| Cited nodes | Nodes / Authors | GCS | LCS |
| 1 | 1 2000 ANNUAL REVIEW OF GENETICS 34():77-137
Lee TI; Young RA
Transcription of eukaryotic protein-coding genes | 9 | 0
|
| 2 | 2 2000 ANNUAL REVIEW OF GENETICS 34():331-358
McEachern MJ; Krauskopf A; Blackburn EH
Telomeres and their control | 71 | 1
|
| 2 | 3 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(2):793-798
Frye RA
Phylogenetic classification of prokaryotic and eukaryotic Sir2- like proteins | 32 | 28
|
| 2 | 4 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 275(2):455-459
Kyrylenko S; Korhonen P; Kyrylenko O; Roschier M; Salminen A
Expression of transcriptional repressor proteins mSin3A and 3B during aging and replicative senescence | 2 | 1
|
| 4 | 5 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 278(3):685-690
Landry J; Slama JT; Sternglanz R
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins | 18 | 18
|
| 1 | 6 2000 BIOESSAYS 22(9):836-845
Turner BM
Histone acetylation and an epigenetic code | 81 | 8
|
| 3 | 7 2000 CELL 103(3):423-433
Goldmark JP; Fazzio TG; Estep PW; Church GM; Tsukiyama T
The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p | 26 | 0
|
| 1 | 8 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():253-263
Blackburn EH; Chan S; Chang J; Fulton TB; Krauskopf A; McEachern M; Prescott J; Roy J; Smith C; Wang H
Molecular manifestations and molecular determinants of telomere capping | 2 | 0
|
| 4 | 9 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():297-302
Imai S; Johnson FB; Marciniak RA; McVey M; Park PU; Guarente L
Sir2: An NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging | 0 | 0
|
| 3 | 10 2000 CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 10(3-4):303-325
Davie JR; Moniwa M
Control of chromatin remodeling | 5 | 0
|
| 3 | 11 2000 CURRENT BIOLOGY 10(19):R708-R711
Gottschling DE
Gene silencing: Two faces of SIR2 | 16 | 9
|
| 1 | 12 2000 CURRENT OPINION IN GENETICS & DEVELOPMENT 10(2):169-177
Cooper JP
Telomere transitions in yeast: the end of the chromosome as we know it | 13 | 3
|
| 1 | 13 2000 CURRENT OPINION IN MICROBIOLOGY 3(2):132-137
Gartenberg MR
The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more | 26 | 11
|
| 1 | 14 2000 EMBO JOURNAL 19(11):2641-2651
Cuperus G; Shafaatian F; Shore D
Locus specificity determinants in the multifunctional yeast silencing protein Sir2 | 12 | 9
|
| 1 | 15 2000 EMBO JOURNAL 19(22):6131-6140
Pile LA; Wassarman DA
Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression | 7 | 1
|
| 1 | 16 2000 EXPERIMENTAL GERONTOLOGY 35(6-7):671-676
Jazwinski SM
Metabolic mechanisms of yeast ageing | 4 | 0
|
| 3 | 17 2000 FOOD TECHNOLOGY AND BIOTECHNOLOGY 38(4):253-262
Pina B
Many ways of transcriptional regulation in yeast | 0 | 0
|
| 1 | 18 2000 GENES & DEVELOPMENT 14(9):1021-1026
Guarente L
Sir2 links chromatin silencing, metabolism, and aging | 73 | 43
|
| 1 | 19 2000 GENES & DEVELOPMENT 14(15):1872-1885
Ashrafi K; Lin SS; Manchester JK; Gordon JI
Sip2p and its partner Snf1p kinase affect aging in S-cerevisiae | 15 | 6
|
| 1 | 20 2000 GENES & DEVELOPMENT 14(20):2551-2569
Lemon B; Tjian R
Orchestrated response: a symphony of transcription factors for gene control | 85 | 1
|
| 2 | 21 2000 GENETICS 156(3):933-941
Dula ML; Holmes SG
MGA2 and SPT23 are modifiers of transcriptional silencing in yeast | 2 | 1
|
| 2 | 22 2000 GENOMICS 69(3):355-369
Yang YH; Chen YH; Zhang CY; Nimmakayalu MA; Ward DC; Weissman S
Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene | 8 | 5
|
| 1 | 23 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(51):40273-40281
Viswanath RL; Rose SD; Swift GH; MacDonald RJ
A binary mechanism for the selective action of a pancreatic beta-cell transcriptional silencer | 1 | 0
|
| 3 | 24 2000 JOURNAL OF MEDICAL GENETICS 37(12):905-915
Johnson CA
Chromatin modification and disease | 2 | 0
|
| 1 | 25 2000 MECHANISMS OF AGEING AND DEVELOPMENT 116(2-3):65-76
Tanaka M; Gong JS; Zhang J; Yamada Y; Borgeld HJ; Yagi K
Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis | 10 | 0
|
| 1 | 26 2000 MECHANISMS OF AGEING AND DEVELOPMENT 118(1-2):23-34
Lansdorp PM
Repair of telomeric DNA prior to replicative senescence | 11 | 0
|
| 2 | 27 2000 MECHANISMS OF AGEING AND DEVELOPMENT 120(1-3):1-22
Gershon H; Gershon D
The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review | 3 | 0
|
| 1 | 28 2000 MOLECULAR AND CELLULAR BIOLOGY 20(18):6904-6912
Wang AH; Kruhlak MJ; Wu J; Bertos NR; Vezmar M; Posner BI; Bazett-Jones DP; Yang XJ
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins | 38 | 8
|
| 1 | 29 2000 MOLECULAR AND CELLULAR BIOLOGY 20(19):7247-7258
Keller SA; Mao YF; Struffi P; Margulies C; Yurk CE; Anderson AR; Amey RL; Moore S; Ebels JM; Foley K; Corado M; Arnosti DN
dCtBP-dependent and -independent repression activities of the Drosophila knirps protein | 10 | 2
|
| 1 | 30 2000 MOLECULAR AND CELLULAR BIOLOGY 20(19):7401-7409
Roder K; Hung MS; Lee TL; Lin TY; Xiao HY; Isobe KI; Juang JL; Shen CKJ
Transcriptional repression by Drosophila methyl-CpG-binding proteins | 8 | 0
|
| 1 | 31 2000 MOLECULAR AND CELLULAR BIOLOGY 20(24):9103-9112
Schubeler D; Lorincz MC; Cimbora DM; Telling A; Feng YQ; Bouhassira EE; Groudine M
Genomic targeting of methylated DNA: Influence of methylation on transcription, replication, chromatin structure, and histone acetylation | 16 | 1
|
| 1 | 32 2000 MOLECULAR CELL 6(6):1297-1307
Reid JL; Iyer VR; Brown PO; Struhl K
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase | 27 | 1
|
| 0 | 33 2000 NATURE 403(6771):795-800
Imai S; Armstrong CM; Kaeberlein M; Guarente L
Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase | 179 | 179
|
| 6 | 34 2000 NATURE 408(6809):255-262
Guarente L; Kenyon C
Genetic pathways that regulate ageing in model organisms | 78 | 10
|
| 1 | 35 2000 NATURE BIOTECHNOLOGY 18(6):575-576
Strohman RC
Organization becomes cause in the matter | 3 | 0
|
| 1 | 36 2000 NATURE CELL BIOLOGY 2(6):E107-E112
Carmo-Fonseca M; Mendes-Soares L; Campos I
To be or not to be in the nucleolus | 42 | 0
|
| 1 | 37 2000 NUCLEIC ACIDS RESEARCH 28(21):4189-4196
Flores-Saaib RD; Courey AJ
Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression | 7 | 0
|
| 1 | 38 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(11):5807-5811
Landry J; Sutton A; Tafrov ST; Heller RC; Stebbins J; Pillus L; Sternglanz R
The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases | 88 | 82
|
| 1 | 39 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(12):6658-6663
Smith JS; Brachmann CB; Celic I; Kenna MA; Muhammad S; Starai VJ; Avalos JL; Escalante-Semerena JC; Grubmeyer C; Wolberger C; Boeke JD
A phylogenetically conserved NAD(+)-dependent protein deacetylase activity in the Sir2 protein family | 68 | 61
|
| 4 | 40 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(25):13708-13713
Bernstein BE; Tong JK; Schreiber SL
Genomewide studies of histone deacetylase function in yeast | 45 | 22
|
| 7 | 41 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(26):14030-14032
Shore D
The Sir2 protein family: A novel deacetylase for gene silencing and more | 15 | 7
|
| 5 | 42 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(26):14178-14182
Tanner KG; Landry J; Sternglanz R; Denu JM
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O- acetyl-ADP-ribose | 33 | 28
|
| 1 | 43 2000 SCIENCE 288(5470):1385-1389
Lewis JD; Tollervey D
Like attracts like: Getting RNA processing together in the nucleus | 61 | 0
|
| 3 | 44 2000 SCIENCE 289(5487):2126-2128
Lin SJ; Defossez PA; Guarente L
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae | 72 | 34
|
| 1 | 45 2000 SEIKAGAKU 72(10):1231-1244
Ishikawa T
Telomere heterochromatin in yeast | 0 | 0
|
| 2 | 46 2000 TRENDS IN BIOCHEMICAL SCIENCES 25(12):619-623
Wu JS; Grunstein M
25 years after the nucleosome model: chromatin modifications | 37 | 6
|
| 2 | 47 2000 TRENDS IN GENETICS 16(11):506-511
Jazwinski SM
Metabolic control and ageing | 11 | 4
|
| 1 | 48 2001 ASM NEWS 67(5):259-265
Jarwinski SM
Metabolic control and yeast aging | 0 | 0
|
| 2 | 49 2001 BIOCHEMISTRY 40(8):2599-2605
Waterborg JH
Dynamics of histone acetylation in Saccharomyces cerevisiae | 5 | 1
|
| 2 | 50 2001 BIOCHEMISTRY 40(35):10671-10676
Clemente S; Franco L; Lopez-Rodas G
Distinct site specificity of two pea histone deacetylase complexes | 0 | 0
|
| 5 | 51 2001 BIOCHEMISTRY 40(43):12855-12863
Brosch G; Dangl M; Graessle S; Loidl A; Trojer P; Brandtner EM; Mair K; Walton JD; Baidyaroy D; Loidl P
An inhibitor-resistant histone deacetylase in the plant pathogenic fungus Cochliobolus carbonum | 0 | 0
|
| 17 | 52 2001 BIOCHEMISTRY 40(51):15456-15463
Sauve AA; Celic I; Avalos J; Deng HT; Boeke JD; Schramm VL
Chemistry of gene silencing: The mechanism of NAD(+)-dependent deacetylation reactions | 5 | 5
|
| 2 | 53 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):227-241
Grigoryev SA
Higher-order folding of heterochromatin: Protein bridges span the nucleosome arrays | 2 | 0
|
| 7 | 54 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):243-252
Bertos NR; Wang AH; Yang XJ
Class II histone deacetylases: Structure, function, and regulation | 11 | 1
|
| 7 | 55 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):337-348
Fischle W; Kiermer V; Dequiedt F; Verdin E
The emerging role of class II histone deacetylases | 4 | 2
|
| 8 | 56 2001 BIOESSAYS 23(4):327-332
Defossez PA; Lin SJ; McNabb DS
Sound silencing: the Sir2 protein and cellular senescence | 3 | 3
|
| 7 | 57 2001 BIOESSAYS 23(8):683-690
Turner J; Crossley M
The CtBP family: enigmatic and enzymatic transcriptional co- repressors | 15 | 2
|
| 1 | 58 2001 CANCER CHEMOTHERAPY AND PHARMACOLOGY 48():S20-S26
Yoshida M; Furumai R; Nishiyama M; Komatsu Y; Nishino N; Horinouchi S
Histone deacetylase as a new target for cancer chemotherapy | 3 | 1
|
| 1 | 59 2001 CANCER LETTERS 166(1):55-64
Nair AR; Boersma LJ; Schiltz L; Chaudry A; Muschel RJ
Paradoxical effects of trichostatin A: inhibition of NF-Y- associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA | 3 | 0
|
| 1 | 60 2001 CANCER RESEARCH 61(12):4820-4826
Singal R; van Wert J; Bashambu M
Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells | 6 | 1
|
| 1 | 61 2001 CELL 104(5):639-642
Gasser SM
Positions of potential: Nuclear organization and gene expression | 23 | 0
|
| 13 | 62 2001 CELL 105(2):161-164
Dutnall RN; Pillus L
Deciphering NAD-dependent deacetylases | 1 | 1
|
| 11 | 63 2001 CELL 105(2):269-279
Min JR; Landry J; Sternglanz R; Xu RM
Crystal structure of a SIR2 homolog-NAD complex | 20 | 15
|
| 2 | 64 2001 CELL 106(6):661-673
Blackburn EH
Switching and signaling at the telomere | 32 | 0
|
| 13 | 65 2001 CELL 107(2):137-148
Luo JY; Nikolaev AY; Imai S; Chen DL; Su F; Shiloh A; Guarente L; Gu W
Negative control of p53 by Sir2 alpha promotes cell survival under stress | 25 | 11
|
| 5 | 66 2001 CELL 107(2):149-159
Vaziri H; Dessain SK; Eagon EN; Imai SI; Frye RA; Pandita TK; Guarente L; Weinberg RA
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase | 21 | 9
|
| 3 | 67 2001 CELLULAR AND MOLECULAR LIFE SCIENCES 58(5-6):704-720
Graessle S; Loidl P; Brosch G
Histone acetylation: plants and fungi as model systems for the investigation of histone deacetylases | 4 | 2
|
| 2 | 68 2001 CELLULAR AND MOLECULAR LIFE SCIENCES 58(14):2108-2116
Matuoka K; Chen KY; Takenawa T
Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation | 0 | 0
|
| 1 | 69 2001 CURRENT MEDICINAL CHEMISTRY 8(12):1505-1511
Jung M
Inhibitors of histone deacetylase as new anticancer agents | 4 | 0
|
| 9 | 70 2001 CURRENT OPINION IN CELL BIOLOGY 13(2):232-238
Moazed D
Enzymatic activities of Sir2 and chromatin silencing | 19 | 12
|
| 7 | 71 2001 CURRENT OPINION IN GASTROENTEROLOGY 17(6):545-550
Guandalini S; Gokhale R
Update on immunologic basis of celiac disease | 0 | 0
|
| 8 | 72 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(2):162-166
Khochbin S; Verdel A; Lemercier C; Seigneurin-Berny D
Functional significance of histone deacetylase diversity | 23 | 3
|
| 8 | 73 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(2):189-198
Shore D
Telomeric chromatin: replicating and wrapping up chromosome ends | 16 | 1
|
| 7 | 74 2001 CURRENT OPINION IN ONCOLOGY 13(6):477-483
Marks PA; Richon VM; Breslow R; Rifkind RA
Histone deacetylase inhibitors as new cancer drugs | 15 | 1
|
| 3 | 75 2001 DEVELOPMENT 128(20):4045-4055
Benard C; McCright B; Zhang Y; Felkai S; Lakowski B; Hekimi S
The C-elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length | 2 | 0
|
| 4 | 76 2001 EMBO JOURNAL 20(1-2):197-209
Perrod S; Cockell MM; Laroche T; Renauld H; Ducrest AL; Bonnard C; Gasser SM
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast | 15 | 14
|
| 3 | 77 2001 EMBO JOURNAL 20(3):520-531
Donze D; Kamakaka RT
RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae | 10 | 1
|
| 2 | 78 2001 EMBO JOURNAL 20(6):1353-1362
Muth V; Nadaud S; Grummt I; Voit R
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription | 12 | 8
|
| 6 | 79 2001 EMBO JOURNAL 20(16):4522-4535
Ghidelli S; Donze D; Dhillon N; Kamakaka RT
Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities | 7 | 6
|
| 3 | 80 2001 EXPERIMENTAL CELL RESEARCH 265(1):90-103
Barlow AL; van Drunen CM; Johnson CA; Tweedie S; Bird A; Turner BM
DSIR2 and dHDAC6: Two novel, inhibitor-resistant deacetylases in Drosophila melanogaster | 12 | 5
|
| 2 | 81 2001 EXPERIMENTAL GERONTOLOGY 36(7):1049-1062
von Zglinicki T; Burkle A; Kirkwood TBL
Stress, DNA damage and ageing - an integrative approach | 7 | 0
|
| 4 | 82 2001 FEBS LETTERS 499(1-2):101-106
Wagner M; Brosch G; Zwerschke W; Seto E; Loidl P; Jansen-Durr P
Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2 | 4 | 2
|
| 1 | 83 2001 FRONTIERS IN BIOSCIENCE 6():D610-D629
Wang CG; Fu MF; Mani S; Wadler S; Senderowicz AM; Pestell RG
Histone acetylation and the cell-cycle in cancer | 5 | 3
|
| 25 | 84 2001 GENE 279(1):1-16
Gasser SM; Cockell MM
The molecular biology of the SIR proteins | 4 | 0
|
| 3 | 85 2001 GENES & DEVELOPMENT 15(2):147-157
Gardner KA; Fox CA
The Sir1 protein's association with a silenced chromosome domain | 4 | 3
|
| 3 | 86 2001 GENES & DEVELOPMENT 15(8):955-967
Rusche LN; Rine J
Conversion of a gene-specific repressor to a regional silencer | 5 | 4
|
| 8 | 87 2001 GENES & DEVELOPMENT 15(21):2786-2796
Courey AJ; Jia ST
Transcriptional repression: the long and the short of it | 7 | 0
|
| 4 | 88 2001 GENES & DEVELOPMENT 15(22):2991-3004
Pijnappel WWMP; Schaft D; Roguev A; Shevchenko A; Tekotte H; Wilm M; Rigaut G; Seraphin B; Aasland R; Stewart AF
The S-cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program | 2 | 0
|
| 1 | 89 2001 GENETICS 158(2):919-924
Klar AJS; Srikantha T; Soll DR
A histone deacetylation inhibitor and mutant promote colony- type switching of the human pathogen Candida albicans | 2 | 0
|
| 2 | 90 2001 HUMAN MOLECULAR GENETICS 10(10):1085-1092
Wan MM; Zhao KJ; Lee SSJ; Francke U
MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome | 10 | 0
|
| 1 | 91 2001 INTERNATIONAL JOURNAL FOR PARASITOLOGY 31(11):1157-1165
Horn D
Nuclear gene transcription and chromatin in Trypanosoma brucei | 2 | 0
|
| 3 | 92 2001 JOURNAL OF BACTERIOLOGY 183(15):4614-4625
Srikantha T; Tsai L; Daniels K; Klar AJS; Soll DR
The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans | 2 | 0
|
| 12 | 93 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(42):38837-38843
Grozinger CM; Chao ED; Blackwell HE; Moazed D; Schreiber SL
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening | 7 | 4
|
| 6 | 94 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(50):47733-47741
Pflum MKH; Tong JK; Lane WS; Schreiber SL
Histone deacetylase I phosphorylation promotes enzymatic activity and complex formation | 4 | 0
|
| 3 | 95 2001 JOURNAL OF MOLECULAR BIOLOGY 308(1):27-38
Taplick J; Kurtev V; Kroboth K; Posch M; Lechner T; Seiser C
Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1 | 6 | 2
|
| 3 | 96 2001 JOURNAL OF THEORETICAL BIOLOGY 213(4):599-608
Jazwinski SM; Wawryn J
Profiles of random change during aging contain hidden information about longevity and the aging process | 0 | 0
|
| 1 | 97 2001 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 56(2):M67-M70
Perls T
Genetic and phenotypic markers among centenarians | 4 | 1
|
| 8 | 98 2001 M S-MEDECINE SCIENCES 17(6-7):764-767
Defossez PA
Sir2: a deacetylase involved in aging control | 0 | 0
|
| 7 | 99 2001 MECHANISMS OF AGEING AND DEVELOPMENT 122(9):865-882
Jazwinski SM
New clues to old yeast | 2 | 1
|
| 7 | 100 2001 MECHANISMS OF AGEING AND DEVELOPMENT 122(15):1651-1662
Hasty P
The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals | 1 | 0
|
| 2 | 101 2001 MOLECULAR AND CELLULAR BIOLOGY 21(8):2726-2735
Deckert J; Struhl K
Histone acetylation at promoters is differentially affected by specific activators and repressors | 18 | 1
|
| 5 | 102 2001 MOLECULAR AND CELLULAR BIOLOGY 21(10):3514-3522
Sutton A; Heller RC; Landry J; Choy JS; Sirko A; Sternglanz R
A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex | 6 | 5
|
| 2 | 103 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5710-5722
Shirra MK; Patton-Vogt J; Ulrich A; Liuta-Tehlivets O; Kohlwein SD; Henry SA; Arndt KM
Inhibition of acetyl coenzyme a carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae | 1 | 0
|
| 5 | 104 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5992-6005
Wang AH; Yang XJ
Histone deacetylase 4 possesses intrinsic nuclear import and export signals | 5 | 1
|
| 5 | 105 2001 MOLECULAR AND CELLULAR BIOLOGY 21(18):6091-6101
Guenther MG; Barak O; Lazar MA
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3 | 12 | 3
|
| 3 | 106 2001 MOLECULAR AND CELLULAR BIOLOGY 21(19):6606-6614
Xie WW; Gai XW; Zhu YX; Zappulla DC; Sternglanz R; Voytas DF
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p | 3 | 0
|
| 3 | 107 2001 MOLECULAR BIOLOGY OF THE CELL 12(9):2800-2812
Thrower DA; Bloom K
Dicentric chromosome stretching during anaphase reveals roles of Sir2/Ku in chromatin compaction in budding yeast | 4 | 0
|
| 1 | 108 2001 MOLECULAR BIOTECHNOLOGY 17(1):1-13
Imhof A; Becker PB
Modifications of the histone N-terminal domains - Evidence for an "epigenetic code"? | 5 | 0
|
| 8 | 109 2001 MOLECULAR CELL 8(3):489-498
Moazed D
Common themes in mechanisms of gene silencing | 18 | 4
|
| 3 | 110 2001 MOLECULAR CELL 8(6):1231-1241
Thomson S; Clayton AL; Mahadevan LC
Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction | 3 | 0
|
| 1 | 111 2001 MOLECULAR PHARMACOLOGY 60(2):394-402
Tikoo K; Lau SS; Monks TJ
Histone H3 phosphorylation is coupled to poly-(ADP- ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells | 1 | 0
|
| 4 | 112 2001 NATURE 410(6825):227-230
Tissenbaum HA; Guarente L
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans | 45 | 24
|
| 2 | 113 2001 NATURE GENETICS 29(3):332-336
Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage | 6 | 0
|
| 10 | 114 2001 NATURE STRUCTURAL BIOLOGY 8(7):621-625
Finnin MS; Donigian JR; Pavletich NP
Structure of the histone deacetylase SIRT2 | 9 | 7
|
| 2 | 115 2001 NUCLEIC ACIDS RESEARCH 29(16):3439-3447
Miska EA; Langley E; Wolf D; Karlsson C; Pines J; Kouzarides T
Differential localization of HDAC4 orchestrates muscle differentiation | 6 | 1
|
| 2 | 116 2001 NUCLEIC ACIDS RESEARCH 29(20):4114-4124
Hirschler-Laszkiewicz I; Cavanaugh A; Hu QY; Catania J; Avantaggiati ML; Rothblum LI
The role of acetylation in rDNA transcription | 2 | 0
|
| 2 | 117 2001 ONCOGENE 20(28):3716-3725
Wang LL; Hiebert SW
TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3 | 4 | 1
|
| 2 | 118 2001 PLANT CELL 13(7):1609-1624
Baidyaroy D; Brosch G; Ahn JH; Graessle S; Wegener S; Tonukari NJ; Caballero O; Loidl P; Walton JD
A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus | 1 | 1
|
| 1 | 119 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(1):87-92
Furumai R; Komatsu Y; Nishino N; Khochbin S; Yoshida M; Horinouchi S
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin | 19 | 9
|
| 1 | 120 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(1):200-205
Tian L; Chen ZJ
Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development | 15 | 1
|
| 4 | 121 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(2):415-420
Tanny JC; Moazed D
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product | 27 | 24
|
| 2 | 122 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(3):1188-1193
Asher G; Lotem J; Cohen B; Sachs L; Shaul Y
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase-1 | 12 | 0
|
| 2 | 123 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(4):1454-1458
You A; Tong JK; Grozinger CM; Schreiber SL
CoREST is an integral component of the CoREST-human histone deacetylase complex | 18 | 7
|
| 2 | 124 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(17):9730-9735
Chang YL; Peng YH; Pan IC; Sun DS; King B; Huang DH
Essential role of Drosophila Hdac1 in homeotic gene silencing | 3 | 0
|
| 5 | 125 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(19):10572-10577
Zhou XB; Marks PA; Rifkind RA; Richon VM
Cloning and characterization of a histone deacetylase, HDAC9 | 19 | 6
|
| 3 | 126 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(20):11075-11080
Schaus SE; Cavalieri D; Myers AG
Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure | 3 | 0
|
| 16 | 127 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(26):15113-15118
Bedalov A; Gatbonton T; Irvine WP; Gottschling DE; Simon JA
Identification of a small molecule inhibitor of Sir2p | 4 | 3
|
| 1 | 128 2001 SCIENCE 291(5504):646-650
Kirchmaier AL; Rine J
DNA replication-independent silencing in S-cerevisiae | 15 | 4
|
| 2 | 129 2001 SCIENCE 293(5532):1074-1080
Jenuwein T; Allis CD
Translating the histone code | 140 | 6
|
| 9 | 130 2001 STRUCTURE 9(12):1127-1133
Marmorstein R
Structure of histone deacetylases: Insights into substrate recognition and catalysis | 0 | 0
|
| 1 | 131 2001 TOXICOLOGY LETTERS 120(1-3):143-150
Thompson SL; Konfortova G; Gregory RI; Reik W; Dean W; Feil R
Environmental effects on genomic imprinting in mammals | 0 | 0
|
| 1 | 132 2001 TRENDS IN BIOCHEMICAL SCIENCES 26(7):405-407
Dlakic M
Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold | 6 | 1
|
| 2 | 133 2001 TRENDS IN ENDOCRINOLOGY AND METABOLISM 12(7):294-300
Kramer OH; Gottlicher M; Heinzel T
Histone deacetylase as a therapeutic target | 4 | 1
|
| 6 | 134 2001 TRENDS IN GENETICS 17(7):391-392
Guarente L
SIR2 and aging - the exception that proves the rule | 3 | 2
|
| 5 | 135 2001 TRENDS IN GENETICS 17(12):712-718
Hekimi S; Burgess J; Bussiere F; Meng Y; Benard C
Genetics of lifespan in C-elegans: molecular diversity, physiological complexity, mechanistic simplicity | 1 | 0
|
| 1 | 136 2001 YEAST 18(6):499-509
MacLean M; Harris N; Piper PW
Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms | 2 | 0
|
| 1 | 137 2001 ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE 34(6):486-490
Warner HR
The case for supporting basic research in gerontology | 0 | 0
|
| 3 | 138 2002 ANTI-CANCER DRUGS 13(1):1-13
Vigushin DM; Coombes RC
Histone deacetylase inhibitors in cancer treatment | 2 | 0
|
| 2 | 139 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295(1):187-192
Maehara K; Uekawa N; Isobe KI
Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene | 0 | 0
|
| 2 | 140 2002 BIOCHEMISTRY 41(15):4901-4910
Venditti S; Di Stefano G; D'Eletto M; Di Mauro E
Genetic remodeling and transcriptional remodeling of subtelomeric heterochromatin are different | 0 | 0
|
| 1 | 141 2002 BIOCHIMIE 84(4):279-289
Cornuel JF; Moraillon A; Gueron M
Participation of yeast inosine 5 '-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand | 0 | 0
|
| 3 | 142 2002 BRITISH JOURNAL OF CANCER 86(6):917-923
de Nigris F; Cerutti J; Morelli C; Califano D; Chiariotti L; Viglietto G; Santelli G; Fusco A
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues | 0 | 0
|
| 3 | 143 2002 CELL 109(4):437-446
Robyr D; Suka Y; Xenarios I; Kurdistani SK; Wang A; Suka N; Grunstein M
Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases | 3 | 0
|
| 8 | 144 2002 CELL 109(4):447-458
Rosenberg MI; Parkhurst SM
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination | 0 | 0
|
| 18 | 145 2002 CHEMISTRY & BIOLOGY 9(1):3-16
Grozinger CM; Schreiber SL
Deacetylase enzymes: biological functions and the use of small- molecule inhibitors | 1 | 0
|
| 2 | 146 2002 CURRENT BIOLOGY 12(9):712-723
Pletcher SD; Macdonald SJ; Marguerie R; Certa U; Stearns SC; Goldstein DB; Partridge L
Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster | 0 | 0
|
| 5 | 147 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):362-369
Perls T; Kunkel L; Puca A
The genetics of aging | 1 | 0
|
| 17 | 148 2002 CURRENT OPINION IN HEMATOLOGY 9(4):322-332
Melnick A; Licht JD
Histone deacetylases as therapeutic targets in hematologic malignancies | 0 | 0
|
| 3 | 149 2002 CYTOKINE & GROWTH FACTOR REVIEWS 13(3):259-276
Fu MF; Wang CG; Wang J; Zafonte BT; Lisanti MP; Pestell RG
Acetylation in hormone signaling and the cell cycle | 0 | 0
|
| 6 | 150 2002 DEVELOPMENTAL CELL 2(1):9-19
Tissenbaum HA; Guarente L
Model organisms as a guide to mammalian aging | 0 | 0
|
| Cited nodes | Nodes / Authors | GCS | LCS |
| 20 | 151 2002 EMBO JOURNAL 21(10):2383-2396
Langley E; Pearson M; Faretta M; Bauer UM; Frye RA; Minucci S; Pelicci PG; Kouzarides T
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence | 2 | 0
|
| 3 | 152 2002 GENES & DEVELOPMENT 16(12):1528-1539
Luo KH; Vega-Palas MA; Grunstein M
Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast | 0 | 0
|
| 1 | 153 2002 GENES TO CELLS 7(2):99-113
Johzuka K; Horiuchi T
Replication fork block protein, Fob1, acts as an rDNA region specific recombinator in S-cerevisiae | 0 | 0
|
| 2 | 154 2002 GENETICS 160(1):49-62
Lewis LK; Karthikeyan G; Westmoreland JW; Resnick MA
Differential suppression of DNA repair deficiencies of yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase) | 1 | 0
|
| 11 | 155 2002 GENETICS 160(3):877-889
Sandmeier JJ; Celic I; Boeke JD; Smith JS
Telomeiric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway | 0 | 0
|
| 7 | 156 2002 GUIDE TO YEAST GENETICS AND MOLECULAR AND CELL BIOLOGY, PT B 350():165-186
Van Leeuwen F; Gottschling DE
Assays for gene silencing in yeast | 0 | 0
|
| 3 | 157 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(3):1897-1905
Singal R; Wang SZ; Sargent T; Zhu SZ; Ginder GD
Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex | 0 | 0
|
| 10 | 158 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6656-6666
Fischer DD; Cai R; Bhatia U; Asselbergs FAM; Song CZ; Terry R; Trogani N; Widmer R; Atadja P; Cohen D
Isolation and characterization of a novel class II histone deacetylase, HDAC10 | 1 | 0
|
| 7 | 159 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(11):9590-9597
Johnson CA; White DA; Lavender JS; O'Neill LP; Turner BM
Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co- immunoprecipitate with the ATP-dependent chaperone protein Hsp70 | 0 | 0
|
| 22 | 160 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(15):12632-12641
Borra MT; O'Neill FJ; Jackson MD; Marshall B; Verdin E; Foltz KR; Denu JM
Conserved enzymatic production and biological effect of O- acetyl-ADP-ribose by silent information regulator 2-like NAD(+)-dependent deacetylases | 0 | 0
|
| 10 | 161 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18535-18544
Jackson AD; Denu JM
Structural identification of 2 '- and 3 '-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta- NAD(+)-dependent histone/protein deacetylases | 0 | 0
|
| 16 | 162 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18881-18890
Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA
Manipulation of a nuclear NAD(+) salvage pathway delays aging without altering steady-state NAD(+) levels | 0 | 0
|
| 7 | 163 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(28):25748-25755
Gao L; Cueto MA; Asselbergs F; Atadja P
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family | 0 | 0
|
| 11 | 164 2002 JOURNAL OF CELL SCIENCE 115(4):689-698
Jepsen K; Rosenfeld MG
Biological roles and mechanistic actions of co-repressor complexes | 1 | 0
|
| 4 | 165 2002 JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 50(2):359-368
Perls T; Kunkel LM; Puca AA
The genetics of exceptional human longevity | 0 | 0
|
| 2 | 166 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(2-3):65-73
Martin GM
Keynote: mechanisms of senescence complificationists versus simplificationists | 0 | 0
|
| 6 | 167 2002 MOLECULAR AND CELLULAR BIOLOGY 22(2):421-429
Merker RJ; Klein HL
hpr1 Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae | 1 | 0
|
| 3 | 168 2002 MOLECULAR AND CELLULAR BIOLOGY 22(3):835-848
Kuzmichev A; Zhang Y; Erdjument-Bromage H; Tempst P; Reinberg D
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | 2 | 0
|
| 4 | 169 2002 MOLECULAR AND CELLULAR BIOLOGY 22(7):2170-2181
Bjerling P; Silverstein RA; Thon G; Caudy A; Grewal S; Ekwall K
Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity | 1 | 0
|
| 3 | 170 2002 MOLECULAR AND CELLULAR BIOLOGY 22(9):3024-3034
Dufourcq P; Victor M; Gay F; Calvo D; Hodgkin J; Shi Y
Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis | 1 | 0
|
| 6 | 171 2002 MOLECULAR AND CELLULAR BIOLOGY 22(12):4136-4146
Hoopes LLM; Budd M; Choe W; Tao WT; Campbell JL
Mutations in DNA replication genes reduce yeast life span | 0 | 0
|
| 15 | 172 2002 MOLECULAR AND CELLULAR BIOLOGY 22(12):4167-4180
Hoppe GJ; Tanny JC; Rudner AD; Gerber SA; Danaie S; Gygi SP; Moazed D
Steps in assembly of silent chromatin in yeast: Sir3- independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation | 0 | 0
|
| 12 | 173 2002 MOLECULAR BIOLOGY OF THE CELL 13(4):1427-1438
Armstrong CM; Kaeberlein M; Imai SI; Guarente L
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity | 0 | 0
|
| 12 | 174 2002 MOLECULAR BIOLOGY OF THE CELL 13(7):2207-2222
Rusche LN; Kirchmaier AL; Rine J
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae | 0 | 0
|
| 6 | 175 2002 NATURE 418(6895):344-348
Lin SJ; Kaeberlein M; Andalis AA; Sturtz LA; Defossez PA; Culotta VC; Fink GR; Guarente L
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration | 1 | 0
|
| 4 | 176 2002 NEUROBIOLOGY OF AGING 23(2):255-262
Mori N; Mizuno T; Murai K; Nakano I; Yamashita H
Effect of age on the gene expression of neural-restrictive silencing factor NRSF/REST | 0 | 0
|
| 5 | 177 2002 NUCLEIC ACIDS RESEARCH 30(2):475-481
Vaute O; Nicolas E; Vandel L; Trouche D
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases | 1 | 0
|
| 22 | 178 2002 NUCLEIC ACIDS RESEARCH 30(7):1465-1482
Huang Y
Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe | 0 | 0
|
| 3 | 179 2002 ONCOGENE 21(4):512-521
Tham WH; Zakian VA
Transcriptional silencing at Saccharomyces telomeres: implications for other organisms | 0 | 0
|
| 1 | 180 2002 PHARMACOGENOMICS 3(4):469-484
Perls T; Puca A
The genetics of aging - implications for pharmacogenomics | 0 | 0
|
| 3 | 181 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(2):838-843
Kang HL; Benzer S; Min KT
Life extension in Drosophila by feeding a drug | 0 | 0
|
| 5 | 182 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(13):8695-8700
Bernstein BE; Humphrey EL; Erlich RL; Schneider R; Bouman P; Liu JS; Kouzarides T; Schreiber SL
Methylation of histone H3 Lys 4 in coding regions of active genes | 0 | 0
|
| 11 | 183 2002 REDOX CELL BIOLOGY AND GENETICS, PT B 353():282-300
Smith JS; Avalos J; Celic I; Muhammad S; Wolberger C; Boeke JD
SIR2 family of NAD(+)-dependent protein deacetylases | 0 | 0
|
| 4 | 184 2002 SCIENCE 295(5561):1895-1897
Zhang QH; Piston DW; Goodman RH
Regulation of corepressor function by nuclear NADH | 3 | 0
|