional role of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2 alpha target gene in Hep3B and Kelly cells | 0 | 0 |
95 | 3 | 71 | 12 2003 ANNALS OF MEDICINE 35(3):183-190 Wiesener MS; Maxwell PH HIF and oxygen sensing; as important to life as the air we breathe? | 1 | 6 |
96 | 1 | 34 | 41 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20235-20239 Wright G; Higgin JJ; Raines RT; Steenbergen C; Murphy E Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes | 2 | 3 |
97 | 1 | 28 | 31 2003 FEBS LETTERS 549(1-3):105-109 Yasinska IM; Sumbayev VV S-nitrosation of Cys-800 of HIF-1 alpha protein activates its interaction with p300 and stimulates its transcriptional activity | 1 | 2 |
98 | 1 | 55 | 46 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(40):39076-39084 Yoo YG; Oh SH; Park ES; Cho H; Lee N; Park H; Kim DK; Yu DY; Seong JK; Lee MO Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1 alpha through activation of mitogen-activated protein kinase pathway | 0 | 0 |
99 | 13 | 185 | 79 2004 EXPERT OPINION ON THERAPEUTIC PATENTS 14(7):951-966 Zhong H Targeting hypoxia-inducible factor-1 for therapy and prevention | 0 | 0 |
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