| # | Cited
nodes | Nodes / Authors | GCS | LCS |
| 1 | 1 | 1 2001 CELL 107(1):1-3
Semenza GL
HIF-1, O-2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus | 31 | 16
|
| 2 | 0 | 2 2001 CELL 107(1):43-54
Epstein ACR; Gleadle JM; McNeill LA; Hewitson KS; O'Rourke J; Mole DR; Mukherji M; Metzen E; Wilson MI; Dhanda A; Tian YM; Masson N; Hamilton DL; Jaakkola P; Barstead R; Hodgkin J; Maxwell PH; Pugh CW; Schofield CJ; Ratcliffe PJ
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | 121 | 121
|
| 3 | 1 | 3 2002 ADVANCES IN CANCER RESEARCH, VOL 85 85():1-12
Conaway RC; Conaway JW
The Von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription | 0 | 0
|
| 4 | 1 | 4 2002 ADVANCES IN ENZYME REGULATION, VOL 42, PROCEEDINGS 42():333-347
Mole DR; Pugh CW; Ratcliffe PJ; Maxwell PH
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex | 0 | 0
|
| 5 | 1 | 5 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(1):C178-C186
Agani FH; Puchowicz M; Chavez JC; Pichiule P; LaManna J
Role of nitric oxide in the regulation of HIF-1 alpha expression during hypoxia | 0 | 0
|
| 6 | 1 | 6 2002 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 283(5):L922-L931
Schroedl C; McClintock DS; Budinger GRS; Chandel NS
Hypoxic but not anoxic stabilization of HIF-1 alpha requires mitochondrial reactive oxygen species | 1 | 0
|
| 7 | 2 | 7 2002 ANNALS OF ONCOLOGY 13():25-28
Bicknell R
An update of new targets for cancer treatment: vessels and matrix | 0 | 0
|
| 8 | 2 | 8 2002 ANNUAL REVIEW OF MICROBIOLOGY 56():539-565
Tan MW
Cross-species infections and their analysis | 0 | 0
|
| 9 | 1 | 9 2002 BACTERIAL PATHOGENESIS, PT C 358():13-28
Tan MW
Identification of host and pathogen factors involved in virulence using Caenorhabditis elegans | 0 | 0
|
| 10 | 1 | 10 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 290(1):294-299
Kanaya K; Tsai AL; Kamitani T
Cobalt- and nickel-binding property of cullin-2 | 0 | 0
|
| 11 | 2 | 11 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 291(4):908-914
Liu LX; Lu HW; Luo YX; Date T; Belanger AJ; Vincent KA; Akita GY; Goldberg M; Cheng SH; Gregory RJ; Jiang CW
Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1 | 2 | 0
|
| 12 | 1 | 12 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293(1):446-450
Wilson WJ; Poellinger L
The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells | 0 | 0
|
| 13 | 1 | 13 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 294(3):700-709
Li ZB; Wang DK; Na X; Schoen SR; Messing EM; Wu G
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor | 0 | 0
|
| 14 | 1 | 14 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 296(2):343-349
Oehme F; Ellinghaus P; Kolkhof P; Smith TJ; Ramakrishnan S; Hutter J; Schramm M; Flamme I
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors | 0 | 0
|
| 15 | 7 | 15 2002 BIOCHEMICAL JOURNAL 367():571-575
McNeill LA; Hewitson KS; Claridge TD; Seibel JF; Horsfall LE; Schofield CJ
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 | 0 | 0
|
| 16 | 1 | 16 2002 BIOCHEMICAL PHARMACOLOGY 64(5-6):903-911
Kietzmann T; Krones-Herzig A; Jungermann K
Signaling cross-talk between hypoxia and glucose via hypoxia- inducible factor 1 and glucose response elements | 0 | 0
|
| 17 | 2 | 17 2002 BIOCHEMICAL PHARMACOLOGY 64(5-6):993-998
Semenza GL
Signal transduction to hypoxia-inducible factor 1 | 1 | 0
|
| 18 | 1 | 18 2002 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 80(4):421-426
Lieb ME; Menzies K; Moschella MC; Ni RJ; Taubman MB
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation | 0 | 0
|
| 19 | 2 | 19 2002 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12(12):1547-1550
McNeill LA; Hewitson KS; Gleadle JM; Horsfall LE; Oldham NJ; Maxwell PH; Pugh CW; Ratcliffe PJ; Schofield CJ
The use of dioxygen by HIF prolyl hydroxylase (PHD1) | 3 | 3
|
| 20 | 1 | 20 2002 BLOOD 100(7):2623-2628
Stolze I; Berchner-Pfannschmidt U; Freitag P; Wotzlaw C; Rossler J; Frede S; Acker H; Fandrey J
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells | 0 | 0
|
| 21 | 1 | 21 2002 BLOOD 100(8):3008-3016
Mecklenburgh KI; Walmsley SR; Cowburn AS; Wiesener M; Reed BJ; Upton PD; Deighton J; Greening AP; Chilvers ER
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis | 0 | 0
|
| 22 | 1 | 22 2002 BLOOD CELLS MOLECULES AND DISEASES 28(1):57-62
Ang SO; Chen H; Gordeuk VR; Sergueeva AI; Polyakova LA; Miasnikova GY; Kralovics R; Stockton DW; Prchal JT
Endemic polycythemia in Russia: Mutation in the VHL gene | 2 | 1
|
| 23 | 6 | 23 2002 BLOOD PURIFICATION 20(5):445-450
Ratcliffe PJ
From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway | 0 | 0
|
| 24 | 1 | 24 2002 CANCER CELL 1(3):237-246
Kondo K; Klco J; Nakamura E; Lechpammer M; Kaelin WG
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein | 6 | 1
|
| 25 | 1 | 25 2002 CANCER CELL 1(3):247-255
Maranchie JK; Vasselli JR; Riss J; Bonifacino JS; Linehan WM; Klausner RD
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma | 4 | 1
|
| 26 | 1 | 26 2002 CANCER CELL 1(5):459-468
Mandriota SJ; Turner KJ; Davies DR; Murray PG; Morgan NV; Sowter HM; Wykoff CC; Maher ER; Harris AL; Ratcliffe PJ; Maxwell PH
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron | 0 | 0
|
| 27 | 1 | 27 2002 CANCER RESEARCH 62(12):3387-3394
Comerford KM; Wallace TJ; Karhausen J; Louis NA; Montalto MC; Colgan SP
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene | 1 | 0
|
| 28 | 4 | 28 2002 CELL 111(5):709-720
Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW
Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 1 | 1
|
| 29 | 1 | 29 2002 CIRCULATION 106(21):2741-2746
Patterson C; Cyr D
Welcome to the machine - A cardiologist's introduction to protein folding and degradation | 0 | 0
|
| 30 | 1 | 30 2002 CLINICAL MEDICINE 2(4):356-362
Maxwell PH
Oxygen homeostasis and cancer: insights from a rare disease | 0 | 0
|
| 31 | 1 | 31 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 133(1):1-16
Nikinmaa M
Oxygen-dependent cellular functions - why fishes and their aquatic environment are a prime choice of study | 0 | 0
|
| 32 | 3 | 32 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 133(4):475-481
Hofer T; Desbaillets I; Hopfl G; Wenger RH; Gassmann M
Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy | 0 | 0
|
| 33 | 1 | 33 2002 CURRENT OPINION IN CHEMICAL BIOLOGY 6(2):193-201
Ryle MJ; Hausinger RP
Non-heme iron oxygenases | 7 | 2
|
| 34 | 1 | 34 2002 CURRENT OPINION IN MICROBIOLOGY 5(1):97-101
Aballay A; Ausubel FM
Caenorhabditis elegans as a host for the study of host-pathogen interactions | 3 | 1
|
| 35 | 1 | 35 2002 CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 11(4):445-450
Franch HA
Pathways of proteolysis affecting renal cell growth | 1 | 0
|
| 36 | 3 | 36 2002 CURRENT OPINION IN STRUCTURAL BIOLOGY 12(6):822-830
VanDemark AP; Hill CP
Structural basis of ubiquitylation | 0 | 0
|
| 37 | 1 | 37 2002 EVOLUTION & DEVELOPMENT 4(5):344-353
Mitchell B; Crews ST
Expression of the Artemia trachealess gene in the salt gland and epipod | 0 | 0
|
| 38 | 5 | 38 2002 EXPERT OPINION ON THERAPEUTIC PATENTS 12(6):777-788
Mabjeesh NJ; Frazier MC; Simons JW; Zhong H
Hypoxia-directed cancer therapy | 0 | 0
|
| 39 | 4 | 39 2002 FASEB JOURNAL 16(14):U348-U369
Wiesener MS; Jurgensen JS; Rosenberger C; Scholze C; Horstrup JH; Warnecke C; Mandriota S; Bechmann I; Frei UA; Pugh CW; Ratcliffe PJ; Bachmann S; Maxwell PH; Eckardt KU
Widespread, hypoxia-inducible expression of HIF-2 alpha in distinct cell populations of different organs | 0 | 0
|
| 40 | 3 | 40 2002 FASEB JOURNAL 16(10):1151-1162
Wenger RH
Cellular adaptation to hypoxia: O-2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O-2- regulated gene expression | 5 | 1
|
| 41 | 2 | 41 2002 FEBS LETTERS 517(1-3):7-12
Zhang ZH; Ren JS; Harlos K; McKinnon CH; Clifton IJ; Schofield CJ
Crystal structure of a clavaminate synthase-Fe(II)-2- oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements | 3 | 2
|
| 42 | 2 | 42 2002 FEBS LETTERS 529(2-3):309-312
Wang J; Buss JL; Chen GH; Ponka P; Pantopoulos K
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzo ate generates effective iron deficiency in cultured cells | 0 | 0
|
| 43 | 1 | 43 2002 FREE RADICAL BIOLOGY AND MEDICINE 32(9):790-796
Levine RL
Carbonyl modified proteins in cellular regulation, aging, and disease | 2 | 0
|
| 44 | 1 | 44 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(3):356-363
Creighton-Gutteridge M; Tyrrell RM
A novel iron chelator that does not induce HIF-1 activity | 1 | 0
|
| 45 | 2 | 45 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(9):1231-1242
Michiels C; Minet E; Mottet D; Raes M
Regulation of gene expression by oxygen: NF-kappa B and HIF-1, two extremes | 0 | 0
|
| 46 | 2 | 46 2002 GENES & DEVELOPMENT 16(12):1466-1471
Lando D; Peet DJ; Gorman JJ; Whelan DA; Whitelaw ML; Bruick RK
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor | 13 | 11
|
| 47 | 1 | 47 2002 HIGH ALTITUDE MEDICINE & BIOLOGY 3(2):177-193
Levine BD
Intermittent hypoxic training: Fact and fancy | 0 | 0
|
| 48 | 2 | 48 2002 JOURNAL OF BIOCHEMISTRY 131(4):523-531
Nakajima H; Ishida T; Tanaka H; Horiike K
Accurate measurement of near-micromolar oxygen concentrations in aqueous solutions based on enzymatic extradiol cleavage of 4-chlorocatechol: Applications to improved low-oxygen experimental systems and quantitative assessment of back diffusion of oxygen from the atmosphere | 0 | 0
|
| 49 | 1 | 49 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6183-6187
Minchenko A; Leshchinsky I; Opentanova I; Sang NL; Srinivas V; Armstead V; Caro J
Hypoxia-inducible factor-1-mediated expression of the 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene - Its possible role in the Warburg effect | 5 | 3
|
| 50 | 1 | 50 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(11):9262-9267
Katschinski DM; Le L; Heinrich D; Wagner KF; Hofer T; Schindler SG; Wenger RH
Heat induction of the unphosphorylated form of hypoxia- inducible factor-1 alpha is dependent on heat shock protein-90 activity | 4 | 4
|
| 51 | 1 | 51 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(16):13508-13517
Alvarez-Tejado M; Alfranca A; Aragones J; Vara A; Landazuri MO; del Peso L
Lack of evidence for the involvement of the phosphoinositide 3- kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension | 4 | 0
|
| 52 | 1 | 52 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(17):15162-15170
Arsham AM; Plas DR; Thompson CB; Simon MC
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription | 3 | 2
|
| 53 | 1 | 53 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(20):18238-18243
Riihimaa P; Nissi R; Page AP; Winter AD; Keskiaho K; Kivirikko KI; Myllyharju J
Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties | 3 | 3
|
| 54 | 1 | 54 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23111-23115
Lu HS; Forbes RA; Verma A
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis | 1 | 0
|
| 55 | 1 | 55 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23367-23373
Osada M; Imaoka S; Sugimoto T; Hiroi T; Funae Y
NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1 | 0 | 0
|
| 56 | 2 | 56 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23508-23514
Gradin K; Takasaki C; Fujii-Kuriyama Y; Sogawa K
The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine | 1 | 1
|
| 57 | 2 | 57 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23965-23971
Hieta R; Myllyharju J
Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana | 1 | 1
|
| 58 | 7 | 58 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26351-26355
Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | 10 | 10
|
| 59 | 2 | 59 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(32):29187-29196
Myllyharju J; Kukkola L; Winter AD; Page AP
The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits | 1 | 1
|
| 60 | 5 | 60 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(33):29936-29944
Isaacs JS; Jung YJ; Mimnaugh EG; Martinez A; Cuttitta F; Neckers LM
Hsp90 regulates a von Hippel Lindau-independent hypoxia- inducible factor-1 alpha-degradative pathway | 4 | 2
|
| 61 | 2 | 61 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(36):32405-32408
Makino Y; Kanopka A; Wilson WJ; Tanaka H; Poellinger L
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus | 0 | 0
|
| 62 | 1 | 62 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(38):34773-34784
Dirmeier R; O'Brien KM; Engle M; Dodd A; Spears E; Poyton RO
Exposure of yeast cells to anoxia induces transient oxidative stress - Implications for the induction of hypoxic genes | 0 | 0
|
| 63 | 2 | 63 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38205-38211
Fukuda R; Hirota K; Fan F; Do Jung Y; Ellis LM; Semenza GL
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells | 1 | 0
|
| 64 | 5 | 64 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38723-38730
Ruas JL; Poellinger L; Pereira T
Functional analysis of hypoxia-inducible factor-1 alpha- mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein | 1 | 1
|
| 65 | 7 | 65 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):39792-39800
Huang JH; Zhao Q; Mooney SM; Lee FS
Sequence determinants in hypoxia-inducible factor-1 alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3 | 0 | 0
|
| 66 | 4 | 66 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117
Chan DA; Sutphin PD; Denko NC; Giaccia AJ
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 0 | 0
|
| 67 | 9 | 67 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755
Huang LE; Pete EA; Schau M; Milligan J; Gu J
Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 0 | 0
|
| 68 | 1 | 68 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(50):48403-48409
Page EL; Robitaille GA; Pouyssegur J; Richard DE
Induction of hypoxia-inducible factor-1 alpha by transcriptional and translational mechanisms | 0 | 0
|
| 69 | 2 | 69 2002 JOURNAL OF KOREAN MEDICAL SCIENCE 17(5):581-588
Chun YS; Kim MS; Park JW
Oxygen-dependent and -independent regulation of HIF-1alpha | 0 | 0
|
| 70 | 2 | 70 2002 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34(7):765-774
Belanger AJ; Lu HW; Date L; Liu LX; Vincent KA; Akita GY; Cheng SH; Gregory RJ; Jiang CW
Hypoxia up-regulates expression of peroxisome proliferator- activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: Role of hypoxia inducible factor 1 alpha | 1 | 0
|
| 71 | 2 | 71 2002 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34(8):1063-1073
Malhotra R; Tyson DGW; Sone H; Aoki K; Kumagai AK; Brosius FC
Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1 alpha levels in cardiac myocytes | 0 | 0
|
| 72 | 3 | 72 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(9):562-575
Acker T; Plate KH
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology | 0 | 0
|
| 73 | 3 | 73 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(11):703-714
Kim KR; Moon HE; Kim KW
Hypoxia-induced angiogenesis in human hepatocellular carcinoma | 0 | 0
|
| 74 | 2 | 74 2002 LABORATORY INVESTIGATION 82(10):1305-1317
Wolf G; Harendza S; Schroeder R; Wenzel U; Zahner G; Butzmann U; Freeman RS; Stahl RAK
Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20 | 0 | 0
|
| 75 | 1 | 75 2002 M S-MEDECINE SCIENCES 18(1):70-78
Gothie E; Pouyssegur J
HIF-1: a central regulator of hypoxia | 0 | 0
|
| 76 | 1 | 76 2002 MICROSCOPY RESEARCH AND TECHNIQUE 58(5):412-420
Des Tombe AL; Van Beek-Harmsen BJ; Lee-De Groot MBE; Van Der Laarse WJ
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium | 0 | 0
|
| 77 | 1 | 77 2002 MICROSCOPY RESEARCH AND TECHNIQUE 59(1):41-48
Goonewardene TI; Sowter HM; Harris AL
Hypoxia-induced pathways in breast cancer | 0 | 0
|
| 78 | 1 | 78 2002 MOLECULAR AND CELLULAR BIOLOGY 22(9):2984-2992
Sang NL; Fang J; Srinivas V; Leshchinsky I; Caro J
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein- independent, hydroxylation-regulated association with p300/CBP | 9 | 8
|
| 79 | 1 | 79 2002 MOLECULAR AND CELLULAR BIOLOGY 22(15):5319-5336
Groulx I; Lee S
Oxygen-dependent ubiquitination and degradation of hypoxia- inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein | 2 | 0
|
| 80 | 2 | 80 2002 MOLECULAR AND CELLULAR BIOLOGY 22(19):6842-6853
Lavista-Llanos S; Centanin L; Irisarri M; Russo DM; Gleadle JM; Bocca SN; Muzzopappa M; Ratcliffe PJ; Wappner P
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar | 0 | 0
|
| 81 | 4 | 81 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014
Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT
Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 0 | 0
|
| 82 | 1 | 82 2002 MOLECULAR AND CELLULAR BIOLOGY 22(21):7405-7416
Koumenis C; Naczki C; Koritzinsky M; Rastani S; Diehl A; Sonenberg N; Koromilas A; Wouters BG
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2 alpha | 0 | 0
|
| 83 | 2 | 83 2002 MOLECULAR BIOLOGY OF THE CELL 13(5):1473-1483
Padilla PA; Nystul TG; Zager RA; Johnson ACM; Roth MB
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans | 0 | 0
|
| 84 | 2 | 84 2002 MOLECULAR PHARMACOLOGY 62(5):975-982
Hur E; Kim HH; Choi SM; Kim JH; Yim S; Kwon HJ; Choi Y; Kim DK; Lee MO; Park H
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1 alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat- shock protein inhibitor radicicol | 0 | 0
|
| 85 | 3 | 85 2002 MOLECULES AND CELLS 14(1):9-15
Lee E; Yim S; Lee SK; Park H
Two transactivation domains of hypoxia-inducible factor-1 alpha regulated by the MEK-1/p42/p44 MAPK pathway | 0 | 0
|
| 86 | 1 | 86 2002 NATURE 417(6892):975-978
Hon WC; Wilson MI; Harlos K; Claridge TDW; Schofield CJ; Pugh CW; Maxwell PH; Ratcliffe PJ; Stuart DI; Jones EY
Structural basis for the recognition of hydroxyproline in alpha IF-1 alpha by pVHL | 11 | 10
|
| 87 | 4 | 87 2002 NATURE GENETICS 32(4):614-621
Ang SO; Chen H; Hirota K; Gordeuk VR; Jelinek J; Guan YL; Liu EL; Sergueeva AI; Miasnikova GY; Mole D; Maxwell PH; Stockton DW; Semenza GL; Prchal JT
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia | 0 | 0
|
| 88 | 1 | 88 2002 NATURE REVIEWS CANCER 2(1):38-47
Harris AL
Hypoxia - A key regulatory factor in tumour growth | 10 | 3
|
| 89 | 10 | 89 2002 NATURE REVIEWS CANCER 2(9):673-682
Kaelin WG
Molecular basis of the VHL hereditary cancer syndrome | 4 | 0
|
| 90 | 1 | 90 2002 NEPHROLOGY 7():S21-S25
Pugh CW; Maxwell PH; Ratcliffe PJ
Oxygen mediated gene regulation | 0 | 0
|
| 91 | 1 | 91 2002 NEPHROLOGY DIALYSIS TRANSPLANTATION 17(3):356-359
Wiesener MS; Eckardt KU
Erythropoietin, tumours and the von Hippel-Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing | 0 | 0
|
| 92 | 1 | 92 2002 ONCOGENE 21(44):6713-6721
Erez N; Milyavsky M; Goldfinger N; Peles E; Gudkov AV; Rotter V
Falkor, a novel cell growth regulator isolated by a functional genetic screen | 0 | 0
|
| 93 | 1 | 93 2002 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 443(4):503-507
Hofer T; Wenger RH; Gassmann M
Oxygen sensing, HIF-1 alpha stabilization and potential therapeutic strategies | 1 | 2
|
| 94 | 2 | 94 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5367-5372
Freedman SJ; Sun ZYJ; Poy F; Kung AL; Livingston DM; Wagner G; Eck MJ
Structural basis for recruitment of CBP/p300 by hypoxia- inducible factor-1 alpha | 10 | 7
|
| 95 | 1 | 95 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10305-10309
Hansson LO; Friedler A; Freund S; Rudiger S; Fersht AR
Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53 | 0 | 0
|
| 96 | 2 | 96 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10423-10428
Willam C; Masson N; Tian YM; Mahmood SA; Wilson MI; Bicknell R; Eckardt KU; Maxwell PH; Ratcliffe PJ; Pugh CW
Peptide blockade of HIF alpha degradation modulates cellular metabolism and angiogenesis | 0 | 0
|
| 97 | 8 | 97 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572
Semenza GL
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 0 | 0
|
| 98 | 2 | 98 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464
Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 0 | 0
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