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gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye WJ, Wolfe MS, Selkoe DJ
PNAS 100 (11): 6382-6387 MAY 27 2003

Nodes: 104, Authors: 411, Journals: 46, Outer References: 3380, Words: 475
Collection span: 2003 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
Page 1 of 2: [  1  2 ]

#LCRNCRNode / Date / Journal / AuthorLCSGCS
11601 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
38
21252 2003 FEBS LETTERS 550 (1-3): 30-34
Hebert SS; Godin C; Levesque G
Oligomerization of human presenilin-1 fragments
23
31293 2003 FEBS LETTERS 553 (1-2): 151-156
Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al.
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation
01
41444 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
51625 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
24
61636 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
1925
71337 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
3549
81448 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
324
91469 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
1623
1017310 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436
Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin
1625
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1115111 2003 MOLECULAR AND CELLULAR NEUROSCIENCE 24 (3): 646-655
Harrison SM; Harper AJ; Hawkins J; Duddy G; Grau E; et al.
BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes
27
1211112 2003 NACHRICHTEN AUS DER CHEMIE 51 (12): 1261-1263
Gross M
Amyloid diseases - Little progress, major questions
00
1315213 2003 NEUROBIOLOGY OF DISEASE 14 (2): 194-204
Baulac S; LaVoie MJ; Kimberly WT; Strahle J; Wolfe MS; et al.
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
910
1402914 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (11): 6382-6387
Kimberly WT; LaVoie MJ; Ostaszewski BL; Ye WJ; Wolfe MS; et al.
gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
104104
1526715 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080
Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al.
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
2434
1619216 2004 ANNALS OF INTERNAL MEDICINE 140 (8): 627-638
Selkoe DJ
Alzheimer disease: Mechanistic understanding predicts novel therapies
06
1722617 2004 ANNALS OF NEUROLOGY 55 (5): 604-606
Hutton M
Presenilin mutations associated with fronto-temporal dementia
01
1828418 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
12
1954819 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
2065820 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
#LCRNCRNode / Date / Journal / AuthorLCSGCS
2146921 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
2212922 2004 BIOCHEMISTRY 43 (42): 13532-13540
Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al.
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42
01
2313823 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938
Esler WP; Das C; Wolfe MS
Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties
11
24129524 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
00
25110325 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335
Johansson J; Weaver TE; Tjernberg LO
Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide
03
26126026 2004 CLINICAL GENETICS 66 (1): 1-16
Wellington CL
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
00
27210327 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
28611728 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
03
2952829 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383
Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
25
3035830 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3118231 2004 CURRENT PHARMACEUTICAL DESIGN 10 (25): 3113-3121
Lahiri DK; Rogers JT; Greig NH; Sambamurti K
Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents
00
3213332 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
3345533 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
3413434 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (22): 4485-4494
Pastorcic M; Das HK
Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells - The role of Ets factors in the regulation of presenilin 1
00
35319035 2004 EXPERT OPINION ON THERAPEUTIC PATENTS 14 (10): 1403-1420
Larner A
Secretases as therapeutic targets in Alzheimer's disease: patents 2000-2004
00
361836 2004 GENETIC ENGINEERING NEWS 24 (16): 28-+
Haberman AB
Therapeutic strategies in animal models
00
37230537 2004 HUMAN GENETICS 114 (5): 413-438
Bertoli-Avella AM; Oostra BA; Heutink P
Chasing genes in Alzheimer's and Parkinson's disease
02
3815938 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al.
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
13
39114439 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65
Pasternak SH; Callahan JW; Mahuran DJ
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
03
4034340 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1011
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4143841 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
4223642 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
59
4374843 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
4473744 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315
Edbauer D; Kaether C; Steiner H; Haass C
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
11
4524045 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
4667546 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
13
47105647 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
78
4843648 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156
Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
01
4934849 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
03
5077650 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954
Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al.
Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes
310
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5122951 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463
Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
5215552 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49105-49112
Ghersi E; Noviello C; D'Adamio L
Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner
00
5335353 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00
5424154 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 51654-51660
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al.
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
02
5516655 2004 JOURNAL OF CELL BIOLOGY 166 (1): 73-83
Gupta-Rossi N; Six E; LeBail O; Logeat F; Chastagner P; et al.
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor
110
5626256 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
Gowrishankar K; Zeidler MG; Vincenz C
Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
01
5721457 2004 JOURNAL OF MEDICINAL CHEMISTRY 47 (26): 6485-6489
Bakshi P; Wolfe MS
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase
00
5815958 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
5954259 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
78
6015760 2004 JOURNAL OF NEUROCHEMISTRY 90 (4): 800-806
da Costa CA; Ayral E; Hernandez JF; St George-Hyslop P; Checler F
Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
6133761 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
45
6296262 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
00
6355163 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237
Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
00
6415664 2004 JOURNAL OF NEUROSCIENCE 24 (12): 2942-2952
Yan XX; Li T; Rominger CM; Prakash SR; Wong PC; et al.
Binding sites of gamma-secretase inhibitors in rodent brain: Distribution, postnatal development, and effect of deafferentation
22
651211365 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
26
66115266 2004 JOURNAL OF PSYCHIATRY & NEUROSCIENCE 29 (6): 427-441
Kar S; Slowikowski SPM; Westaway D; Mount HTJ
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease
00
6716267 2004 JOURNAL OF VIROLOGY 78 (7): 3489-3501
Ray N; Enquist LW
Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses
02
6825168 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383
Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al.
Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins
01
69110469 2004 NATURE CELL BIOLOGY 6 (11): 1054-1061
Selkoe DJ
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
00
7023670 2004 NATURE MEDICINE 10 (9): 959-965
He WX; Lu YF; Qahwash I; Hu XY; Chang AS; et al.
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
02
#LCRNCRNode / Date / Journal / AuthorLCSGCS
71311171 2004 NATURE REVIEWS NEUROSCIENCE : S26-S33
Koo EH; Kopan R
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
00
72106372 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272
Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al.
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
33
73112573 2004 NEUROCHEMICAL RESEARCH 29 (3): 637-650
Canevari L; Abramov AY; Duchen MR
Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress
05
74110674 2004 NEUROCHEMICAL RESEARCH 29 (6): 1317-1331
Kim SI; Voshol H; van Oostrum J; Hastings TG; Cascio M; et al.
Neuroproteomics: Expression profiling of the brain's proteomes in health and disease
05
7515675 2004 NEUROSCIENCE 125 (4): 1009-1017
Hartmann J; Erb C; Ebert U; Baumann KH; Popp A; et al.
Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice
02
7645876 2004 NEUROSCIENCE 129 (3): 615-628
Siman R; Salidas S
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
00
7715477 2004 ONCOGENE 23 (42): 7076-7086
Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al.
Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor
01
78110578 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
24
79210279 2004 PHARMACOLOGICAL RESEARCH 50 (4): 419-431
Stoppini M; Andreola A; Foresti G; Bellotti V
Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing
01
8087380 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
211
#LCRNCRNode / Date / Journal / AuthorLCSGCS
8112581 2004 SCIENCE 306 (5694): 269-271
Weng AP; Ferrando AA; Lee W; Morris JP; Silverman LB; et al.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
010
8212782 2004 SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS 1030: 330-338
Repetto E; Russo C; Venezia V; Nizzari M; Nitsch RM; et al.
BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter
00
8392583 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
8455384 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
8523685 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
86110986 2005 EXPERIMENTAL CELL RESEARCH 303 (2): 343-359
Baladron V; Ruiz-Hidalgo MJ; Nueda ML; Diaz-Guerra MJM; Garcia-Ramirez JJ; et al.
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats
00
8782587 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
8855488 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
89115389 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
90127790 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
91136891 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
92110892 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832
Xie J; Guo Q
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
00
93104493 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
9445094 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
9573195 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
9653596 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020
Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
00
9714397 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169
Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM
A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities
11
981628298 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
99113699 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
100568100 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
00

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