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Mon Aug 28 12:20:35 2006

A gain-of-function mutation of JAK2 in myeloproliferative disorders
Kralovics R, Passamonti F, Buser AS, Teo S, Tiedt R, et al.
NEW ENGLAND JOURNAL OF MEDICINE 352 (17): 1779-1790 APR 28 2005
and the citing papers
Nodes: 169, Authors: 715, Journals: 56, Cited References: 4826, Words: 597
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Collection span: 2005 - 2006
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The 2001 World Health Organization and updated European clinical and pathological criteria for the diagnosis, classification, and staging of the Philadelphia chromosome-negative chronic myeloproliferative disorders
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Khwaja A
The role of Janus kinases in haemopoiesis and haematological malignancy
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5120841 2005 MAYO CLINIC PROCEEDINGS 80 (9): 1220-1232
Tefferi A; Barbui T
bcr/abl-negative, classic myeloproliferative disorders: Diagnosis and treatment
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Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML)
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Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies
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8319152 2005 SEMINARS IN HEMATOLOGY 42 (4): 206-220
Tefferi A; Spivak JL
Polycythemia vera: Scientific advances and current practice
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9118933 2005 JOURNAL OF CLINICAL ONCOLOGY 23 (26): 6285-6295
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Genetics of myeloid malignancies: Pathogenetic and clinical implications
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Clinical and laboratory features, pathobiology of platelet-mediated thrombosis and bleeding complications, and the molecular etiology of essential thrombocythemia and polycythemia vera: Therapeutic implications
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Thiele J; Kvasnicka HM
A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders
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Chalandon Y; Schwaller J
Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies
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13117540 2005 MAYO CLINIC PROCEEDINGS 80 (7): 947-958
Tefferi A; Gilliland DG
The JAK2(V617F) tyrosine kinase mutation in myeloproliferative disorders: Status report and immediate implications for disease classification and diagnosis
1424
147173147 2006 MAYO CLINIC PROCEEDINGS 81 (4): 553-563
Tefferi A; Elliot MA; Pardanani A
Atypical myeloproliferative disorders: Diagnosis and management
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152515268 2006 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 130 (8): 1126-1132
Cao M; Olsen RJ; Zu YL
Polycythemia vera - New clinicopathologic perspectives
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1611148159 2006 SEMINARS IN THROMBOSIS AND HEMOSTASIS 32 (3): 219-230
Thiele J; Kvasnicka HM
Clinicopathological criteria for differential diagnosis of thrombocythemias in various myeloproliferative disorders
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177143144 2006 LEUKEMIA & LYMPHOMA 47 (2): 177-194
Nelson ME; Steensma DP
JAK2 V617F in myeloid disorders: What do we know now, and where are we headed?
25
1811129166 2006 SEMINARS IN THROMBOSIS AND HEMOSTASIS 32 (4): 381-398
Bellucci S; Michiels JJ
The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia
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19112345 2005 NEW ENGLAND JOURNAL OF MEDICINE 353 (2): 172-187
Krause DS; Van Etten RA
Tyrosine kinases as targets for cancer therapy
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20112175 2006 BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY 19 (3): 455-469
Tefferi A
The diagnosis of polycythemia vera: New tests and old dictums
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21111858 2005 SEMINARS IN ONCOLOGY 32 (4): 422-431
Odenike O; Tefferi A
Conventional and new treatment options for myelofibrosis with myeloid metaplasia
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222115119 2006 HEMATOLOGICAL ONCOLOGY 24 (2): 56-63
Reilly JT
Idiopathic myelofibrosis: pathogenesis to treatment
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23110951 2005 SEMINARS IN HEMATOLOGY 42 (4): 196-205
Bench AJ; Pahl HL
Chromosomal abnormalities and molecular markers in myeloproliferative disorders
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24210831 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (12): 3339-3347
Kaushansky K
The molecular mechanisms that control thrombopoiesis
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251010888 2006 BLOOD 107 (11): 4214-4222
Schafer AI
Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia
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26110455 2005 SEMINARS IN HEMATOLOGY 42 (4): 248-258
Barosi G; Hoffman R
Idiopathic myelofibrosis
22
27310376 2006 BIOCHEMICAL PHARMACOLOGY 71 (6): 713-721
Valentino L; Pierre J
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28410169 2006 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 130 (8): 1133-1143
Ahmed A; Chang CC
Chronic idiopathic myelofibrosis - Clinicopathologic features, pathogenesis, and prognosis
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29198153 2006 PHARMACOGENOMICS 7 (4): 597-612
Ma PC; Zhang XD; Wang ZHJ
High-throughput mutational analysis of the human cancer genome
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3019426 2005 INTERNATIONAL JOURNAL OF HEMATOLOGY 82 (2): 93-99
Choudhary C; Muller-Tidow C; Berdel WE; Serve H
Signal transduction of oncogenic Flt3
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31109470 2006 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 130 (8): 1144-1150
Sanchez S; Ewton A
Essential thrombocythemia - A review of diagnostic and pathologic features
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3219025 2005 INTERNATIONAL JOURNAL OF HEMATOLOGY 82 (2): 85-92
Kiyoi H; Yanada M; Ozeki K
Clinical significance of FLT3 in leukemia
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3318660 2005 VIRCHOWS ARCHIV 447 (6): 909-919
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Ancillary techniques in bone marrow pathology: molecular diagnostics on bone marrow trephine biopsies
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Zhao ZJ; Vainchenker W; Krantz SB; Casadevall N; Constantinescu SN
Role of tyrosine kinases and phosphatases in Polycythemia vera
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3518430 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (10): 2618-2624
Amaravadi R; Thompson CB
The survival kinases Akt and Pim as potential pharmacological targets
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3638156 2005 SEMINARS IN HEMATOLOGY 42 (4): 266-273
Skoda R; Prchal JT
Lessons from familial myeloproliferative disorders
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3718035 2005 LEUKEMIA 19 (10): 1739-1744
Delaval B; Lelievre H; Birnbaum D
Myeloproliferative disorders: the centrosome connection
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3818054 2005 SEMINARS IN HEMATOLOGY 42 (4): 230-238
Finazzi G; Harrison C
Essential thrombocythemia
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3918091 2006 BLOOD 108 (1): 123-133
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Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
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4017932 2005 JOURNAL OF CLINICAL INVESTIGATION 115 (12): 3370-3377
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Platelet genomics and proteomics in human heat and disease
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41179148 2006 MOLECULAR AND CELLULAR BIOLOGY 26 (11): 4052-4062
Mazurkiewicz-Munoz AM; Argetsinger LS; Kouadio JLK; Stensballe A; Jensen ON; et al.
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor
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4247824 2005 HEMATOLOGY 10: 215-223
Michiels JJ
Clinical, pathological and molecular features of the chronic myeloproliferative disorders: MPD 2005 and beyond
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4317848 2005 PATHOLOGY 37 (6): 479-492
Jack A
Organisation of neoplastic haematopathology services: a UK perspective
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44277107 2006 CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 57 (3): 245-253
Bruns HA; Kaplan MH
The role of constitutively active Stat6 in leukemia and lymphoma
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Variegation of the phenotype induced by the Gatal(low) mutation in mice of different genetic backgrounds
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Aspirin for the control of platelet activation and prevention of thrombosis in essential thrombocythemia and polycythemia vera: Current insights and rationale for future studies
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4717274 2006 BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY 19 (3): 399-412
Chagraoui H; Wendling F; Vainchenker W
Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models
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4827277 2006 BLOOD 107 (3): 907-915
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Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
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49272113 2006 GROWTH FACTORS 24 (1): 89-95
Ingley E; Klinken SP
Cross-regulation of JAK and Src kinases
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A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects
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Villeval JL; James C; Pisani DF; Casadevall N; Vainchenker W
New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients
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5346866 2006 ANNALS OF HEMATOLOGY 85 (4): 226-232
Thiele J; Kvasnicka HM
Grade of bone marrow fibrosis is associated with relevant hematological findings - a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis
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Activating alleles of JAK3 in acute megakaryoblastic leukemia
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JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained
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Janus kinases affect thrombopoietin receptor cell surface localization and stability
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Gnatenko DV; Bahou WF
Recent advances in platelet transcriptomics
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Tefferi A; Gilliland DG
JAK2 in myeloproliferative disorders is not just another kinase
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STAT1 acts as a tumor promoter for leukemia development
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Long-term outcome of 231 patients with essential thrombocythemia - Prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia
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Tefferi A; Lasho TL; Schwager SM; Steensma DP; Mesa RA; et al.
The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates
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Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells
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Diagnosis and therapy of polycythemia vera
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Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
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Kralovics R; Passamonti F; Buser AS; Teo S; Tiedt R; et al.
A gain-of-function mutation of JAK2 in myeloproliferative disorders
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Mutation of protein kinase JAK2 in polycythemia vera: new perspectives in physiopathology and therapy
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Kaushansky K
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense
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STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP alpha
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Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin
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Chen G; Prchal JT
Polycythemia vera and its molecular basis: An update
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Briere JB
Budd-Chiari syndrome and portal vein thrombosis associated with myeloproliferative disorders: Diagnosis and management
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Walz C; Crowley BJ; Hudon HE; Gramlich JL; Neuberg DS; et al.
Activated Jak2 with the V617F point mutation promotes G(1)/S phase transition
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75342160 2006 SEMINARS IN THROMBOSIS AND HEMOSTASIS 32 (3): 246-250
Mossuz P
Influence of the assays of endogenous colony formation and serum erythropoietin on the diagnosis of polycythemia vera and essential thrombocythemia
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7624129 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (51): 41893-41899
Staerk J; Kallin A; Demoulin JB; Vainchenker W; Constantinescu SN
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation - Cross-talk with IGF1 receptor
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Rinaldi A; Kwee I; Poretti G; Mensah A; Pruneri G; et al.
Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas
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Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders
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FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13) (p13;q12) translocation
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The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
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Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status
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Gisslinger H
Update on diagnosis and management of essential thrombocythemia
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8423620 2005 HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 90 (7): 871-874
Cazzola M; Skoda R
Gain of function, loss of control - A molecular basis for chronic myeloproliferative disorders
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Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
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Increased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status
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MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia
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Harrison CN
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Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia
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Passamonti F; Rumi E; Pietra D; Della Porta MG; Boveri E; et al.
Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34(+) cells into peripheral blood in myeloproliferative disorders
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Patel RK; Lea NC; Heneghan MA; Westwood NB; Milojkovic D; et al.
Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome
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Cazzola M; Passamonti F
Not just clonal expansion of hematopoietic cells, but also activation of their progeny in the pathogenesis of myeloproliferative disorders
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941934146 2006 LEUKEMIA RESEARCH 30 (6): 739-744
Tefferi A; Pardanani A
Mutation screening for JAK2(V617F): When to order the test and how to interpret the results
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9513227 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (24): 22788-22792
Zhao RX; Xing S; Li Z; Fu XQ; Li QS; et al.
Identification of an acquired JAK2 mutation in Polycythemia vera
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Quantification of clonal hematopoiesis in polycythemia vera
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9783193 2006 BLOOD 108 (1): 346-352
Bellanne-Chantelot C; Chaumarel I; Labopin M; Bellanger F; Barbu V; et al.
Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders
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Wolanskyj AP; Lasho TL; Schwager SM; McClure RF; Wadleigh M; et al.
JAK2(V617F) mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance
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Erythropoietin-independent erythroid colony formation by bone marrow progenitors exposed to interleukin-11 and interleukin-8
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Campbell PJ; Scott LM; Buck G; Wheatley K; East CL; et al.
Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study
1625

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