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Mon Aug 28 12:20:33 2006

A gain-of-function mutation of JAK2 in myeloproliferative disorders
Kralovics R, Passamonti F, Buser AS, Teo S, Tiedt R, et al.
NEW ENGLAND JOURNAL OF MEDICINE 352 (17): 1779-1790 APR 28 2005
and the citing papers
Nodes: 169, Authors: 715, Journals: 56, Cited References: 4826, Words: 597
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Collection span: 2005 - 2006
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
11521 2005 ARCHIVES OF INTERNAL MEDICINE 165 (22): 2651-2658
Chim CS; Kwong YL; Lie AKW; Ma SK; Chan CC; et al.
Long-term outcome of 231 patients with essential thrombocythemia - Prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia
12
21452 2005 BLOOD 105 (11): 4187-4190
Kaushansky K
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense
2438
31243 2005 BLOOD 106 (4): 1207-1209
Steensma DP; Dewald GW; Lasho TL; Powell HL; McClure RF; et al.
The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes
5063
41484 2005 BLOOD 106 (6): 2162-2168
Jones AV; Kreil S; Zoi K; Waghorn K; Curtis C; et al.
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
5156
51105 2005 BLOOD 106 (8): 2920-2921
Scott LM; Campbell PJ; Baxter EJ; Todd T; Stephens P; et al.
The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders
88
63186 2005 BLOOD 106 (10): 3370-3373
Jelinek J; Oki Y; Gharibyan V; Bueso-Ramos C; Prchal JT; et al.
JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
2328
71217 2005 BLOOD 106 (10): 3374-3376
Kralovics R; Teo SS; Buser AS; Brutsche M; Tiedt R; et al.
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
1011
84228 2005 BLOOD 106 (10): 3377-3379
Levine RL; Loriaux M; Huntly BJP; Loh ML; Beran M; et al.
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
1823
91749 2005 BLOOD 106 (13): 4102-4113
Martelli F; Ghinassi B; Panetta B; Alfani E; Gatta V; et al.
Variegation of the phenotype induced by the Gatal(low) mutation in mice of different genetic backgrounds
00
101610 2005 BRITISH JOURNAL OF HAEMATOLOGY 130 (5): 797-799
Lasho TL; Mesa R; Gilliland DG; Tefferi A
Mutation studies in CD3(+), CD19(+) and CD34(+) cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes
66
#LCRNCRNode / Date / Journal / AuthorLCSGCS
111611 2005 BRITISH JOURNAL OF HAEMATOLOGY 130 (5): 800-801
Cario H; Goerttler PS; Steimle C; Levine RL; Pahl HL
The JAK2V617F mutation is acquired secondary to the predisposing alteration in familial polycythaemia vera
23
121812 2005 BRITISH JOURNAL OF HAEMATOLOGY 130 (6): 964-965
Sulong S; Case M; Minto L; Wilkins B; Hall A; et al.
The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia
34
132713 2005 BRITISH JOURNAL OF HAEMATOLOGY 130 (6): 968-968
Johan MF; Goodeve AC; Bowen DT; Frew ME; Reilly JT
JAK2 V617F Mutation is uncommon in chronic myelomonocytic leukaemia
44
1432714 2005 BRITISH JOURNAL OF HAEMATOLOGY 131 (2): 166-171
Tefferi A; Sirhan S; Lasho TL; Schwager SM; Li CY; et al.
Concomitant neutrophil JAK2(V617F) mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythaemia
1215
1523015 2005 BRITISH JOURNAL OF HAEMATOLOGY 131 (2): 208-213
Wolanskyj AP; Lasho TL; Schwager SM; McClure RF; Wadleigh M; et al.
JAK2(V617F) mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance
1925
1655216 2005 BRITISH JOURNAL OF HAEMATOLOGY 131 (3): 320-328
Tefferi A; Lasho TL; Schwager SM; Steensma DP; Mesa RA; et al.
The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates
1116
1711917 2005 CANCER RESEARCH 65 (20): 9152-9154
Fitzgibbon J; Smith LL; Raghavan M; Smith ML; Debernardi S; et al.
Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias
05
1815718 2005 CELL CYCLE 4 (8): 1053-1056
Tefferi A; Gilliland DG
JAK2 in myeloproliferative disorders is not just another kinase
712
1912919 2005 EXPERIMENTAL HEMATOLOGY 33 (11): 1299-1308
Corre-Buscail I; Pineau D; Boissinot M; Hermouet S
Erythropoietin-independent erythroid colony formation by bone marrow progenitors exposed to interleukin-11 and interleukin-8
00
2023620 2005 HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 90 (7): 871-874
Cazzola M; Skoda R
Gain of function, loss of control - A molecular basis for chronic myeloproliferative disorders
88
#LCRNCRNode / Date / Journal / AuthorLCSGCS
21117821 2005 HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 90 (7): 949-968
Chalandon Y; Schwaller J
Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies
05
2241022 2005 HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 90 (12): 1696-1697
McLornan DP; Percy MJ; Jones AV; Cross NCP; McMullin MF
Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation
22
2341923 2005 HEMATOLOGICAL ONCOLOGY 23 (3-4): 91-93
Percy MJ; McMullin MF
The V617F JAK2 mutation and the myeloproliferative disorders
12
2447824 2005 HEMATOLOGY 10: 215-223
Michiels JJ
Clinical, pathological and molecular features of the chronic myeloproliferative disorders: MPD 2005 and beyond
44
2519025 2005 INTERNATIONAL JOURNAL OF HEMATOLOGY 82 (2): 85-92
Kiyoi H; Yanada M; Ozeki K
Clinical significance of FLT3 in leukemia
01
2619426 2005 INTERNATIONAL JOURNAL OF HEMATOLOGY 82 (2): 93-99
Choudhary C; Muller-Tidow C; Berdel WE; Serve H
Signal transduction of oncogenic Flt3
11
2713227 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (24): 22788-22792
Zhao RX; Xing S; Li Z; Fu XQ; Li QS; et al.
Identification of an acquired JAK2 mutation in Polycythemia vera
5556
2816128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (29): 27251-27261
Royer Y; Staerk J; Costuleanu M; Courtoy PJ; Constantinescu SN
Janus kinases affect thrombopoietin receptor cell surface localization and stability
611
2924129 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (51): 41893-41899
Staerk J; Kallin A; Demoulin JB; Vainchenker W; Constantinescu SN
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation - Cross-talk with IGF1 receptor
89
3018430 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (10): 2618-2624
Amaravadi R; Thompson CB
The survival kinases Akt and Pim as potential pharmacological targets
012
#LCRNCRNode / Date / Journal / AuthorLCSGCS
31210831 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (12): 3339-3347
Kaushansky K
The molecular mechanisms that control thrombopoiesis
05
3217932 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (12): 3370-3377
Macaulay IC; Carr P; Gusnanto A; Ouwehand WH; Fitzgerald D; et al.
Platelet genomics and proteomics in human heat and disease
04
33118933 2005 JOURNAL OF CLINICAL ONCOLOGY 23 (26): 6285-6295
Frohling S; Scholl C; Gilliland DG; Levine RL
Genetics of myeloid malignancies: Pathogenetic and clinical implications
214
3432934 2005 LANCET 366 (9501): 1945-1953
Campbell PJ; Scott LM; Buck G; Wheatley K; East CL; et al.
Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study
1625
3518035 2005 LEUKEMIA 19 (10): 1739-1744
Delaval B; Lelievre H; Birnbaum D
Myeloproliferative disorders: the centrosome connection
03
361836 2005 LEUKEMIA 19 (10): 1843-1844
Tono C; Xu G; Toki T; Takahashi Y; Sasaki S; et al.
JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia
22
372837 2005 LEUKEMIA 19 (10): 1847-1849
Antonioli E; Guglielmelli P; Pancrazzi A; Bogani C; Verrucci M; et al.
Clinical implications of the JAK2 V617F mutation in essential thrombocythemia
1417
382738 2005 LEUKEMIA 19 (12): 2359-2360
Ohyashiki K; Aota Y; Akahane D; Gotoh A; Miyazawa K; et al.
The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients
57
3911839 2005 M S-MEDECINE SCIENCES 21 (6-7): 669-670
Ugo V; James C; Vainchenker W
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
00
40117540 2005 MAYO CLINIC PROCEEDINGS 80 (7): 947-958
Tefferi A; Gilliland DG
The JAK2(V617F) tyrosine kinase mutation in myeloproliferative disorders: Status report and immediate implications for disease classification and diagnosis
1424
#LCRNCRNode / Date / Journal / AuthorLCSGCS
41120841 2005 MAYO CLINIC PROCEEDINGS 80 (9): 1220-1232
Tefferi A; Barbui T
bcr/abl-negative, classic myeloproliferative disorders: Diagnosis and treatment
13
4233942 2005 MOLECULAR INTERVENTIONS 5 (4): 211-215
Pesu M; O'Shea J; Hennighausen L; Silvennoinen O
Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders
33
4304743 2005 NEW ENGLAND JOURNAL OF MEDICINE 352 (17): 1779-1790
Kralovics R; Passamonti F; Buser AS; Teo S; Tiedt R; et al.
A gain-of-function mutation of JAK2 in myeloproliferative disorders
168168
4411544 2005 NEW ENGLAND JOURNAL OF MEDICINE 353 (1): 85-86
Barbui T; Finazzi G
When and how to treat essential thrombocythemia
16
45112345 2005 NEW ENGLAND JOURNAL OF MEDICINE 353 (2): 172-187
Krause DS; Van Etten RA
Tyrosine kinases as targets for cancer therapy
354
462546 2005 NEW ENGLAND JOURNAL OF MEDICINE 353 (13): 1416-1417
Tefferi A; Lasho TL; Gilliland G
JAK2 mutations in myeloproliferative disorders
35
471847 2005 ONCOGENE 24 (48): 7125-7126
Mahon FX
JAK the trigger
01
4817848 2005 PATHOLOGY 37 (6): 479-492
Jack A
Organisation of neoplastic haematopathology services: a UK perspective
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4923649 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (52): 18962-18967
Lu XH; Levine R; Tong W; Wernig G; Pikman Y; et al.
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
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5032850 2005 SEMINARS IN HEMATOLOGY 42 (4): 181-183
Skoda R; Prchal JT
Chronic myeloproliferative disorders - Introduction
22
#LCRNCRNode / Date / Journal / AuthorLCSGCS
51110951 2005 SEMINARS IN HEMATOLOGY 42 (4): 196-205
Bench AJ; Pahl HL
Chromosomal abnormalities and molecular markers in myeloproliferative disorders
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52319152 2005 SEMINARS IN HEMATOLOGY 42 (4): 206-220
Tefferi A; Spivak JL
Polycythemia vera: Scientific advances and current practice
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5338553 2005 SEMINARS IN HEMATOLOGY 42 (4): 221-229
Zhao ZJ; Vainchenker W; Krantz SB; Casadevall N; Constantinescu SN
Role of tyrosine kinases and phosphatases in Polycythemia vera
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5418054 2005 SEMINARS IN HEMATOLOGY 42 (4): 230-238
Finazzi G; Harrison C
Essential thrombocythemia
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55110455 2005 SEMINARS IN HEMATOLOGY 42 (4): 248-258
Barosi G; Hoffman R
Idiopathic myelofibrosis
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5638156 2005 SEMINARS IN HEMATOLOGY 42 (4): 266-273
Skoda R; Prchal JT
Lessons from familial myeloproliferative disorders
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571557 2005 SEMINARS IN ONCOLOGY 32 (4): 357-358
Odenike O
Myelofibrosis with myeloid metaplasia: Where is the biology leading us?
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58111858 2005 SEMINARS IN ONCOLOGY 32 (4): 422-431
Odenike O; Tefferi A
Conventional and new treatment options for myelofibrosis with myeloid metaplasia
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5966959 2005 TRENDS IN MOLECULAR MEDICINE 11 (12): 546-554
James C; Ugo V; Casadevall N; Constantinescu SN; Vainchenker W
A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects
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Fend F; Bock O; Kremer M; Specht K; Quintanilla-Martinez L
Ancillary techniques in bone marrow pathology: molecular diagnostics on bone marrow trephine biopsies
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Quantification of clonal hematopoiesis in polycythemia vera
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Murugesan G; Aboudola S; Szpurka H; Verbic MA; Maciejewski JP; et al.
Identification of the JAK2 V617F mutation in chronic myeloproliferative disorders using FRET probes and melting curve analysis
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Diagnostic assays for the JAK2 V617F mutation in chronic myeloproliferative disorders
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Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status
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Pargade V; Darnige L; Gaussem P
Acquired mutation of JAK2 tyrosine kinase and polycythaemia vera
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Grade of bone marrow fibrosis is associated with relevant hematological findings - a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis
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Olsen RJ; Tang ZW; Farkas DH; Bernard DW; Zu YL; et al.
Detection of the JAK2(V617F) mutation in myeloproliferative disorders by melting curve analysis using the LightCycler system
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Ahmed A; Chang CC
Chronic idiopathic myelofibrosis - Clinicopathologic features, pathogenesis, and prognosis
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Essential thrombocythemia - A review of diagnostic and pathologic features
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7112971 2006 BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY 19 (3): 361-364
Tefferi A
Classic and atypical myeloproliferative disorders - Preface
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Tefferi A; Gilliland G
Classification of chronic myeloid disorders: From Dameshek towards a semi-molecular system
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Polycythemia vera and its molecular basis: An update
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Chagraoui H; Wendling F; Vainchenker W
Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models
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Tefferi A
The diagnosis of polycythemia vera: New tests and old dictums
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76310376 2006 BIOCHEMICAL PHARMACOLOGY 71 (6): 713-721
Valentino L; Pierre J
JAW/STAT signal transduction: Regulators and implication in hematological malignancies
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7727277 2006 BLOOD 107 (3): 907-915
Zhao W; Kitidis C; Fleming MD; Lodish HF; Ghaffari S
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
03
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Sattler M; Watz C; Crowley BJ; Lengfelder E; Janne PA; et al.
A sensitive high-throughput method to detect activating mutations of Jak2 in peripheral-blood samples
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More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders
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Stevenson WS; Hoyt R; Kiu H; Grigg AP; Szer J; et al.
Point mutations in MYB and the KIX domain of EP300 are uncommon in the human myeloproliferative disorders
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Campbell PJ; Griesshammer M; Dohner K; Dohner H; Kusec R; et al.
V617F mutation in JAK2 is associated idiopathic myelofibrosis
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Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia
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Jones AV; Silver RT; Waghorn K; Curtis C; Kreil S; et al.
Minimal molecular response in polycythemia vera patients treated with imatinib or interferon alpha
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Walczak H
Polycythemia vera erythroblasts: too tough to die
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8535285 2006 BLOOD 107 (9): 3495-3502
Zeuner A; Pedini F; Signore M; Ruscio G; Messina C; et al.
Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells
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Passamonti F; Rumi E; Pietra D; Della Porta MG; Boveri E; et al.
Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34(+) cells into peripheral blood in myeloproliferative disorders
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Levine RL; Belisle C; Wadleigh M; Zahrieh D; Lee S; et al.
X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and NIMM patients with clonal hematopoiesis
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Schafer AI
Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia
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Wernig G; Mercher T; Okabe R; Levine RL; Lee BH; et al.
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
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Wierenga ATJ; Schepers H; Moore MAS; Vellenga E; Schuringa JJ
STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP alpha
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Liu Y; Pop R; Sadegh C; Brugnara C; Haase VH; et al.
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
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Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
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Bellanne-Chantelot C; Chaumarel I; Labopin M; Bellanger F; Barbu V; et al.
Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders
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943694 2006 BRITISH JOURNAL OF HAEMATOLOGY 132 (2): 244-245
Cheung B; Radia D; Pantelidis P; Yadegarfar G; Harrison C
The presence of the JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythaemia
11
9514195 2006 BRITISH JOURNAL OF HAEMATOLOGY 134 (1): 27-36
Rinaldi A; Kwee I; Poretti G; Mensah A; Pruneri G; et al.
Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas
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Ma W; Kantarjian H; Verstovsek S; Jilani I; Gorre M; et al.
Hemizygous/homozygous and heterozygous JAK2 mutation detected in plasma of patients with myeloproliferative diseases: correlation with clinical behaviour
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Khwaja A
The role of Janus kinases in haemopoiesis and haematological malignancy
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Tefferi A; Lasho TL; Schwager SM; Strand JS; Elliott M; et al.
The clinical phenotype of wild-type, heterozygous, and homozygous JAK2(V617F) in polycythemia vera
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Walters DK; Mercher T; Gu TL; O'Hare T; Tyner JW; et al.
Activating alleles of JAK3 in acute megakaryoblastic leukemia
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100154100 2006 CANCER CELL 10 (1): 77-87
Kovacic B; Stoiber D; Moriggl R; Weisz E; Ott RG; et al.
STAT1 acts as a tumor promoter for leukemia development
00

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