| # | Cited
nodes | Nodes / Authors | GCS | LCS |
| 1 | 2 | 1 2001 ADVANCED DRUG DELIVERY REVIEWS 53(2):217-228
Jaffar M; Williams KJ; Stratford IJ
Bioreductive and gene therapy approaches to hypoxic diseases | 2 | 1
|
| 2 | 2 | 2 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 288(4):757-764
Hofer T; Spielmann P; Stengel P; Stier B; Katschinski DM; Desbaillets I; Gassmann M; Wenger RH
Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors | 3 | 0
|
| 3 | 2 | 3 2001 BLOOD 98(2):296-302
Vaux EC; Metzen E; Yeates KM; Ratcliffe PJ
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain | 18 | 13
|
| 4 | 2 | 4 2001 BREAST CANCER RESEARCH 3(5):313-317
Pugh CW; Gleadle J; Maxwell PH
Hypoxia and oxidative stress in breast cancer - Hypoxia signalling pathways | 4 | 0
|
| 5 | 2 | 5 2001 CANCER LETTERS 174(1):1-15
Pluquet O; Hainaut P
Genotoxic and non-genotoxic pathways of p53 induction | 8 | 0
|
| 6 | 2 | 6 2001 CANCER RESEARCH 61(24):8924-8929
Olive PL; Aquino-Parsons C; MacPhail SH; Liao SY; Raleigh JA; Lerman MI; Stanbridge EJ
Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer | 6 | 0
|
| 7 | 3 | 7 2001 CELL 107(1):1-3
Semenza GL
HIF-1, O-2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus | 31 | 20
|
| 8 | 5 | 8 2001 CELL 107(1):43-54
Epstein ACR; Gleadle JM; McNeill LA; Hewitson KS; O'Rourke J; Mole DR; Mukherji M; Metzen E; Wilson MI; Dhanda A; Tian YM; Masson N; Hamilton DL; Jaakkola P; Barstead R; Hodgkin J; Maxwell PH; Pugh CW; Schofield CJ; Ratcliffe PJ
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | 121 | 99
|
| 9 | 2 | 9 2001 CELL GROWTH & DIFFERENTIATION 12(9):447-455
Yang HF; Kaelin WG
Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: Implications for oxygen sensing | 7 | 6
|
| 10 | 3 | 10 2001 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 130(4):435-459
Hochachka PW; Lutz PL
Mechanism, origin, and evolution of anoxia tolerance in animals | 8 | 2
|
| 11 | 2 | 11 2001 DEVELOPMENTAL CELL 1(5):595-604
Rogg LE; Bartel B
Auxin signaling: Derepression through regulated proteolysis | 7 | 0
|
| 12 | 3 | 12 2001 EMBO JOURNAL 20(18):5197-5206
Masson N; Willam C; Maxwell PH; Pugh CW; Ratcliffe PJ
Independent function of two destruction domains in hypoxia- inducible factor-alpha chains activated by prolyl hydroxylation | 60 | 55
|
| 13 | 2 | 13 2001 EMBO REPORTS 2(7):615-620
Berra E; Roux D; Richard DE; Pouyssegur J
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O-2- driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm | 5 | 5
|
| 14 | 2 | 14 2001 EXPERIMENTAL NEPHROLOGY 9(4):235-240
Maxwell PH; Pugh CW; Ratcliffe PJ
Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation | 5 | 2
|
| 15 | 2 | 15 2001 FASEB JOURNAL 15(12):U132-U154
Hofer T; Desbaillets I; Hopfl G; Gassmann M; Wenger RH
Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1 alpha activation cascade: implications for HIF-1 alpha gene therapy | 0 | 0
|
| 16 | 2 | 16 2001 FASEB JOURNAL 15(13):2445-2453
Stroka DM; Burkhardt T; Desbaillets I; Wenger RH; Neil DAH; Bauer C; Gassmann M; Candinas D
HIF-1 is expressed in normoxic tissue and displays an organ- specific regulation under systemic hypoxia | 22 | 8
|
| 17 | 3 | 17 2001 FASEB JOURNAL 15(14):2613-2622
Chilov D; Hofer T; Bauer C; Wenger RH; Gassmann M
Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain | 4 | 1
|
| 18 | 3 | 18 2001 FEBS LETTERS 509(2):225-229
Itoh T; Namba T; Fukuda K; Semenza GL; Hirota K
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane | 0 | 0
|
| 19 | 3 | 19 2001 GENES & DEVELOPMENT 15(19):2497-2502
Bruick RK; McKnight SL
Building better vasculature | 6 | 6
|
| 20 | 2 | 20 2001 GENES & DEVELOPMENT 15(19):2520-2532
Elson DA; Thurston G; Huang LE; Ginzinger DG; McDonald DM; Johnson RS; Arbeit JM
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1 alpha | 24 | 17
|
| 21 | 2 | 21 2001 GENES & DEVELOPMENT 15(20):2675-2686
Mahon PC; Hirota K; Semenza GL
FIH-1: a novel protein that interacts with HIF-1 alpha and VHL to mediate repression of HIF-1 transcriptional activity | 31 | 25
|
| 22 | 3 | 22 2001 GENES & DEVELOPMENT 15(23):3104-3117
Querido E; Blanchette P; Yan Q; Kamura T; Morrison M; Boivin D; Kaelin WG; Conaway RC; Conaway JW; Branton PE
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism, involving a Cullin-containing complex | 15 | 0
|
| 23 | 2 | 23 2001 GENOME RESEARCH 11(12):1996-2008
Ponting CP; Mott R; Bork P; Copley RR
Novel protein domains and repeats in Drosophila melanogaster: Insights into structure, function, and evolution | 3 | 0
|
| 24 | 2 | 24 2001 IUBMB LIFE 51(3):165-173
Gilles-Gonzalez MA
Oxygen signal transduction | 9 | 0
|
| 25 | 2 | 25 2001 IUBMB LIFE 52(1-2):25-28
Gulati P; Klohn PC; Krug H; Gottlicher M; Markova B; Bohmer FD; Herrlich P
Redox regulation in mammalian signal transduction | 2 | 0
|
| 26 | 2 | 26 2001 IUBMB LIFE 52(1-2):43-47
Mole DR; Maxwell PH; Pugh CW; Ratcliffe PJ
Regulation of HIF by the von Hippel-Lindau tumour suppressor: Implications for cellular oxygen sensing | 0 | 0
|
| 27 | 2 | 27 2001 IUBMB LIFE 52(1-2):49-53
Michiels C; Minet E; Michel G; Mottet D; Piret JP; Raes M
HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: Role of MAP kinases | 1 | 0
|
| 28 | 2 | 28 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(32):29748-29753
Kamura T; Burian D; Yan Q; Schmidt SL; Lane WS; Querido E; Branton PE; Shilatifard A; Conaway RC; Conaway JW
MUF1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase | 12 | 2
|
| 29 | 2 | 29 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(43):39805-39811
Sandau KB; Zhou J; Kietzmann T; Brune B
Regulation of the hypoxia-inducible factor 1 alpha by the inflammatory mediators nitric oxide and tumor necrosis factor- alpha in contrast to desferroxamine and phenylarsine oxide | 9 | 5
|
| 30 | 2 | 30 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(47):43611-43617
Okuda H; Saitoh K; Hirai S; Iwai K; Takaki Y; Baba M; Minato N; Ohno S; Shuin T
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C | 6 | 2
|
| 31 | 3 | 31 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(47):44323-44330
Vaux EC; Wood SM; Cockman ME; Nicholls LG; Yeates KM; Pugh CW; Maxwell PH; Ratcliffe PJ
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor | 2 | 2
|
| 32 | 2 | 32 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(51):48066-48076
Duyndam MCA; Hulscher TM; Fontijn D; Pinedo HM; Boven E
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1 alpha protein by the oxidative stressor arsenite | 7 | 1
|
| 33 | 2 | 33 2001 M S-MEDECINE SCIENCES 17(6-7):792-793
L'Allemain G
A new molecular step in hypoxia signalling | 0 | 0
|
| 34 | 2 | 34 2001 MOLECULAR BIOLOGY OF THE CELL 12(12):3839-3851
Tang ZY; Li B; Bharadwaj R; Zhu HH; Ozkan E; Hakala K; Deisenhofer J; Yu HT
APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex | 8 | 0
|
| 35 | 1 | 35 2001 NATURE GENETICS 28(2):107-108
Skene JHP; Cleveland DW
Hypoxia and Lou Gehrig | 0 | 0
|
| 36 | 2 | 36 2001 NEWS IN PHYSIOLOGICAL SCIENCES 16():195-196
Wenger RH; Bauer C
Oxygen sensing: "Hydroxy" translates "oxy" | 1 | 0
|
| 37 | 3 | 37 2001 NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY 75(10):1067-1075
Masuda S
Discovery of tissue-specific regulation of erythropoietin expression and applied biochemical study | 0 | 0
|
| 38 | 2 | 38 2001 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 443(2):240-249
Camenisch G; Stroka DM; Gassmann M; Wenger RH
Attenuation of HIF-1 DNA-binding activity limits hypoxia- inducible endothelin-1 expression | 7 | 4
|
| 39 | 2 | 39 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(14):7916-7921
Jiang HQ; Guo R; Powell-Coffman JA
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia | 12 | 9
|
| 40 | 2 | 40 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(17):9630-9635
Yu F; White SB; Zhao Q; Lee FS
HIF-1 alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation | 38 | 35
|
| 41 | 3 | 41 2001 RADIATION RESEARCH 156(5):447-459
Pajonk F; McBride WH
The proteasome in cancer biology and treatment | 4 | 0
|
| 42 | 2 | 42 2001 SCIENCE 292(5516):449-+
Zhu H; Bunn HF
Signal transduction - How do cells sense oxygen? | 30 | 22
|
| 43 | 0 | 43 2001 SCIENCE 292(5516):464-468
Ivan M; Kondo K; Yang HF; Kim W; Valiando J; Ohh M; Salic A; Asara JM; Lane WS; Kaelin WG
HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O-2 sensing | 225 | 225
|
| 44 | 1 | 44 2001 SCIENCE 292(5516):468-472
Jaakkola P; Mole DR; Tian YM; Wilson MI; Gielbert J; Gaskell SJ; von Kriegsheim A; Hebestreit HF; Mukherji M; Schofield CJ; Maxwell PH; Pugh CW; Ratcliffe PJ
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O-2-regulated prolyl hydroxylation | 228 | 206
|
| 45 | 2 | 45 2001 SCIENCE 293(5528):263-269
Shimura H; Schlossmacher MC; Hattori N; Frosch MP; Trockenbacher A; Schneider R; Mizuno Y; Kosik KS; Selkoe DJ
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease | 112 | 1
|
| 46 | 6 | 46 2001 SCIENCE 294(5545):1337-1340
Bruick RK; McKnight SL
A conserved family of prolyl-4-hydroxylases that modify HIF | 77 | 67
|
| 47 | 3 | 47 2001 SCIENTIST 15(10):15-15
Perkel JM
Seeking a cellular oxygen sensor | 1 | 0
|
| 48 | 2 | 48 2001 TRENDS IN CELL BIOLOGY 11(11):S32-S36
Brahimi-Horn C; Berra E; Pouyssegur J
Hypoxia: the tumor's gateway to progression along the angiogenic pathway | 7 | 0
|
| 49 | 3 | 49 2001 ZOOLOGY-ANALYSIS OF COMPLEX SYSTEMS 104(3-4):192-197
Jewell UR; Gassmann M
Mammalian gene expression in hypoxic conditions | 0 | 0
|
| 50 | 7 | 50 2002 ADVANCES IN CANCER RESEARCH, VOL 85 85():1-12
Conaway RC; Conaway JW
The Von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription | 0 | 0
|
| 51 | 5 | 51 2002 ADVANCES IN ENZYME REGULATION, VOL 42, PROCEEDINGS 42():333-347
Mole DR; Pugh CW; Ratcliffe PJ; Maxwell PH
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex | 0 | 0
|
| 52 | 4 | 52 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(1):C178-C186
Agani FH; Puchowicz M; Chavez JC; Pichiule P; LaManna J
Role of nitric oxide in the regulation of HIF-1 alpha expression during hypoxia | 0 | 0
|
| 53 | 2 | 53 2002 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 282(5):L996-L1003
Graven KK; Molvar C; Roncarati JS; Klahn BD; Lowrey S; Farber HW
Identification of protein disulfide isomerase as an endothelial hypoxic stress protein | 0 | 0
|
| 54 | 6 | 54 2002 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 283(5):L918-L921
Schumacker PT
Hypoxia, anoxia, and O-2 sensing: the search continues | 0 | 0
|
| 55 | 6 | 55 2002 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 283(5):L922-L931
Schroedl C; McClintock DS; Budinger GRS; Chandel NS
Hypoxic but not anoxic stabilization of HIF-1 alpha requires mitochondrial reactive oxygen species | 1 | 1
|
| 56 | 2 | 56 2002 ANALYTICAL CHEMISTRY 74(24):6230-6236
Steen H; Mann M
Analysis of bromotryptophan and hydroxyproline modifications by high-resolution, high-accuracy precursor ion scanning utilizing fragment ions with mass-deficient mass tags | 0 | 0
|
| 57 | 5 | 57 2002 ANNALS OF ONCOLOGY 13():25-28
Bicknell R
An update of new targets for cancer treatment: vessels and matrix | 0 | 0
|
| 58 | 2 | 58 2002 ANNUAL REVIEW OF PLANT BIOLOGY 53():377-398
Leyser O
Molecular genetics of auxin signaling | 0 | 0
|
| 59 | 2 | 59 2002 ANTIOXIDANTS & REDOX SIGNALING 4(2):291-299
Kourembanas S
Hypoxia and carbon monoxide in the vasculature | 1 | 0
|
| 60 | 4 | 60 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 290(1):294-299
Kanaya K; Tsai AL; Kamitani T
Cobalt- and nickel-binding property of cullin-2 | 0 | 0
|
| 61 | 6 | 61 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 291(4):908-914
Liu LX; Lu HW; Luo YX; Date T; Belanger AJ; Vincent KA; Akita GY; Goldberg M; Cheng SH; Gregory RJ; Jiang CW
Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1 | 2 | 0
|
| 62 | 3 | 62 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293(1):446-450
Wilson WJ; Poellinger L
The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells | 0 | 0
|
| 63 | 4 | 63 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 294(3):700-709
Li ZB; Wang DK; Na X; Schoen SR; Messing EM; Wu G
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor | 0 | 0
|
| 64 | 2 | 64 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295(3):657-662
Wang F; Sekine H; Kikuchi Y; Takasaki C; Miura C; Heiwa O; Shuin T; Fujii-Kuriyama Y; Sogawa K
HIF-1 alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway | 0 | 0
|
| 65 | 4 | 65 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 296(1):145-151
Kobayashi T; Yanase H; Iwanaga T; Sasaki R; Nagao M
Epididymis is a novel site of erythropoietin production in mouse reproductive organs | 0 | 0
|
| 66 | 7 | 66 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 297(2):346-352
Enomoto N; Koshikawa N; Gassmann M; Hayashi JI; Takenaga K
Hypoxic induction of hypoxia-inducible factor-1 alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells | 0 | 0
|
| 67 | 3 | 67 2002 BIOCHEMICAL JOURNAL 362():71-79
Chun YS; Choi E; Kim TY; Kim MS; Park JW
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1 alpha gene | 1 | 1
|
| 68 | 14 | 68 2002 BIOCHEMICAL JOURNAL 367():571-575
McNeill LA; Hewitson KS; Claridge TD; Seibel JF; Horsfall LE; Schofield CJ
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 | 0 | 0
|
| 69 | 2 | 69 2002 BIOCHEMICAL PHARMACOLOGY 64(5-6):889-892
Piret JP; Mottet D; Raes M; Michiels C
Is HIF-1 alpha a pro- or an anti-apoptotic protein? | 0 | 0
|
| 70 | 6 | 70 2002 BIOCHEMICAL PHARMACOLOGY 64(5-6):993-998
Semenza GL
Signal transduction to hypoxia-inducible factor 1 | 1 | 0
|
| 71 | 2 | 71 2002 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1603(1):31-46
Le NTV; Richardson DR
The role of iron in cell cycle progression and the proliferation of neoplastic cells | 0 | 0
|
| 72 | 3 | 72 2002 BIOLOGICAL CHEMISTRY 383(3-4):489-502
Petrat F; de Groot H; Sustmann R; Rauen U
The chelatable iron pool in living cells: A methodically defined quantity | 4 | 0
|
| 73 | 4 | 73 2002 BIOLOGY OF REPRODUCTION 67(3):995-1002
Powell JD; Elshtein R; Forest DJ; Palladino MA
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1 alpha messenger RNA expression | 0 | 0
|
| 74 | 7 | 74 2002 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12(12):1547-1550
McNeill LA; Hewitson KS; Gleadle JM; Horsfall LE; Oldham NJ; Maxwell PH; Pugh CW; Ratcliffe PJ; Schofield CJ
The use of dioxygen by HIF prolyl hydroxylase (PHD1) | 3 | 3
|
| 75 | 2 | 75 2002 BLOOD 99(5):1552-1555
Hildebrandt W; Alexander S; Bartsch P; Droge W
Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O-2 chemosensitivity | 3 | 0
|
| 76 | 3 | 76 2002 BLOOD 99(10):3562-3565
Wiesener MS; Seyfarth M; Warnecke C; Jurgensen JS; Rosenberger C; Morgan NV; Maher ER; Frei U; Eckardt KU
Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma | 0 | 0
|
| 77 | 2 | 77 2002 BLOOD 99(10):3851-3853
Richard S; Croisille L; Yvart J; Casadeval N; Eschwege P; Aghakhani N; David P; Gaudric A; Scigalla P; Hermine O
Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy | 1 | 1
|
| 78 | 4 | 78 2002 BLOOD 100(7):2623-2628
Stolze I; Berchner-Pfannschmidt U; Freitag P; Wotzlaw C; Rossler J; Frede S; Acker H; Fandrey J
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells | 0 | 0
|
| 79 | 4 | 79 2002 BLOOD 100(8):3008-3016
Mecklenburgh KI; Walmsley SR; Cowburn AS; Wiesener M; Reed BJ; Upton PD; Deighton J; Greening AP; Chilvers ER
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis | 0 | 0
|
| 80 | 3 | 80 2002 BLOOD CELLS MOLECULES AND DISEASES 28(1):57-62
Ang SO; Chen H; Gordeuk VR; Sergueeva AI; Polyakova LA; Miasnikova GY; Kralovics R; Stockton DW; Prchal JT
Endemic polycythemia in Russia: Mutation in the VHL gene | 2 | 1
|
| 81 | 12 | 81 2002 BLOOD PURIFICATION 20(5):445-450
Ratcliffe PJ
From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway | 0 | 0
|
| 82 | 7 | 82 2002 CANCER CELL 1(3):237-246
Kondo K; Klco J; Nakamura E; Lechpammer M; Kaelin WG
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein | 6 | 2
|
| 83 | 3 | 83 2002 CANCER CELL 1(3):247-255
Maranchie JK; Vasselli JR; Riss J; Bonifacino JS; Linehan WM; Klausner RD
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma | 4 | 1
|
| 84 | 6 | 84 2002 CANCER CELL 1(5):459-468
Mandriota SJ; Turner KJ; Davies DR; Murray PG; Morgan NV; Sowter HM; Wykoff CC; Maher ER; Harris AL; Ratcliffe PJ; Maxwell PH
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron | 0 | 0
|
| 85 | 2 | 85 2002 CANCER LETTERS 181(2):233-238
Zhong H; Mabjeesh NJ; Willard MT; Simons JW
Nuclear expression of hypoxia-inducible factor 1 alpha protein is heterogeneous in human malignant cells under normoxic conditions | 1 | 1
|
| 86 | 2 | 86 2002 CANCER RESEARCH 62(6):1682-1687
Bauer AL; Paulding WR; Striet JB; Schnell PO; Czyzyk-Krzeska MF
Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells | 1 | 1
|
| 87 | 3 | 87 2002 CANCER RESEARCH 62(9):2478-2482
Mabjeesh NJ; Post DE; Willard MT; Kaur B; Van Meir EG; Simons JW; Zhong H
Geldanamycin induces degradation of hypoxia-inducible factor 1 alpha protein via the proteosome pathway in prostate cancer cells | 4 | 4
|
| 88 | 1 | 88 2002 CANCER RESEARCH 62(15):4316-4324
Rapisarda A; Uranchimeg B; Scudiero DA; Selby M; Sausville EA; Shoemaker RH; Melillo G
Identification of small molecule inhibitors of hypoxia- inducible factor 1 transcriptional activation pathway | 1 | 1
|
| 89 | 2 | 89 2002 CANCER RESEARCH 62(23):6924-6927
Chong TW; Horwitz LD; Moore JW; Sowter HM; Harris AL
A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines | 0 | 0
|
| 90 | 10 | 90 2002 CELL 111(5):709-720
Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW
Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 1 | 1
|
| 91 | 3 | 91 2002 CIRCULATION 106(21):2741-2746
Patterson C; Cyr D
Welcome to the machine - A cardiologist's introduction to protein folding and degradation | 0 | 0
|
| 92 | 4 | 92 2002 CIRCULATION RESEARCH 90(2):E25-E33
Kim CH; Cho YS; Chun YS; Park JW; Kim MS
Early expression of myocardial HIF-1 alpha in response to mechanical stresses - Regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway | 4 | 3
|
| 93 | 3 | 93 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 131(3):569-574
Tini M; Jewell UR; Camenisch G; Chilov D; Gassman M
Generation and application of chicken egg-yolk antibodies | 0 | 0
|
| 94 | 7 | 94 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 133(1):1-16
Nikinmaa M
Oxygen-dependent cellular functions - why fishes and their aquatic environment are a prime choice of study | 0 | 0
|
| 95 | 7 | 95 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 133(4):475-481
Hofer T; Desbaillets I; Hopfl G; Wenger RH; Gassmann M
Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy | 0 | 0
|
| 96 | 2 | 96 2002 CURRENT BIOLOGY 12(19):R663-R665
Lord JM; Frigerio L
ER quality control: A function for sugars in the cytosol | 0 | 0
|
| 97 | 4 | 97 2002 CURRENT OPINION IN CHEMICAL BIOLOGY 6(2):193-201
Ryle MJ; Hausinger RP
Non-heme iron oxygenases | 7 | 2
|
| 98 | 2 | 98 2002 CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 11(1):37-42
Karumanchi SA; Merchan J; Sukhatme VP
Renal cancer: molecular mechanisms and newer therapeutic options | 3 | 1
|
| 99 | 7 | 99 2002 CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 11(4):445-450
Franch HA
Pathways of proteolysis affecting renal cell growth | 1 | 0
|
| 100 | 7 | 100 2002 CURRENT OPINION IN STRUCTURAL BIOLOGY 12(6):822-830
VanDemark AP; Hill CP
Structural basis of ubiquitylation | 0 | 0
|
| # | Cited
nodes | Nodes / Authors | GCS | LCS |
| 101 | 2 | 101 2002 DEVELOPMENTAL CELL 2(3):331-341
Yun Z; Maecker HL; Johnson RS; Giaccia AJ
Inhibition of PPAR gamma 2 gene expression by the HIF-1- regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia | 3 | 0
|
| 102 | 3 | 102 2002 EMBO REPORTS 3(2):177-182
Ohh M; Kim WY; Moslehi JJ; Chen YZ; Chau V; Read MA; Kaelin WG
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells | 7 | 0
|
| 103 | 2 | 103 2002 EUKARYOTIC CELL 1(3):481-490
Jiang YD; Vasconcelles MJ; Wretzel S; Light A; Gilooly L; McDaid K; Oh CS; Martin CE; Goldberg MA
Mga2p processing by hypoxia and unsaturated fatty acids in Saccharomyces cerevisiae: Impact on LORE-dependent gene expression | 1 | 0
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| 104 | 2 | 104 2002 EUROPEAN JOURNAL OF CANCER 38(2):240-257
Wouters BG; Weppler SA; Koritzinsky M; Landuyt W; Nuyts S; Theys J; Chiu RK; Lambin P
Hypoxia as a target for combined modality treatments | 1 | 0
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| 105 | 2 | 105 2002 EXPERIMENTAL HEMATOLOGY 30(12):1419-1427
Figueroa YG; Chan AK; Ibrahim R; Tang Y; Burow ME; Alam J; Scandurro AB; Beckman BS
NF-kappa B plays a key role in hypoxia-inducible factor-1- regulated erythropoietin gene expression | 0 | 0
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| 106 | 12 | 106 2002 EXPERT OPINION ON THERAPEUTIC PATENTS 12(6):777-788
Mabjeesh NJ; Frazier MC; Simons JW; Zhong H
Hypoxia-directed cancer therapy | 0 | 0
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| 107 | 2 | 107 2002 FASEB JOURNAL 16(1):U183-U206
Scheid A; Wenger RH; Schaffer L; Camenisch I; Distler O; Ferenc A; Cristina H; Ryan HE; Johnson RS; Wagner KF; Stauffer UG; Bauer C; Gassmann M; Meuli M
Physiologically low oxygen concentrations determined in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor beta 3 | 0 | 0
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| 108 | 1 | 108 2002 FASEB JOURNAL 16(9):U300-U321
Iervolino A; Trisciuoglio D; Ribatti D; Candiloro A; Biroccio A; Zupi G; Del Bufalo D
Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity | 0 | 0
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| 109 | 12 | 109 2002 FASEB JOURNAL 16(14):U348-U369
Wiesener MS; Jurgensen JS; Rosenberger C; Scholze C; Horstrup JH; Warnecke C; Mandriota S; Bechmann I; Frei UA; Pugh CW; Ratcliffe PJ; Bachmann S; Maxwell PH; Eckardt KU
Widespread, hypoxia-inducible expression of HIF-2 alpha in distinct cell populations of different organs | 0 | 0
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| 110 | 19 | 110 2002 FASEB JOURNAL 16(10):1151-1162
Wenger RH
Cellular adaptation to hypoxia: O-2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O-2- regulated gene expression | 5 | 1
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| 111 | 3 | 111 2002 FEBS LETTERS 512(1-3):157-162
Stiehl DP; Jelkmann W; Wenger RH; Hellwig-Burgel T
Normoxic induction of the hypoxia-inducible factor 1 alpha by insulin and interleukin-1 beta involves the phosphatidylinositol 3-kinase pathway | 7 | 4
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| 112 | 2 | 112 2002 FEBS LETTERS 513(1):2-10
Pawson T; Raina M; Nash P
Interaction domains: from simple binding events to complex cellular behavior | 4 | 0
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| 113 | 5 | 113 2002 FEBS LETTERS 529(2-3):309-312
Wang J; Buss JL; Chen GH; Ponka P; Pantopoulos K
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzo ate generates effective iron deficiency in cultured cells | 0 | 0
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| 114 | 4 | 114 2002 FREE RADICAL BIOLOGY AND MEDICINE 32(9):790-796
Levine RL
Carbonyl modified proteins in cellular regulation, aging, and disease | 2 | 0
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| 115 | 4 | 115 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(3):356-363
Creighton-Gutteridge M; Tyrrell RM
A novel iron chelator that does not induce HIF-1 activity | 1 | 0
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| 116 | 8 | 116 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(9):1231-1242
Michiels C; Minet E; Mottet D; Raes M
Regulation of gene expression by oxygen: NF-kappa B and HIF-1, two extremes | 0 | 0
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| 117 | 17 | 117 2002 GENES & DEVELOPMENT 16(12):1441-1445
Kaelin WG
How oxygen makes its presence felt | 3 | 2
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| 118 | 7 | 118 2002 GENES & DEVELOPMENT 16(12):1466-1471
Lando D; Peet DJ; Gorman JJ; Whelan DA; Whitelaw ML; Bruick RK
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor | 13 | 12
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| 119 | 1 | 119 2002 GENOME RESEARCH 12(7):1048-1059
Lespinet O; Wolf YI; Koonin EV; Aravind L
The role of lineage-specific gene family expansion in the evolution of eukaryotes | 4 | 0
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| 120 | 3 | 120 2002 GLYCOBIOLOGY 12(2):17R-27R
West CM; van der Wel H; Gaucher EA
Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins | 3 | 0
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| 121 | 1 | 121 2002 HEPATOLOGY 35(2):332-340
Adachi S; Okuno M; Matsushima-Nishiwaki R; Takano Y; Kojima S; Friedman SL; Moriwaki H; Okano Y
Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma | 4 | 0
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| 122 | 3 | 122 2002 HIGH ALTITUDE MEDICINE & BIOLOGY 3(2):177-193
Levine BD
Intermittent hypoxic training: Fact and fancy | 0 | 0
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| 123 | 2 | 123 2002 HISTOLOGY AND HISTOPATHOLOGY 17(1):301-321
Zagzag D; Capo V
Angiogenesis in the central nervous system: a role for vascular endothelial growth factor/vascular permeability factor and tenascin-C. Common molecular effectors in cerebral neoplastic and non-neoplastic "angiogenic diseases" | 0 | 0
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| 124 | 2 | 124 2002 INTERNAL MEDICINE 41(2):79-83
Semenza GL
Involvement of hypoxia-inducible factor 1 in human cancer | 2 | 1
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| 125 | 2 | 125 2002 JOURNAL OF APPLIED PHYSIOLOGY 92(6):2501-2507
Balanos GM; Dorrington KL; Robbins PA
Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1 | 0 | 0
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| 126 | 5 | 126 2002 JOURNAL OF BIOCHEMISTRY 131(4):523-531
Nakajima H; Ishida T; Tanaka H; Horiike K
Accurate measurement of near-micromolar oxygen concentrations in aqueous solutions based on enzymatic extradiol cleavage of 4-chlorocatechol: Applications to improved low-oxygen experimental systems and quantitative assessment of back diffusion of oxygen from the atmosphere | 0 | 0
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| 127 | 1 | 127 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(1):9-12
Bae MK; Ahn MY; Jeong JW; Bae MH; Lee YM; Bae SK; Park JW; Kim KR; Kim KW
Jab1 interacts directly with HIF-1 alpha and regulates its stability | 7 | 5
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| 128 | 7 | 128 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6183-6187
Minchenko A; Leshchinsky I; Opentanova I; Sang NL; Srinivas V; Armstead V; Caro J
Hypoxia-inducible factor-1-mediated expression of the 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene - Its possible role in the Warburg effect | 5 | 3
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| 129 | 4 | 129 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(11):9262-9267
Katschinski DM; Le L; Heinrich D; Wagner KF; Hofer T; Schindler SG; Wenger RH
Heat induction of the unphosphorylated form of hypoxia- inducible factor-1 alpha is dependent on heat shock protein-90 activity | 4 | 4
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| 130 | 7 | 130 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(16):13508-13517
Alvarez-Tejado M; Alfranca A; Aragones J; Vara A; Landazuri MO; del Peso L
Lack of evidence for the involvement of the phosphoinositide 3- kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension | 4 | 0
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| 131 | 6 | 131 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(17):15162-15170
Arsham AM; Plas DR; Thompson CB; Simon MC
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription | 3 | 2
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| 132 | 2 | 132 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(18):15586-15591
Hyman LE; Kwon E; Ghosh S; McGee J; Chachulska AMB; Jackson T; Baricos WH
Binding to Elongin C inhibits degradation of interacting proteins in yeast | 0 | 0
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| 133 | 6 | 133 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23111-23115
Lu HS; Forbes RA; Verma A
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis | 1 | 0
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| 134 | 4 | 134 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23367-23373
Osada M; Imaoka S; Sugimoto T; Hiroi T; Funae Y
NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1 | 0 | 0
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| 135 | 5 | 135 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23508-23514
Gradin K; Takasaki C; Fujii-Kuriyama Y; Sogawa K
The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine | 1 | 1
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| 136 | 4 | 136 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23965-23971
Hieta R; Myllyharju J
Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana | 1 | 0
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| 137 | 12 | 137 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26351-26355
Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | 10 | 10
|
| 138 | 10 | 138 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(33):29936-29944
Isaacs JS; Jung YJ; Mimnaugh EG; Martinez A; Cuttitta F; Neckers LM
Hsp90 regulates a von Hippel Lindau-independent hypoxia- inducible factor-1 alpha-degradative pathway | 4 | 2
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| 139 | 5 | 139 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(36):32405-32408
Makino Y; Kanopka A; Wilson WJ; Tanaka H; Poellinger L
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus | 0 | 0
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| 140 | 5 | 140 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38205-38211
Fukuda R; Hirota K; Fan F; Do Jung Y; Ellis LM; Semenza GL
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells | 1 | 0
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| 141 | 11 | 141 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38723-38730
Ruas JL; Poellinger L; Pereira T
Functional analysis of hypoxia-inducible factor-1 alpha- mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein | 1 | 1
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| 142 | 14 | 142 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):39792-39800
Huang JH; Zhao Q; Mooney SM; Lee FS
Sequence determinants in hypoxia-inducible factor-1 alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3 | 0 | 0
|
| 143 | 7 | 143 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117
Chan DA; Sutphin PD; Denko NC; Giaccia AJ
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 0 | 0
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| 144 | 18 | 144 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755
Huang LE; Pete EA; Schau M; Milligan J; Gu J
Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 0 | 0
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| 145 | 3 | 145 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(45):42953-42957
Grosfeld A; Andre J; Hauguel-de-Mouzon S; Berra E; Pouyssegur J; Guerre-Millo M
Hypoxia-inducible factor 1 transactivates the human leptin gene promoter | 0 | 0
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| 146 | 4 | 146 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(50):48403-48409
Page EL; Robitaille GA; Pouyssegur J; Richard DE
Induction of hypoxia-inducible factor-1 alpha by transcriptional and translational mechanisms | 0 | 0
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| 147 | 3 | 147 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(51):50081-50086
Liu XH; Kirschenbaum A; Lu M; Yao S; Dosoretz A; Holland JF; Levine AC
Prostaglandin E-2 induces hypoxia-inducible factor-1 alpha stabilization and nuclear localization in a human prostate cancer cell line | 0 | 0
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| 148 | 2 | 148 2002 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 128(7):358-362
Anastasiadis AG; Ghafar MA; Salomon L; Vacherot F; Benedit P; Chen MW; Shabsigh A; Burchardt M; Chopin DK; Shabsigh R; Buttyan R
Human hormone-refractory prostate cancers can harbor mutations in the 0(2)-dependent degradation domain of hypoxia inducible factor-1 alpha (HIF-1 alpha) | 0 | 0
|
| 149 | 3 | 149 2002 JOURNAL OF EXPERIMENTAL ZOOLOGY 294(1):17-29
Powell WH; Hahn ME
Identification and functional characterization of hypoxia- inducible factor 2 alpha from the estuarine teleost, Fundulus heteroclitus: Interaction of HIF-2 alpha with two ARNT2 splice variants | 1 | 1
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| 150 | 10 | 150 2002 JOURNAL OF KOREAN MEDICAL SCIENCE 17(5):581-588
Chun YS; Kim MS; Park JW
Oxygen-dependent and -independent regulation of HIF-1alpha | 0 | 0
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| 151 | 3 | 151 2002 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34(8):1063-1073
Malhotra R; Tyson DGW; Sone H; Aoki K; Kumagai AK; Brosius FC
Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1 alpha levels in cardiac myocytes | 0 | 0
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| 152 | 9 | 152 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(9):562-575
Acker T; Plate KH
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology | 0 | 0
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| 153 | 8 | 153 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(11):703-714
Kim KR; Moon HE; Kim KW
Hypoxia-induced angiogenesis in human hepatocellular carcinoma | 0 | 0
|
| 154 | 2 | 154 2002 JOURNAL OF NEUROSURGERY 97(3):658-667
Jensen RL; Soleau S; Bhayani MK; Christiansen D
Expression of hypoxia inducible factor-1 alpha and correlation with preoperative embolization of meningiomas | 0 | 0
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| 155 | 2 | 155 2002 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13(7):1721-1732
Rosenberger C; Mandriota S; Jurgensen JS; Wiesener MS; Horstrup JH; Frei U; Ratcliffe PJ; Maxwell PH; Bachmann S; Eckardt KU
Expression of hypoxia-inducible factor-1 alpha and -2 alpha in hypoxic and ischemic rat kidneys | 2 | 2
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| 156 | 3 | 156 2002 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13(7):1974-1976
Fine LG; Norman JT
The breathing kidney | 0 | 0
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| 157 | 2 | 157 2002 JOURNAL OF THE NATIONAL CANCER INSTITUTE 94(20):1569-1575
Yao M; Yoshida M; Kishida T; Nakaigawa N; Baba M; Kobayashi K; Miura T; Moriyama M; Nagashima Y; Nakatani Y; Kubota Y; Kondo K
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma | 0 | 0
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| 158 | 5 | 158 2002 M S-MEDECINE SCIENCES 18(1):70-78
Gothie E; Pouyssegur J
HIF-1: a central regulator of hypoxia | 0 | 0
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| 159 | 3 | 159 2002 METHODS 28(2):259-266
Tang Y; Schmitt-Ott K; Qian KP; Kagiyama S; Phillips MI
Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases | 0 | 0
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| 160 | 4 | 160 2002 MICROSCOPY RESEARCH AND TECHNIQUE 59(1):41-48
Goonewardene TI; Sowter HM; Harris AL
Hypoxia-induced pathways in breast cancer | 0 | 0
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| 161 | 2 | 161 2002 MICROSCOPY RESEARCH AND TECHNIQUE 59(3):178-187
Paulding WR; Schnell PO; Bauer AL; Striet JB; Nash JA; Kuznetsova AV; Czyzyk-Krzeska MF
Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen-sensitive neuroendocrine cells | 0 | 0
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| 162 | 3 | 162 2002 MICROSCOPY RESEARCH AND TECHNIQUE 59(3):234-242
Kummer W; Yamamoto Y
Cellular distribution of oxygen sensor candidates - Oxidases, cytochromes, K+-channels - in the carotid body | 0 | 0
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| 163 | 2 | 163 2002 MOLECULAR AND CELLULAR BIOLOGY 22(1):12-22
Alfranca A; Gutierrez MD; Vara A; Aragones J; Vidal F; Landazuri MO
c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription | 2 | 1
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| 164 | 2 | 164 2002 MOLECULAR AND CELLULAR BIOLOGY 22(6):1947-1960
Hansen WJ; Ohh M; Moslehi J; Kondo K; Kaelin WG; Welch WJ
Diverse effects of mutations in Exon II of the von Hippel- Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity | 4 | 1
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| 165 | 3 | 165 2002 MOLECULAR AND CELLULAR BIOLOGY 22(8):2515-2523
Laderoute KR; Calaoagan JM; Gustafson-Brown C; Knapp AM; Li GC; Mendonca HL; Ryan HE; Wang ZH; Johnson RS
The response of c-Jun/AP-1 to chronic hypoxia is hypoxia- inducible factor 1 alpha dependent | 0 | 0
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| 166 | 8 | 166 2002 MOLECULAR AND CELLULAR BIOLOGY 22(9):2984-2992
Sang NL; Fang J; Srinivas V; Leshchinsky I; Caro J
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein- independent, hydroxylation-regulated association with p300/CBP | 9 | 9
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| 167 | 7 | 167 2002 MOLECULAR AND CELLULAR BIOLOGY 22(15):5319-5336
Groulx I; Lee S
Oxygen-dependent ubiquitination and degradation of hypoxia- inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein | 2 | 0
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| 168 | 8 | 168 2002 MOLECULAR AND CELLULAR BIOLOGY 22(19):6842-6853
Lavista-Llanos S; Centanin L; Irisarri M; Russo DM; Gleadle JM; Bocca SN; Muzzopappa M; Ratcliffe PJ; Wappner P
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar | 0 | 0
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| 169 | 10 | 169 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014
Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT
Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 0 | 0
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| 170 | 5 | 170 2002 MOLECULAR AND CELLULAR BIOLOGY 22(21):7405-7416
Koumenis C; Naczki C; Koritzinsky M; Rastani S; Diehl A; Sonenberg N; Koromilas A; Wouters BG
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2 alpha | 0 | 0
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| 171 | 2 | 171 2002 MOLECULAR AND CELLULAR NEUROSCIENCE 20(2):307-322
Henrich M; Hoffmann K; Konig P; Gruss M; Fischbach T; Godecke A; Hempelmann G; Kummer W
Sensory neurons respond to hypoxia with NO production associated with mitochondria | 0 | 0
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| 172 | 6 | 172 2002 MOLECULAR BIOLOGY OF THE CELL 13(5):1473-1483
Padilla PA; Nystul TG; Zager RA; Johnson ACM; Roth MB
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans | 0 | 0
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| 173 | 2 | 173 2002 MOLECULAR ENDOCRINOLOGY 16(2):234-243
Marti HH; Katschinski DM; Wagner KF; Schaffer L; Stier B; Wenger RH
Isoform-specific expression of hypoxia-inducible factor-1 alpha during the late stages of mouse spermiogenesis | 3 | 2
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| 174 | 3 | 174 2002 MOLECULAR GENETICS AND METABOLISM 77(1-2):44-56
Sakamoto KM
Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies | 0 | 0
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| 175 | 6 | 175 2002 MOLECULAR PHARMACOLOGY 62(5):975-982
Hur E; Kim HH; Choi SM; Kim JH; Yim S; Kwon HJ; Choi Y; Kim DK; Lee MO; Park H
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1 alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat- shock protein inhibitor radicicol | 0 | 0
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| 176 | 7 | 176 2002 MOLECULES AND CELLS 14(1):9-15
Lee E; Yim S; Lee SK; Park H
Two transactivation domains of hypoxia-inducible factor-1 alpha regulated by the MEK-1/p42/p44 MAPK pathway | 0 | 0
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| 177 | 7 | 177 2002 NATURE 417(6892):975-978
Hon WC; Wilson MI; Harlos K; Claridge TDW; Schofield CJ; Pugh CW; Maxwell PH; Ratcliffe PJ; Stuart DI; Jones EY
Structural basis for the recognition of hydroxyproline in alpha IF-1 alpha by pVHL | 11 | 10
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| 178 | 2 | 178 2002 NATURE 418(6896):438-442
Yoshida Y; Chiba T; Tokunaga F; Kawasaki H; Iwai K; Suzuki T; Ito Y; Matsuoka K; Yoshida M; Tanaka K; Tai T
E3 ubiquitin ligase that recognizes sugar chains | 3 | 2
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| 179 | 7 | 179 2002 NATURE GENETICS 32(4):614-621
Ang SO; Chen H; Hirota K; Gordeuk VR; Jelinek J; Guan YL; Liu EL; Sergueeva AI; Miasnikova GY; Mole D; Maxwell PH; Stockton DW; Semenza GL; Prchal JT
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia | 0 | 0
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| 180 | 6 | 180 2002 NATURE REVIEWS CANCER 2(1):38-47
Harris AL
Hypoxia - A key regulatory factor in tumour growth | 10 | 4
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| 181 | 20 | 181 2002 NATURE REVIEWS CANCER 2(9):673-682
Kaelin WG
Molecular basis of the VHL hereditary cancer syndrome | 4 | 0
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| 182 | 4 | 182 2002 NEPHROLOGY 7():S21-S25
Pugh CW; Maxwell PH; Ratcliffe PJ
Oxygen mediated gene regulation | 0 | 0
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| 183 | 3 | 183 2002 NEPHROLOGY DIALYSIS TRANSPLANTATION 17():3-7
Zhu H; Jackson T; Bunn HF
Detecting and responding to hypoxia | 2 | 1
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| 184 | 4 | 184 2002 NEPHROLOGY DIALYSIS TRANSPLANTATION 17(3):356-359
Wiesener MS; Eckardt KU
Erythropoietin, tumours and the von Hippel-Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing | 0 | 0
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| 185 | 1 | 185 2002 NEUROBIOLOGY OF DISEASE 11(1):53-63
Schenck A; Van de Bor V; Bardoni B; Giangrande A
Novel features of dFMR1, the Drosophila orthologue of the fragile X mental retardation protein | 0 | 0
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| 186 | 2 | 186 2002 NEUROCHEMICAL RESEARCH 27(10):1105-1112
Jin K; Mao XO; Eshoo MW; del Rio G; Rao R; Chen D; Simon RP; Greenberg DA
cDNA microarray analysis of changes in gene expression induced by neuronal hypoxia in vitro | 0 | 0
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| 187 | 2 | 187 2002 OBESITY RESEARCH 10(8):856-856
Guerre-Millo M; Grosfeld A; Issad T
Leptin is a hypoxia-inducible gene | 1 | 0
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| 188 | 2 | 188 2002 ONCOGENE 21(2):282-290
Williams KJ; Telfer BA; Airley RE; Peters HPW; Sheridan MR; van der Kogel AJ; Harris AL; Stratford IJ
A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis | 3 | 2
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| 189 | 3 | 189 2002 ONCOGENE 21(22):3507-3516
Gemmill RM; Bemis LT; Lee JP; Sozen MA; Baron A; Zeng C; Erickson PF; Hooper JE; Drabkin HA
The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway | 1 | 0
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| 190 | 8 | 190 2002 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 443(4):503-507
Hofer T; Wenger RH; Gassmann M
Oxygen sensing, HIF-1 alpha stabilization and potential therapeutic strategies | 1 | 2
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| 191 | 3 | 191 2002 PHYSIOLOGICAL REVIEWS 82(2):373-428
Glickman MH; Ciechanover A
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction | 17 | 0
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| 192 | 3 | 192 2002 PLACENTA 23():S58-S68
De Marco CS; Caniggia I
Mechanisms of oxygen sensing in human trophoblast cells | 0 | 0
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| 193 | 2 | 193 2002 PLANT CELL 14():S81-S95
Kepinski S; Leyser O
Ubiquitination and auxin signaling: A degrading story | 4 | 0
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| 194 | 2 | 194 2002 PRESSE MEDICALE 31(12):562-564
Allain H; Bentue-Ferrer D
The effect of almitrine/raubasine on the cerebral mechanism of elderly patients | 0 | 0
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| 195 | 5 | 195 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5271-5276
Dames SA; Martinez-Yamout M; De Guzman RN; Dyson HJ; Wright PE
Structural basis for Hif-1 alpha/CBP recognition in the cellular hypoxic response | 10 | 8
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| 196 | 6 | 196 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5367-5372
Freedman SJ; Sun ZYJ; Poy F; Kung AL; Livingston DM; Wagner G; Eck MJ
Structural basis for recruitment of CBP/p300 by hypoxia- inducible factor-1 alpha | 10 | 8
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| 197 | 5 | 197 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10305-10309
Hansson LO; Friedler A; Freund S; Rudiger S; Fersht AR
Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53 | 0 | 0
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| 198 | 6 | 198 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10423-10428
Willam C; Masson N; Tian YM; Mahmood SA; Wilson MI; Bicknell R; Eckardt KU; Maxwell PH; Ratcliffe PJ; Pugh CW
Peptide blockade of HIF alpha degradation modulates cellular metabolism and angiogenesis | 0 | 0
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| 199 | 16 | 199 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572
Semenza GL
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 0 | 0
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| 200 | 10 | 200 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464
Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 0 | 0
|
| # | Cited
nodes | Nodes / Authors | GCS | LCS |
| 201 | 11 | 201 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356
Dann CE; Bruick RK; Deisenhofer J
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 0 | 0
|
| 202 | 5 | 202 2002 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 130(3):223-233
Lahiri S; Di Giulio C; Roy A
Lessons from chronic intermittent and sustained hypoxia at high altitudes | 0 | 0
|
| 203 | 10 | 203 2002 RESPIRATORY RESEARCH 3(1):art. no.-26
Haddad JJ
Oxygen-sensing mechanisms and the regulation of redox- responsive transcription factors in development and pathophysiology | 0 | 0
|
| 204 | 5 | 204 2002 SCIENCE 295(5556):807-808
Bruick RK; McKnight SL
Transcription - Oxygen sensing gets a second wind | 7 | 4
|
| 205 | 6 | 205 2002 SCIENCE 295(5556):858-861
Lando D; Peet DJ; Whelan DA; Gorman JJ; Whitelaw ML
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch | 50 | 39
|
| 206 | 5 | 206 2002 SCIENCE 296(5571):1254-1258
Conaway RC; Brower CS; Conaway JW
Gene expression - Emerging roles of ubiquitin in transcription regulation | 16 | 1
|
| 207 | 8 | 207 2002 SCIENCE 296(5574):1886-1889
Min JH; Yang HF; Ivan M; Gertler F; Kaelin WG; Pavletich NP
Structure of an HIF-1 alpha-pVHL complex: Hydroxyproline recognition in signaling | 11 | 10
|
| 208 | 2 | 208 2002 SCIENCE 297(5578):96-99
Kwon YT; Kashina AS; Davydov IV; Hu RG; An JY; Seo JW; Du F; Varshavsky A
An essential role of N-terminal arginylation in cardiovascular development | 4 | 0
|
| 209 | 2 | 209 2002 SCIENCE 297(5582):793-797
Hellmann H; Estelle M
Plant development: Regulation by protein degradation | 3 | 0
|
| 210 | 8 | 210 2002 SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 13(1):29-37
Maxwell PH; Ratcliffe PJ
Oxygen sensors and angiogenesis | 3 | 2
|
| 211 | 3 | 211 2002 SEMINARS IN NEPHROLOGY 22(2):89-99
Neumann HPH; Hoegerle S; Manz T; Brenner K; Iliopoulos O
How many pathways to pheochromocytoma? | 0 | 0
|
| 212 | 3 | 212 2002 STRUCTURE 10(1):93-103
Wilmouth RC; Turnbull JJ; Welford RWD; Clifton IJ; Prescott AG; Schofield CJ
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana | 5 | 1
|
| 213 | 1 | 213 2002 TRENDS IN BIOCHEMICAL SCIENCES 27(5):235-241
Kile BT; Schulman BA; Alexander WS; Nicola NA; Martin HME; Hilton DJ
The SOCS box: a tale of destruction and degradation | 3 | 1
|
| 214 | 13 | 214 2002 TRENDS IN CARDIOVASCULAR MEDICINE 12(8):362-367
Vincent KA; Feron O; Kelly RA
Harnessing the response to tissue hypoxia - HIF-1 alpha and therapeutic angiogenesis | 0 | 0
|
| 215 | 5 | 215 2002 TRENDS IN MOLECULAR MEDICINE 8(4):S62-S67
Semenza GL
HIF-1 and tumor progression: pathophysiology and therapeutics | 11 | 5
|
| 216 | 5 | 216 2002 TRENDS IN PHARMACOLOGICAL SCIENCES 23(12):576-582
Bikfalvi A; Bicknell R
Recent advances in angiogenesis, anti-angiogenesis and vascular targeting | 0 | 0
|
| 217 | 9 | 217 2003 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 284(2):C439-C446
Zhou J; Fandrey J; Schumann J; Tiegs G; Brune B
NO and TNF-alpha released from activated macrophages stabilize HIF-1 alpha in resting tubular LLC-PK1 cells | 0 | 0
|
| 218 | 7 | 218 2003 CLINICAL CANCER RESEARCH 9(1):433-440
Park JH; Kim TY; Jong HS; Kim TY; Chun YS; Park JW; Lee CT; Jung HC; Kim NK; Bang YJ
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1 alpha in gastric cancer cells | 0 | 0
|
| 219 | 7 | 219 2003 EXPERIMENTAL BIOLOGY AND MEDICINE 228(1):1-14
Fisher JW
Erythropoietin: Physiology and pharmacology update | 0 | 0
|
| 220 | 9 | 220 2003 FRONTIERS IN BIOSCIENCE 8():D100-D116
Brat DJ; Kaur B; Van Meir EG
Genetic modulation of hypoxia induced gene expression and angiogenesis: Relevance to brain tumors | 0 | 0
|
| 221 | 14 | 221 2003 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 36(1):120-127
Choi KS; Bae MK; Jeong JW; Moon HE; Kim KW
Hypoxia-induced angiogenesis during carcinogenesis | 0 | 0
|
| 222 | 11 | 222 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(3):1802-1806
Elkins JM; Hewitson KS; McNeill LA; Seibel JF; Schlemminger I; Pugh CW; Ratcliffe PJ; Schofield CJ
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha | 0 | 0
|
| 223 | 3 | 223 2003 JOURNAL OF CELLULAR PHYSIOLOGY 194(1):30-44
Mottet D; Michel G; Renard P; Ninane N; Raes M; Michiels C
Role of ERK and calcium in the hypoxia-induced activation of HIF-1 | 0 | 0
|
| 224 | 1 | 224 2003 SEMINARS IN CANCER BIOLOGY 13(1):5-14
Fang S; Lorick KL; Jensen JP; Weissman AM
RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer | 0 | 0
|
| 225 | 12 | 225 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89
Pugh CW; Ratcliffe PJ
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis | 0 | 0
|
| 226 | 2 | 226 2003 YEAST 20(1):39-51
Passoth V; Cohn M; Schafer B; Hahn-Hagerdal B; Klinner U
Analysis of the hypoxia-induced ADH2 promoter of the respiratory yeast Pichia stipitis reveals a new mechanism for sensing of oxygen limitation in yeast | 0 | 0
|