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Author(s): Trasande L (Trasande, Leonardo); Cronk C (Cronk, Chris); Durkin M (Durkin, Maureen); Weiss M (Weiss, Marianne); Schoeller D (Schoeller, Dale); Gall E (Gall, Elizabeth); Hewitt J (Hewitt, Jeanne); Carrel A (Carrel, Aaron); Landrigan P (Landrigan, Philip); Gillman M (Gillman, Matthew)
Title: Environment and Obesity in the National Children's Study
Source: CIENCIA & SAUDE COLETIVA 15 (1): 195-210
Date: 2010 JAN
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY 10029 USA.
Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA. Med Coll Wisconsin, Milwaukee, WI USA. Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI 53706 USA. Marquette Univ, Coll Nursing, Milwaukee, WI 53233 USA. Univ Wisconsin, Interdept Program Nutr Sci, Madison, WI 53706 USA. Univ Wisconsin, Marine & Freshwater Biomed Sci Ctr, Milwaukee, WI 53201 USA. Univ Wisconsin, Dept Pediat, Madison, WI 53706 USA. Harvard Univ, Med School, Dept Ambulatory Care & Prevent, Cambridge, MA 02138 USA. Reprint: Trasande, L, Mt Sinai Sch Med, Dept Community & Prevent Med, 1 Gustave
L Levy Pl,Box 1043, New York, NY 10029 USA. E-mail: leo.trasande@mssm.edu
Author Keywords: Bisphenol A; Built environment; Endocrine disruptors; Diet; Obesity;
Physical activity
KeyWords Plus: BODY-MASS INDEX; LIFE-COURSE APPROACH; FOOD-FREQUENCY QUESTIONNAIRES;
CHRONIC DISEASE EPIDEMIOLOGY; X-RAY ABSORPTIOMETRY; UNITED-STATES;
BISPHENOL-A; CHILDHOOD OVERWEIGHT; PHYSICAL-ACTIVITY; RISK-FACTORS
Abstract: We describe the approach taken by the National Children's Study (NCS) to understanding the role of environmental factors in the development of obesity. We review the literature with regard to the two core hypotheses in the NCS that relate to environmental origins of obesity and describe strategies that will be used to test each hypothesis. Although it is clear that obesity in an individual results from an imbalance between energy intake and expenditure, control of the obesity epidemic will require understanding of factors in the modern built environment and chemical exposures that may have the capacity to disrupt the link between energy intake and expenditure. Through its embrace of the life-course approach to epidemiology, the NCS will be able to study the origins of obesity from preconception through late adolescence, including factors ranging from genetic inheritance to individual behaviors to the social, built, and natural environ-ment and chemical exposures. It will have sufficient statistical power to examine interactions among these multiple influences, including gene-environment and gene-obesity interactions. A major sec-ondary benefit will derive from the banking of specimens for future analysis.
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