#	Cited nodes	Nodes / Authors	GCS	LCS
12601	9	6959 1990 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 68(9):1278-1285 WOODCROFT KJ; BEND JR N-ARALKYLATED DERIVATIVES OF 1-AMINOBENZOTRIAZOLE AS ISOZYME- SELECTIVE, MECHANISM-BASED INHIBITORS OF GUINEA-PIG HEPATIC CYTOCHROME-P-450 DEPENDENT MONOOXYGENASE ACTIVITY	18	13
12602	10	7034 1990 DRUG METABOLISM AND DISPOSITION 18(6):1031-1037 WOODCROFT KJ; SZCZEPAN EW; KNICKLE LC; BEND JR 3 N-ARALKYLATED DERIVATIVES OF 1-AMINOBENZOTRIAZOLE AS POTENT AND ISOZYME-SELECTIVE, MECHANISM-BASED INHIBITORS OF GUINEA-PIG PULMONARY CYTOCHROME-P-450 INVITRO	23	13
12603	24	10614 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(5):589-599 Woodcroft KJ; Webb CD; Yao M; Weedon AC; Bend JR Metabolism of the cytochrome P450 mechanism-based inhibitor N- benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: Comparative study with 1-aminobenzotriazole	7	5
12604	9	9633 1995 DRUG METABOLISM REVIEWS 27(3):471-495 WOODROOFFE AJM; BAYLISS MK; PARK GR THE EFFECTS OF HYPOXIA ON DRUG-METABOLIZING-ENZYMES	5	0
12605	6	3658 1978 JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 29(12):1096-1097 WOODS L; WISEMAN A POSSIBLE REMOVAL OF BENZO(A)PYRENE FROM SOME FOODS USING CYTOCHROME-P-450 FROM BREWERS-YEAST	1	0
12606	12	4051 1980 BIOCHIMICA ET BIOPHYSICA ACTA 613(1):52-61 WOODS LFJ; WISEMAN A BENZO(A)PYRENE HYDROXYLASE FROM SACCHAROMYCES-CEREVISIAE - SUBSTRATE BINDING, SPECTRAL AND KINETIC DATA	18	5
12607	12	10975 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 353(1):109-115 Woods ST; Sadleir J; Downs T; Triantopoulos T; Headlam MJ; Tuckey RC Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462	9	3
12608	3	1496 1971 BIOCHEMICAL PHARMACOLOGY 20(6):1071-& WOODWARD B; TAYLOR NF; BRUNT RV EFFECT OF 3-DEOXY-3-FLUORO-D-GLUCOSE ON GLYCOLYTIC INTERMEDIATES AND ADENINE NUCLEOTIDES IN RESTING CELLS OF SACCHAROMYCES-CEREVISIAE	15	1
12609	3	5553 1986 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 136(1):169-176 WOOLLARD PM STEREOCHEMICAL DIFFERENCE BETWEEN 12-HYDROXY-5,8,10,14- EICOSATETRAENOIC ACID IN PLATELETS AND PSORIATIC LESIONS	145	26
12610	4	10335 1996 MARINE ENVIRONMENTAL RESEARCH 42(1-4):297-301 Wootton AN; Goldfarb PS; Lemaire P; OHara SCM; Livingstone DR Characterization of the presence and seasonal variation of a CYP1A-like enzyme in digestive gland of the common mussel, Mytilus edulis	15	5
12611	4	9800 1995 MARINE ENVIRONMENTAL RESEARCH 39(1-4):21-26 WOOTTON AN; HERRING C; SPRY JA; WISEMAN A; LIVINGSTONE DR; GOLDFARB PS EVIDENCE FOR THE EXISTENCE OF CYTOCHROME-P450 GENE FAMILIES (CYP1A, 3A, 4A, 11A) AND MODULATION OF GENE-EXPRESSION (CYP1A) IN THE MUSSEL MYTILUS SPP	27	9
12612	53	11593 1999 CRITICAL REVIEWS IN TOXICOLOGY 29(1):59-124 Wormhoudt LW; Commandeur JNM; Vermeulen NPE Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-Transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity	91	8
12613	19	10107 1996 CHEMICO-BIOLOGICAL INTERACTIONS 101(3):175-192 Wormhoudt LW; Ploemen JHTM; deWaziers I; Commandeur JNM; Beaune PH; vanBladeren PJ; Vermeulen NPE Inter-individual variability in the oxidation of 1,2- dibromoethane: Use of heterologously expressed human cytochrome P450 and human liver microsomes	9	3
12614	7	13001 2003 BIOCHEMISTRY 42(23):7068-7076 Worrall JAR; Reinle W; Bernhardt R; Ubbink M Transient protein interactions studied by NMR spectroscopy: The case of cytochrome C and adrenodoxin	0	0
12615	9	7417 1991 BIOCHEMICAL PHARMACOLOGY 42(2):381-390 WORTELBOER HM; DEKRUIF CA; VANIERSEL AAJ; FALKE HE; NOORDHOEK J; BLAAUBOER BJ COMPARISON OF CYTOCHROME P450 ISOENZYME PROFILES IN RAT-LIVER AND HEPATOCYTE CULTURES - THE EFFECTS OF MODEL INDUCERS ON APOPROTEINS AND BIOTRANSFORMATION ACTIVITIES	103	27
12616	9	7911 1992 BIOCHEMICAL PHARMACOLOGY 43(7):1439-1447 WORTELBOER HM; DEKRUIF CA; VANIERSEL AAJ; FALKE HE; NOORDHOEK J; BLAAUBOER BJ ACID REACTION-PRODUCTS OF INDOLE-3-CARBINOL AND THEIR EFFECTS ON CYTOCHROME P450 AND PHASE-II ENZYMES IN RAT AND MONKEY HEPATOCYTES	30	6
12617	5	8115 1992 FOOD AND CHEMICAL TOXICOLOGY 30(1):17-& WORTELBOER HM; DEKRUIF CA; VANIERSEL AAJ; NOORDHOEK J; BLAAUBOER BJ; VANBLADEREN PJ; FALKE HE EFFECTS OF COOKED BRUSSELS-SPROUTS ON CYTOCHROME-P-450 PROFILE AND PHASE-II ENZYMES IN LIVER AND SMALL INTESTINAL-MUCOSA OF THE RAT	38	10
12618	8	8117 1992 FOOD AND CHEMICAL TOXICOLOGY 30(7):589-599 WORTELBOER HM; VANDERLINDEN ECM; DEKRUIF CA; NOORDHOEK J; BLAAUBOER BJ; VANBLADEREN PJ; FALKE HE EFFECTS OF INDOLE-3-CARBINOL ON BIOTRANSFORMATION ENZYMES IN THE RAT - INVIVO CHANGES IN LIVER AND SMALL INTESTINAL-MUCOSA IN COMPARISON WITH PRIMARY HEPATOCYTE CULTURES	53	7
12619	8	12320 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 388(2):276-280 Woyski D; Cupp-Vickery JR Enhanced expression of cytochrome P450s from lac-based plasmids using lactose as the inducer	1	0
12620	7	7802 1991 XENOBIOTICA 21(2):193-203 WRIGHT AWE; WINZOR DJ; REILLY PEB CIMETIDINE - AN INHIBITOR AND AN INDUCER OF RAT-LIVER MICROSOMAL CYTOCHROME-P-450	11	2
12621	14	11521 1999 BIOCHEMICAL SOCIETY TRANSACTIONS 27(4):387-391 Wright MC The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor	3	2
12622	16	10556 1997 BIOCHEMICAL PHARMACOLOGY 54(7):841-846 Wright MC; Edwards RJ; Pimenta M; Ribeiro V; Ratra GS; Lechner MC; Paine AJ Developmental changes in the constitutive and inducible expression of cytochrome P450 3A2	14	7
12623	13	8943 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 201(2):973-979 WRIGHT MC; PAINE AJ INDUCTION OF THE CYTOCHROME-P450-3A SUBFAMILY IN RAT-LIVER CORRELATES WITH THE BINDING OF INDUCERS TO A MICROSOMAL PROTEIN	21	12
12624	18	10357 1996 MOLECULAR PHARMACOLOGY 50(4):856-863 Wright MC; Wang XJ; Pimenta M; Ribeiro V; Paine AJ; Lechner MC Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid	22	14
12625	10	7241 1990 MOLECULAR PHARMACOLOGY 38(2):207-213 WRIGHTON SA; BRIAN WR; SARI MA; IWASAKI M; GUENGERICH FP; RAUCY JL; MOLOWA DT; VANDENBRANDEN M STUDIES ON THE EXPRESSION AND METABOLIC CAPABILITIES OF HUMAN LIVER CYTOCHROME P450IIIA5 (HLP3)	229	109
12626	5	9320 1994 PHARMACEUTICAL RESEARCH 11(6):921-924 WRIGHTON SA; RING BJ INHIBITION OF HUMAN CYP3A CATALYZED 1'-HYDROXY MIDAZOLAM FORMATION BY KETOCONAZOLE, NIFEDIPINE, ERYTHROMYCIN, CIMETIDINE, AND NIZATIDINE	87	22
12627	3	11619 1999 DRUG METABOLISM REVIEWS 31(1):15-28 Wrighton SA; Ring BJ Predicting drug interactions and pharmacokinetic variability with in vitro methods: The olanzapine experience	10	2
12628	8	6717 1989 MOLECULAR PHARMACOLOGY 36(1):97-105 WRIGHTON SA; RING BJ; WATKINS PB; VANDENBRANDEN M IDENTIFICATION OF A POLYMORPHICALLY EXPRESSED MEMBER OF THE HUMAN CYTOCHROME P-450III FAMILY	158	83
12629	28	12051 2000 DRUG METABOLISM REVIEWS 32(3-4):339-361 Wrighton SA; Schuetz EG; Thummel KE; Shen DD; Korzekwa KR; Watkins PB The human CYP3A subfamily: Practical considerations	24	6
12630	67	8038 1992 CRITICAL REVIEWS IN TOXICOLOGY 22(1):1-21 WRIGHTON SA; STEVENS JC THE HUMAN HEPATIC CYTOCHROMES-P450 INVOLVED IN DRUG-METABOLISM	540	184
12631	12	8412 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 306(1):240-245 WRIGHTON SA; STEVENS JC; BECKER GW; VANDENBRANDEN M ISOLATION AND CHARACTERIZATION OF HUMAN LIVER CYTOCHROME-P450 2C19 - CORRELATION BETWEEN 2C19 AND S-MEPHENYTOIN-4'- HYDROXYLATION	206	55
12632	3	5764 1987 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 258(1):292-297 WRIGHTON SA; THOMAS PE; RYAN DE; LEVIN W PURIFICATION AND CHARACTERIZATION OF ETHANOL-INDUCIBLE HUMAN HEPATIC CYTOCHROME-P-450HLJ1	118	67
12633	5	6365 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 268(1):144-151 WRIGHTON SA; VANDENBRANDEN M ISOLATION AND CHARACTERIZATION OF HUMAN-FETAL LIVER CYTOCHROME P450HLP2 - A 3RD MEMBER OF THE P450III GENE FAMILY	72	55
12634	9	8268 1992 MOLECULAR PHARMACOLOGY 41(1):76-82 WRIGHTON SA; VANDENBRANDEN M; BECKER GW; BLACK SD; THOMAS PE 2 MONOCLONAL-ANTIBODIES RECOGNIZING DIFFERENT EPITOPES ON RAT CYTOCHROME IIB1 REACT WITH HUMAN IIE1	29	14
12635	7	10306 1996 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 24(5):461-473 Wrighton SA; VandenBranden M; Ring BJ The human drug metabolizing cytochromes P450	42	7
12636	35	8600 1993 DRUG METABOLISM REVIEWS 25(4):453-484 WRIGHTON SA; VANDENBRANDEN M; STEVENS JC; SHIPLEY LA; RING BJ; RETTIE AE; CASHMAN JR IN-VITRO METHODS FOR ASSESSING HUMAN HEPATIC DRUG-METABOLISM - THEIR USE IN DRUG DEVELOPMENT	140	44
12637	2	10458 1997 ACTA PHARMACOLOGICA SINICA 18(2):176-179 Wu B; Wang CW; Xu JR; Zhu JQ Effect of epidermal growth factor on cultured rat hepatocytes poisoned by CCl4	2	0
12638	5	1705 1971 VIRCHOWS ARCHIV ABTEILUNG B ZELLPATHOLOGIE 9(2):97-& WU BC; VALLE RT; WHITE LAE; SOHAL RS; ARCOS JC; ARGUS MF; BURCH GE MITOCHONDRIAL ULTRASTRUCTURE AND ENERGY TRANSDUCTION IN RAT HEART DURING PROGRESSIVE THIAMINE DEFICIENCY	15	0
12639	4	12838 2002 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50(2):378-383 Wu CC; Sheen LY; Chen HW; Kuo WW; Tsai SJ; Lii CK Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats	4	0
12640	3	1927 1972 JOURNAL OF BIOLOGICAL CHEMISTRY 247(6):1899-& WU CSC; BROWN WD; DUFFY P INTERACTION OF MYOGLOBIN AND CYTOCHROME-C	31	1
12641	5	8531 1993 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 35(1):30-34 WU D; OTTON SV; SPROULE BA; BUSTO U; INABA T; KALOW W; SELLERS EM INHIBITION OF HUMAN CYTOCHROME P450 2D6 (CYP2D6) BY METHADONE	46	7
12642	12	7653 1991 JOURNAL OF CLINICAL INVESTIGATION 88(2):519-523 WU DA; CHUNG BC MUTATIONS OF P450C21 (STEROID-21-HYDROXYLASE) AT CYS428, VAL281, AND SER268 RESULT IN COMPLETE, PARTIAL, OR NO LOSS OF ENZYMATIC-ACTIVITY, RESPECTIVELY	51	10
12643	16	7523 1991 DNA AND CELL BIOLOGY 10(3):201-209 WU DA; HU MC; CHUNG BC EXPRESSION AND FUNCTIONAL-STUDY OF WILD-TYPE AND MUTANT HUMAN CYTOCHROME-P450C21 IN SACCHAROMYCES-CEREVISIAE	16	9
12644	18	9252 1994 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 270(1):407-413 WU DF; CEDERBAUM AI CHARACTERIZATION OF PYRAZOLE AND 4-METHYLPYRAZOLE INDUCTION OF CYTOCHROME P4502E1 IN RAT-KIDNEY	12	3
12645	14	5066 1984 BIOCHEMISTRY 23(1):28-33 WU ES; YANG CS LATERAL DIFFUSION OF CYTOCHROME-P-450 IN PHOSPHOLIPID-BILAYERS	19	9
12646	10	8908 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 308(2):380-386 WU FF; VERGERES G; WASKELL L KINETICS OF THE REDUCTION OF CYTOCHROME B(5) WITH MUTATIONS IN ITS MEMBRANE-BINDING DOMAIN	7	3
12647	6	6507 1989 CANCER RESEARCH 49(9):2337-2343 WU HQ; MASSETBROWN J; TWEEDIE DJ; MILEWICH L; FRENKEL RA; MARTINWIXTROM C; ESTABROOK RW; PROUGH RA INDUCTION OF MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE AND CYTOCHROME P-450IVA1 (P-450LA-OMEGA) BY DEHYDROEPIANDROSTERONE IN RATS - A POSSIBLE PEROXISOMAL PROLIFERATOR	74	74
12648	4	12748 2002 CHINESE JOURNAL OF CHEMISTRY 20(11):1225-1234 Wu J; Wang YH; Gan JH; Wang WH; Sun BY; Huang ZX; Xia ZX Structures of cytochrome b(5) mutated at the charged surface- residues and their interactions with cytochrome c	0	0
12649	1	203 1963 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14(1):79-& WU R CONTROL OF GLYCOLYSIS BY PHOSPHOFRUCTOKINASE IN SLICES OF RAT LIVER, NOVIKOFF HEPATOMA, AND ADENOCARCINOMAS	4	0
12650	1	280 1964 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14(1):79-& WU R CONTROL OF GLYCOLYSIS BY PHOSPHOFRUCTOKINASE IN SLICES OF RAT LIVER NOVIKOFF HEPATOMA + ADENOCARCINOMAS	49	5
12651	1	9877 1995 SEIKAGAKU 67(11):1307-1311 WU RF; ICHIKAWA Y METABOLIC ENZYMES OF NEUROTOXIN - 1-METHYL-4-PHENYL-1,2,3,6- TETRAHYDROPYRIDINE (MPTP) AND PARKINSONS-DISEASE	0	0
12652	40	10748 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(19):12551-12559 Wu S; Chen WN; Murphy E; Gabel S; Tomer KB; Foley J; Steenbergen C; Falck JR; Moomaw CR; Zeldin DC Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.	53	26
12653	44	10235 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(7):3460-3468 Wu S; Moomaw CR; Tomer KB; Falck JR; Zeldin DC Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart	75	46
12654	4	11808 1999 NEUROPHARMACOLOGY 38(7):979-989 Wu SN; Li HF; Jan CR; Shen AY Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH(3) cells	18	1
12655	8	5577 1986 BIOCHEMICAL PHARMACOLOGY 35(20):3607-3612 WU YR; CONWAY JG; KAUFFMAN FC; THURMAN RG STIMULATION OF MIXED-FUNCTION OXIDATION BY NADPH IN PERFUSED MOUSE LIVERS - STUDIES WITH SAPONIN-PERMEABILIZED TISSUE	5	2
12656	5	7238 1990 MOLECULAR PHARMACOLOGY 38(1):128-133 WU YR; KAUFFMAN FC; QU W; GANEY P; THURMAN RG UNIQUE ROLE OF OXYGEN IN REGULATION OF HEPATIC MONOOXYGENATION AND GLUCURONIDATION	16	5
12657	4	11085 1998 BRITISH JOURNAL OF HAEMATOLOGY 102(2):575-577 Wu YS; Huang CH; Wan Y; Huang QJ; Zhu ZY Identification of a novel point mutation (Leu72Pro) in the NADH-cytochrome b5 reductase gene of a patient with hereditary methaemoglobinaemia type I	10	2
12658	4	11744 1999 JOURNAL OF LIPID RESEARCH 40(12):2195-2203 Wu ZL; Martin KO; Javitt NB; Chiang JYL Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1	22	3
12659	1	195 1963 ACTA HAEMATOLOGICA 30(1):16-& WULFF HR HISTOCHEMICAL STUDIES OF LEUKOCYTES FROM AN INFLAMMATORY EXUDATE .3. DI- AND TRIPHOSPHOPYRIDINE NUCLEOTIDE - LINKED DEHYDROGENASES	12	0
12660	1	5088 1984 BIOTECHNOLOGY AND BIOENGINEERING 26(4):301-307 WUMPELMANN M; KJAERGAARD L; JOERGENSEN BB ETHANOL-PRODUCTION WITH SACCHAROMYCES-CEREVISIAE UNDER AEROBIC CONDITIONS AT DIFFERENT POTASSIUM CONCENTRATIONS	4	0
12661	1	71 1959 JOURNAL OF GENERAL PHYSIOLOGY 42(5):1005-1011 WYATT GR; MEYER WL THE CHEMISTRY OF INSECT HEMOLYMPH .3. GLYCEROL	62	2
12662	3	10512 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 346(2):180-186 Wyllie S; Liehr JG Release of iron from ferritin storage by redox cycling of stilbene and steroid estrogen metabolites: A mechanism of induction of free radical damage by estrogen	21	0
12663	10	9818 1995 MOLECULAR PHARMACOLOGY 47(6):1148-1155 WYSS A; GUSTAFSSON JA; WARNER M CYTOCHROMES P450 OF THE 2D SUBFAMILY IN RAT-BRAIN	26	13
12664	8	12661 2002 ACTA PHARMACOLOGICA SINICA 23(5):471-476 Xia XY; Peng RX; Yu JP; Wang H; Wang J In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes	0	0
12665	6	11233 1998 GENE 209(1-2):123-129 Xiang SH; Parsons HK; Murray M Identification of a novel transcriptional silencer in the protein-coding region of the human CYP2C9 gene	7	3
12666	7	10746 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(6):3238-3245 Xiao GH; Falkner KC; Xie YQ; Lindahl RG; Prough RA cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression	15	1
12667	14	9615 1995 DRUG METABOLISM AND DISPOSITION 23(6):642-650 XIAO GH; PINAIRE JA; RODRIGUES AD; PROUGH RA REGULATION OF THE AH GENE BATTERY VIA AH RECEPTOR-DEPENDENT AND INDEPENDENT PROCESSES IN CULTURED ADULT-RAT HEPATOCYTES	20	6
12668	18	11306 1998 JOURNAL OF PHYSIOLOGY-LONDON 508(3):777-792 Xiao YF; Huang L; Morgan JP Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells	30	7
12669	1	11229 1998 FREE RADICAL BIOLOGY AND MEDICINE 25(8):979-988 Xie CS; Lovell MA; Markesbery WR Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity	21	0
12670	7	10856 1997 PHARMACOGENETICS 7(2):115-119 Xie HG; Huang SL; Xu ZH; Xiao XS; He N; Zhou HH Evidence for the effect of gender on activity of (S)- mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population	14	1
12671	33	12307 2001 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 41():815-850 Xie HG; Kim RB; Wood AJJ; Stein CM Molecular basis of ethnic differences in drug disposition and response	30	1
12672	16	12664 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1257-1270 Xie HG; Prasad HC; Kim RB; Stein CM CYP2C9 allelic variants: ethnic distribution and functional significance	1	0
12673	4	7466 1991 BLOOD VESSELS 28(6):475-489 XIE JM; WANG Y; GREENBERG SS SKF-525A DOES NOT INHIBIT RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR FROM RAT THORACIC AORTA AND DOG MESENTERIC AND FEMORAL-ARTERY	5	0
12674	21	12049 2000 DRUG METABOLISM AND DISPOSITION 28(11):1311-1316 Xie Q; Zhang QY; Zhang Y; Su T; Gu J; Kaminsky LS; Ding XX Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart	2	1
12675	2	8604 1993 ENDOCRINOLOGY 132(6):2438-2444 XIONG YT; HALES DB THE ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA IN THE REGULATION OF MOUSE LEYDIG-CELL STEROIDOGENESIS	59	2
12676	5	12808 2002 EUROPEAN JOURNAL OF ENDOCRINOLOGY 147(6):717-725 Xita N; Georgiou I; Tsatsoulis A The genetic basis of polycystic ovary syndrome	0	0
12677	1	10304 1996 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 14(12):1675-1680 Xu A; Linderholm K; Peng L; Hulse J Development and validation of an LC-MS-MS method for the determination of terfenadine in human plasma	10	1
12678	4	9487 1995 BIOCHEMICAL PHARMACOLOGY 49(4):453-460 XU BQ; AASMUNDSTAD TA; BJORNEBOE A; CHRISTOPHERSEN AS; MORLAND J ETHYLMORPHINE O-DEETHYLATION IN ISOLATED RAT HEPATOCYTES - INVOLVEMENT OF CODEINE O-DEMETHYLATION ENZYME-SYSTEMS	7	2
12679	8	10550 1997 BIOCHEMICAL PHARMACOLOGY 53(4):603-609 Xu BQ; Aasmundstad TA; Christophersen AS; Morland J; Bjorneboe A Evidence for CYP2D1-mediated primary and secondary O- dealkylation of ethylmorphine and codeine in rat liver microsomes	5	3
12680	2	13090 2003 LIFE SCIENCES 72(17):1953-1962 Xu BQ; Ishii M; Ding LR; Fischer NE; Inaba T Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6	0	0
12681	12	12663 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1245-1256 Xu C; Goodz S; Sellers EA; Tyndale RF CYP2A6 genetic variation and potential consequences	1	0
12682	1	11475 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 363(2):202-212 Xu G; Goodridge AG Function of a C-rich sequence in the polypyrimidine/polypurine tract of the promoter of the chicken malic enzyme gene depends on promoter context	4	0
12683	6	12805 2002 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 58(5):333-337 Xu P; Huang SL; Zhu RH; Han XM; Zhou HH Phenotypic polymorphism of CYP2A6 activity in a Chinese population	0	0
12684	8	6646 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(30):17674-17680 XU XX; XU TS; ROBERTSON DG; LAMBETH JD GTP STIMULATES PREGNENOLONE GENERATION IN ISOLATED RAT ADRENAL MITOCHONDRIA	29	2
12685	10	9240 1994 JOURNAL OF NUTRITIONAL BIOCHEMISTRY 5(6):308-313 XU ZM; SQUIRES EJ; BRAY TM EFFECTS OF DIETARY ZINC-DEFICIENCY ON THE EXPRESSION OF HEPATIC-MICROSOMAL CYTOCHROME-P450 2E1 IN RATS	2	0
12686	6	11525 1999 BIOCHEMISTRY 38(37):11961-11972 Xue LL; Wang YH; Xie Y; Yao P; Wang WH; Qian W; Huang ZX; Wu J; Xia ZX Effect of mutation at valine 61 on the three-dimensional structure, stability, and redox potential of cytochrome b(5)	15	2
12687	23	12976 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):113-126 Xue LL; Zgoda VG; Arison B; Correia MA Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase	0	0
12688	19	9534 1995 BIOCHIMIE 77(7-8):594-603 YABUSAKI Y ARTIFICIAL P450/REDUCTASE FUSION ENZYMES - WHAT CAN WE LEARN FROM THEIR STRUCTURES	7	6
12689	3	6179 1988 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 7(10):701-711 YABUSAKI Y; MURAKAMI H; SAKAKI T; SHIBATA M; OHKAWA H GENETICALLY ENGINEERED MODIFICATION OF P450 MONOOXYGENASES - FUNCTIONAL-ANALYSIS OF THE AMINO-TERMINAL HYDROPHOBIC REGION AND HINGE REGION OF THE P450/REDUCTASE FUSED ENZYME	58	31
12690	12	12028 2000 CURRENT GENETICS 37(1):65-73 Yadav JS; Loper JC Cytochrome P450 oxidoreductase gene and its differentially terminated cDNAs from the white rot fungus Phanerochaete chrysosporium	6	1
12691	9	1383 1970 LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 9(20):1189-& YAFFE SJ PRESENCE OF A MONOOXYGENASE SYSTEM IN HUMAN FETAL LIVER MICROSOMES	160	34
12692	4	1420 1971 ACTA PHARMACOLOGICA ET TOXICOLOGICA 29():240-& YAFFE SJ; RANE A DEVELOPMENTAL ASPECTS OF PHARMACOKINETICS	7	1
12693	6	10171 1996 ENDOCRINOLOGY 137(10):4331-4338 Yagci A; Muller J Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis	6	0
12694	7	10170 1996 ENDOCRINOLOGY 137(6):2406-2414 Yagci A; Oertle M; Seiler H; Schmid D; Campofranco C; Muller J Potassium induces multiple steroidogenic enzymes in cultured rat zona glomerulosa cells	7	1
12695	5	1097 1969 JOURNAL OF BIOCHEMISTRY 65(2):215-& YAGO N; ICHII S SUBMITOCHONDRIAL DISTRIBUTION OF COMPONENTS OF STEROID 11BETA- HYDROXYLASE AND CHOLESTEROL SIDECHAIN-CLEAVING ENZYME SYSTEMS IN HOG ADRENAL CORTEX	142	34
12696	4	1340 1970 JOURNAL OF BIOCHEMISTRY 68(6):775-& YAGO N; KOBAYASH.S; SEKIYAMA S; KUROKAWA H; IWAI Y; SUZUKI I; ICHII S FURTHER STUDIES ON SUBMITOCHONDRIAL LOCALIZATION OF CHOLESTEROL SIDECHAIN-CLEAVING ENZYME SYSTEM IN HOG ADRENAL CORTEX BY SONIC TREATMENT	52	17
12697	4	1940 1972 JOURNAL OF CELL BIOLOGY 52(3):503-& YAGO N; SEKI M; SEKIYAMA S; SHIRAGAI A; SATO F; IWAI Y; KOBAYASH.S; KUROKAWA H GROWTH AND DIFFERENTIATION OF MITOCHONDRIA IN REGENERATING RAT ADRENAL-CORTEX - CORRELATED BIOCHEMICAL AND STEREOLOGICAL APPROACH	26	1
12698	1	2779 1975 DOKLADY AKADEMII NAUK SSSR 221(6):1465-1468 YAGUZHINSKII LS; BOGUSLAVSKII LI; VOLKOV AG; RAKHMANINOVA AB ATP SYNTHESIS CONNECTED WITH FUNCTIONING OF MEMBRANE PROTON PUMPS AT OCTANE-WATER IN INTERFACE	14	0
12699	11	8467 1993 BIOCHEMICAL PHARMACOLOGY 45(9):1783-1789 YAMADA H; FUJISAKI H; KANEKO H; ISHII Y; HAMAGUCHI T; OGURI K PICROTOXIN AS A POTENT INDUCER OF RAT HEPATIC CYTOCHROME-P450, CYP2B1 AND CYP2B2	16	0
12700	8	6387 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 273(1):26-33 YAMADA H; HONDA S; OGURI K; YOSHIMURA H A RABBIT LIVER CONSTITUTIVE FORM OF CYTOCHROME-P450 RESPONSIBLE FOR AMPHETAMINE DEAMINATION	14	7

#	Cited nodes	Nodes / Authors	GCS	LCS
12701	13	7886 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 299(2):248-254 YAMADA H; KANEKO H; TAKEUCHI K; OGURI K; YOSHIMURA H TISSUE-SPECIFIC EXPRESSION, INDUCTION, AND INHIBITION THROUGH METABOLIC INTERMEDIATE-COMPLEX FORMATION OF GUINEA-PIG CYTOCHROME-P450 BELONGING TO THE CYP2B SUBFAMILY	12	6
12702	2	7456 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1092(2):233-243 YAMADA J; SAKUMA M; IKEDA T; FUKUDA K; SUGA T CHARACTERISTICS OF DEHYDROEPIANDROSTERONE AS A PEROXISOME PROLIFERATOR	76	26
12703	4	7348 1991 ANALYTICAL BIOCHEMISTRY 199(1):132-136 YAMADA J; SAKUMA M; SUGA T ASSAY OF FATTY-ACID OMEGA-HYDROXYLATION USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE LABELING REAGENT, 3- BROMOMETHYL-7-METHOXY-1,4-BENZOXAZIN-2-ONE (BRMB)	17	4
12704	9	7965 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1137(2):231-236 YAMADA J; SAKUMA M; SUGA T INDUCTION OF PEROXISOMAL BETA-OXIDATION ENZYMES BY DEHYDROEPIANDROSTERONE AND ITS SULFATE IN PRIMARY CULTURES OF RAT HEPATOCYTES	19	4
12705	7	11720 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(45):32279-32286 Yamada K; Ogawa H; Honda S; Harada N; Okazaki T A GCM motif protein is involved in placenta-specific expression of human aromatase gene	16	0
12706	7	2032 1973 AMERICAN JOURNAL OF PHYSIOLOGY 224(6):1420-1424 YAMADA M EFFECT OF ENVIRONMENTAL-TEMPERATURE ON ACTIVITY OF ALPHA- GLYCEROPHOSPHATE DEHYDROGENASES	8	1
12707	5	2266 1973 JOURNAL OF BIOCHEMISTRY 73(2):227-233 YAMADA M STUDIES ON L-GLYCEROL-3-PHOSPHATE DEHYDROGENASES IN JAPANESE- QUAIL, COTURNIX-COTURNIX-JAPONICA .2. COMPARISON OF ACTIVITY OF MITOCHONDRIAL AND CYTOPLASMIC L-GLYCEROL-3-PHOSPHATE DEHYDROGENASES IN TESTES AND LIVER OF DEVELOPING MALE JAPANESE- QUAIL	10	4
12708	2	2344 1973 POULTRY SCIENCE 52(4):1375-1382 YAMADA M BIOCHEMICAL STUDIES ON SHELL GLAND OF JAPANESE-QUAIL, COTURNIX- COTURNIX-JAPONICA .1. EFFECT OF A DEVELOPING EGG LOCATION ON ACTIVITY OF GLYCOLYTIC AND OTHER ENZYMES IN SHELL GLAND	9	1
12709	1	7139 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(19):11035-11043 YAMADA M; INDO K; NISHIGAMI T; NAKASHO K; MIYAJI H PROGESTERONE-BINDING SITE OF ADULT MALE-RAT LIVER-MICROSOMES	10	1
12710	7	9158 1994 HEPATOLOGY 20(5):1271-1280 YAMADA M; NISHIGAMI T; NAKASHO K; NISHIMOTO Y; MIYAJI H RELATIONSHIP BETWEEN SIGMA-LIKE SITE AND PROGESTERONE-BINDING SITE OF ADULT MALE-RAT LIVER-MICROSOMES	22	0
12711	6	2382 1974 AMERICAN JOURNAL OF PHYSIOLOGY 227(3):729-733 YAMADA M; TERADA T L-ALPHA-GLYCEROL 3-PHOSPHATE AS AN OXIDATIVE SUBSTRATE FOR COCK SPERMATOZOA	6	0
12712	6	11075 1998 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(7):1403-1411 Yamada T; Imaishi H; Oka A; Ohkawa H Molecular cloning and expression in Saccharomyces cerevisiae of tobacco NADPH-cytochrome P450 oxidoreductase cDNA	2	1
12713	10	12207 2000 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 68(1):11-25 Yamada T; Kambara Y; Imaishi H; Ohkawa H Molecular cloning of novel cytochrome P450 species induced by chemical treatments in cultured tobacco cells	4	0
12714	12	4306 1981 BIOCHIMICA ET BIOPHYSICA ACTA 649(2):343-354 YAMAKURA F; KIDO T; KIMURA T CHARACTERIZATION OF CYTOCHROME P-450SCC-CONTAINING LIPOSOMES	20	5
12715	5	12219 2000 PHYTOCHEMISTRY 53(1):7-12 Yamamoto H; Katano N; Ooi A; Inoue K Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450	11	1
12716	4	6236 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(25):12224-12227 YAMAMOTO H; NAGANO T; HIROBE M CARBON-TETRACHLORIDE TOXICITY ON ESCHERICHIA-COLI EXACERBATED BY SUPEROXIDE	16	0
12717	6	9705 1995 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 27(8):741-746 YAMAMOTO I; WATANABE K; NARIMATSU S; YOSHIMURA H RECENT ADVANCES IN THE METABOLISM OF CANNABINOIDS	10	2
12718	3	2512 1974 ENDOCRINOLOGY 95(2):606-612 YAMAMOTO K; DEGROOT LJ PEROXIDASE AND NADPH-CYTOCHROME C REDUCTASE-ACTIVITY DURING THYROID HYPERPLASIA AND INVOLUTION	30	4
12719	12	12138 2000 JOURNAL OF CLINICAL ONCOLOGY 18(11):2301-2308 Yamamoto N; Tamura T; Kamiya Y; Sekine I; Kunitoh H; Saijo N Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol	7	0
12720	3	1626 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(17):5540-& YAMAMOTO S; HIRATA F; YAMAUCHI T; NOZAKI M; HIROMI K; HAYAISHI O NEW SPECTRAL SPECIES OF L-LYSINE MONOOXYGENASE, A FLAVOPROTEIN	16	3
12721	4	5449 1985 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 233(1):176-180 YAMAMOTO S; NAKADATE T; UZUMAKI H; KATO R LIPOXYGENASE INHIBITORS AND CYCLIC AMP-MEDIATED INSULIN- SECRETION CAUSED BY FORSKOLIN, THEOPHYLLINE AND DIBUTYRYL CYCLIC-AMP	8	1
12722	4	2024 1972 ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE B 27(9):1056-& YAMAMOTO S; YAMAUCHI T; HIRATA F; HIROMI K; HYAISHI O; NOZAKI M SPECTROPHOTOMETRIC STUDIES ON LYSINE MONOOXYGENASE, A FLAVOPROTEIN	1	0
12723	1	6591 1989 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 25(10):1493-1497 YAMAMOTO T; FUKUOKA M; YASUMURA T; OKADA H INVIVO AND INVITRO EFFECTS OF THE ANTIFUNGAL AGENT MICONAZOLE ON ESTROGEN BIOSYNTHESIS IN HUMAN-BREAST CANCER	2	1
12724	13	13035 2003 DRUG METABOLISM AND DISPOSITION 31(1):60-66 Yamamoto T; Hagima N; Nakamura M; Kohno Y; Nagata K; Yamazoe Y Differences in cytochrome P450 forms involved in the metabolism of N,N-dipropyl-2-[4-methoxy-3-(2- phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a novel sigma ligand, in human liver and intestine	0	0
12725	6	9490 1995 BIOCHEMICAL PHARMACOLOGY 49(7):965-970 YAMAMOTO W; MASUDA M; KAZUSAKA A; IMAOKA S; FUNAE Y; FUJITA S PURIFICATION AND CHARACTERIZATION OF A FORM OF CYTOCHROME-P450 FROM BEAR LIVER-MICROSOMES	2	0
12726	10	11253 1998 JOURNAL OF BIOCHEMISTRY 124(3):503-508 Yamamoto Y; Ishizuka M; Takada A; Fujita S Cloning, tissue distribution, and functional expression of two novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24	4	1
12727	8	10071 1996 BIOMEDICAL RESEARCH-TOKYO 17(5):331-337 Yamamoto Y; Nakamura A; Tasaki T; Umeda S; Sugimoto C; Imaoka S; Funae Y; Masuda M; Kazusaka A; Fujita S Impaired expression in da rats of catalytically active P450BTL, immunochemically distinguishable from P4502D1: Immunological evidence with specific anti-peptide antibodies	8	5
12728	1	3183 1976 PLANT AND CELL PHYSIOLOGY 17(1):17-21 YAMAMOTO Y; NISHIMURA M CHARACTERISTICS OF LIGHT-INDUCED H+ TRANSPORT IN SPINACH CHLOROPLAST AT LOWER TEMPERATURES .2. POSSIBLE ROLE OF STRUCTURED WATER IN H+ TRANSPORT OF CHLOROPLAST NEAR 0DEGREESC	13	1
12729	13	11359 1998 PHARMACOGENETICS 8(1):73-82 Yamamoto Y; Tasaki T; Nakamura A; Iwata H; Kazusaka A; Gonzalez FJ; Fujita S Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2	20	9
12730	5	12626 2001 PLANT CELL REPORTS 20(7):655-662 Yamamura Y; Ogihara Y; Mizukami H Cinnamic acid 4-hydroxylase from Lithospermum erythrorhizon: cDNA cloning and gene expression	2	0
12731	2	221 1963 BIOCHIMICA ET BIOPHYSICA ACTA 77(4):592-& YAMANAKA T; OKUNUKI K; TOKUYAMA S CYTOCHROMES PURIFIED FROM LARVA, PUPA AND ADULT HOUSEFLY, MUSCA DOMESTICA L	28	7
12732	14	12679 2002 ANALYTICA CHIMICA ACTA 465(1-2):227-236 Yamane M High-performance liquid chromatography-thermo spray ionization- mass spectrometry of the oxidation products of polyunsaturated- fatty acids	0	0
12733	11	9826 1995 NEUROSCIENCE LETTERS 200(3):203-206 Yamane M; Abe A Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat	3	3
12734	18	10268 1996 JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS 678(2):339-343 Yamane M; Abe A High-performance liquid chromatography-thermospray mass spectrometry of 5,6-dihydroxyeicosatrienoate-1,5-lactone from tissue homogenates	3	2
12735	11	9217 1994 JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS 662(1):91-96 YAMANE M; ABE A; NAKAJIMA M HIGH-PERFORMANCE LIQUID CHROMATOGRAPY THERMOSPRAY MASS- SPECTROMETRY OF OMEGA-HYDROXY POLYUNSATURATED FATTY-ACIDS FROM RAT-BRAIN HOMOGENATE	14	9
12736	12	10265 1996 JOURNAL OF CHROMATOGRAPHY A 730(1-2):91-98 Yamane M; Abe A; Shimizu S; Nakajima M Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma	3	2
12737	14	9215 1994 JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS 652(2):123-136 YAMANE M; ABE A; YAMANE S HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS- SPECTROMETRY OF EPOXY POLYUNSATURATED FATTY-ACIDS AND EPOXYHYDROXY POLYUNSATURATED FATTY-ACIDS FROM AN INCUBATION MIXTURE OF RAT-TISSUE HOMOGENATE	11	8
12738	13	11092 1998 CANCER LETTERS 122(1-2):51-59 Yamane M; Shimizu S; Abe A; Yamane S Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2	2	1
12739	7	6715 1989 MOLECULAR PHARMACOLOGY 36(1):83-88 YAMANO S; AOYAMA T; MCBRIDE OW; HARDWICK JP; GELBOIN HV; GONZALEZ FJ HUMAN NADPH-P450 OXIDOREDUCTASE - COMPLEMENTARY-DNA CLONING, SEQUENCE AND VACCINIA VIRUS-MEDIATED EXPRESSION AND LOCALIZATION OF THE CYPOR GENE TO CHROMOSOME-7	23	9
12740	1	6732 1989 NUCLEIC ACIDS RESEARCH 17(12):4888-4888 YAMANO S; NAGATA K; YAMAZOE Y; KATO R; GELBOIN HV; GONZALEZ FJ CDNA AND DEDUCED AMINO-ACID SEQUENCES OF HUMAN P450 IIA3 (CYP2A3)	24	13
12741	5	6466 1989 BIOCHEMISTRY 28(18):7340-7348 YAMANO S; NHAMBURO PT; AOYAMA T; MEYER UA; INABA T; KALOW W; GELBOIN HV; MCBRIDE OW; GONZALEZ FJ CDNA CLONING AND SEQUENCE AND CDNA-DIRECTED EXPRESSION OF HUMAN P450-IIB1 - IDENTIFICATION OF A NORMAL AND 2 VARIANT CDNAS DERIVED FROM THE CYP2B LOCUS ON CHROMOSOME-19 AND DIFFERENTIAL EXPRESSION OF THE IIB MESSENGER-RNAS IN HUMAN-LIVER	123	67
12742	12	6911 1990 BIOCHEMISTRY 29(5):1322-1329 YAMANO S; TATSUNO J; GONZALEZ FJ THE CYP2A3-GENE PRODUCT CATALYZES COUMARIN 7-HYDROXYLATION IN HUMAN LIVER-MICROSOMES	271	121
12743	4	1641 1971 JOURNAL OF FERMENTATION TECHNOLOGY 49(2):103-& YAMASHIR.K; MIHARA A; TANI Y; FUKUI S STUDIES ON METABOLISM OF SACCHAROMYCES SAKE .5. RECOVERY OF RESPIRATION OF CELLS GROWN WITH ALPHA-PHENETHYL ALCOHOL	0	0
12744	0	1364 1970 JOURNAL OF FERMENTATION TECHNOLOGY 48(7):381-& YAMASHIR.K; NISHIHAR.H; TANI Y; FUKUI S STUDIES ON METABOLISM OF SACCHAROMYCES-SAKE .2. EFFECT OF ETHANOL AND PHENETHYL ALCOHOL ON RESPIRATION AND FERMENTATION OF SACCHAROMYCES-SAKE	3	0
12745	10	8261 1992 MARINE POLLUTION BULLETIN 24(6):316-321 YAMASHITA N; SHIMADA T; TANABE S; YAMAZAKI H; TATSUKAWA R CYTOCHROME-P-450 FORMS AND ITS INDUCIBILITY BY PCB ISOMERS IN BLACK-HEADED GULLS AND BLACK-TAILED GULLS	16	1
12746	2	4309 1981 BIOCHIMICA ET BIOPHYSICA ACTA 666(3):442-445 YAMASHOJI S; KAJIMOTO G ANTIOXIDANT EFFECT OF CUPRIC COMPLEX ON NADPH-DEPENDENT LIPID- PEROXIDATION IN RAT-LIVER MICROSOMES	1	0
12747	2	2635 1974 XENOBIOTICA 4(12):765-777 YAMATO C; TAKAHASHI T; FUJITA T; KURIYAMA S; HIROSE N STUDIES ON METABOLISM OF TRAZODONE .2. METABOLIC-FATE AFTER INTRAVENOUS ADMINISTRATION AND EFFECTS ON LIVER MICROSOMAL DRUG-METABOLIZING-ENZYMES IN RATS	13	0
12748	31	12282 2000 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 120(12):1347-1357 Yamazaki H Roles of human cytochrome P450 enzymes involved in drug metabolism and toxicological studies	0	0
12749	11	7486 1991 CARCINOGENESIS 12(1):133-139 YAMAZAKI H; DEGAWA M; FUNAE Y; IMAOKA S; INUI Y; GUENGERICH FP; SHIMADA T ROLES OF DIFFERENT CYTOCHROME-P450 ENZYMES IN BIOACTIVATION OF THE POTENT HEPATOCARCINOGEN 3-METHOXY-4-AMINOAZOBENZENE BY RAT AND HUMAN LIVER-MICROSOMES	25	11
12750	29	10502 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 342(2):329-337 Yamazaki H; Gillam EMJ; Dong MS; Johnson WW; Guengerich FP; Shimada T Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: Effects of cytochrome P450-P450 and cytochrome P450-b(5) interactions	44	27
12751	15	12194 2000 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 472(1-2):129-138 Yamazaki H; Hatanaka N; Kizu R; Hayakawa K; Shimada N; Guengerich FP; Nakajima M; Yokoi T Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1- nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1	9	4
12752	16	10794 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283(2):434-442 Yamazaki H; Inoue K; Shaw PM; Checovich WJ; Guengerich FP; Shimada T Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: Effects of contents of these two forms in individual human samples	44	10
12753	18	11423 1998 XENOBIOTICA 28(2):103-115 Yamazaki H; Inoue K; Shimada T Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes	22	9
12754	18	10649 1997 DRUG METABOLISM AND DISPOSITION 25(2):168-174 Yamazaki H; Inoue K; Turvy CG; Guengerich FP; Shimada T Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome p450 enzymes	29	12
12755	18	9565 1995 CARCINOGENESIS 16(9):2167-2170 YAMAZAKI H; INUI Y; WRIGHTON SA; GUENGERICH FP; SHIMADA T PROCARCINOGEN ACTIVATION BY CYTOCHROME-P450 3A4 AND 3A5 EXPRESSED IN ESCHERICHIA-COLI AND BY HUMAN LIVER-MICROSOMES	22	16
12756	12	8005 1992 CARCINOGENESIS 13(10):1789-1794 YAMAZAKI H; INUI Y; YUN CH; GUENGERICH FP; SHIMADA T CYTOCHROME P450 2E1 AND 2A6 ENZYMES AS MAJOR CATALYSTS FOR METABOLIC-ACTIVATION OF N-NITROSODIALKYLAMINES AND TOBACCO- RELATED NITROSAMINES IN HUMAN LIVER-MICROSOMES	207	60
12757	36	10253 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(44):27438-27444 Yamazaki H; Johnson WW; Ueng YF; Shimada T; Guengerich FP Lack of electron transfer from cytochrome b(5) in stimulation of catalytic activities of cytochrome P450 3A4 - Characterization of a reconstituted cytochrome P450 3A4 NADPH- cytochrome P450 reductase system and studies with apo- cytochrome b(5)	63	43
12758	2	4588 1982 CHEMOSPHERE 11(3):349-353 YAMAZAKI H; KAGITA T; FUJIWARA M; KISHI T; KAKIUCHI Y; WATABE K; KONDO M METABOLISM OF 3-HYDROXYBENZO(A)PYRENE IN RAT, ISOLATED HEPATOCYTES AND KIDNEY	1	0
12759	8	9038 1994 CARCINOGENESIS 15(3):465-470 YAMAZAKI H; MIMURA M; ODA Y; GONZALEZ FJ; ELBAYOUMY K; CHAE YH; GUENGERICH FP; SHIMADA T ACTIVATION OF TRANS-1,2-DIHYDRO-1,2-DIHYDROXY-6-AMINOCHRYSENE TO GENOTOXIC METABOLITES BY RAT AND HUMAN CYTOCHROMES P450	11	9
12760	12	8978 1994 BIOCHEMICAL PHARMACOLOGY 48(7):1524-1527 YAMAZAKI H; MIMURA M; SUGAHARA C; SHIMADA T CATALYTIC ROLES OF RAT AND HUMAN CYTOCHROME-P450-2A ENZYMES IN TESTOSTERONE 7-ALPHA-HYDROXYLATION AND COUMARIN 7-HYDROXYLATION	26	18
12761	21	11612 1999 DRUG METABOLISM AND DISPOSITION 27(9):999-1004 Yamazaki H; Nakajima M; Nakamura M; Asahi S; Shimada N; Gillam EMJ; Guengerich FP; Shimada T; Yokoi T Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes	19	11
12762	23	12939 2002 PROTEIN EXPRESSION AND PURIFICATION 24(3):329-337 Yamazaki H; Nakamura M; Komatsu T; Ohyama K; Hatanaka N; Asahi S; Shimada N; Guengerich FP; Shimada T; Nakajima M; Yokoi T Roles of NADPH-P450 reductase and apo- and holo-cytochrome b(5) on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli	7	4
12763	20	10025 1996 BIOCHEMICAL PHARMACOLOGY 52(2):301-309 Yamazaki H; Nakano M; Gillam EMJ; Bell LC; Guengerich FP; Shimada T Requirements for cytochrome b(5) in the oxidation of 7- ethoxycoumarin, chlorzoxazone, aniline, and N- nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes	28	14
12764	31	9941 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 325(2):174-182 Yamazaki H; Nakano M; Imai Y; Ueng YF; Guengerich FP; Shimada T Roles of cytochrome b(5) in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes	79	45
12765	3	7096 1990 INTERNATIONAL JOURNAL OF BIOCHEMISTRY 22(1):39-41 YAMAZAKI H; NISHIGUCHI K; SERASINGHE P; NAKANISHI S DIFFERENTIAL LOCALIZATION OF MICROSOMAL MIXED-FUNCTION OXIDASE ACTIVITY IN PERIPORTAL AND PERIVENOUS HEPATOCYTES ISOLATED FROM RAT-LIVER	3	1
12766	10	8001 1992 CARCINOGENESIS 13(6):979-985 YAMAZAKI H; ODA Y; FUNAE Y; IMAOKA S; INUI Y; GUENGERICH FP; SHIMADA T PARTICIPATION OF RAT-LIVER CYTOCHROME P450-2E1 IN THE ACTIVATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE TO PRODUCTS GENOTOXIC IN AN ACETYLTRANSFERASE-OVEREXPRESSING SALMONELLA-TYPHIMURIUM STRAIN (NM2009)	53	15
12767	22	11109 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(6):659-665 Yamazaki H; Shaw PM; Guengerich FP; Shimada T Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes	36	12
12768	16	7925 1992 BIOCHEMICAL PHARMACOLOGY 44(5):913-920 YAMAZAKI H; SHIMADA T ACTIVATION OF 6-AMINOCHRYSENE TO GENOTOXIC PRODUCTS BY DIFFERENT FORMS OF RAT-LIVER CYTOCHROME-P450 IN AN O- ACETYLTRANSFERASE-OVEREXPRESSING SALMONELLA-TYPHIMURIUM STRAIN (NM2009)	9	2
12769	28	10511 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 346(1):161-169 Yamazaki H; Shimada T Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes	48	21
12770	24	10558 1997 BIOCHEMICAL PHARMACOLOGY 54(11):1195-1203 Yamazaki H; Shimada T Human liver cytochrome P450 enzymes involved in the 7- hydroxylation of R- and S-warfarin enantiomers	25	4
12771	7	11439 1998 XENOBIOTICA 28(10):995-1004 Yamazaki H; Shimada T Formation in vitro of an inhibitory cytochrome P450 center dot Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes	3	0
12772	25	11875 1999 XENOBIOTICA 29(3):231-241 Yamazaki H; Shimada T Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes	15	5
12773	40	12523 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(33):30885-30891 Yamazaki H; Shimada T; Martin MV; Guengerich FP Stimulation of cytochrome P450 reactions by apo-cytochrome b(5) - Evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5, or heme oxygenase	9	6
12774	7	12267 2000 XENOBIOTICA 30(1):61-70 Yamazaki H; Suzuki M; Tane K; Shimada N; Nakajima M; Yokoi T In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone	25	3
12775	7	11727 1999 JOURNAL OF CHROMATOGRAPHY B 721(1):13-19 Yamazaki H; Tanaka M; Shimada T Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O- deethylation by human liver cytochrome P450 enzymes	18	7
12776	24	9511 1995 BIOCHEMISTRY 34(26):8380-8389 YAMAZAKI H; UENG YF; SHIMADA T; GUENGERICH FP ROLES OF DIVALENT METAL-IONS IN OXIDATIONS CATALYZED BY RECOMBINANT CYTOCHROME-P450 3A4 AND REPLACEMENT OF NADPH- CYTOCHROME P450 REDUCTASE WITH OTHER FLAVOPROTEINS, FERREDOXIN, AND OXYGEN SURROGATES	69	52
12777	2	7122 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(2):652-659 YAMAZAKI I; PIETTE LH; GROVER TA KINETIC-STUDIES ON SPIN TRAPPING OF SUPEROXIDE AND HYDROXYL RADICALS GENERATED IN NADPH-CYTOCHROME-P-450 REDUCTASE-PARAQUAT SYSTEMS - EFFECT OF IRON CHELATES	51	3
12778	18	5387 1985 ENVIRONMENTAL HEALTH PERSPECTIVES 64():331-342 YAMAZAKI I; TAMURA M; NAKAJIMA R; NAKAMURA M PHYSIOLOGICAL-ASPECTS OF FREE-RADICAL REACTIONS	9	0
12779	3	370 1965 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 21(6):582-& YAMAZAKI I; YOKOTA K; NAKAJIMA R OSCILLATORY OXIDATIONS OF REDUCED PYRIDINE NUCLEOTIDE BY PEROXIDASE	96	8
12780	5	7100 1990 INTERNATIONAL JOURNAL OF BIOCHEMISTRY 22(10):1147-1152 YAMAZAKI M; ICHIKAWA Y SOME PROPERTIES OF THE APOENZYME OF NADPH-ADRENO-FERREDOXIN REDUCTASE FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	1	0
12781	6	8672 1993 JOURNAL OF BIOCHEMISTRY 114(5):652-657 YAMAZAKI S; SATO K; SUHARA K; SAKAGUCHI M; MIHARA K; OMURA T IMPORTANCE OF THE PROLINE-RICH REGION FOLLOWING SIGNAL-ANCHOR SEQUENCE IN THE FORMATION OF CORRECT CONFORMATION OF MICROSOMAL CYTOCHROME P-450S	70	40
12782	7	8354 1992 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 112(10):679-692 YAMAZOE Y ENZYMES INVOLVED IN METABOLIC-ACTIVATION OF CARCINOGENIC CHEMICALS AND THEIR HORMONAL-REGULATION	0	0
12783	3	6082 1988 BIOCHEMICAL PHARMACOLOGY 37(13):2503-2506 YAMAZOE Y; ABUZEID M; YAMAUCHI K; MURAYAMA N; SHIMADA M; KATO R ENHANCEMENT BY ALLOXAN-INDUCED DIABETES OF THE RATE OF METABOLIC-ACTIVATION OF 3 PYROLYSATE CARCINOGENS VIA INCREASE IN THE P-448-H CONTENT IN RAT-LIVER	17	2
12784	12	7119 1990 JOURNAL OF BIOCHEMISTRY 108(4):599-603 YAMAZOE Y; LING X; MURAYAMA N; GONG DW; NAGATA K; KATO R MODULATION OF HEPATIC LEVEL OF MICROSOMAL TESTOSTERONE 7-ALPHA- HYDROXYLASE, P-450A (P450IIA), BY THYROID-HORMONE AND GROWTH- HORMONE IN RAT-LIVER	28	10
12785	11	6368 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 268(2):567-575 YAMAZOE Y; MURAYAMA N; SHIMADA M; YAMAUCHI K; KATO R CYTOCHROME-P450 IN LIVERS OF DIABETIC RATS - REGULATION BY GROWTH-HORMONE AND INSULIN	67	19
12786	9	5691 1986 JOURNAL OF BIOLOGICAL CHEMISTRY 261(18):8429-8433 YANAGIBASHI K; HALL PF ROLE OF ELECTRON-TRANSPORT IN THE REGULATION OF THE LYASE ACTIVITY OF C-21 SIDE-CHAIN CLEAVAGE P-450 FROM PORCINE ADRENAL AND TESTICULAR MICROSOMES	74	28
12787	11	7962 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1130(3):329-332 YANAGIMOTO T; ITOH S; MULLERENOCH D; KAMATAKI T MOUSE-LIVER CYTOCHROME-P-450 (P-450IIIAM1) - ITS CDNA CLONING AND INDUCIBILITY BY DEXAMETHASONE	44	19
12788	20	9010 1994 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1201(3):405-410 YANAGIMOTO T; ITOH S; SAWADA M; HASHIMOTO H; KAMATAKI T MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A MOUSE CYTOCHROME-P-450 (CYP3A-13) - EXAMINATION OF CYP3A-13 ENZYME TO ACTIVATE AFLATOXIN B-1 (AFB(1))	29	14
12789	18	10496 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 340(2):215-218 Yanagimoto T; Itoh S; Sawada M; Kamataki T Mouse cytochrome P450 (Cyp3a11): Predominant expression in liver and capacity to activate aflatoxin B-1	24	11
12790	14	10513 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 346(2):269-276 Yanagita K; Sagami I; Shimizu T Distal site and surface mutations of cytochrome P450 1A2 markedly enhance dehalogenation of chlorinated hydrocarbons	10	2
12791	4	6274 1988 MOLECULAR AND CELLULAR ENDOCRINOLOGY 59(3):249-253 YANASE T; KAGIMOTO M; MATSUI N; SIMPSON ER; WATERMAN MR COMBINED 17-ALPHA-HYDROXYLASE/17,20-LYASE DEFICIENCY DUE TO A STOP CODON IN THE N-TERMINAL REGION OF 17-ALPHA-HYDROXYLASE CYTOCHROME-P-450	39	13
12792	8	6649 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(30):18076-18082 YANASE T; KAGIMOTO M; SUZUKI S; HASHIBA K; SIMPSON ER; WATERMAN MR DELETION OF A PHENYLALANINE IN THE N-TERMINAL REGION OF HUMAN CYTOCHROME-P-45017-ALPHA RESULTS IN PARTIAL COMBINED 17-ALPHA- HYDROXYLASE/17,20-LYASE DEFICIENCY	62	21
12793	9	7161 1990 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 70(5):1325-1329 YANASE T; SANDERS D; SHIBATA A; MATSUI N; SIMPSON ER; WATERMAN MR COMBINED 17-ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY DUE TO A 7-BASEPAIR DUPLICATION IN THE N-TERMINAL REGION OF THE CYTOCHROME-P45017-ALPHA (CYP17) GENE	40	14
12794	23	7542 1991 ENDOCRINE REVIEWS 12(1):91-108 YANASE T; SIMPSON ER; WATERMAN MR 17-ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY - FROM CLINICAL INVESTIGATION TO MOLECULAR DEFINITION	128	34
12795	13	7966 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1139(4):275-279 YANASE T; WATERMAN MR; ZACHMANN M; WINTER JSD; SIMPSON ER; KAGIMOTO M MOLECULAR-BASIS OF APPARENT ISOLATED 17,20-LYASE DEFICIENCY - COMPOUND HETEROZYGOUS MUTATIONS IN THE C-TERMINAL REGION (ARG(496)-]CYS, GLN(461)-]STOP) ACTUALLY CAUSE COMBINED 17- ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY	39	12
12796	9	11608 1999 DRUG METABOLISM AND DISPOSITION 27(5):600-604 Yanev S; Kent UM; Pandova B; Hollenberg PF Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates	13	3
12797	11	12581 2001 MOLECULAR PHARMACOLOGY 60(2):310-320 Yang BC; Graham L; Dikalov S; Mason RP; Falck JR; Liao JK; Zeldin DC Overexpression of cytochrome P450CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells	10	2
12798	12	2394 1974 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 160(2):623-630 YANG CS ALTERATIONS OF ARYL-HYDROCARBON HYDROXYLASE SYSTEM DURING RIBOFLAVIN DEPLETION AND REPLETION	28	8
12799	3	2811 1975 FEBS LETTERS 54(1):61-64 YANG CS ASSOCIATION BETWEEN CYTOCHROME-P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN MICROSOMAL MEMBRANE	59	46
12800	12	3391 1977 JOURNAL OF BIOLOGICAL CHEMISTRY 252(1):293-298 YANG CS INTERACTIONS BETWEEN SOLUBILIZED CYTOCHROME-P-450 AND HEPATIC MICROSOMES - CHARACTERIZATIONS OF BINDING AND ENHANCED CATALYTIC ACTIVITIES	42	19

#	Cited nodes	Nodes / Authors	GCS	LCS
12801	28	3431 1977 LIFE SCIENCES 21(8):1047-1057 YANG CS ORGANIZATION AND INTERACTION OF MONOXYGENASE ENZYMES IN MICROSOMAL MEMBRANE	55	26
12802	8	9032 1994 CANCER RESEARCH 54(7):S1982-S1986 YANG CS; SMITH TJ; HONG JY CYTOCHROME-P-450 ENZYMES AS TARGETS FOR CHEMOPREVENTION AGAINST CHEMICAL CARCINOGENESIS AND TOXICITY - OPPORTUNITIES AND LIMITATIONS	100	7
12803	13	2445 1974 BIOCHEMICAL PHARMACOLOGY 23(22):3129-3138 YANG CS; STRICKHA.FS INHIBITION OF HEPATIC MIXED-FUNCTION OXIDASE ACTIVITY BY PROPYL GALLATE	61	15
12804	9	2856 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(20):7968-7972 YANG CS; STRICKHART FS INTERACTIONS BETWEEN SOLUBILIZED CYTOCHROME-P-450 AND HEPATIC MICROSOMES	33	19
12805	9	3533 1978 BIOCHEMICAL PHARMACOLOGY 27(19):2376-2378 YANG CS; STRICKHART FS DIFFERENCES BETWEEN HYDROPEROXIDE-DEPENDENT AND NADPH-DEPENDENT MICROSOMAL ARYL-HYDROCARBON HYDROXYLASE-ACTIVITIES	8	7
12806	18	3297 1977 BIOCHIMICA ET BIOPHYSICA ACTA 465(2):362-370 YANG CS; STRICKHART FS; KICHA LP EFFECT OF TEMPERATURE ON MONOXYGENASE REACTIONS IN MICROSOMAL MEMBRANE	76	43
12807	9	3532 1978 BIOCHEMICAL PHARMACOLOGY 27(19):2321-2326 YANG CS; STRICKHART FS; KICHA LP ANALYSIS OF ARYL-HYDROCARBON HYDROXYLASE ASSAY	50	7
12808	28	6296 1988 PHARMACOLOGY & THERAPEUTICS 38(1):53-72 YANG CS; YOO JSH DIETARY-EFFECTS ON DRUG-METABOLISM BY THE MIXED-FUNCTION OXIDASE SYSTEM	53	15
12809	12	7037 1990 DRUG METABOLISM REVIEWS 22(2-3):147-159 YANG CS; YOO JSH; ISHIZAKI H; HONG JY CYTOCHROME-P450IIE1 - ROLES IN NITROSAMINE METABOLISM AND MECHANISMS OF REGULATION	256	68
12810	2	6284 1988 MOLECULAR PHARMACOLOGY 34(1):67-73 YANG HYL; NAMKUNG MJ; JUCHAU MR CYTOCHROME-P-450-DEPENDENT BIOTRANSFORMATION OF A SERIES OF PHENOXAZONE ETHERS IN THE RAT CONCEPTUS DURING EARLY ORGANOGENESIS - EVIDENCE FOR MULTIPLE P-450 ISOENZYMES	56	19
12811	5	6447 1989 BIOCHEMICAL PHARMACOLOGY 38(22):4027-4036 YANG HYL; NAMKUNG MJ; JUCHAU MR IMMUNODETECTION, IMMUNOINHIBITION, IMMUNOQUANTITATION AND BIOCHEMICAL ANALYSES OF CYTOCHROME-P-450IA1 IN TISSUES OF THE RAT CONCEPTUS DURING THE PROGRESSION OF ORGANOGENESIS	24	11
12812	3	12416 2001 CHINESE JOURNAL OF PHYSIOLOGY 44(3):111-119 Yang JG; Yu CC; Li PS Dexamethasone enhances follicle stimulating hormone-induced p450scc mRNA expression and progesterone production in pig granulosa cells	0	0
12813	8	9593 1995 CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY 18(2):111-127 YANG JH; RHIM JS 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN - MOLECULAR MECHANISM OF CARCINOGENESIS AND ITS IMPLICATION IN HUMAN IN-VITRO MODEL	3	0
12814	16	13118 2003 WORLD JOURNAL OF GASTROENTEROLOGY 9(2):359-363 Yang LQ; Li SJ; Cao YF; Man XB; Yu WF; Wang HY; Wu MC Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases	0	0
12815	14	8930 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 315(2):438-444 YANG MX; CEDERBAUM AI FRACTIONATION OF LIVER-MICROSOMES WITH POLYETHYLENE-GLYCOL AND PURIFICATION OF NADH-CYTOCHROME B(5) OXIDOREDUCTASE AND CYTOCHROME B(5)	14	7
12816	13	9464 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 324(2):282-292 Yang MX; Cederbaum AI Role of cytochrome b(5) in NADH-dependent microsomal reduction of ferric complexes, lipid peroxidation, and hydrogen peroxide generation	11	2
12817	14	9968 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 331(1):69-78 Yang MX; Cederbaum AI Interaction of ferric complexes with NADH-Cytochrome b5 reductase and cytochrome b5: Lipid peroxidation, H2O2 generation, and ferric reduction	9	1
12818	1	11680 1999 GENETIC EPIDEMIOLOGY 17(4):253-273 Yang P; Schwartz AG; McAllister AE; Swanson GM; Aston CE Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis	7	0
12819	8	13083 2003 JOURNAL OF PHYCOLOGY 39(3):555-560 Yang S; Wu RSS; Mok HOL; Zhang ZP; Kong RYC Identification of a novel cytochrome P450 cDNA, CYP97E1, from the marine diatom Skeletonema costatum Bacillariophyceae	0	0
12820	6	9948 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 327(1):61-70 Yang SX; Pollock HG; Rawitch AB Glycosylation in human thyroglobulin: Location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin	7	0
12821	9	11602 1999 DRUG METABOLISM AND DISPOSITION 27(1):102-109 Yang TJ; Krausz KW; Sai Y; Gonzalez FJ; Gelboin HV Eight inhibitory monoclonal antibodies define the role of individual P-450S in human liver microsomal diazepam, 7- ethoxycoumarin, and imipramine metabolism	18	9
12822	8	11363 1998 PHARMACOGENETICS 8(5):375-382 Yang TJ; Sai Y; Krausz KW; Gonzalez FJ; Gelboin HV Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver	11	2
12823	2	8338 1992 TOXICOLOGY LETTERS 60(3):307-314 YANG W; JIANG TR; ACOSTA D; DAVIS PJ PRODUCTION OF A TOXIC, NOVEL MAMMALIAN METABOLITE OF N- METHYLCARBAZOLE PREDICTED BY A FUNGAL CELL MODEL OF MAMMALIAN METABOLISM	4	0
12824	8	8603 1993 ENDOCRINOLOGY 132(5):1977-1982 YANG XM; IWAMOTO K; WANG M; ARTWOHL J; MASON JI; PANG SY INHERITED CONGENITAL ADRENAL-HYPERPLASIA IN THE RABBIT IS CAUSED BY A DELETION IN THE GENE ENCODING CYTOCHROME-P450 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME	29	4
12825	12	10973 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 352(2):271-280 Yang YH; Wang JL; Miranda CL; Buhler DR CYP2M1: Cloning, sequencing, and expression of a new cytochrome P450 from rainbow trout liver with fatty acid (omega-6)- hydroxylation activity	9	4
12826	9	11679 1999 GENERAL PHARMACOLOGY 33(4):325-336 Yang ZW; Zhang AM; Altura BT; Altura BM Hydrogen peroxide-induced endothelium-dependent relaxation of rat aorta - Involvement of Ca2+ and other cellular metabolites	14	0
12827	7	8264 1992 MOLECULAR AND CELLULAR BIOLOGY 12(6):2847-2854 YANO M; FALVEY E; GONZALEZ FJ ROLE OF THE LIVER-ENRICHED TRANSCRIPTION FACTOR DBP IN EXPRESSION OF THE CYTOCHROME P450 CYP2C6 GENE	39	12
12828	4	6511 1989 CANCER RESEARCH 49(19):5352-5357 YANO M; HIGASHI T; KANO S; TATEISHI N; KIDO Y; MORI T; HIGASHI K; SAKAMOTO Y DECREASED ACTIVATION OF CARCINOGENS IN THE LIVER OF CARCINOGEN- RESISTANT RATS	12	1
12829	13	12161 2000 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 294(1):387-395 Yao DG; Ding SH; Burchell B; Wolf CR; Friedberg T Detoxication of vinca alkaloids by human P450CYP3A4-mediated metabolism: Implications for the development of drug resistance	7	3
12830	10	7937 1992 BIOCHEMISTRY 31(21):5060-5067 YAO EF; DENISON MS DNA-SEQUENCE DETERMINANTS FOR BINDING OF TRANSFORMED AH- RECEPTOR TO A DIOXIN-RESPONSIVE ENHANCER	70	8
12831	1	12383 2001 BIOMEDICAL CHROMATOGRAPHY 15(2):141-144 Yao TW; Zeng S Stereoselective determination of p-hydroxyphenylphenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives	3	0
12832	11	9646 1995 ENVIRONMENTAL HEALTH PERSPECTIVES 103(4):366-371 YAO Y; HOFFER A; CHANG CY; PUGA A DIOXIN ACTIVATES HIV-1 GENE-EXPRESSION BY AN OXIDATIVE STRESS PATHWAY REQUIRING A FUNCTIONAL CYTOCHROME-P450 CYP1A1 ENZYME	12	2
12833	8	3998 1980 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 202(2):491-498 YASUKOCHI Y; OKITA RT; MASTERS BSS COMPARISON OF THE PROPERTIES OF DETERGENT-SOLUBILIZED NADPH- CYTOCHROME P-450 REDUCTASES FROM PIG-LIVER AND KIDNEY IMMUNOCHEMICAL, KINETIC, AND RECONSTITUTIVE PROPERTIES	21	9
12834	4	2234 1973 EXPERIMENTAL CELL RESEARCH 80(2):361-371 YASUMASU I; ASAMI K; SHOGER RL; FUJIWARA A GLYCOLYSIS OF SEA-URCHIN EGGS - RATE-LIMITING STEPS AND ACTIVATION AT FERTILIZATION	43	1
12835	8	8727 1993 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 264(1):89-94 YASUMORI T; CHEN L; NAGATA K; YAMAZOE Y; KATO R SPECIES-DIFFERENCES IN STEREOSELECTIVE METABOLISM OF MEPHENYTOIN BY CYTOCHROME P450 (CYP2C AND CYP3A)	26	11
12836	11	9331 1994 PHARMACOGENETICS 4(6):323-331 YASUMORI T; LI QH; YAMAZOE Y; UEDA M; TSUZUKI T; KATO R LACK OF LOW K-M DIAZEPAM N-DEMETHYLASE IN LIVERS OF POOR METABOLIZERS FOR S-MEPHENYTOIN 4'-HYDROXYLATION	21	7
12837	5	6708 1989 MOLECULAR PHARMACOLOGY 35(4):443-449 YASUMORI T; MURAYAMA N; YAMAZOE Y; ABE A; NOGI Y; FUKASAWA T; KATO R EXPRESSION OF A HUMAN P-450IIC GENE IN YEAST-CELLS USING GALACTOSE-INDUCIBLE EXPRESSION SYSTEM	58	35
12838	15	8805 1993 PHARMACOGENETICS 3(6):291-301 YASUMORI T; NAGATA K; YANG SK; CHEN LS; MURAYAMA N; YAMAZOE Y; KATO R CYTOCHROME-P450 MEDIATED METABOLISM OF DIAZEPAM IN HUMAN AND RAT - INVOLVEMENT OF HUMAN CYP2C IN N-DEMETHYLATION IN THE SUBSTRATE CONCENTRATION-DEPENDENT MANNER	69	27
12839	13	7607 1991 JOURNAL OF BIOCHEMISTRY 109(5):711-717 YASUMORI T; YAMAZOE Y; KATO R CYTOCHROME-P-450 HUMAN-2 (P-450IIC9) IN MEPHENYTOIN HYDROXYLATION POLYMORPHISM IN HUMAN LIVERS - DIFFERENCES IN SUBSTRATE AND STEREOSELECTIVITIES AMONG MICROHETEROGENEOUS P- 450IIC SPECIES EXPRESSED IN YEASTS	33	17
12840	5	3575 1978 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 59(1):45-49 YAWETZ A; AGOSIN M; PERRY AS SPECTRAL AND CATALYTIC PROPERTIES OF CYTOCHROME-P-450 FROM FOUR WILD BIRD SPECIES	10	0
12841	18	11066 1998 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1381(1):12-26 Yawetz A; Woodin BR; Stegeman JJ Cytochromes P450 in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins	5	1
12842	20	11201 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 6(1):13-25 Yawetz A; Zilberman B; Woodin B; Stegeman JJ Cytochromes P-4501A, P-4503A and P-4502B in liver and heart of Mugil capito treated with CYP1A inducers	0	0
12843	6	10539 1997 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 239(3):660-665 Ye XQ; Lu LM; Gill SS Suppression of cytochrome P450 Cyp2f2 mRNA levels in mice by the peroxisome proliferator diethylhexylphthalate	7	1
12844	2	6861 1990 BIOCHEMICAL JOURNAL 265(1):95-100 YEA CM; CROSS AR; JONES OTG PURIFICATION AND SOME PROPERTIES OF THE 45 KDA DIPHENYLENE IODONIUM-BINDING FLAVOPROTEIN OF NEUTROPHIL NADPH OXIDASE	54	2
12845	6	7312 1990 TRANSPLANTATION PROCEEDINGS 22(3):1203-1207 YEE GC PHARMACOKINETIC INTERACTIONS BETWEEN CYCLOSPORINE AND OTHER DRUGS	21	2
12846	5	7313 1990 TRANSPLANTATION PROCEEDINGS 22(3):1327-1330 YEE GC PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF CYCLOSPORINE IN BONE-MARROW TRANSPLANTATION	11	0
12847	9	6999 1990 CLINICAL PHARMACOKINETICS 19(5):400-415 YEE GC; MCGUIRE TR PHARMACOKINETIC DRUG-INTERACTIONS WITH CYCLOSPORINE .2.	79	8
12848	13	12126 2000 JOURNAL OF BIOMEDICAL SCIENCE 7(2):144-151 Yeh JR; Hsu LC; Chung BC Sp1-like proteins function in the transcription of human ferredoxin genes	1	0
12849	7	10300 1996 JOURNAL OF ORGANIC CHEMISTRY 61(3):838-841 Yeola SN; Saleh SA; Brash AR; Prakash C; Taber DF; Blair IA Synthesis of 10(S)-hydroxyeicosatetraenoic acid: A novel cytochrome P-450 metabolite of arachidonic acid	7	1
12850	15	9517 1995 BIOCHEMISTRY 34(45):14733-14740 YEOM H; SLIGAR SG; LI HY; POULOS TL; FULCO AJ THE ROLE OF THR268 IN OXYGEN ACTIVATION OF CYTOCHROME P450(BM- 3)	44	18
12851	7	5285 1985 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 243(2):408-419 YEOWELL HN; LINKO P; HODGSON E; GOLDSTEIN JA INDUCTION OF SPECIFIC CYTOCHROME-P-450 ISOZYMES BY METHYLENEDIOXYPHENYL COMPOUNDS AND ANTAGONISM BY 3- METHYLCHOLANTHRENE	30	19
12852	8	6907 1990 BIOCHEMISTRY 29(3):713-718 YEOWELL HN; MCCLELLANGREEN PD; NEGISHI M; GOLDSTEIN JA CHARACTERIZATION OF A CDNA FOR THE UNEXPRESSED FORM OF CYTOCHROME P-450G FROM THE (-G) RAT AND DIFFERENTIATION OF ITS MESSENGER-RNA FROM THAT OF THE (+G) PHENOTYPE USING SPECIFIC OLIGOPROBES	7	4
12853	4	6281 1988 MOLECULAR PHARMACOLOGY 33(3):272-278 YEOWELL HN; WAXMAN DJ; LEBLANC GA; LINKO P; GOLDSTEIN JA INDUCTION OF RAT CYTOCHROME-P-450-3 AND ITS MESSENGER-RNA BY 3,4,5,3',4',5'-HEXACHLOROBIPHENYL	13	7
12854	2	11771 1999 LANGMUIR 15(20):6829-6836 Yeung C; Purves T; Kloss AA; Kuhl TL; Sligar S; Leckband D Cytochrome c recognition of immobilized, orientational variants of cytochrome b(5): Direct force and equilibrium binding measurements	12	1
12855	2	6187 1988 DRUG METABOLISM AND DISPOSITION 16(4):600-604 YEUNG JM; TAYLOR WG METABOLISM OF N,N-DIETHYL-META-TOLUAMIDE (DEET) BY LIVER- MICROSOMES FROM MALE AND FEMALE RATS - SIMULTANEOUS QUANTITATION OF DEET AND ITS METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY	13	0
12856	5	3288 1977 BIOCHEMICAL PHARMACOLOGY 26(22):2117-2120 YIH TD; VANROSSUM JM KS-VALUES OF SOME HOMOLOGOUS SERIES OF BARBITURATES AND RELATIONSHIP WITH LIPOPHILICITY AND METABOLIC-CLEARANCE	35	6
12857	11	12268 2000 XENOBIOTICA 30(2):141-154 Yin H; Racha J; Li SY; Olejnik N; Satoh H; Moore D Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation	23	3
12858	12	11356 1998 PHARMACEUTICAL RESEARCH 15(4):517-524 Yokoi T; Kamataki T Genetic polymorphism of drug metabolizing enzymes: New mutations in CYP2D6 and CYP2A6 genes in Japanese	31	3
12859	7	11248 1998 JAPANESE JOURNAL OF CANCER RESEARCH 89(10):1028-1032 Yokose T; Doy M; Kakiki M; Horie T; Matsuzaki Y; Mukai K Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach	3	1
12860	14	11870 1999 VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 434(5):401-411 Yokose T; Doy M; Taniguchi T; Shimada T; Kakiki M; Horie T; Matsuzaki Y; Mukai K Immunohistochemical study of cytochrome P4502C and 3A in human non-neoplastic and neoplastic tissues	21	10
12861	6	7693 1991 JOURNAL OF VETERINARY MEDICAL SCIENCE 53(4):683-690 YOKOTA H; OHGIYA N; YUASA A DECREASE OF CYTOCHROME-P-450 HAVING ARYLHYDROCARBON HYDROXYLASE AND INCREASE OF UDP-GLUCURONYLTRANSFERASE GLUCURONIZING PHENOLIC XENOBIOTICS IN RAT-LIVER NODULE	1	0
12862	1	8151 1992 JOURNAL OF BIOCHEMISTRY 112(3):309-313 YOKOTA H; YUASA A ACTIVATION AND STABILIZATION OF UDP-GLUCURONOSYLTRANSFERASE BY LYSOPHOSPHATIDYLCHOLINE	5	0
12863	14	7556 1991 EUROPEAN JOURNAL OF BIOCHEMISTRY 196(3):531-536 YOKOTANI N; KUSUNOSE E; SOGAWA K; KAWASHIMA H; KINOSAKI M; KUSUNOSE M; FUJIIKURIYAMA Y CDNA CLONING AND EXPRESSION OF THE MESSENGER-RNA FOR CYTOCHROME P-450KD WHICH SHOWS A FATTY-ACID OMEGA-HYDROXYLATING ACTIVITY	26	17
12864	9	7055 1990 EUROPEAN JOURNAL OF BIOCHEMISTRY 187(1):23-29 YOKOTANI N; SOGAWA K; MATSUBARA S; GOTOH O; KUSUNOSE E; KUSUNOSE M; FUJIIKURIYAMA Y CDNA CLONING OF CYTOCHROME-P-450 RELATED TO P-450P-2 FROM THE CDNA LIBRARY OF HUMAN-PLACENTA - GENE STRUCTURE AND EXPRESSION	23	19
12865	2	8465 1993 BIOCHEMICAL PHARMACOLOGY 45(8):1721-1724 YOKOYAMA H; HORIE T; AWAZU S LIPID-PEROXIDATION IN RAT-LIVER MICROSOMES DURING NAPROXEN METABOLISM	8	3
12866	4	9159 1994 HUMAN & EXPERIMENTAL TOXICOLOGY 13(12):831-838 YOKOYAMA H; HORIE T; AWAZU S LIPID-PEROXIDATION AND CHEMILUMINESCENCE DURING NAPROXEN METABOLISM IN RAT-LIVER MICROSOMES	6	1
12867	6	9491 1995 BIOCHEMICAL PHARMACOLOGY 49(7):991-996 YOKOYAMA H; HORIE T; AWAZU S OXIDATIVE STRESS IN ISOLATED RAT HEPATOCYTES DURING NAPROXEN METABOLISM	7	0
12868	2	107 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(3):845-852 YONETANI T STUDIES ON CYTOCHROME OXIDASE .1. ABSOLUTE AND DIFFERENCE ABSORPTION SPECTRA	323	32
12869	2	111 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(11):3138-3143 YONETANI T STUDIES ON CYTOCHROME OXIDASE .2. STEADY STATE PROPERTIES	80	10
12870	4	133 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(6):1680-& YONETANI T STUDIES ON CYTOCHROME OXIDASE .3. IMPROVED PREPARATION AND SOME PROPERTIES	517	33
12871	2	690 1967 JOURNAL OF BIOLOGICAL CHEMISTRY 242(17):3926-& YONETANI T; SCHLEYER H ELECTROMAGNETIC PROPERTIES OF HEMOPROTEINS .2. EFFECT OF PHYSICAL STATES ON ELECTRON PARAMAGNETIC RESONANCE PARAMETERS OF HEMOPROTEINS	35	1
12872	2	544 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(22):5347-& YONETANI T; WILSON DF; SEAMONDS B STUDIES ON CYTOCHROME C PEROXIDASE .8. EFFECT OF TEMPERATURE ON LIGHT ABSORPTIONS OF ENZYME AND ITS DERIVATIVES	93	15
12873	1	739 1968 ADVANCES IN CHEMISTRY SERIES (77):233-& YONG FC DISCUSSION OF ROLE OF CYTOCHROME P-450 IN MIXED-FUNCTION OXIDATIONS	0	0
12874	8	7178 1990 JOURNAL OF NUTRITION 120(12):1718-1726 YOO JSH; HONG JY; NING SM; YANG CS ROLES OF DIETARY CORN-OIL IN THE REGULATION OF CYTOCHROMES-P450 AND GLUTATHIONE S-TRANSFERASES IN RAT-LIVER	49	11
12875	10	7671 1991 JOURNAL OF NUTRITION 121(7):959-965 YOO JSH; NING SM; PANTUCK CB; PANTUCK EJ; YANG CS REGULATION OF HEPATIC-MICROSOMAL CYTOCHROME-P450IIE1 LEVEL BY DIETARY LIPIDS AND CARBOHYDRATES IN RATS	68	14
12876	10	6877 1990 BIOCHEMICAL PHARMACOLOGY 39(3):519-525 YOO JSH; PARK HS; NING SM; LEE MJ; YANG CS EFFECTS OF THIAMINE-DEFICIENCY ON HEPATIC CYTOCHROMES-P450 AND DRUG-METABOLIZING ENZYME-ACTIVITIES	13	6
12877	9	7919 1992 BIOCHEMICAL PHARMACOLOGY 43(12):2535-2542 YOO JSH; SMITH TJ; NING SM; LEE MJ; THOMAS PE; YANG CS MODULATION OF THE LEVELS OF CYTOCHROMES-P450 IN RAT-LIVER AND LUNG BY DIETARY-LIPID	32	7
12878	7	12923 2002 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 73(2):74-86 Yoon KS; Nelson JO; Clark JM Selective induction of abamectin metabolism by dexamethasone, 3-methylcholanthrene, and phenobarbital in Colorado potato beetle, Leptinotarsa decemlineata (Say)	2	0
12879	3	1342 1970 JOURNAL OF BIOCHEMISTRY 68(6):849-& YOSHIDA K; IIZUKA T; OGURA Y EFFECT OF PH ON OPTICAL ABSORPTION SPECTRUM AND EFFECTIVE NUMBER OF BOHR MAGNETON OF HORSE ERYTHROCYTE CATALASE IN RANGE FROM 77 DEGREESK TO 267 DEGREES K	16	2
12880	8	4150 1980 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 50(5):895-899 YOSHIDA K; OSHIMA H; TROEN P STUDIES OF THE HUMAN TESTIS .13. PROPERTIES OF NICOTINAMIDE ADENINE-DINUCLEOTIDE (REDUCED FORM)-LINKED 17-ALPHA- HYDROXYLATION	10	0
12881	17	6836 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 280(2):346-351 YOSHIDA S; HIRAI A; TAMURA Y; YOSHIDA S POSSIBLE INVOLVEMENT OF ARACHIDONIC-ACID METABOLITES OF CYTOCHROME-P450 MONOOXYGENASE PATHWAY IN VASOPRESSIN-STIMULATED GLYCOGENOLYSIS IN ISOLATED RAT HEPATOCYTES	19	16
12882	6	3702 1978 TOXICOLOGY AND APPLIED PHARMACOLOGY 46(1):215-225 YOSHIDA T; JORDAN L; NEAL RA EFFECT OF ETHYLENEBISDIISOTHIOCYANATO SULFIDE (EBIS) ON HEPATIC MONO-OXYGENASE ACTIVITY	7	0
12883	3	3031 1976 BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 15(4):421-424 YOSHIDA T; NOMURA M; SUZUKI Y; UCHIYAMA M INHIBITION OF HEPATIC UDP-GLUCURONYLTRANSFERASE ACTIVITY BY ORGANOPHOSPHATE INSECTICIDES AND BY CARBON-DISULFIDE IN MICE	5	0
12884	11	5164 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(3):1655-1660 YOSHIDA Y; AOYAMA Y YEAST CYTOCHROME-P-450 CATALYZING LANOSTEROL 14-ALPHA- DEMETHYLATION .1. PURIFICATION AND SPECTRAL PROPERTIES	130	28
12885	12	11941 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(3):799-804 Yoshida Y; Aoyama Y; Noshiro M; Gotoh O Sterol 14-demethylase P450 (CYP51) provides a breakthrough for the discussion on the evolution of cytochrome P450 gene superfamily	13	4
12886	10	4629 1982 JOURNAL OF BIOCHEMISTRY 91(5):1651-1659 YOSHIDA Y; IMAI Y; HASHIMOTOYUTSUDO C SPECTROPHOTOMETRIC EXAMINATION OF EXOGENOUS-LIGAND COMPLEXES OF FERRIC CYTOCHROME-P-450 - CHARACTERIZATION OF THE AXIAL LIGAND TRANS TO THIOLATE IN THE NATIVE FERRIC LOW-SPIN FORM	35	9
12887	3	1043 1969 BIOCHIMICA ET BIOPHYSICA ACTA 189(3):461-& YOSHIDA Y; KUMAOKA H PURIFICATION OF CYTOCHROME B5-LIKE HEMOPROTEIN FROM ANAEROBICALLY GROWN YEAST	13	2
12888	14	1917 1972 JOURNAL OF BIOCHEMISTRY 71(5):915-& YOSHIDA Y; KUMAOKA H INTERCONVERSION OF HIGH-SPIN AND LOW-SPIN STATES OF CYTOCHROME P-450 SOLUBILIZED FROM YEAST MICROSOMES	18	10
12889	17	2839 1975 JOURNAL OF BIOCHEMISTRY 78(3):455-468 YOSHIDA Y; KUMAOKA H STUDIES ON SUBSTRATE-INDUCED SPECTRAL CHANGE OF CYTOCHROME-P- 450 IN LIVER-MICROSOMES	79	52
12890	23	2841 1975 JOURNAL OF BIOCHEMISTRY 78(4):785-794 YOSHIDA Y; KUMAOKA H STUDIES ON MICROSOMAL ELECTRON-TRANSPORT SYSTEM OF ANAEROBICALLY GROWN YEAST .3. SPECTRAL CHARACTERIZATION OF CYTOCHROME-P-450	23	9
12891	6	2545 1974 JOURNAL OF BIOCHEMISTRY 75(6):1211-1219 YOSHIDA Y; KUMAOKA H; SATO R STUDIES ON MICROSOMAL ELECTRON-TRANSPORT SYSTEM OF ANAEROBICALLY GROWN YEAST .2. PURIFICATION AND CHARACTERIZATION OF CYTOCHROME B5	39	7
12892	12	10744 1997 JOURNAL OF BIOCHEMISTRY 122(6):1122-1128 Yoshida Y; Noshiro M; Aoyama Y; Kawamoto T; Horiuchi T; Gotoh O Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase .2. Evolutionary analysis of protein and gene structures	27	9
12893	2	4933 1983 JOURNAL OF PHARMACOBIO-DYNAMICS 6(12):954-962 YOSHIHARA S; NAGATA K; YOSHIMURA H DIFFERENT RESPONSIVENESS OF HEPATIC AND PULMONARY MICROSOMAL MIXED-FUNCTION OXIDASES TO PHENOBARBITAL-TYPE AND 3- METHYLCHOLANTHRENE-TYPE POLYCHLORINATED-BIPHENYLS IN RATS	6	2
12894	6	1336 1970 JOURNAL OF BIOCHEMISTRY 68(4):487-& YOSHIMOT.A; ITO H; TOMITA K COFACTOR REQUIREMENTS OF ENZYME SYNTHESIZING PROSTAGLANDIN IN BOVINE SEMINAL VESICLES	142	0
12895	8	7813 1991 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 111(12):737-755 YOSHIMURA H OUR DRUG-METABOLISM STUDIES DURING THE LAST 4 DECADES	1	0
12896	11	7118 1990 JOURNAL OF BIOCHEMISTRY 108(4):544-548 YOSHIMURA R; KUSUNOSE E; YOKOTANI N; YAMAMOTO S; KUBOTA I; KUSUNOSE M PURIFICATION AND CHARACTERIZATION OF 2 FORMS OF FATTY-ACID OMEGA-HYDROXYLASE CYTOCHROME-P-450 FROM RABBIT KIDNEY CORTEX MICROSOMES	13	11
12897	2	11370 1998 PHARMACOLOGY 57(6):286-294 Yoshimura T; Itoh S; Tsujikawa K; Yamada E; Ishii T; Iemura O; Kameda Y; Mimura T; Kohama Y Effect of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D- 3 on the expression of vitamin-D-responsive genes in vitamin-D- deficient mice	1	0
12898	3	4661 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(13):7786-7793 YOSHINAGA T; SASSA S; KAPPAS A THE OCCURRENCE OF MOLECULAR-INTERACTIONS AMONG NADPH- CYTOCHROME-C REDUCTASE, HEME OXYGENASE, AND BILIVERDIN REDUCTASE IN HEME DEGRADATION	39	1
12899	4	7143 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(24):14612-14617 YOSHIOKA H; LANG M; WONG G; NEGISHI M A SPECIFIC CIS-ACTING ELEMENT REGULATES INVITRO TRANSCRIPTION OF SEX-DEPENDENT MOUSE STEROID 16-ALPHA-HYDROXYLASE (C-P45016- ALPHA) GENE	16	9
12900	7	12555 2001 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 297(3):1166-1175 Yoshisue K; Nagayama S; Shindo T; Kawaguchi Y Effects of 5-flourouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats	3	1

#	Cited nodes	Nodes / Authors	GCS	LCS
12901	2	558 1966 NATURE 212(5061):483-& YOSHIZAW.T; WALD G VISUAL PIGMENTS AND KEILIN-HARTREE EFFECT	15	0
12902	1	249 1963 NATURE 197(487):1279-& YOSHIZAWA T; WALD G PRE-LUMIRHODOPSIN AND BLEACHING OF VISUAL PIGMENTS	388	1
12903	7	6773 1989 TOXICOLOGY AND APPLIED PHARMACOLOGY 101(2):179-195 YOST GS; BUCKPITT AR; ROTH RA; MCLEMORE TL CONTEMPORARY-ISSUES IN TOXICOLOGY - MECHANISMS OF LUNG INJURY BY SYSTEMICALLY ADMINISTERED CHEMICALS	31	5
12904	14	11864 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 158(2):197-205 You L; Chan SK; Brace JM; Archibeque-Engle S; Casanova M; Corton JC; Heck HD Modulation of testosterone-metabolizing hepatic cytochrome P- 450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p '-DDE	13	4
12905	4	12574 2001 MOLECULAR AND CELLULAR ENDOCRINOLOGY 178(1-2):207-214 You L; Sar M; Bartolucci E; Ploch S; Whitt M Induction of hepatic aromatase by p,p '-DDE in adult male rats	4	1
12906	3	779 1968 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 31(6):925-& YOUNG DG; HALL PF COFACTOR REQUIREMENTS FOR CONVERSION OF CHOLESTEROL SULFATE TO PREGNENOLONE SULFATE BY A SUBMITOCHONDRIAL SYSTEM FROM BOVINE ADRENAL CORTEX	12	5
12907	8	1018 1969 BIOCHEMISTRY 8(7):2987-& YOUNG DG; HALL PF SIDE-CHAIN CLEAVAGE OF CHOLESTEROL AND CHOLESTEROL SULFATE BY ENZYMES FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	40	12
12908	6	1518 1971 BIOCHEMISTRY 10(8):1496-& YOUNG DG; HALL PF STEROID HYDROXYLATION IN BOVINE ADRENOCORTICAL MITOCHONDRIA - COMPETITION BETWEEN SIDE-CHAIN CLEAVAGE OF CHOLESTEROL AND 11BETA HYDROXYLATION	19	11
12909	6	1207 1970 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 38(2):184-& YOUNG DG; HOLROYD JD; HALL PF ENZYMATIC AND SPECTRAL PROPERTIES OF SOLUBILIZED CYTOCHROME P- 450 FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	14	12
12910	9	3182 1976 PHYTOCHEMISTRY 15(3):379-385 YOUNG O; BEEVERS H MIXED-FUNCTION OXIDASES FROM GERMINATING CASTOR BEAN ENDOSPERM	62	9
12911	1	6416 1989 BIOCHEMICAL JOURNAL 257(2):541-548 YOUNG PR; BRIEDIS AV PURIFICATION AND KINETIC MECHANISM OF THE MAJOR GLUTATHIONE S- TRANSFERASE FROM BOVINE BRAIN	17	1
12912	2	6935 1990 BIOCHIMICA ET BIOPHYSICA ACTA 1038(1):114-118 YOUNG PR; BRIEDIS AV BINDING OF INHIBITORS TO THE MAJOR GLUTATHIONE S-TRANSFERASE FROM BOVINE BRAIN - COMPETITIVE-BINDING BETWEEN BILIRUBIN AND GLUTATHIONE	6	0
12913	4	1265 1970 BIOCHIMICA ET BIOPHYSICA ACTA 215(1):119-& YOUNG RB; BRYSON MJ; SWEAT ML II-DEOXYSTEROID-INDUCED SPECTRAL RESPONSES IN ADRENAL GLAND MICROSOMES	1	1
12914	4	2320 1973 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 4(6):585-591 YOUNG RB; BRYSON MJ; SWEAT ML; STREET JC COMPLEXING OF DDT AND O,PDDD WITH ADRENAL CYTOCHROME-P-450 HYDROXYLATING SYSTEMS	18	2
12915	25	11153 1998 CRITICAL REVIEWS IN TOXICOLOGY 28(1):1-33 Youssef J; Badr M Extraperoxisomal targets of peroxisome proliferators: Mitochondrial, microsomal, and cytosolic effects. Implications for health and disease	19	0
12916	5	1827 1972 BIOCHIMICA ET BIOPHYSICA ACTA 267(2):268-& YSEBAERT.M; VANNESTE WH; MASON HS ANOMALOUS ESR SIGNAL FROM RAPIDLY FROZEN LIVER-MICROSOMES	4	0
12917	3	9310 1994 MUTATION RESEARCH 312(1):25-31 YSERN P; RIERA J; SITJES J; LLAGOSTERA M ACTIVATION OF 4-NITRO-O-PHENYLENEDIAMINE BY THE S2 FRACTION OF ZEA-MAYS TO MUTAGENIC PRODUCT(S)	7	0
12918	1	8262 1992 MECHANISMS OF AGEING AND DEVELOPMENT 65(1):17-33 YU BP; SUESCUN EA; YANG SY EFFECT OF AGE-RELATED LIPID-PEROXIDATION ON MEMBRANE FLUIDITY AND PHOSPHOLIPASE-A2 - MODULATION BY DIETARY RESTRICTION	84	0
12919	4	12727 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(8):2479-2483 Yu BW; Ruppert M; Stockigt J Deoxysarpagine hydroxylase - A novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia	0	0
12920	5	13111 2003 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 17(4):307-313 Yu C; Shin YG; Kosmeder JW; Pezzuto JM; van Breemen RB Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate	0	0
12921	13	2546 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(1):94-101 YU CA; GUNSALUS IC; KATAGIRI M; SUHARA K; TAKEMORI S CYTOCHROME P-450CAM .1. CRYSTALLIZATION AND PROPERTIES	133	43
12922	3	4043 1980 BIOCHEMISTRY 19(15):3579-3585 YU CA; YU L ISOLATION AND PROPERTIES OF A MITOCHONDRIAL PROTEIN THAT CONVERTS SUCCINATE-DEHYDROGENASE INTO SUCCINATE-UBIQUINONE OXIDOREDUCTASE	64	0
12923	19	10160 1996 DRUG METABOLISM AND DISPOSITION 24(11):1254-1262 Yu L; Waxman DJ Role of cytochrome P450 in oxazaphosphorine metabolism - Deactivation via N-dechloroethylation and activation via 4- hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450	28	5
12924	4	2121 1973 BIOCHEMISTRY 12(3):540-546 YU L; YU CA; KING TE ROLE OF PHOSPHOLIPID IN SUCCINATE CYTOCHROME C REDUCTASE	48	3
12925	14	11753 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 288(3):928-937 Yu LJ; Drewes P; Gustafsson K; Brain EGC; Hecht JED; Waxman DJ In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: Impact on pharmacokinetics and antitumor activity	20	1
12926	13	12441 2001 DRUG METABOLISM AND DISPOSITION 29(3):304-312 Yu LJ; Matias J; Scudiero DA; Hite KM; Monks A; Sausville EA; Waxman DJ P450 enzyme expression patterns in the NCI human tumor cell line panel	12	3
12927	6	13011 2003 BIOORGANIC & MEDICINAL CHEMISTRY 11(13):2803-2821 Yu M; Alonso-Galicia M; Sun CW; Roman RJ; Ono N; Hirano H; Ishimoto T; Reddy YK; Katipally KR; Reddy KM; Gopal VR; Yu J; Takhi M; Falck JR 20-hydroxyeicosatetraenoic acid (20-HETE): Structural determinants for renal vasoconstriction	0	0
12928	1	4167 1980 JOURNAL OF RAMAN SPECTROSCOPY 9(3):166-171 YU NT; SRIVASTAVA RB RESONANCE RAMAN-SPECTROSCOPY OF HEME-PROTEINS WITH INTENSIFIED VIDICON DETECTORS - STUDIES OF LOW-FREQUENCY MODES AND EXCITATION PROFILES IN CYTOCHROME-C AND HEMOGLOBIN	44	1
12929	15	10037 1996 BIOCHEMISTRY 35(20):6289-6296 Yu XC; Liang C; Strobel HW Kinetics of substrate reaction in the course of hydroperoxide- mediated inactivation of cytochrome P450 1A1	5	3
12930	4	4799 1983 BIOCHEMISTRY 22(1):143-149 YUAN PM; NAKAJIN S; HANIU M; SHINODA M; HALL PF; SHIVELY JE STEROID 21-HYDROXYLASE (CYTOCHROME-P-450) FROM PORCINE ADRENOCORTICAL MICROSOMES - MICROSEQUENCE ANALYSIS OF CYSTEINE- CONTAINING PEPTIDES	59	16
12931	13	10488 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 339(1):55-63 Yuan W; Sequeira DJ; Cawley GF; Eyer CS; Backes WL Time course for the modulation of hepatic cytochrome P450 after administration of ethylbenzene and its correlation with toluene metabolism	7	2
12932	18	10575 1997 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1334(2-3):361-372 Yuan W; Serron SC; Haddican MM; Cawley GF; Eyer CS; Backes WL Ethylbenzene modulates the expression of different cytochrome P-450 isozymes by discrete multistep processes	7	4
12933	10	9405 1995 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 37(1):C259-C270 YUAN XJ; TOD ML; RUBIN LJ; BLAUSTEIN MP INHIBITION OF CYTOCHROME-P-450 REDUCES VOLTAGE-GATED K+ CURRENTS IN PULMONARY ARTERIAL MYOCYTES	38	0
12934	2	5971 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(11):3609-3613 YUBISUI T; NAITOH Y; ZENNO SH; TAMURA M; TAKESHITA M; SAKAKI Y MOLECULAR-CLONING OF CDNAS OF HUMAN-LIVER AND PLACENTA NADH- CYTOCHROME-B5 REDUCTASE	49	13
12935	5	12512 2001 JOURNAL OF BIOCHEMISTRY 129(5):709-716 Yubisui T; Takahashi F; Takabayashi T; Fujiwara S; Kawamura K Characterization of cytochrome b(5) in the ascidian Polyandrocarpa misakiensis and budding-specific expression	1	0
12936	2	10739 1997 INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH 27(1):55-59 Yucel G; Yesilkaya A; Aksu TA; Yegin A; Ahciguzel Y Increased resistance to oxidative stress in normal and glucose- 6-phosphate dehydrogenase-deficient hemolysates in the presence of enzyme substrates	0	0
12937	7	12400 2001 CARCINOGENESIS 22(6):943-950 Yueh MF; Nguyen N; Famourzadeh M; Strassburg CP; Oda Y; Guengerich FP; Tukey RH The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2- mediated genotoxicity by aromatic and heterocyclic amines	7	0
12938	13	5490 1985 STEROIDS 45(1):53-72 YUEN EH; GOOLD RD; WILSON BJ EFFECT OF SOME SYNTHETIC STEROIDS ON RAT-LIVER FUNCTION	1	0
12939	5	11699 1999 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 75(9):1189-1199 Yukawa O; Nakajima T; Yukawa M; Ozawa T; Yamada T Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low- dose irradiation	7	0
12940	12	2353 1973 RADIATION RESEARCH 56(1):140-149 YUKAWA O; NAKAZAWA T SITES OF X-IRRADIATION-INDUCED DAMAGE IN MICROSOMAL DRUG- METABOLIZING ENZYME-SYSTEM OF RAT-LIVER DURING DEVELOPMENT	6	2
12941	13	2613 1974 RADIATION RESEARCH 58(1):101-110 YUKAWA O; NAKAZAWA T DAMAGES IN MICROSOMAL DRUG-METABOLIZING ENZYME-SYSTEM AFTER PARTIAL X-IRRADIATION OF RAT-LIVER	16	4
12942	5	4120 1980 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 37(6):621-631 YUKAWA O; NAKAZAWA T RADIATION-INDUCED LIPID-PEROXIDATION AND MEMBRANE-BOUND ENZYMES IN LIVER-MICROSOMES	57	3
12943	2	5018 1984 ALCOHOL AND ALCOHOLISM 19(2):101-107 YUKI T; HASHIMOTO T; OHKUMA S; TAMURA J; KURIYAMA K ALTERATION OF ACETALDEHYDE METABOLISM IN CARBON TETRACHLORIDE- INTOXICATED RAT-LIVER - ANALYSIS USING LIVER PERFUSION SYSTEM	7	5
12944	5	4013 1980 BIOCHEMICAL JOURNAL 186(1):119-126 YUKI T; THURMAN RG SWIFT INCREASE IN ALCOHOL METABOLISM - TIME COURSE FOR THE INCREASE IN HEPATIC OXYGEN-UPTAKE AND THE INVOLVEMENT OF GLYCOLYSIS	95	7
12945	20	10981 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 356(2):229-238 Yun CH; Ahn T; Guengerich FP Conformational change and activation of cytochrome P450 2B1 induced by salt and phospholipid	8	3
12946	24	7943 1992 BIOCHEMISTRY 31(43):10556-10563 YUN CH; HAMMONS GJ; JONES G; MARTIN MV; HOPKINS NE; ALWORTH WL; GUENGERICH FP MODIFICATION OF CYTOCHROME-P450 1A2 ENZYMES BY THE MECHANISM- BASED INACTIVATOR 2-ETHYNYLNAPHTHALENE AND THE PHOTOAFFINITY LABEL 4-AZIDOBIPHENYL	42	24
12947	18	12362 2001 BIOCHEMISTRY 40(14):4521-4530 Yun CH; Miller GP; Guengerich FP Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: Structure-activity relationships and simulation of rate constants of individual steps in catalysis	4	3
12948	6	11006 1998 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 243(3):808-810 Yun CH; Park HJ; Kim SJ; Kim HK Identification of cytochrome P450 1A1 in human brain	2	0
12949	19	7734 1991 MOLECULAR PHARMACOLOGY 40(5):679-685 YUN CH; SHIMADA T; GUENGERICH FP PURIFICATION AND CHARACTERIZATION OF HUMAN LIVER MICROSOMAL CYTOCHROME-P-450 2A6	202	89
12950	26	7990 1992 CANCER RESEARCH 52(7):1868-1874 YUN CH; SHIMADA T; GUENGERICH FP ROLES OF HUMAN LIVER CYTOCHROME-P4502C AND CYTOCHROME-P4503A ENZYMES IN THE 3-HYDROXYLATION OF BENZO(A)PYRENE	61	24
12951	19	10258 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(49):31312-31316 Yun CH; Song M; Ahn T; Kim H Conformational change of cytochrome p450 1A2 induced by sodium chloride	20	9
12952	19	10752 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(32):19725-19730 Yun CH; Song M; Kim H Conformational change of cytochrome P450 1A2 induced by phospholipids and detergents	18	9
12953	26	7840 1992 ANESTHESIOLOGY 77(3):467-474 YUN CH; WOOD M; WOOD AJJ; GUENGERICH FP IDENTIFICATION OF THE PHARMACOGENETIC DETERMINANTS OF ALFENTANIL METABOLISM - CYTOCHROME P-450-3A4 - AN EXPLANATION OF THE VARIABLE ELIMINATION CLEARANCE	87	25
12954	10	8270 1992 MOLECULAR PHARMACOLOGY 41(3):474-479 YUN YP; CASAZZA JP; SOHN DH; VEECH RL; SONG BJ PRETRANSLATIONAL ACTIVATION OF CYTOCHROME-P450IIE DURING KETOSIS INDUCED BY A HIGH-FAT DIET	40	14
12955	3	2733 1975 BIOCHEMISTRY 14(14):3107-3114 YURCHENCO PD; ATKINSON PH FUCOSYL-GLYCOPROTEIN AND PRECURSOR POOLS IN HELA-CELLS	24	0
12956	2	11210 1998 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 10(6):503-507 Yurdaydin C; Swain MG; Mininberg ED; Vergalla J; Kleiner D; Paul SM; Jones EA Effect of inhibition of ornithine decarboxylase activity in a model of acute hepatocellular necrosis	0	0
12957	5	5081 1984 BIOCHIMICA ET BIOPHYSICA ACTA 798(2):167-174 YUSA T; CRAPO JD; FREEMAN BA HYPEROXIA ENHANCES LUNG AND LIVER NUCLEAR SUPEROXIDE GENERATION	61	4
12958	2	3480 1978 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 35(2):337-343 ZABRISKIE DW; HUMPHREY AE ESTIMATION OF FERMENTATION BIOMASS CONCENTRATION BY MEASURING CULTURE FLUORESCENCE	76	3
12959	4	2876 1975 LIFE SCIENCES 16(11):1689-1692 ZACHARIAH PK; JUCHAU MR INTERACTIONS OF STEROIDS WITH HUMAN PLACENTAL CYTOCHROME-P-450 IN PRESENCE OF CARBON-MONOXIDE	20	15
12960	12	3421 1977 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 8(3):221-228 ZACHARIAH PK; JUCHAU MR INHIBITION OF HUMAN PLACENTAL MIXED-FUNCTION OXIDATIONS WITH CARBON-MONOXIDE - REVERSAL WITH MONOCHROMATIC LIGHT	34	8
12961	1	3756 1979 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 91(4):1445-1452 ZAHLTEN RN; NEJTEK ME ACETYL COA MEDIATED SPECIFIC-INHIBITION OF MALIC ENZYME (EC- 1.1.1.40) FROM RAT-LIVER AND SKELETAL-MUSCLE CYTOPLASM	4	0
12962	5	5837 1987 BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 38(3):449-455 ZAIDI SSA; BANERJEE BD ENZYMATIC DETOXICATION OF DDT TO DDD BY RAT-LIVER - EFFECTS OF SOME INDUCERS AND INHIBITORS OF CYTOCHROME-P-450 ENZYME-SYSTEM	5	0
12963	3	3201 1976 SOVIET PLANT PHYSIOLOGY 23(3):440-444 ZAITSEVA MG; TITOVA ZV ADP-O VALUES THAT EXCEED THEORETICAL VALUES	0	0
12964	12	7820 1992 ACTA BIOCHIMICA POLONICA 39(4):335-343 ZAJWORONIUK H; RZECZYCKI W EFFECT OF MESITYLENE ON ETHANOL-METABOLISM IN RAT-LIVER MICROSOMES	0	0
12965	9	3032 1976 BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 81(4):509-512 ZAKHAROVA NE; MORDVINOV VA; TSYRLOV IB; LYAKHOVICH VV INDUCTION OF LIVER MICROSOMAL MONOOXYGENASES IN EXPERIMENTAL CHOLESTASIS	0	0
12966	5	3462 1977 VOPROSY MEDITSINSKOI KHIMII 23(2):181-185 ZAKHAROVA NE; POSPELOVA LN; GROMOVA OA; TSYRLOV IB; LYAKHOVICH VV MECHANISM OF INHIBITION OF MICROSOMAL MONOOXYGENASES FROM RAT- LIVER IN DYNAMICS OF CHOLESTASIS DEVELOPMENT	0	0
12967	2	2141 1973 BIOCHIMICA ET BIOPHYSICA ACTA 309(1):67-74 ZAKIM D; GOLDENBE.J; VESSEY DA DIFFERENTIATION OF HOMOLOGOUS FORMS OF HEPATIC MICROSOMAL UDP- GLUCURONYLTRANSFERASE .1. EVIDENCE FOR GLUCURONIDATION OF ORTHO-AMINOPHENOL AND PARA-NITROPHENOL BY SEPARATE ENZYMES	50	1
12968	7	4794 1983 BIOCHEMICAL PHARMACOLOGY 32(24):3749-3754 ZALESKA MM; GESSNER PK METABOLISM OF PARALDEHYDE TO ACETALDEHYDE IN LIVER-MICROSOMES - EVIDENCE FOR THE INVOLVEMENT OF CYTOCHROME-P-450	9	2
12969	4	12327 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 390(2):287-294 Zamora R; Vodovotz Y; Alarcon L; Betten B; Loughran PA; Aulak KS; Stuehr DJ; Gibson KF; Billiar TR Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli	2	0
12970	6	10328 1996 JOURNAL OF THE NATIONAL CANCER INSTITUTE 88(3-4):183-192 Zang EA; Wynder EL Differences in lung cancer risk between men and women: Examination of the evidence	142	3
12971	10	9792 1995 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 45(1):47-58 ZANGAR RC; BUHLER DR; SPRINGER DL NEONATAL EXPOSURE TO XENOBIOTICS ALTERS ADULT HEPATIC PROTEIN- KINASE-C-ALPHA LEVELS AND TESTOSTERONE-METABOLISM - DIFFERENTIAL-EFFECTS BY DIETHYLSTILBESTROL AND PHENOBARBITAL	4	1
12972	13	12906 2002 MOLECULAR PHARMACOLOGY 61(4):892-904 Zangar RC; Kimzey AL; Okita JR; Wunschel DS; Edwards RJ; Kim H; Okita RT Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway	4	0
12973	18	10482 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 337(2):217-224 Zangar RC; Novak RF Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes	24	4
12974	10	8753 1993 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 38(1):43-55 ZANGAR RC; SPRINGER DL; BUHLER DR ALTERATIONS IN CYTOCHROME-P-450 LEVELS IN ADULT-RATS FOLLOWING NEONATAL EXPOSURE TO XENOBIOTICS	13	4
12975	18	10423 1996 TOXICOLOGY AND APPLIED PHARMACOLOGY 141(1):110-116 Zangar RC; Woodcroft KJ; Novak RF Differential effects of ciprofibrate on renal and hepatic cytochrome P450 2E1 expression	9	3
12976	8	10594 1997 BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 58(4):511-517 Zanger M; Graff S; Braunbeck T; Alberti G; Kohler HR Detection and induction of cytochrome P450IA (CYP 1A) like proteins in Julus scandinavius (Diplopoda) and Oniscus asellus (Isopoda): A first analysis	4	0
12977	10	7705 1991 METHODS IN ENZYMOLOGY 206():201-209 ZANGER UM IMMUNOISOLATION OF HUMAN MICROSOMAL CYTOCHROMES-P450 USING AUTOANTIBODIES	4	1
12978	4	6307 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(21):8256-8260 ZANGER UM; HAURI HP; LOEPER J; HOMBERG JC; MEYER UA ANTIBODIES AGAINST HUMAN CYTOCHROME-P-450DB1 IN AUTOIMMUNE HEPATITIS TYPE-II	173	46
12979	8	8103 1992 FASEB JOURNAL 6(2):719-723 ZANGER UM; KAGAWA N; LUND J; WATERMAN MR DISTINCT BIOCHEMICAL-MECHANISMS FOR CAMP-DEPENDENT TRANSCRIPTION OF CYP17 AND CYP21	27	14
12980	5	6113 1988 BIOCHEMISTRY 27(15):5447-5454 ZANGER UM; VILBOIS F; HARDWICK JP; MEYER UA ABSENCE OF HEPATIC CYTOCHROME P450BUFI CAUSES GENETICALLY DEFICIENT DEBRISOQUINE OXIDATION IN MAN	162	58
12981	8	9247 1994 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 268(3):1565-1570 ZANNIKOS PN; BANDYOPADHYAY AM; ROBERTSON LW; BLOUIN RA CYTOCHROME-P450 2B ENZYME-INDUCTION DEFECT AFTER 2,2',4,4',5,5'-HEXACHLOROBIPHENYL TREATMENT IN THE FA/FA ZUCKER RAT	1	0
12982	11	1790 1972 BIOCHEMICAL PHARMACOLOGY 21(10):1377-& ZANNONI VG; FLYNN EJ; LYNCH M ASCORBIC-ACID AND DRUG-METABOLISM	128	12
12983	9	7389 1991 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 180(2):645-651 ZAPHIROPOULOS PG CDNA CLONING AND REGULATION OF A NOVEL RAT CYTOCHROME-P450 OF THE 2C GENE SUBFAMILY (P450IIC24)	9	7
12984	3	10393 1996 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93(13):6536-6541 Zaphiropoulos PG Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping	17	3
12985	6	6781 1989 TRENDS IN PHARMACOLOGICAL SCIENCES 10(4):149-153 ZAPHIROPOULOS PG; MODE A; NORSTEDT G; GUSTAFSSON JA REGULATION OF SEXUAL-DIFFERENTIATION IN DRUG AND STEROID- METABOLISM	105	31
12986	4	6304 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(12):4214-4217 ZAPHIROPOULOS PG; MODE A; STROM A; MOLLER C; FERNANDEZ C; GUSTAFSSON JA CDNA CLONING, SEQUENCE, AND REGULATION OF A MAJOR FEMALE- SPECIFIC AND GROWTH HORMONE-INDUCIBLE RAT-LIVER CYTOCHROME-P- 450 ACTIVE IN 15-BETA-HYDROXYLATION OF STEROID SULFATES	70	43
12987	9	9473 1995 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 212(2):433-441 ZAPHIROPOULOS PG; SKANTZ A; ELIASSON M; AHLBERG MB CYTOCHROME-P450 GENES EXPRESSED IN PORCINE OVARIES - IDENTIFICATION OF NOVEL FORMS, EVIDENCE FOR GENE CONVERSION, AND EVOLUTIONARY RELATIONSHIPS	7	3
12988	9	7226 1990 MOLECULAR ENDOCRINOLOGY 4(1):53-58 ZAPHIROPOULOS PG; STROM A; ROBERTSON JA; GUSTAFSSON JA STRUCTURAL AND REGULATORY ANALYSIS OF THE MALE-SPECIFIC RAT- LIVER CYTOCHROME-P-450-G - REPRESSION BY CONTINUOUS GROWTH- HORMONE ADMINISTRATION	17	7
12989	8	7012 1990 DNA AND CELL BIOLOGY 9(1):49-56 ZAPHIROPOULOS PG; WESTIN S; STROM A; MODE A; GUSTAFSSON JA STRUCTURAL AND REGULATORY ANALYSIS OF A CYTOCHROME-P450 GENE (CYP2C12) EXPRESSED PREDOMINANTLY IN FEMALE RAT-LIVER	27	14
12990	1	389 1965 BIOCHIMICA ET BIOPHYSICA ACTA 99(3):557-& ZATTI M; ROSSI F EARLY CHANGES OF HEXOSE MONOPHOSPHATE PATHWAY ACTIVITY AND OF NADPH OXIDATION IN PHAGOCYTIZING LEUCOCYTES	54	0
12991	2	13020 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(4):767-775 Zaugg CE; Spaniol M; Kaufmann P; Bellahcene M; Barbosa V; Tolnay M; Buser PT; Krahenbuhl S Myocardial function and energy metabolism in carnitine- deficient rats	0	0
12992	15	9634 1995 DRUG METABOLISM REVIEWS 27(3):497-516 ZBAIDA S THE MECHANISM OF MICROSOMAL AZOREDUCTION - PREDICTIONS BASED ON ELECTRONIC ASPECTS OF STRUCTURE-ACTIVITY-RELATIONSHIPS	5	0
12993	12	8063 1992 DRUG METABOLISM AND DISPOSITION 20(6):902-908 ZBAIDA S; BREWER CF; LEVINE WG SUBSTRATES FROM MICROSOMAL AZOREDUCTASE - HAMMETT SUBSTITUENT EFFECTS, NMR-STUDIES, AND RESPONSE TO INHIBITORS	2	1
12994	4	5219 1984 PHARMACEUTICAL RESEARCH (6):277-279 ZBAIDA S; GILHAR D; SILMANGREENSPAN J REPLACING THE MIXED-FUNCTION OXIDASE N-DEMETHYLATION BY HYDROGEN-PEROXIDE AND EITHER HEMOGLOBIN OR FERROUS SULFATE	2	1
12995	2	5647 1986 EUROPEAN JOURNAL OF BIOCHEMISTRY 154(3):603-605 ZBAIDA S; KARIV R; FISCHER P; SILMANGREENSPAN J; TASHMA Z REACTION OF CIMETIDINE WITH FENTON REAGENT - A BIOMIMETIC MODEL FOR THE MIXED-FUNCTION OXIDASE DRUG-METABOLISM	7	0
12996	2	51 1959 BIOCHEMISCHE ZEITSCHRIFT 331(4):254-272 ZEBE E; DELBRUCK A; BUCHER T UBER DEN GLYCERIN-1-P-CYCLUS IM FLUGMUSKEL VON LOCUSTA MIGRATORIA	144	47
12997	6	8940 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 200(1):120-125 ZEILMAKER WM; VANTKLOOSTER GAE; GREMMELSGEHRMANN JF; VANMIERT ASJPAM; HORBACH GJMJ CDNA AND DEDUCED AMINO-ACID-SEQUENCE OF A DWARF GOAT LIVER CYTOCHROME-P450 FRAGMENT BELONGING TO THE CYP2C GENE SUBFAMILY	6	4
12998	4	4249 1981 ANNUAL REVIEW OF NUTRITION 1():95-121 ZEISEL SH DIETARY CHOLINE - BIOCHEMISTRY, PHYSIOLOGY, AND PHARMACOLOGY	151	0
12999	47	12525 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(39):36059-36062 Zeldin DC Epoxygenase pathways of arachidonic acid metabolism	19	0
13000	22	9452 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 322(1):76-86 ZELDIN DC; DUBOIS RN; FALCK JR; CAPDEVILA JH MOLECULAR-CLONING, EXPRESSION AND CHARACTERIZATION OF AN ENDOGENOUS HUMAN CYTOCHROME-P450 ARACHIDONIC-ACID EPOXYGENASE ISOFORM	47	28

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