Outer References Missing Links? Journal list All-Author list Citation Matrix HistCite Guide
Wed Oct 30 11:45:58 2002
HOT PAPERS:
Landry J, Sutton A, Tafrov ST, et al. "The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases"
P NATL ACAD SCI USA 97 (11): 5807-5811 MAY 23 2000
Imai S, Armstrong CM, Kaeberlein M, et al. "Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase"
NATURE 403 (6771): 795-800 FEB 17 2000
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Nodes / AuthorsGCSLCS
11 2000 ANNUAL REVIEW OF GENETICS 34():77-137
Lee TI; Young RA
Transcription of eukaryotic protein-coding genes
140
22 2000 ANNUAL REVIEW OF GENETICS 34():331-358
McEachern MJ; Krauskopf A; Blackburn EH
Telomeres and their control
802
23 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(2):793-798
Frye RA
Phylogenetic classification of prokaryotic and eukaryotic Sir2- like proteins
3835
24 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 275(2):455-459
Kyrylenko S; Korhonen P; Kyrylenko O; Roschier M; Salminen A
Expression of transcriptional repressor proteins mSin3A and 3B during aging and replicative senescence
31
45 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 278(3):685-690
Landry J; Slama JT; Sternglanz R
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins
2020
16 2000 BIOESSAYS 22(9):836-845
Turner BM
Histone acetylation and an epigenetic code
878
37 2000 CELL 103(3):423-433
Goldmark JP; Fazzio TG; Estep PW; Church GM; Tsukiyama T
The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p
280
18 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():253-263
Blackburn EH; Chan S; Chang J; Fulton TB; Krauskopf A; McEachern M; Prescott J; Roy J; Smith C; Wang H
Molecular manifestations and molecular determinants of telomere capping
20
49 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():297-302
Imai S; Johnson FB; Marciniak RA; McVey M; Park PU; Guarente L
Sir2: An NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging
00
310 2000 CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 10(3-4):303-325
Davie JR; Moniwa M
Control of chromatin remodeling
50
311 2000 CURRENT BIOLOGY 10(19):R708-R711
Gottschling DE
Gene silencing: Two faces of SIR2
1610
112 2000 CURRENT OPINION IN GENETICS & DEVELOPMENT 10(2):169-177
Cooper JP
Telomere transitions in yeast: the end of the chromosome as we know it
143
113 2000 CURRENT OPINION IN MICROBIOLOGY 3(2):132-137
Gartenberg MR
The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more
2812
114 2000 CURRENT OPINION IN MICROBIOLOGY 3(6):582-588
Whiteway M
Transcriptional control of cell type and morphogenesis in Candida albicans
100
115 2000 EMBO JOURNAL 19(11):2641-2651
Cuperus G; Shafaatian F; Shore D
Locus specificity determinants in the multifunctional yeast silencing protein Sir2
1411
116 2000 EMBO JOURNAL 19(22):6131-6140
Pile LA; Wassarman DA
Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
71
117 2000 EXPERIMENTAL GERONTOLOGY 35(6-7):671-676
Jazwinski SM
Metabolic mechanisms of yeast ageing
40
318 2000 FOOD TECHNOLOGY AND BIOTECHNOLOGY 38(4):253-262
Pina B
Many ways of transcriptional regulation in yeast
00
119 2000 GENES & DEVELOPMENT 14(9):1021-1026
Guarente L
Sir2 links chromatin silencing, metabolism, and aging
7648
120 2000 GENES & DEVELOPMENT 14(15):1872-1885
Ashrafi K; Lin SS; Manchester JK; Gordon JI
Sip2p and its partner Snf1p kinase affect aging in S-cerevisiae
178
121 2000 GENES & DEVELOPMENT 14(20):2551-2569
Lemon B; Tjian R
Orchestrated response: a symphony of transcription factors for gene control
931
222 2000 GENETICS 156(3):933-941
Dula ML; Holmes SG
MGA2 and SPT23 are modifiers of transcriptional silencing in yeast
21
223 2000 GENOMICS 69(3):355-369
Yang YH; Chen YH; Zhang CY; Nimmakayalu MA; Ward DC; Weissman S
Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
96
124 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(51):40273-40281
Viswanath RL; Rose SD; Swift GH; MacDonald RJ
A binary mechanism for the selective action of a pancreatic beta-cell transcriptional silencer
10
325 2000 JOURNAL OF MEDICAL GENETICS 37(12):905-915
Johnson CA
Chromatin modification and disease
20
126 2000 MECHANISMS OF AGEING AND DEVELOPMENT 116(2-3):65-76
Tanaka M; Gong JS; Zhang J; Yamada Y; Borgeld HJ; Yagi K
Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis
100
127 2000 MECHANISMS OF AGEING AND DEVELOPMENT 118(1-2):23-34
Lansdorp PM
Repair of telomeric DNA prior to replicative senescence
120
228 2000 MECHANISMS OF AGEING AND DEVELOPMENT 120(1-3):1-22
Gershon H; Gershon D
The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review
41
129 2000 MOLECULAR AND CELLULAR BIOLOGY 20(18):6904-6912
Wang AH; Kruhlak MJ; Wu J; Bertos NR; Vezmar M; Posner BI; Bazett-Jones DP; Yang XJ
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
429
130 2000 MOLECULAR AND CELLULAR BIOLOGY 20(19):7247-7258
Keller SA; Mao YF; Struffi P; Margulies C; Yurk CE; Anderson AR; Amey RL; Moore S; Ebels JM; Foley K; Corado M; Arnosti DN
dCtBP-dependent and -independent repression activities of the Drosophila knirps protein
102
131 2000 MOLECULAR AND CELLULAR BIOLOGY 20(19):7401-7409
Roder K; Hung MS; Lee TL; Lin TY; Xiao HY; Isobe KI; Juang JL; Shen CKJ
Transcriptional repression by Drosophila methyl-CpG-binding proteins
90
132 2000 MOLECULAR AND CELLULAR BIOLOGY 20(24):9103-9112
Schubeler D; Lorincz MC; Cimbora DM; Telling A; Feng YQ; Bouhassira EE; Groudine M
Genomic targeting of methylated DNA: Influence of methylation on transcription, replication, chromatin structure, and histone acetylation
191
133 2000 MOLECULAR CELL 6(6):1297-1307
Reid JL; Iyer VR; Brown PO; Struhl K
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase
301
034 2000 NATURE 403(6771):795-800
Imai S; Armstrong CM; Kaeberlein M; Guarente L
Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase
196196
635 2000 NATURE 408(6809):255-262
Guarente L; Kenyon C
Genetic pathways that regulate ageing in model organisms
9713
136 2000 NATURE BIOTECHNOLOGY 18(6):575-576
Strohman RC
Organization becomes cause in the matter
30
137 2000 NATURE CELL BIOLOGY 2(6):E107-E112
Carmo-Fonseca M; Mendes-Soares L; Campos I
To be or not to be in the nucleolus
440
138 2000 NUCLEIC ACIDS RESEARCH 28(21):4189-4196
Flores-Saaib RD; Courey AJ
Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression
80
139 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(11):5807-5811
Landry J; Sutton A; Tafrov ST; Heller RC; Stebbins J; Pillus L; Sternglanz R
The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases
9999
140 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(12):6658-6663
Smith JS; Brachmann CB; Celic I; Kenna MA; Muhammad S; Starai VJ; Avalos JL; Escalante-Semerena JC; Grubmeyer C; Wolberger C; Boeke JD
A phylogenetically conserved NAD(+)-dependent protein deacetylase activity in the Sir2 protein family
7670
441 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(25):13708-13713
Bernstein BE; Tong JK; Schreiber SL
Genomewide studies of histone deacetylase function in yeast
4824
742 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(26):14030-14032
Shore D
The Sir2 protein family: A novel deacetylase for gene silencing and more
188
543 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(26):14178-14182
Tanner KG; Landry J; Sternglanz R; Denu JM
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O- acetyl-ADP-ribose
4136
144 2000 SCIENCE 288(5470):1385-1389
Lewis JD; Tollervey D
Like attracts like: Getting RNA processing together in the nucleus
640
345 2000 SCIENCE 289(5487):2126-2128
Lin SJ; Defossez PA; Guarente L
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
7939
146 2000 SEIKAGAKU 72(10):1231-1244
Ishikawa T
Telomere heterochromatin in yeast
00
247 2000 TRENDS IN BIOCHEMICAL SCIENCES 25(12):619-623
Wu JS; Grunstein M
25 years after the nucleosome model: chromatin modifications
437
248 2000 TRENDS IN GENETICS 16(11):506-511
Jazwinski SM
Metabolic control and ageing
124
149 2001 ASM NEWS 67(5):259-265
Jarwinski SM
Metabolic control and yeast aging
00
250 2001 BIOCHEMISTRY 40(8):2599-2605
Waterborg JH
Dynamics of histone acetylation in Saccharomyces cerevisiae
51
251 2001 BIOCHEMISTRY 40(35):10671-10676
Clemente S; Franco L; Lopez-Rodas G
Distinct site specificity of two pea histone deacetylase complexes
00
552 2001 BIOCHEMISTRY 40(43):12855-12863
Brosch G; Dangl M; Graessle S; Loidl A; Trojer P; Brandtner EM; Mair K; Walton JD; Baidyaroy D; Loidl P
An inhibitor-resistant histone deacetylase in the plant pathogenic fungus Cochliobolus carbonum
00
1753 2001 BIOCHEMISTRY 40(51):15456-15463
Sauve AA; Celic I; Avalos J; Deng HT; Boeke JD; Schramm VL
Chemistry of gene silencing: The mechanism of NAD(+)-dependent deacetylation reactions
88
254 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):227-241
Grigoryev SA
Higher-order folding of heterochromatin: Protein bridges span the nucleosome arrays
20
755 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):243-252
Bertos NR; Wang AH; Yang XJ
Class II histone deacetylases: Structure, function, and regulation
121
756 2001 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 79(3):337-348
Fischle W; Kiermer V; Dequiedt F; Verdin E
The emerging role of class II histone deacetylases
52
857 2001 BIOESSAYS 23(4):327-332
Defossez PA; Lin SJ; McNabb DS
Sound silencing: the Sir2 protein and cellular senescence
44
758 2001 BIOESSAYS 23(8):683-690
Turner J; Crossley M
The CtBP family: enigmatic and enzymatic transcriptional co- repressors
182
159 2001 CANCER CHEMOTHERAPY AND PHARMACOLOGY 48():S20-S26
Yoshida M; Furumai R; Nishiyama M; Komatsu Y; Nishino N; Horinouchi S
Histone deacetylase as a new target for cancer chemotherapy
31
160 2001 CANCER LETTERS 166(1):55-64
Nair AR; Boersma LJ; Schiltz L; Chaudry A; Muschel RJ
Paradoxical effects of trichostatin A: inhibition of NF-Y- associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA
30
161 2001 CANCER RESEARCH 61(12):4820-4826
Singal R; van Wert J; Bashambu M
Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells
91
162 2001 CELL 104(5):639-642
Gasser SM
Positions of potential: Nuclear organization and gene expression
250
1363 2001 CELL 105(2):161-164
Dutnall RN; Pillus L
Deciphering NAD-dependent deacetylases
21
1164 2001 CELL 105(2):269-279
Min JR; Landry J; Sternglanz R; Xu RM
Crystal structure of a SIR2 homolog-NAD complex
2217
265 2001 CELL 106(6):661-673
Blackburn EH
Switching and signaling at the telomere
401
1366 2001 CELL 107(2):137-148
Luo JY; Nikolaev AY; Imai S; Chen DL; Su F; Shiloh A; Guarente L; Gu W
Negative control of p53 by Sir2 alpha promotes cell survival under stress
3617
567 2001 CELL 107(2):149-159
Vaziri H; Dessain SK; Eagon EN; Imai SI; Frye RA; Pandita TK; Guarente L; Weinberg RA
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
3115
368 2001 CELLULAR AND MOLECULAR LIFE SCIENCES 58(5-6):704-720
Graessle S; Loidl P; Brosch G
Histone acetylation: plants and fungi as model systems for the investigation of histone deacetylases
52
269 2001 CELLULAR AND MOLECULAR LIFE SCIENCES 58(14):2108-2116
Matuoka K; Chen KY; Takenawa T
Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation
00
170 2001 CURRENT MEDICINAL CHEMISTRY 8(12):1505-1511
Jung M
Inhibitors of histone deacetylase as new anticancer agents
80
971 2001 CURRENT OPINION IN CELL BIOLOGY 13(2):232-238
Moazed D
Enzymatic activities of Sir2 and chromatin silencing
2114
772 2001 CURRENT OPINION IN GASTROENTEROLOGY 17(6):545-550
Guandalini S; Gokhale R
Update on immunologic basis of celiac disease
00
873 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(2):162-166
Khochbin S; Verdel A; Lemercier C; Seigneurin-Berny D
Functional significance of histone deacetylase diversity
253
874 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(2):189-198
Shore D
Telomeric chromatin: replicating and wrapping up chromosome ends
171
775 2001 CURRENT OPINION IN ONCOLOGY 13(6):477-483
Marks PA; Richon VM; Breslow R; Rifkind RA
Histone deacetylase inhibitors as new cancer drugs
181
376 2001 DEVELOPMENT 128(20):4045-4055
Benard C; McCright B; Zhang Y; Felkai S; Lakowski B; Hekimi S
The C-elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
30
477 2001 EMBO JOURNAL 20(1-2):197-209
Perrod S; Cockell MM; Laroche T; Renauld H; Ducrest AL; Bonnard C; Gasser SM
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
1917
378 2001 EMBO JOURNAL 20(3):520-531
Donze D; Kamakaka RT
RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae
121
279 2001 EMBO JOURNAL 20(6):1353-1362
Muth V; Nadaud S; Grummt I; Voit R
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
1610
680 2001 EMBO JOURNAL 20(16):4522-4535
Ghidelli S; Donze D; Dhillon N; Kamakaka RT
Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities
87
581 2001 EXPERIMENTAL CELL RESEARCH 262(2):75-83
Gray SG; Ekstrom TJ
The human histone deacetylase family
4214
382 2001 EXPERIMENTAL CELL RESEARCH 265(1):90-103
Barlow AL; van Drunen CM; Johnson CA; Tweedie S; Bird A; Turner BM
DSIR2 and dHDAC6: Two novel, inhibitor-resistant deacetylases in Drosophila melanogaster
135
283 2001 EXPERIMENTAL GERONTOLOGY 36(7):1049-1062
von Zglinicki T; Burkle A; Kirkwood TBL
Stress, DNA damage and ageing - an integrative approach
80
184 2001 EXPERIMENTAL GERONTOLOGY 36(8):1265-1275
Bandyopadhyay D; Timchenko N; Suwa T; Hornsby PJ; Campisi J; Medrano EE
The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells
30
485 2001 FEBS LETTERS 499(1-2):101-106
Wagner M; Brosch G; Zwerschke W; Seto E; Loidl P; Jansen-Durr P
Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2
42
186 2001 FRONTIERS IN BIOSCIENCE 6():D610-D629
Wang CG; Fu MF; Mani S; Wadler S; Senderowicz AM; Pestell RG
Histone acetylation and the cell-cycle in cancer
93
2587 2001 GENE 279(1):1-16
Gasser SM; Cockell MM
The molecular biology of the SIR proteins
50
388 2001 GENES & DEVELOPMENT 15(2):147-157
Gardner KA; Fox CA
The Sir1 protein's association with a silenced chromosome domain
64
389 2001 GENES & DEVELOPMENT 15(8):955-967
Rusche LN; Rine J
Conversion of a gene-specific repressor to a regional silencer
75
890 2001 GENES & DEVELOPMENT 15(21):2786-2796
Courey AJ; Jia ST
Transcriptional repression: the long and the short of it
120
491 2001 GENES & DEVELOPMENT 15(22):2991-3004
Pijnappel WWMP; Schaft D; Roguev A; Shevchenko A; Tekotte H; Wilm M; Rigaut G; Seraphin B; Aasland R; Stewart AF
The S-cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program
20
192 2001 GENETICS 158(2):919-924
Klar AJS; Srikantha T; Soll DR
A histone deacetylation inhibitor and mutant promote colony- type switching of the human pathogen Candida albicans
30
293 2001 HUMAN MOLECULAR GENETICS 10(10):1085-1092
Wan MM; Zhao KJ; Lee SSJ; Francke U
MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome
100
194 2001 INTERNATIONAL JOURNAL FOR PARASITOLOGY 31(11):1157-1165
Horn D
Nuclear gene transcription and chromatin in Trypanosoma brucei
20
395 2001 JOURNAL OF BACTERIOLOGY 183(15):4614-4625
Srikantha T; Tsai L; Daniels K; Klar AJS; Soll DR
The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans
30
1296 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(42):38837-38843
Grozinger CM; Chao ED; Blackwell HE; Moazed D; Schreiber SL
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
115
697 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(50):47733-47741
Pflum MKH; Tong JK; Lane WS; Schreiber SL
Histone deacetylase I phosphorylation promotes enzymatic activity and complex formation
50
498 2001 JOURNAL OF MOLECULAR BIOLOGY 308(1):27-38
Taplick J; Kurtev V; Kroboth K; Posch M; Lechner T; Seiser C
Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1
62
399 2001 JOURNAL OF THEORETICAL BIOLOGY 213(4):599-608
Jazwinski SM; Wawryn J
Profiles of random change during aging contain hidden information about longevity and the aging process
00
1100 2001 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 56(2):M67-M70
Perls T
Genetic and phenotypic markers among centenarians
51
8101 2001 M S-MEDECINE SCIENCES 17(6-7):764-767
Defossez PA
Sir2: a deacetylase involved in aging control
00
7102 2001 MECHANISMS OF AGEING AND DEVELOPMENT 122(9):865-882
Jazwinski SM
New clues to old yeast
21
7103 2001 MECHANISMS OF AGEING AND DEVELOPMENT 122(15):1651-1662
Hasty P
The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals
30
2104 2001 MOLECULAR AND CELLULAR BIOLOGY 21(8):2726-2735
Deckert J; Struhl K
Histone acetylation at promoters is differentially affected by specific activators and repressors
211
5105 2001 MOLECULAR AND CELLULAR BIOLOGY 21(10):3514-3522
Sutton A; Heller RC; Landry J; Choy JS; Sirko A; Sternglanz R
A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex
96
2106 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5710-5722
Shirra MK; Patton-Vogt J; Ulrich A; Liuta-Tehlivets O; Kohlwein SD; Henry SA; Arndt KM
Inhibition of acetyl coenzyme a carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae
20
5107 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5992-6005
Wang AH; Yang XJ
Histone deacetylase 4 possesses intrinsic nuclear import and export signals
61
5108 2001 MOLECULAR AND CELLULAR BIOLOGY 21(18):6091-6101
Guenther MG; Barak O; Lazar MA
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
153
3109 2001 MOLECULAR AND CELLULAR BIOLOGY 21(19):6606-6614
Xie WW; Gai XW; Zhu YX; Zappulla DC; Sternglanz R; Voytas DF
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p
30
3110 2001 MOLECULAR BIOLOGY OF THE CELL 12(9):2800-2812
Thrower DA; Bloom K
Dicentric chromosome stretching during anaphase reveals roles of Sir2/Ku in chromatin compaction in budding yeast
40
1111 2001 MOLECULAR BIOTECHNOLOGY 17(1):1-13
Imhof A; Becker PB
Modifications of the histone N-terminal domains - Evidence for an "epigenetic code"?
60
8112 2001 MOLECULAR CELL 8(3):489-498
Moazed D
Common themes in mechanisms of gene silencing
215
4113 2001 MOLECULAR CELL 8(6):1231-1241
Thomson S; Clayton AL; Mahadevan LC
Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction
40
1114 2001 MOLECULAR PHARMACOLOGY 60(2):394-402
Tikoo K; Lau SS; Monks TJ
Histone H3 phosphorylation is coupled to poly-(ADP- ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells
30
4115 2001 NATURE 410(6825):227-230
Tissenbaum HA; Guarente L
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
5228
2116 2001 NATURE GENETICS 29(3):332-336
Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
70
10117 2001 NATURE STRUCTURAL BIOLOGY 8(7):621-625
Finnin MS; Donigian JR; Pavletich NP
Structure of the histone deacetylase SIRT2
119
2118 2001 NUCLEIC ACIDS RESEARCH 29(16):3439-3447
Miska EA; Langley E; Wolf D; Karlsson C; Pines J; Kouzarides T
Differential localization of HDAC4 orchestrates muscle differentiation
71
2119 2001 NUCLEIC ACIDS RESEARCH 29(20):4114-4124
Hirschler-Laszkiewicz I; Cavanaugh A; Hu QY; Catania J; Avantaggiati ML; Rothblum LI
The role of acetylation in rDNA transcription
30
2120 2001 ONCOGENE 20(28):3716-3725
Wang LL; Hiebert SW
TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3
41
2121 2001 PLANT CELL 13(7):1609-1624
Baidyaroy D; Brosch G; Ahn JH; Graessle S; Wegener S; Tonukari NJ; Caballero O; Loidl P; Walton JD
A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus
11
1122 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(1):87-92
Furumai R; Komatsu Y; Nishino N; Khochbin S; Yoshida M; Horinouchi S
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
219
1123 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(1):200-205
Tian L; Chen ZJ
Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development
201
4124 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(2):415-420
Tanny JC; Moazed D
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
3229
2125 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(3):1188-1193
Asher G; Lotem J; Cohen B; Sachs L; Shaul Y
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase-1
140
2126 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(4):1454-1458
You A; Tong JK; Grozinger CM; Schreiber SL
CoREST is an integral component of the CoREST-human histone deacetylase complex
197
3127 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(15):8584-8589
Georgel PT; DeBeer MAP; Pietz G; Fox CA; Hansen JC
Sir3-dependent assembly of supramolecular chromatin structures in vitro
31
2128 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(17):9730-9735
Chang YL; Peng YH; Pan IC; Sun DS; King B; Huang DH
Essential role of Drosophila Hdac1 in homeotic gene silencing
40
5129 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(19):10572-10577
Zhou XB; Marks PA; Rifkind RA; Richon VM
Cloning and characterization of a histone deacetylase, HDAC9
237
3130 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(20):11075-11080
Schaus SE; Cavalieri D; Myers AG
Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure
40
16131 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(26):15113-15118
Bedalov A; Gatbonton T; Irvine WP; Gottschling DE; Simon JA
Identification of a small molecule inhibitor of Sir2p
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1132 2001 SCIENCE 291(5504):646-650
Kirchmaier AL; Rine J
DNA replication-independent silencing in S-cerevisiae
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2133 2001 SCIENCE 293(5532):1074-1080
Jenuwein T; Allis CD
Translating the histone code
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10134 2001 STRUCTURE 9(12):1127-1133
Marmorstein R
Structure of histone deacetylases: Insights into substrate recognition and catalysis
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1135 2001 TOXICOLOGY LETTERS 120(1-3):143-150
Thompson SL; Konfortova G; Gregory RI; Reik W; Dean W; Feil R
Environmental effects on genomic imprinting in mammals
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1136 2001 TRENDS IN BIOCHEMICAL SCIENCES 26(7):405-407
Dlakic M
Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold
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3137 2001 TRENDS IN ENDOCRINOLOGY AND METABOLISM 12(7):294-300
Kramer OH; Gottlicher M; Heinzel T
Histone deacetylase as a therapeutic target
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6138 2001 TRENDS IN GENETICS 17(7):391-392
Guarente L
SIR2 and aging - the exception that proves the rule
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5139 2001 TRENDS IN GENETICS 17(12):712-718
Hekimi S; Burgess J; Bussiere F; Meng Y; Benard C
Genetics of lifespan in C-elegans: molecular diversity, physiological complexity, mechanistic simplicity
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1140 2001 ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE 34(6):486-490
Warner HR
The case for supporting basic research in gerontology
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3141 2002 ANTI-CANCER DRUGS 13(1):1-13
Vigushin DM; Coombes RC
Histone deacetylase inhibitors in cancer treatment
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2142 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295(1):187-192
Maehara K; Uekawa N; Isobe KI
Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene
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2143 2002 BIOCHEMISTRY 41(15):4901-4910
Venditti S; Di Stefano G; D'Eletto M; Di Mauro E
Genetic remodeling and transcriptional remodeling of subtelomeric heterochromatin are different
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1144 2002 BIOCHIMIE 84(4):279-289
Cornuel JF; Moraillon A; Gueron M
Participation of yeast inosine 5 '-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand
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3145 2002 BRITISH JOURNAL OF CANCER 86(6):917-923
de Nigris F; Cerutti J; Morelli C; Califano D; Chiariotti L; Viglietto G; Santelli G; Fusco A
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
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1146 2002 CANCER RESEARCH 62(17):4916-4921
Furumai R; Matsuyama A; Kobashi N; Lee KH; Nishiyama N; Nakajima I; Tanaka A; Komatsu Y; Nishino N; Yoshida M; Horinouchi S
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases
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4147 2002 CELL 109(4):437-446
Robyr D; Suka Y; Xenarios I; Kurdistani SK; Wang A; Suka N; Grunstein M
Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases
51
8148 2002 CELL 109(4):447-458
Rosenberg MI; Parkhurst SM
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination
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19149 2002 CHEMISTRY & BIOLOGY 9(1):3-16
Grozinger CM; Schreiber SL
Deacetylase enzymes: biological functions and the use of small- molecule inhibitors
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1150 2002 CLINICAL CANCER RESEARCH 8(3):662-664
Richon VM; O'Brien JP
Histone deacetylase inhibitors: A new class of potential therapeutic agents for cancer treatment
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Cited
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Nodes / AuthorsGCSLCS
3151 2002 CLINICS IN GERIATRIC MEDICINE 18(3):383-+
Kirkland JL
The biology of senescence: potential for prevention of disease
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2152 2002 CURRENT BIOLOGY 12(9):712-723
Pletcher SD; Macdonald SJ; Marguerie R; Certa U; Stearns SC; Goldstein DB; Partridge L
Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster
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5153 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):362-369
Perls T; Kunkel L; Puca A
The genetics of aging
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18154 2002 CURRENT OPINION IN HEMATOLOGY 9(4):322-332
Melnick A; Licht JD
Histone deacetylases as therapeutic targets in hematologic malignancies
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3155 2002 CYTOKINE & GROWTH FACTOR REVIEWS 13(3):259-276
Fu MF; Wang CG; Wang J; Zafonte BT; Lisanti MP; Pestell RG
Acetylation in hormone signaling and the cell cycle
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6156 2002 DEVELOPMENTAL CELL 2(1):9-19
Tissenbaum HA; Guarente L
Model organisms as a guide to mammalian aging
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21157 2002 EMBO JOURNAL 21(10):2383-2396
Langley E; Pearson M; Faretta M; Bauer UM; Frye RA; Minucci S; Pelicci PG; Kouzarides T
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
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4158 2002 EMBO JOURNAL 21(17):4654-4662
Wardleworth BN; Russell RJM; Bell SD; Taylor GL; White MF
Structure of Alba: an archaeal chromatin protein modulated by acetylation
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7159 2002 EXPERIMENTAL GERONTOLOGY 37(8-9):1023-1030
Jiang JC; Wawryn J; Kumara HMCS; Jazwinski SM
Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast
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3160 2002 GENES & DEVELOPMENT 16(12):1528-1539
Luo KH; Vega-Palas MA; Grunstein M
Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast
00
1161 2002 GENES TO CELLS 7(2):99-113
Johzuka K; Horiuchi T
Replication fork block protein, Fob1, acts as an rDNA region specific recombinator in S-cerevisiae
10
2162 2002 GENETICS 160(1):49-62
Lewis LK; Karthikeyan G; Westmoreland JW; Resnick MA
Differential suppression of DNA repair deficiencies of yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase)
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11163 2002 GENETICS 160(3):877-889
Sandmeier JJ; Celic I; Boeke JD; Smith JS
Telomeiric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway
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6164 2002 GENETICS 161(4):1411-1423
Kasulke D; Seitz S; Ehrenhofer-Murray AE
A role for the Saccharomyces cerevisiae RENT complex protein Net1 in HMR silencing
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7165 2002 GENETICS 162(1):59-71
Grunweller A; Ehrenhofer-Murray AE
A novel yeast silencer: The 2 mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity
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7166 2002 GUIDE TO YEAST GENETICS AND MOLECULAR AND CELL BIOLOGY, PT B 350():165-186
Van Leeuwen F; Gottschling DE
Assays for gene silencing in yeast
10
3167 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(3):1897-1905
Singal R; Wang SZ; Sargent T; Zhu SZ; Ginder GD
Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex
10
3168 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(7):4778-4781
Carmen AA; Milne L; Grunstein M
Acetylation of the yeast histone H4N terminus regulates its binding to heterochromatin protein SIR3
21
11169 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6656-6666
Fischer DD; Cai R; Bhatia U; Asselbergs FAM; Song CZ; Terry R; Trogani N; Widmer R; Atadja P; Cohen D
Isolation and characterization of a novel class II histone deacetylase, HDAC10
21
7170 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(11):9590-9597
Johnson CA; White DA; Lavender JS; O'Neill LP; Turner BM
Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co- immunoprecipitate with the ATP-dependent chaperone protein Hsp70
10
23171 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(15):12632-12641
Borra MT; O'Neill FJ; Jackson MD; Marshall B; Verdin E; Foltz KR; Denu JM
Conserved enzymatic production and biological effect of O- acetyl-ADP-ribose by silent information regulator 2-like NAD(+)-dependent deacetylases
33
10172 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18535-18544
Jackson AD; Denu JM
Structural identification of 2 '- and 3 '-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta- NAD(+)-dependent histone/protein deacetylases
00
16173 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18881-18890
Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA
Manipulation of a nuclear NAD(+) salvage pathway delays aging without altering steady-state NAD(+) levels
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8174 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(28):25748-25755
Gao L; Cueto MA; Asselbergs F; Atadja P
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family
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16175 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(37):34489-34498
Chang JH; Kim HC; Hwang KY; Lee JW; Jackson SP; Bell SD; Cho Y
Structural basis for the NAD-dependent deacetylase mechanism of Sir2
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16176 2002 JOURNAL OF CELL BIOLOGY 158(4):647-657
Schwer B; North BJ; Frye RA; Ott M; Verdin E
The human silent information regulator NO homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
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12177 2002 JOURNAL OF CELL SCIENCE 115(4):689-698
Jepsen K; Rosenfeld MG
Biological roles and mechanistic actions of co-repressor complexes
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3178 2002 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34(7):717-724
Oh H; Schneider MD
The emerging role of telomerase in cardiac muscle cell growth and survival
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7179 2002 JOURNAL OF MOLECULAR BIOLOGY 322(1):41-52
Cioci F; Vogelauer M; Camilloni G
Acetylation and accessibility of rDNA chromatin in Saccharomyces cerevisiae in Delta top1 and Delta sir2 mutants
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4180 2002 JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 50(2):359-368
Perls T; Kunkel LM; Puca AA
The genetics of exceptional human longevity
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2181 2002 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 57(9):B333-B338
Butler RN; Fossel M; Harman SM; Heward CB; Olshansky SJ; Perls TT; Rothman DJ; Rothman SM; Warner HR; West MD; Wright WE
Is there an antiaging medicine?
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2182 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(2-3):65-73
Martin GM
Keynote: mechanisms of senescence complificationists versus simplificationists
30
5183 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(6):567-573
Campisi J
Between Scylla and Charybdis: p53 links tumor suppression and aging
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16184 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(8):857-867
Sinclair DA
Paradigms and pitfalls of yeast longevity research
00
6185 2002 MOLECULAR AND CELLULAR BIOLOGY 22(2):421-429
Merker RJ; Klein HL
hpr1 Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae
10
3186 2002 MOLECULAR AND CELLULAR BIOLOGY 22(3):835-848
Kuzmichev A; Zhang Y; Erdjument-Bromage H; Tempst P; Reinberg D
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)
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4187 2002 MOLECULAR AND CELLULAR BIOLOGY 22(7):2170-2181
Bjerling P; Silverstein RA; Thon G; Caudy A; Grewal S; Ekwall K
Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity
10
4188 2002 MOLECULAR AND CELLULAR BIOLOGY 22(9):3024-3034
Dufourcq P; Victor M; Gay F; Calvo D; Hodgkin J; Shi Y
Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis
10
6189 2002 MOLECULAR AND CELLULAR BIOLOGY 22(12):4136-4146
Hoopes LLM; Budd M; Choe W; Tao WT; Campbell JL
Mutations in DNA replication genes reduce yeast life span
00
16190 2002 MOLECULAR AND CELLULAR BIOLOGY 22(12):4167-4180
Hoppe GJ; Tanny JC; Rudner AD; Gerber SA; Danaie S; Gygi SP; Moazed D
Steps in assembly of silent chromatin in yeast: Sir3- independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation
11
12191 2002 MOLECULAR BIOLOGY OF THE CELL 13(4):1427-1438
Armstrong CM; Kaeberlein M; Imai SI; Guarente L
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity
11
12192 2002 MOLECULAR BIOLOGY OF THE CELL 13(7):2207-2222
Rusche LN; Kirchmaier AL; Rine J
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae
00
13193 2002 MOLECULAR CELL 10(3):523-535
Avalos JL; Celic I; Muhammad S; Cosgrove MS; Boeke JD; Wolberger C
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
00
6194 2002 NATURE 418(6895):344-348
Lin SJ; Kaeberlein M; Andalis AA; Sturtz LA; Defossez PA; Culotta VC; Fink GR; Guarente L
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
10
4195 2002 NATURE GENETICS 32(2):273-279
Park JH; Cosgrove MS; Youngman E; Wolberger C; Boeke JD
A core nucleosome surface crucial for transcriptional silencing
00
4196 2002 NEUROBIOLOGY OF AGING 23(2):255-262
Mori N; Mizuno T; Murai K; Nakano I; Yamashita H
Effect of age on the gene expression of neural-restrictive silencing factor NRSF/REST
00
5197 2002 NUCLEIC ACIDS RESEARCH 30(2):475-481
Vaute O; Nicolas E; Vandel L; Trouche D
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases
10
22198 2002 NUCLEIC ACIDS RESEARCH 30(7):1465-1482
Huang Y
Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe
00
3199 2002 ONCOGENE 21(4):512-521
Tham WH; Zakian VA
Transcriptional silencing at Saccharomyces telomeres: implications for other organisms
00
1200 2002 PHARMACOGENOMICS 3(4):469-484
Perls T; Puca A
The genetics of aging - implications for pharmacogenomics
00
3201 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(2):838-843
Kang HL; Benzer S; Min KT
Life extension in Drosophila by feeding a drug
21
5202 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(13):8695-8700
Bernstein BE; Humphrey EL; Erlich RL; Schneider R; Bouman P; Liu JS; Kouzarides T; Schreiber SL
Methylation of histone H3 Lys 4 in coding regions of active genes
00
5203 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11700-11705
Butler LM; Zhou XB; Xu WS; Scher HI; Rifkind RA; Marks PA; Richon VM
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down- regulates thioredoxin
00
11204 2002 REDOX CELL BIOLOGY AND GENETICS, PT B 353():282-300
Smith JS; Avalos J; Celic I; Muhammad S; Wolberger C; Boeke JD
SIR2 family of NAD(+)-dependent protein deacetylases
11
4205 2002 SCIENCE 295(5561):1895-1897
Zhang QH; Piston DW; Goodman RH
Regulation of corepressor function by nuclear NADH
50
16206 2002 TRENDS IN CELL BIOLOGY 12(9):404-406
Smith JS
Human Sir2 and the "silencing' of p53 activity
00

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