| Missing Links? Citation Matrix | Graphs | Glossary HistCite Guide About |
Nodes: 104,
Authors: 411,
Journals: 46,
Outer References: 3380,
Words: 475
Collection span: 2003 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
Page 1 of 2: [ 1 2 ]
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 1 | 60 | 1 2003 BIOCHEMISTRY 42 (47): 13977-13986 Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al. gamma-secretase activity is present in rafts but is not cholesterol-dependent | 3 | 8 |
| 2 | 1 | 25 | 2 2003 FEBS LETTERS 550 (1-3): 30-34 Hebert SS; Godin C; Levesque G Oligomerization of human presenilin-1 fragments | 2 | 3 |
| 3 | 1 | 29 | 3 2003 FEBS LETTERS 553 (1-2): 151-156 Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al. The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation | 0 | 1 |
| 4 | 1 | 44 | 4 2003 HUMAN MOLECULAR GENETICS 12: R201-R206 Martoglio B; Golde TE Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs | 0 | 10 |
| 5 | 1 | 62 | 5 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678 Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA A reporter for amyloid precursor protein gamma-secretase activity in Drosophila | 2 | 4 |
| 6 | 1 | 63 | 6 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002 Kim SH; Ikeuchi T; Yu CJ; Sisodia SS Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates | 19 | 25 |
| 7 | 1 | 33 | 7 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222 LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | 35 | 49 |
| 8 | 1 | 44 | 8 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169 Jung KM; Tan S; Landman N; Petrova K; Murray S; et al. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor | 3 | 24 |
| 9 | 1 | 46 | 9 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291 Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | 16 | 23 |
| 10 | 1 | 73 | 10 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436 Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin | 16 | 25 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 11 | 1 | 51 | 11 2003 MOLECULAR AND CELLULAR NEUROSCIENCE 24 (3): 646-655 Harrison SM; Harper AJ; Hawkins J; Duddy G; Grau E; et al. BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes | 2 | 7 |
| 12 | 1 | 11 | 12 2003 NACHRICHTEN AUS DER CHEMIE 51 (12): 1261-1263 Gross M Amyloid diseases - Little progress, major questions | 0 | 0 |
| 13 | 1 | 52 | 13 2003 NEUROBIOLOGY OF DISEASE 14 (2): 194-204 Baulac S; LaVoie MJ; Kimberly WT; Strahle J; Wolfe MS; et al. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates | 9 | 10 |
| 14 | 0 | 29 | 14 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (11): 6382-6387 Kimberly WT; LaVoie MJ; Ostaszewski BL; Ye WJ; Wolfe MS; et al. gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 | 104 | 104 |
| 15 | 2 | 67 | 15 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080 Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al. A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis | 24 | 34 |
| 16 | 1 | 92 | 16 2004 ANNALS OF INTERNAL MEDICINE 140 (8): 627-638 Selkoe DJ Alzheimer disease: Mechanistic understanding predicts novel therapies | 0 | 6 |
| 17 | 2 | 26 | 17 2004 ANNALS OF NEUROLOGY 55 (5): 604-606 Hutton M Presenilin mutations associated with fronto-temporal dementia | 0 | 1 |
| 18 | 2 | 84 | 18 2004 ANNUAL REVIEW OF GENETICS 38: 709-724 Ehrmann M; Clausen T Proteolysis as aregulatory mechanism | 1 | 2 |
| 19 | 5 | 48 | 19 2004 BIOCHEMISTRY 43 (2): 323-333 Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | 17 | 20 |
| 20 | 6 | 58 | 20 2004 BIOCHEMISTRY 43 (12): 3555-3563 Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation | 5 | 6 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 21 | 4 | 69 | 21 2004 BIOCHEMISTRY 43 (30): 9774-9789 Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al. Purification and characterization of the human gamma-secretase complex | 4 | 6 |
| 22 | 1 | 29 | 22 2004 BIOCHEMISTRY 43 (42): 13532-13540 Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42 | 0 | 1 |
| 23 | 1 | 38 | 23 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938 Esler WP; Das C; Wolfe MS Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties | 1 | 1 |
| 24 | 1 | 295 | 24 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178 Makarova A; Williams SE; Strickland DK Proteases and lipoprotein receptors in Alzheimer's disease | 0 | 0 |
| 25 | 1 | 103 | 25 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335 Johansson J; Weaver TE; Tjernberg LO Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide | 0 | 3 |
| 26 | 1 | 260 | 26 2004 CLINICAL GENETICS 66 (1): 1-16 Wellington CL Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism | 0 | 0 |
| 27 | 2 | 103 | 27 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178 Westlund B; Stilwell G; Sluder A Invertebrate disease models in neurotherapeutic discovery | 0 | 0 |
| 28 | 6 | 117 | 28 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719 Harrison T; Churcher I; Beher D gamma-Secretase as a target for drug intervention in Alzheimer's disease | 0 | 3 |
| 29 | 5 | 28 | 29 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383 Iwatsubo T The gamma-secretase complex: machinery for intramembrane proteolysis | 2 | 5 |
| 30 | 3 | 58 | 30 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588 Wilquet V; De Strooper B Amyloid-beta precursor protein processing in neurodegeneration | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 31 | 1 | 82 | 31 2004 CURRENT PHARMACEUTICAL DESIGN 10 (25): 3113-3121 Lahiri DK; Rogers JT; Greig NH; Sambamurti K Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents | 0 | 0 |
| 32 | 1 | 33 | 32 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| 33 | 4 | 55 | 33 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385 Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al. Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations | 5 | 7 |
| 34 | 1 | 34 | 34 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (22): 4485-4494 Pastorcic M; Das HK Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells - The role of Ets factors in the regulation of presenilin 1 | 0 | 0 |
| 35 | 3 | 190 | 35 2004 EXPERT OPINION ON THERAPEUTIC PATENTS 14 (10): 1403-1420 Larner A Secretases as therapeutic targets in Alzheimer's disease: patents 2000-2004 | 0 | 0 |
| 36 | 1 | 8 | 36 2004 GENETIC ENGINEERING NEWS 24 (16): 28-+ Haberman AB Therapeutic strategies in animal models | 0 | 0 |
| 37 | 2 | 305 | 37 2004 HUMAN GENETICS 114 (5): 413-438 Bertoli-Avella AM; Oostra BA; Heutink P Chasing genes in Alzheimer's and Parkinson's disease | 0 | 2 |
| 38 | 1 | 59 | 38 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331 Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice | 1 | 3 |
| 39 | 1 | 144 | 39 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65 Pasternak SH; Callahan JW; Mahuran DJ The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective | 0 | 3 |
| 40 | 3 | 43 | 40 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693 Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex | 10 | 11 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 41 | 4 | 38 | 41 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152 Lee SF; Shah S; Yu C; Wigley WC; Li H; et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex | 9 | 12 |
| 42 | 2 | 36 | 42 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160 Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor | 5 | 9 |
| 43 | 7 | 48 | 43 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261 Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex | 10 | 10 |
| 44 | 7 | 37 | 44 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315 Edbauer D; Kaether C; Steiner H; Haass C Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1 | 1 | 1 |
| 45 | 2 | 40 | 45 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046 Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles | 2 | 3 |
| 46 | 6 | 75 | 46 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566 Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components | 1 | 3 |
| 47 | 10 | 56 | 47 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345 Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H Identification of distinct gamma-secretase complexes with different APH-1 variants | 7 | 8 |
| 48 | 4 | 36 | 48 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156 Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin | 0 | 1 |
| 49 | 3 | 48 | 49 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426 Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al. Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism | 0 | 3 |
| 50 | 7 | 76 | 50 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954 Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al. Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes | 3 | 10 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 51 | 2 | 29 | 51 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463 Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | 3 | 3 |
| 52 | 1 | 55 | 52 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49105-49112 Ghersi E; Noviello C; D'Adamio L Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner | 0 | 0 |
| 53 | 3 | 53 | 53 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532 Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway | 0 | 0 |
| 54 | 2 | 41 | 54 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 51654-51660 Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria | 0 | 2 |
| 55 | 1 | 66 | 55 2004 JOURNAL OF CELL BIOLOGY 166 (1): 73-83 Gupta-Rossi N; Six E; LeBail O; Logeat F; Chastagner P; et al. Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor | 1 | 10 |
| 56 | 2 | 62 | 56 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111 Gowrishankar K; Zeidler MG; Vincenz C Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD | 0 | 1 |
| 57 | 2 | 14 | 57 2004 JOURNAL OF MEDICINAL CHEMISTRY 47 (26): 6485-6489 Bakshi P; Wolfe MS Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase | 0 | 0 |
| 58 | 1 | 59 | 58 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53 Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein | 4 | 7 |
| 59 | 5 | 42 | 59 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527 Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 | 7 | 8 |
| 60 | 1 | 57 | 60 2004 JOURNAL OF NEUROCHEMISTRY 90 (4): 800-806 da Costa CA; Ayral E; Hernandez JF; St George-Hyslop P; Checler F Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 61 | 3 | 37 | 61 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320 Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding | 4 | 5 |
| 62 | 9 | 62 | 62 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413 Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation | 0 | 0 |
| 63 | 5 | 51 | 63 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237 Ilaya NT; Evin G; Masters CL; Culvenor JG Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle | 0 | 0 |
| 64 | 1 | 56 | 64 2004 JOURNAL OF NEUROSCIENCE 24 (12): 2942-2952 Yan XX; Li T; Rominger CM; Prakash SR; Wong PC; et al. Binding sites of gamma-secretase inhibitors in rodent brain: Distribution, postnatal development, and effect of deafferentation | 2 | 2 |
| 65 | 12 | 113 | 65 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322 Periz G; Fortini ME Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2 | 2 | 6 |
| 66 | 1 | 152 | 66 2004 JOURNAL OF PSYCHIATRY & NEUROSCIENCE 29 (6): 427-441 Kar S; Slowikowski SPM; Westaway D; Mount HTJ Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease | 0 | 0 |
| 67 | 1 | 62 | 67 2004 JOURNAL OF VIROLOGY 78 (7): 3489-3501 Ray N; Enquist LW Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses | 0 | 2 |
| 68 | 2 | 51 | 68 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383 Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins | 0 | 1 |
| 69 | 1 | 104 | 69 2004 NATURE CELL BIOLOGY 6 (11): 1054-1061 Selkoe DJ Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases | 0 | 0 |
| 70 | 2 | 36 | 70 2004 NATURE MEDICINE 10 (9): 959-965 He WX; Lu YF; Qahwash I; Hu XY; Chang AS; et al. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation | 0 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 71 | 3 | 111 | 71 2004 NATURE REVIEWS NEUROSCIENCE : S26-S33 Koo EH; Kopan R Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration | 0 | 0 |
| 72 | 10 | 63 | 72 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272 Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity | 3 | 3 |
| 73 | 1 | 125 | 73 2004 NEUROCHEMICAL RESEARCH 29 (3): 637-650 Canevari L; Abramov AY; Duchen MR Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress | 0 | 5 |
| 74 | 1 | 106 | 74 2004 NEUROCHEMICAL RESEARCH 29 (6): 1317-1331 Kim SI; Voshol H; van Oostrum J; Hastings TG; Cascio M; et al. Neuroproteomics: Expression profiling of the brain's proteomes in health and disease | 0 | 5 |
| 75 | 1 | 56 | 75 2004 NEUROSCIENCE 125 (4): 1009-1017 Hartmann J; Erb C; Ebert U; Baumann KH; Popp A; et al. Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice | 0 | 2 |
| 76 | 4 | 58 | 76 2004 NEUROSCIENCE 129 (3): 615-628 Siman R; Salidas S Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain | 0 | 0 |
| 77 | 1 | 54 | 77 2004 ONCOGENE 23 (42): 7076-7086 Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al. Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor | 0 | 1 |
| 78 | 1 | 105 | 78 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418 Thinakaran G; Parent AT Identification of the role of presenilins beyond Alzheimer's disease | 2 | 4 |
| 79 | 2 | 102 | 79 2004 PHARMACOLOGICAL RESEARCH 50 (4): 419-431 Stoppini M; Andreola A; Foresti G; Bellotti V Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing | 0 | 1 |
| 80 | 8 | 73 | 80 2004 SCIENCE 305 (5687): 1119-1123 Wolfe MS; Kopan R Intramembrane proteotysis: Theme and variations | 2 | 11 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 81 | 1 | 25 | 81 2004 SCIENCE 306 (5694): 269-271 Weng AP; Ferrando AA; Lee W; Morris JP; Silverman LB; et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia | 0 | 10 |
| 82 | 1 | 27 | 82 2004 SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS 1030: 330-338 Repetto E; Russo C; Venezia V; Nizzari M; Nitsch RM; et al. BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter | 0 | 0 |
| 83 | 9 | 25 | 83 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 84 | 5 | 53 | 84 2005 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 85 | 2 | 36 | 85 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 86 | 1 | 109 | 86 2005 EXPERIMENTAL CELL RESEARCH 303 (2): 343-359 Baladron V; Ruiz-Hidalgo MJ; Nueda ML; Diaz-Guerra MJM; Garcia-Ramirez JJ; et al. dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats | 0 | 0 |
| 87 | 8 | 25 | 87 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 88 | 5 | 54 | 88 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 89 | 11 | 53 | 89 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| 90 | 12 | 77 | 90 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 91 | 13 | 68 | 91 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| 92 | 1 | 108 | 92 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832 Xie J; Guo Q PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein | 0 | 0 |
| 93 | 10 | 44 | 93 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 94 | 4 | 50 | 94 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 95 | 7 | 31 | 95 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 96 | 5 | 35 | 96 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020 Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch | 0 | 0 |
| 97 | 1 | 43 | 97 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169 Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities | 1 | 1 |
| 98 | 16 | 282 | 98 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792 Brunkan AL; Goate AM Presenilin function and gamma-secretase activity | 0 | 0 |
| 99 | 11 | 36 | 99 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198 Ma GJ; Li T; Price DL; Wong PC APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | 1 | 1 |
| 100 | 5 | 68 | 100 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73 Brunkan AL; Martinez M; Walker ES; Goate AM Presenilin endoproteolysis is an intrarnolecular cleavage | 0 | 0 |
Page 1 of 2: [ 1 2 ]
Generated by: HistCite 2005.05.14