#	Cited nodes	Nodes / Authors	GCS	LCS
12601	2	12601 2001 NEUROSCIENCE LETTERS 310(2-3):141-144 Nakashima T; Yoshida Y; Miyata S; Kiyohara T Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1 beta in the rat	2	0
12602	27	12602 2001 NEUROSTEROIDS AND BRAIN FUNCTION 46():33-78 Mellon SH; Vaudry H Biosynthesis of neurosteroids and regulation of their synthesis	7	0
12603	4	12603 2001 NEUROSTEROIDS AND BRAIN FUNCTION 46():79-95 Morfin R; Starka L Neurosteroid 7-hydroxylation products in the brain	3	0
12604	5	12604 2001 NEW ENGLAND JOURNAL OF MEDICINE 344(13):984-996 Piscitelli SC; Gallicano KD Drug therapy: Interactions among drugs for HIV and opportunistic infections	46	0
12605	6	12605 2001 NIEREN-UND HOCHDRUCKKRANKHEITEN 30(5):219-223 Lauterbach B; Lohn M; Gollasch M; Luft FC; Haller H; Honeck H; Kargel E; Sicard EB; Schunck WH Action of K-Ca channels by 11,12-epoxyeicosantrienoic acid in freshly isolated vascular muscle cells from cerebral arteries of the rat	0	0
12606	4	12606 2001 NUTRITION AND CANCER PREVENTION 492():83-106 Pinto JT; Lapsia S; Shah A; Santiago H; Kim G Antiproliferative effects of garlic-derived and other allium related compounds	0	0
12607	9	12607 2001 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 41(1-2):188-195 Tsai CF; Lii CK; Yang JJ; Liu KL; Lin WL; Chen HW Prostaglandin E-2 is involved in the increase of cytochrome P- 450 2B1 expression by alpha-tocopheryl succinate in primary rat hepatocytes in the presence of phenobarbital	1	0
12608	15	12608 2001 PATHOLOGIE BIOLOGIE 49(9):696-702 Meskar A; Plee-Gautier E; Amet Y; Berthou F; Lucas D Alcohol-xenobiotics interactions. Role of cytochrome P450 2E1.	1	1
12609	3	12609 2001 PEDIATRIC TRANSPLANTATION 5(2):75-79 Mittal N; Thompson JF; Kato T; Tzakis AG Tacrolimus and diarrhea: Pathogenesis of altered metabolism	6	0
12610	37	12610 2001 PEST MANAGEMENT SCIENCE 57(10):958-967 Scott JG; Wen ZM Cytochromes P450 of insects: the tip of the iceberg	4	0
12611	4	12611 2001 PEST MANAGEMENT SCIENCE 57(10):975-980 Kayser H; Eilinger P Metabolism of diafenthiuron by microsomal oxidation: procide activation and inactivation as mechanisms contributing to selectivity	0	0
12612	8	12612 2001 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 70(2):63-73 Suwanchaichinda C; Brattsten LB Effects of exposure to pesticides on carbaryl toxicity and cytochrome P450 activities in Aedes albopictus larvae (Diptera : Culicidae)	2	0
12613	12	12613 2001 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 70(3):127-141 Dai D; Cao Y; Falls G; Levi PE; Hodgson E; Rose RL Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p- chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide	1	1
12614	16	12614 2001 PHARMACOGENETICS 11(2):111-121 Gellner K; Eiselt R; Hustert E; Arnold H; Koch I; Haberl M; Deglmann CJ; Burk O; Buntefuss D; Escher S; Bishop C; Koebe HG; Brinkmann U; Klenk HP; Kleine K; Meyer UA; Wojnowski L Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene	29	8
12615	4	12615 2001 PHARMACOGENETICS 11(4):317-323 Kwon JT; Nakajima M; Chai S; Yom YK; Kim HK; Yamazaki H; Sohn DR; Yamamoto T; Kuroiwa Y; Yokoi T Nicotine metabolism and CYP2A6 allele frequencies in Koreans	11	2
12616	14	12616 2001 PHARMACOGENETICS 11(5):399-415 Lang T; Klein K; Fischer J; Nussler AK; Neuhaus P; Hofmann U; Eichelbaum M; Schwab M; Zanger UM Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver	27	3
12617	21	12617 2001 PHARMACOGENETICS 11(5):447-458 Eiselt R; Domanski TL; Zibat A; Mueller R; Presecan-Siedel E; Hustert E; Zanger UM; Brockmoller J; Klenk HP; Meyer UA; Khan KK; He YA; Halpert JR; Wojnowski L Identification and functional characterization of eight CYP3A4 protein variants	25	5
12618	19	12618 2001 PHARMACOGENETICS 11(7):597-607 Dai D; Zeldin DC; Blaisdell JA; Chanas B; Coulter SJ; Ghanayem BI; Goldstein JA Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid	15	4
12619	38	12619 2001 PHARMACOGENETICS 11(8):687-698 Hoffman SMG; Nelson DR; Keeney DS Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19	9	3
12620	13	12620 2001 PHARMACOGENETICS 11(9):793-801 Jansson I; Stoilov I; Sarfarazi M; Schenkman JB Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism	4	0
12621	11	12621 2001 PHARMACOLOGY & TOXICOLOGY 88(1):40-44 Pons F; Calvet JH; Haag M; Raeppel V; Keravis T; Frossard N Altered expression of lung cytochrome P450 3A1 in rat after exposure to sulfur mustard	3	1
12622	2	12622 2001 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 359(1783):1055-1072 Bassingthwaighte JB The modelling of a primitive 'sustainable' conservative cell	2	0
12623	15	12623 2001 PHYSIOLOGIA PLANTARUM 111(2):172-181 Mujer CV; Smigocki AC Cytokinin- and wound-inducible cytochrome P450 from Nicotiana plumbaginifolia	1	0
12624	5	12624 2001 PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY 59(2):83-93 Vanetten H; Temporini E; Wasmann C Phytoalexin (and phytoanticipin) tolerance as a virulence trait: why is it not required by all pathogens?	2	0
12625	10	12625 2001 PHYTOPATHOLOGY 91(1):102-110 Schnabel G; Jones AL The 14 alpha-demethylase (CYP51A1) gene is overexpressed in Venturia inaequalis strains resistant to myclobutanil	4	0
12626	5	12626 2001 PLANT CELL REPORTS 20(7):655-662 Yamamura Y; Ogihara Y; Mizukami H Cinnamic acid 4-hydroxylase from Lithospermum erythrorhizon: cDNA cloning and gene expression	2	0
12627	4	12627 2001 PLANT PHYSIOLOGY 126(2):770-779 Shimada Y; Fujioka S; Miyauchi N; Kushiro M; Takatsuto S; Nomura T; Yokota T; Kamiya Y; Bishop GJ; Yoshida S Brassinosteroid-6-oxidases from arabidopsis and tomato catalyze multiple C-6 oxidations in brassinosteroid biosynthesis	12	4
12628	5	12628 2001 PLANTA 213(3):411-417 Nezbedova L; Hesse M; Drandarov K; Bigler L; Werner C Phenol oxidative coupling in the biogenesis of the macrocyclic spermine alkaloids aphelandrine and orantine in Aphelandra sp.	1	0
12629	2	12629 2001 PRESSE MEDICALE 30(10):508-510 Eschwege P; de Ledinghen V; Camilli T; Kulkarni S; Dalbagni G; Droupy S; Jardin A; Benoit G; Weksler BB Cyclooxygenase-2: a new target for epithelial cancer treatments - Arachidonic acid and prostaglandins, inflammation and oncology	1	0
12630	2	12630 2001 PRESSE MEDICALE 30(10):511-514 Eschwege P; de Ledinghen V; Camilli T; Kulkarni S; Dalbagni G; Droupy S; Jardin A; Benoit G; Weksler BB Cyclooxygenase-2: a new target for epithelial cancer treatments - Cyclooxygenases	1	0
12631	30	12631 2001 PROBING OF PROTEINS BY METAL IONS AND THEIR LOW-MOLECULAR- WEIGHT COMPLEXES 38():461-655 Feiters MC Mimicking biological electron transfer and oxygen activation involving iron and copper proteins: A bio(in)organic supramolecular approach	1	0
12632	12	12632 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(1):81-86 Dohr O; Paine MJI; Friedberg T; Roberts GCK; Wolf CR Engineering of a functional human NADH-dependent cytochrome P450 system	5	2
12633	4	12633 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(4):2065-2070 Helliwell CA; Chandler PM; Poole A; Dennis ES; Peacock WJ The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway	27	1
12634	5	12634 2001 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 28(1):61-66 Zhu CL; Li JM; Gao XH; Tian HS; Li XL; Shen B; Wu GL Studies on cytochrome P450 genes in the mosquito, Culex pipiens pallens, in China	0	0
12635	1	12635 2001 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 28(3):372-376 Liu K; Sun J; Liu Y; Zhang QY; Kuang TY ESR studies on the superoxide radicals generated in photosystem II of higher plant	1	0
12636	20	12636 2001 PROTEIN ENGINEERING 14(10):797-802 Bell SG; Harford-Cross CF; Wong LL Engineering the CYP101 system for in vivo oxidation of unnatural substrates	2	1
12637	9	12637 2001 PROTEIN EXPRESSION AND PURIFICATION 23(2):348-358 Barber MJ; Quinn GB Production of a recombinant hybrid hemoflavoprotein: Engineering a functional NADH : cytochrome c reductase	2	2
12638	8	12638 2001 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 109(1-2):53-63 Taguchi M; Imaoka S; Yoshii K; Kobayashi K; Hosokawa M; Shimada N; Funae Y; Chiba K Kinetics of testosterone 6 beta-hydroxylation in the reconstituted system with similar ratios of purified CYP3A4, NADPH-cytochrome P450 oxidoreductase and cytochrome B-5 to human liver microsomes	0	0
12639	16	12639 2001 RESPIRATION PHYSIOLOGY 128(1):79-87 Tesfaigzi Y; Kluger M; Kozak W Clinical and cellular effects of cytochrome P-450 modulators	3	1
12640	15	12640 2001 REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE 41(6):579-586 Haag M; Frossard N; Pons F Cytochromes P450 and glutathione S-transferases: any association with inflammation and asthma?	0	0
12641	2	12641 2001 SAR AND QSAR IN ENVIRONMENTAL RESEARCH 12(4):359-366 Lisitsa AV; Gusev SA; Karuzina II; Archakov AI; Koymans L Cytochrome P450 database	0	0
12642	2	12642 2001 TALANTA 54(5):983-987 Baltes MRH; Dubois JG; Hanocq M Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice	0	0
12643	11	12643 2001 TETRAHEDRON LETTERS 42(25):4131-4133 Falck JR; Reddy YK; Haines DC; Reddy KM; Krishna UM; Graham S; Murry B; Peterson JA Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)	2	1
12644	9	12644 2001 TETRAHEDRON LETTERS 42(41):7211-7212 Falck JR; Kumar PS; Reddy YK; Zou G; Capdevila JH Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling	5	0
12645	11	12645 2001 THEORETICAL AND APPLIED GENETICS 103(6-7):1014-1021 Fischer TC; Klattig JT; Gierl A A general cloning strategy for divergent plant cytochrome P450 genes and its application in Lolium rigidum and Ocimum basilicum	1	0
12646	1	12646 2001 THERAPEUTIC DRUG MONITORING 23(1):21-26 Lee M; Min DI Determination of sildenafil citrate in plasma by high- performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate	5	0
12647	3	12647 2001 TOXICOLOGIC PATHOLOGY 29():155-160 Carmichael PL; Mills JJ; Campbell M; Basu M; Caldwell J Mechanisms of hormonal carcinogenesis in the p53(+/-)- hemizygous knockout mouse: Studies with diethylstilbestrol	2	0
12648	18	12648 2001 TOXICOLOGICAL SCIENCES 60(1):77-91 Bello SM; Franks DG; Stegeman JJ; Hahn ME Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: In vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes	14	0
12649	6	12649 2001 TOXICOLOGY 166(3):139-160 Jokanovic M Biotransformation of organophosphorus compounds	1	0
12650	14	12650 2001 TOXICOLOGY AND APPLIED PHARMACOLOGY 172(3):163-171 Serron SC; Zhang SX; Bergeron RM; Backes WL Effect of hypophysectomy and growth hormone replacement on the modulation of P450 expression after treatment with the aromatic hydrocarbon ethylbenzene	3	0
12651	3	12651 2001 TOXICOLOGY AND APPLIED PHARMACOLOGY 172(3):194-202 Reid MJ; Bornheim LM The effects of phencyclidine pretreatment on cocaine-mediated hepatotoxicity in mice	1	0
12652	11	12652 2001 VOPROSY MEDITSINSKOI KHIMII 47(3):315-328 Prozrovsky TV; Schunck WH; Archakov AI Association of cytochrome P4502B4 with molecular chaperones after hetrologous expression in E.coli.	0	0
12653	20	12653 2001 XENOBIOTICA 31(3):163-176 Shimada T; Watanabe J; Inoue K; Guengerich FP; Gillam EMJ Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432	8	1
12654	17	12654 2001 XENOBIOTICA 31(4):187-204 Renwick AB; Lewis DFV; Fulford S; Surry D; Williams B; Worboys PD; Cai X; Wang RW; Price RJ; Lake BG; Evans DC Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4- trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4	4	1
12655	21	12655 2001 XENOBIOTICA 31(4):223-237 Sakuma T; Honma R; Maguchi S; Tamaki H; Nemoto N Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat	4	1
12656	14	12656 2001 XENOBIOTICA 31(5):265-275 Emoto C; Yamazaki H; Iketaki H; Yamasaki S; Satoh T; Shimizu R; Suzuki S; Shimada N; Nakajima M; Yokoi T Cooperativity of alpha-naphthoflavone in cytochrome P450 3A- dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human	4	0
12657	48	12657 2001 XENOBIOTICA 31(8-9):499-538 Weaver RJ Assessment of drug-drug interactions concepts and approaches	6	1
12658	10	12658 2001 XENOBIOTICA 31(10):713-723 Miyazawa M; Shindo M; Shimada T Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes	1	0
12659	15	12659 2001 XENOBIOTICA 31(12):861-878 Renwick AB; Lavignette G; Worboys PD; Williams B; Surry D; Lewis DFV; Price RJ; Lake BG; Evans DC Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7- benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes	0	0
12660	3	12660 2001 ZEITSCHRIFT FUR GASTROENTEROLOGIE 39(3):225-+ Stickel F; Seitz HK; Hahn EG; Schuppan D Hepatotoxicity of herbal remedies	2	0
12661	8	12661 2002 ACTA PHARMACOLOGICA SINICA 23(5):471-476 Xia XY; Peng RX; Yu JP; Wang H; Wang J In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes	0	0
12662	27	12662 2002 ADVANCED DRUG DELIVERY REVIEWS 54(3):367-383 de Groot MJ; Ekins S Pharmacophore modeling of cytochromes P450	3	0
12663	12	12663 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1245-1256 Xu C; Goodz S; Sellers EA; Tyndale RF CYP2A6 genetic variation and potential consequences	1	0
12664	16	12664 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1257-1270 Xie HG; Prasad HC; Kim RB; Stein CM CYP2C9 allelic variants: ethnic distribution and functional significance	1	0
12665	42	12665 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1271-1294 Lamba JK; Lin YS; Schuetz EG; Thummel KE Genetic contribution to variable human CYP3A-mediated metabolism	1	0
12666	23	12666 2002 ADVANCED SYNTHESIS & CATALYSIS 344(9):932-937 Cirino PC; Arnold FH Regioselectivity and activity of cytochrome P450 BM-3 and mutant F87A in reactions driven by hydrogen peroxide	0	0
12667	4	12667 2002 ALCOHOL AND WINE IN HEALTH AND DISEASE 957():210-229 Bhat KPL; Pezzuto JM Cancer chemopreventive activity of resveratrol	13	0
12668	12	12668 2002 AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 59(21):2061-2069 Ma MK; Woo MH; McLeod HL Genetic basis of drug metabolism	1	0
12669	3	12669 2002 AMERICAN JOURNAL OF MEDICINE 113(9):746-750 Rogers JF; Nafziger AN; Bertino JS Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs	0	0
12670	7	12670 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(1):C85-C92 Lax A; Soler F; Fernandez-Belda F Inhibition of sarcoplasmic reticulum Ca2+-ATPase by miconazole	0	0
12671	8	12671 2002 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 282(2):G338-G348 Takahashi M; Tsuboyama-Kasaoka N; Nakatani T; Ishii M; Tsutsumi S; Aburatani H; Ezaki O Fish oil feeding alters liver gene expressions to defend against PPAR alpha activation and ROS production	4	0
12672	11	12672 2002 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 283(5):H1936-H1942 Snyder GD; Krishna UM; Falck JR; Spector AA Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle	1	0
12673	3	12673 2002 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 283(3):R598-R603 Veauvy CM; Wang YX; Walsh PJ; Perez-Pinzon MA Comparison of the effects of ammonia on brain mitochondrial function in rats and gulf toadfish	0	0
12674	1	12674 2002 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 282(6):F981-F990 Michea L; Combs C; Andrews P; Dmitrieva N; Burg MB Mitochondrial dysfunction is an early event in high-NaCl- induced apoptosis of mIMCD3 cells	3	0
12675	5	12675 2002 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 166(1):118-119 Wasserman K Mitochondrial disorders and exertional intolerance: Controversy continues	0	0
12676	6	12676 2002 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 166(1):119-120 Flaherty KR; Blaivas MM; Wald J; Rubenfire M; Martinez FJ; Weisman IM; Zeballos RJ Mitochondrial disorders and exertional intolerance: Controversy continues	0	0
12677	7	12677 2002 ANAESTHESIST 51(1):2-15 Papp-Jambor C; Jaschinski U; Forst H Cytochrome P450 enzymes and their role in drug interactions	1	0
12678	12	12678 2002 ANALYTICA CHIMICA ACTA 457(2):165-171 Li XF; Ma MS; Cheng A; Zheng J; Tam YK Determination of testosterone and its metabolites using liquid chromatography with elevated column temperature and flow-rate gradient	0	0
12679	14	12679 2002 ANALYTICA CHIMICA ACTA 465(1-2):227-236 Yamane M High-performance liquid chromatography-thermo spray ionization- mass spectrometry of the oxidation products of polyunsaturated- fatty acids	0	0
12680	9	12680 2002 ANALYTICAL BIOCHEMISTRY 300(2):121-131 Endrizzi K; Fischer J; Klein K; Schwab M; Nussler A; Neuhaus P; Eichelbaum M; Zanger UM Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction	0	0
12681	7	12681 2002 ANNALS OF NEUROLOGY 51(1):38-44 Taivassalo T; Abbott A; Wyrick P; Haller RG Venous oxygen levels during aerobic forearm exercise: An index of impaired oxidative metabolism in mitochondrial myopathy	3	1
12682	12	12682 2002 ANNUAL REVIEW OF NUTRITION 22():139-166 Omdahl JL; Morris HA; May BK Hydroxylase enzymes of the vitamin D pathway: Expression, function, and regulation	1	0
12683	38	12683 2002 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 42():1-+ Goodwin B; Redinbo MR; Kliewer SA Regulation of CYP3A gene transcription by the pregnane X receptor	23	5
12684	2	12684 2002 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 42():113-133 Altman RB; Klein TE Challenges for biomedical informatics and pharmacogenomics	6	0
12685	29	12685 2002 ANNUAL REVIEW OF PHYSIOLOGY 64():93-127 Simpson ER; Clyne C; Rubin G; Boon WC; Robertson K; Britt K; Speed C; Jones M Aromatase - A brief overview	8	1
12686	9	12686 2002 ANTICANCER RESEARCH 22(2A):863-868 Liu H; Baliga M; Baliga R Effect of cytochrome p450 2E1 inhibitors on cisplatin-induced cytotoxicity to renal proximal tubular epithelial cells	1	1
12687	5	12687 2002 ANTICANCER RESEARCH 22(3):1699-1703 Huynh HT; Teel RW Effects of plant-derived phenols on rat liver cytochrome p450 2B1 activity	1	0
12688	8	12688 2002 ANTIOXIDANTS & REDOX SIGNALING 4(5):701-709 Jones BE; Liu HL; Lo CR; Koop DR; Czaja MJ Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress	0	0
12689	5	12689 2002 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 68(2):560-568 Buhler B; Witholt B; Hauer B; Schmid A Characterization and application of xylene monooxygenase for multistep biocatalysis	7	1
12690	7	12690 2002 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 58(1):97-105 Ichinose H; Wariishi H; Tanaka H Identification and characterization of novel cytochrome P450 genes from the white-rot basidiomycete, Coriolus versicolor	7	0
12691	10	12691 2002 AQUATIC TOXICOLOGY 60(3-4):269-283 Ortiz-Delgado JB; Sarasquete C; Behrens A; de Canales MLG; Segner H Expression, cellular distribution and induction of cytochrome P4501A (CYP1A) in gilthead seabream, Sparus aurata, brain	0	0
12692	0	12692 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 397(2):137-138 Estabrook RW Introduction - Earl R. Stadtman: A conqueror of enzymes and maker of kings	0	0
12693	7	12693 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 400(1):63-75 Davis CA; Dhawan IK; Johnson MK; Barber MJ Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: Identification of histidines 62 and 85 as the heme axial ligands	0	0
12694	11	12694 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 404(2):326-334 Iba MM; Nguyen T; Fung J CYP1A1 induction by pyridine and its metabolites in HepG2 cells	0	0
12695	16	12695 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 407(1):95-102 Headlam MJ; Tuckey RC The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration	0	0
12696	6	12696 2002 ARCHIVES OF NEUROLOGY 59(9):1395-1402 Haller RG; Vissing J Spontaneous "second wind" and glucose-induced second "second wind" in McArdle disease - Oxidative mechanisms	1	0
12697	5	12697 2002 ARCHIVES OF PHARMACAL RESEARCH 25(3):375-380 Chung I; Jung K No role of protected region B of human cytochrome P4501A2 gene (CYP1A2) as an AP-1 response element	0	0
12698	7	12698 2002 ARCHIVES OF TOXICOLOGY 76(5-6):326-334 Roos PH; Tschirbs S; Welge P; Hack A; Theegarten D; Mogilevski G; Wilhelm M Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH)	0	0
12699	10	12699 2002 ARCHIVES OF TOXICOLOGY 76(11):621-627 Haag M; Leusink-Muis T; Le Bouquin R; Nijkamp FP; Lugnier A; Frossard N; Folkerts G; Pons F Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma	0	0
12700	8	12700 2002 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 52(10):745-753 Fujino H; Yamada I; Shimada S; Nagao T; Yoneda M Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3- hydroxy-3-methylglutaryl coenzyme a reductase - Effects on drug-metabolizing systems in rats and humans	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12701	9	12701 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293(3):969-973 Nakamura K; Ariyoshi N; Yokoi T; Ohgiya S; Chida M; Nagashima K; Inoue K; Kodama T; Shimada N; Kamataki T CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability	0	0
12702	12	12702 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 294(5):1071-1078 Sumita T; Iida T; Yamagami S; Horiuchi H; Takagi M; Ohta A YlALK1 encoding the cytochrome P450ALK1 in Yarrowia lipolytica is transcriptionally induced by n-alkane through two distinct cis-elements on its promoter	0	0
12703	10	12703 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 297(1):65-70 Zhu ZY; Hotchkiss SA; Boobis AR; Edwards RJ Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes	0	0
12704	13	12704 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 298(2):277-281 Barque JP; Abahamid A; Flinois JP; Beaune P; Bonaly J Constitutive overexpression of immunoidentical forms of PCP- induced Euglena gracilis CYP-450	0	0
12705	2	12705 2002 BIOCHEMICAL JOURNAL 362():413-422 Alpert E; Gruzman A; Totary H; Kaiser N; Reich R; Sasson S A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid	2	1
12706	13	12706 2002 BIOCHEMICAL JOURNAL 363():297-303 Lundell K Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]	0	0
12707	9	12707 2002 BIOCHEMICAL PHARMACOLOGY 63(4):615-624 De Matteis F; Dawson SJ; Pons N; Pipino S Bilirubin and uroporphyrinogen oxidation by induced cytochrome P4501A and cytochrome P4502B - Role of polyhalogenated biphenyls of different configuration	0	0
12708	18	12708 2002 BIOCHEMICAL PHARMACOLOGY 63(5):889-896 Kobayashi K; Urashima K; Shimada N; Chiba K Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat	7	1
12709	14	12709 2002 BIOCHEMICAL PHARMACOLOGY 63(9):1599-1608 Morisseau C; Goodrow MH; Newman JW; Wheelock CE; Dowdy DL; Hammock BD Structural refinement of inhibitors of urea-based soluble epoxide hydrolases	4	2
12710	28	12710 2002 BIOCHEMICAL PHARMACOLOGY 64(10):1447-1460 Ma JX; Bradbury JA; King L; Maronpot R; Davis LS; Breyer MD; Zeldin DC Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform	0	0
12711	16	12711 2002 BIOCHEMISTRY 41(7):2311-2321 Bureik M; Schiffler B; Hiraoka Y; Vogel F; Bernhardt R Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1	2	1
12712	15	12712 2002 BIOCHEMISTRY 41(26):8310-8320 Usanov SA; Graham SE; Lepesheva GI; Azeva TN; Strushkevich NV; Gilep AA; Estabrook RW; Peterson JA Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: Evaluating site-directed mutations by molecular modeling	0	0
12713	19	12713 2002 BIOCHEMISTRY 41(30):9438-9447 Kim JS; Ahn T; Yim SK; Yun CH Differential effect of copper (II) on the cytochrome P450 enzymes and NADPH-cytochrome P450 reductase: Inhibition of cytochrome P450-catalyzed reactions by copper (II) ion	0	0
12714	17	12714 2002 BIOCHEMISTRY 41(36):11025-11034 Guengerich FP; Miller GP; Hanna IH; Martin MV; Leger S; Black C; Chauret N; Silva JM; Trimble LA; Yergey JA; Nicoll-Griffith DA Diversity in the oxidation of substrates by cytochrome P450 2D6: Lack of an obligatory role of aspartate 301 - Substrate electrostatic bonding	8	5
12715	9	12715 2002 BIOCHEMISTRY 41(46):13514-13525 Kariakin A; Davydov D; Peterson JA; Jung C A new approach to the study of protein-protein interaction by FTIR: Complex formation between cytochrome P450BM-3 heme domain and FMN reductase domain	0	0
12716	7	12716 2002 BIOCHEMISTRY 41(49):14499-14508 Prasad S; Mitra S Role of protein and substrate dynamics in catalysis by Pseudomonas putida cytochrome P450(cam)	0	0
12717	12	12717 2002 BIOCHEMISTRY-MOSCOW 67(4):456-467 Shkumatov VM; Usova EV; Poljakov YS; Frolova NS; Radyuk VG; Mauersberger S; Chernogolov AA; Honeck H; Schunck WH Biotransformation of steroids by a recombinant yeast strain expressing bovine cytochrome P-45017 alpha	1	0
12718	5	12718 2002 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1595(1-2):80-93 Lange R; Balny C UV-visible derivative spectroscopy under high pressure	3	0
12719	12	12719 2002 BIOLOGICAL CHEMISTRY 383(6):923-932 Rueff J; Gaspar J; Kranendonk M DNA polymorphisms as modulators of genotoxicity and cancer	0	0
12720	34	12720 2002 BIOLOGICAL CHEMISTRY 383(10):1537-1551 Bureik M; Lisurek M; Bernhardt R The human steroid hydroxylases CYP11B1 and CYP11B2	0	0
12721	56	12721 2002 BIOLOGICAL CHEMISTRY 383(10):1553-1564 Guengerich FP Rate-limiting steps in cytochrome P450 catalysis	0	0
12722	10	12722 2002 BIOLOGICAL TRACE ELEMENT RESEARCH 89(2):177-190 Iscan M; Ada AO; Coban T; Kapucuoglu N; Aydin A; Isimer A Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats	0	0
12723	1	12723 2002 BIOLOGICHESKIE MEMBRANY 19(6):451-471 Azizova OA Role of free radical processes in the development of atherosclerosis	0	0
12724	5	12724 2002 BIOMARKERS 7(3):209-229 Nia AB; Kleinjans JCS; Van Schooten FJ Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons	1	0
12725	3	12725 2002 BIOMEDICAL CHROMATOGRAPHY 16(3):199-202 Maboudou P; Matheiu D; Bachelet H; Wiart JF; Lhermitte M Detection of oxidative stress. Interest of GC-MS for malondialdehyde and formaldehyde monitoring	1	0
12726	2	12726 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(4):969-973 Ohta T; Nagahashi M; Hosoi S; Tsukamoto S Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor	2	1
12727	4	12727 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(8):2479-2483 Yu BW; Ruppert M; Stockigt J Deoxysarpagine hydroxylase - A novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia	0	0
12728	4	12728 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(9):2981-2985 Tsukamoto S; Tomise K; Miyakawa K; Cha BC; Abe T; Hamada T; Hirota H; Ohta T CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper	1	0
12729	5	12729 2002 BIOPHYSICAL JOURNAL 82(1):99-108 Reijenga KA; Westerhoff HV; Kholodenko BN; Snoep JL Control analysis for autonomously oscillating biochemical networks	6	0
12730	4	12730 2002 BIOPHYSICAL JOURNAL 82(5):2811-2825 Huang SH; Heikal AA; Webb WW Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein	4	0
12731	17	12731 2002 BIOSENSORS & BIOELECTRONICS 17(1-2):119-131 Tsotsou GE; Cass AEG; Gilardi G High throughput assay for cytochrome P450BM3 for screening libraries of substrates and combinatorial mutants	2	1
12732	10	12732 2002 BIOSENSORS & BIOELECTRONICS 17(3):233-238 Shumyantseva VV; Bulko TV; Schmid RD; Archakov AI Photochemical properties of a riboflavins/cytochrome P4502B4 complex	1	1
12733	5	12733 2002 BIOTECHNOLOGY AND BIOENGINEERING 80(1):33-41 Panke S; Held M; Wubbolts MG; Witholt B; Schmid A Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase	6	1
12734	13	12734 2002 BRITISH JOURNAL OF CANCER 87(6):681-686 Martinez C; Garcia-Martin E; Pizarro RM; Garcia-Gamito FJ; Agundez JAG Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy	1	0
12735	4	12735 2002 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 53(4):393-397 Cho JY; Yu KS; Jang IJ; Yang BH; Shin SG; Yim DS Omeprazole hydroxylation is inhibited by a single dose of moclobemide in homozygotic EM genotype for CYP2C19	1	0
12736	9	12736 2002 BRITISH JOURNAL OF PHARMACOLOGY 135(4):977-986 Krauskopf A; Buetler TM; Nguyen NSD; Mace K; Ruegg UT Cyclosporin A-induced free radical generation is not mediated by cytochrome P-450	1	0
12737	3	12737 2002 BUNSEKI KAGAKU 51(1):13-19 Maehana K; Tani H; Kamataki T; Kamidate T Affinity partitioning of histidine-tagged cytochrome b(5) and an oligopeptide in an aqueous micellar two-phase system containing a metal-chelating polymer	0	0
12738	5	12738 2002 CANADIAN JOURNAL OF MICROBIOLOGY 48(1):49-59 Morgan CA; Wyndham RC Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a	1	0
12739	3	12739 2002 CARCINOGENESIS 23(7):1095-1102 Grover PL; Martin FL The initiation of breast and prostate cancer	0	0
12740	2	12740 2002 CELL BIOCHEMISTRY AND FUNCTION 20(1):47-59 Hemmings SJ; Pulga VB; Tran ST; Uwiera RRE Differential inhibitory effects of carbon tetrachloride on the hepatic plasma membrane, mitochondrial and endoplasmic reticular calcium transport systems: implications to hepatotoxicity	1	0
12741	44	12741 2002 CELLULAR AND MOLECULAR LIFE SCIENCES 59(5):780-789 Capdevila JH; Harris RC; Falck JR Microsomal cytochrome P450 and eicosanoid metabolism	1	1
12742	2	12742 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(3):332-342 Platt KL; Degenhardt C; Grupe S; Frank H; Seidel A Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites	0	0
12743	5	12743 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(7):927-934 Miller RT Dinitrobenzene-mediated production of peroxynitrite by neuronal nitric oxide synthase	1	0
12744	17	12744 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(12):1561-1571 Blobaum AL; Kent UM; Alworth WL; Hollenberg PF Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: Characterization of reactive intermediate adducts to the heme and apoprotein	0	0
12745	18	12745 2002 CHEMICAL REVIEWS 102(4):1019-1065 Lee J; Chen L; West AH; Richter-Addo GB Interactions of organic nitroso compounds with metals	2	0
12746	2	12746 2002 CHEMICAL SENSES 27(6):529-537 Giorgi D; Rouquier S Identification of V1R-like putative pheromone receptor sequences in non-human primates. Characterization of V1R pseudogenes in marmoset, a primate species that possesses an intact vomeronasal organ	1	0
12747	11	12747 2002 CHEMISTRY & BIOLOGY 9(5):555-565 Valderrama B; Ayala M; Vazquez-Duhalt R Suicide inactivation of peroxidases and the challenge of engineering more robust enzymes	0	0
12748	4	12748 2002 CHINESE JOURNAL OF CHEMISTRY 20(11):1225-1234 Wu J; Wang YH; Gan JH; Wang WH; Sun BY; Huang ZX; Xia ZX Structures of cytochrome b(5) mutated at the charged surface- residues and their interactions with cytochrome c	0	0
12749	13	12749 2002 CLINICA CHIMICA ACTA 325(1-2):117-125 Abraham P; Wilfred G; Ramakrishna B Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat	0	0
12750	7	12750 2002 CLINICAL NEUROPHARMACOLOGY 25(5):280-289 Mula M; Monaco F Antiepileptic-antipsychotic drug interactions: A critical review of the evidence	0	0
12751	51	12751 2002 CLINICAL PHARMACOKINETICS 41(12):959-998 Alcorn J; McNamara PJ Ontogeny of hepatic and renal systemic clearance pathways in infants - Part I	3	0
12752	12	12752 2002 CLINICAL PHARMACOLOGY & THERAPEUTICS 71(3):196-204 Garcia-Martin E; Martinez C; Pizarro RM; Garcia-Gamito FJ; Gullsten H; Raunio H; Agundez JAG CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity	2	0
12753	7	12753 2002 CNS DRUGS 16(4):229-247 Naguib M; Koorn R Interactions between psychotropics, anaesthetics and electroconvulsive therapy - Implications for drug choice and patient management	1	0
12754	15	12754 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 132(2):181-191 Tilley RE; Kemp GD; Teramitsu I; Hall AJ Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus)	0	0
12755	18	12755 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 133(4):613-624 Arukwe A Complementary DNA cloning, sequence analysis and differential organ expression of beta-naphthoflavone-inducible cytochrome P4501A in Atlantic salmon (Salmo salar)	0	0
12756	52	12756 2002 CRITICAL REVIEWS IN TOXICOLOGY 32(5):391-411 Hukkanen J; Pelkonen A; Hakkola J; Raunio H Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung	2	0
12757	19	12757 2002 CURRENT DRUG METABOLISM 3(1):39-59 de Kanter R; Monshouwer M; Meijer DKF; Groothuis GMM Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues	3	0
12758	2	12758 2002 CURRENT DRUG METABOLISM 3(1):97-113 Perek N; Denoyer D The multidrug resistance mechanisms and their interactions with the radiopharmaceutical probes used for an in vivo detection	0	0
12759	9	12759 2002 CURRENT DRUG METABOLISM 3(3):233-255 Conaway CC; Yang YM; Chung FL Isothiocyanates as cancer chemopreventive agents: Their biological activities and metabolism in rodents and humans	2	0
12760	7	12760 2002 CURRENT DRUG METABOLISM 3(5):481-490 Rushmore TH; Kong ANT Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes	3	0
12761	121	12761 2002 CURRENT DRUG METABOLISM 3(6):561-597 Danielson PB The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans	4	0
12762	27	12762 2002 CURRENT OPINION IN BIOTECHNOLOGY 13(6):557-564 Urlacher V; Schmid RD Biotransformations using prokaryotic P450 monooxygenases	1	1
12763	22	12763 2002 CURRENT OPINION IN CHEMICAL BIOLOGY 6(2):130-135 Cirino PC; Arnold FH Protein engineering of oxygenases for biocatalysis	8	2
12764	29	12764 2002 CURRENT PHARMACEUTICAL DESIGN 8(15):1335-1347 Patterson LH; Murray GI Tumour cytochrome P450 and drug activation	3	0
12765	18	12765 2002 CYTOCHROME P450, PT C 357():261-276 Shou MG Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450	0	0
12766	14	12766 2002 CYTOCHROME P450, PT C 357():301-310 Kamataki B; Fujita K Mutagenesis testing based on bacterial expression of human P450s	0	0
12767	12	12767 2002 CYTOCHROME P450, PT C 357():370-381 Kutchan TM; Schroder J Selected cell cultures and induction methods for cloning and assaying cytochromes P450 in alkaloid pathways	0	0
12768	1	12768 2002 DIGESTION 66(2):79-88 Kiba T The role of the autonomic nervous system in liver regeneration and apoptosis - Recent developments	1	0
12769	1	12769 2002 DNA AND CELL BIOLOGY 21(4):281-295 Stojiljkovic I; Perkins-Balding D Processing of heme and heme-containing proteins by bacteria	2	0
12770	11	12770 2002 DRUG METABOLISM AND DISPOSITION 30(1):86-95 Wang QM; Halpert JR Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P4502B6 substrates and protein homology modeling	11	3
12771	10	12771 2002 DRUG METABOLISM AND DISPOSITION 30(2):177-182 Shaw AA; Hall SD; Franklin MR; Galinsky RE The influence of L-glutamine on the depression of hepatic cytochrome P450 activity in male rats caused by total parenteral nutrition	1	0
12772	6	12772 2002 DRUG METABOLISM AND DISPOSITION 30(3):235-239 Suzuki H; Kneller MB; Haining RL; Trager WF; Rettie AE (+)-N-3-benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19	2	0
12773	5	12773 2002 DRUG METABOLISM AND DISPOSITION 30(3):270-275 Fisher MB; Jackson D; Kaerner A; Wrighton SA; Borel AG Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarinin human liver microsomes treated with alamethicin	0	0
12774	10	12774 2002 DRUG METABOLISM AND DISPOSITION 30(3):314-318 Zhang WJ; Ramamoorthy Y; Kilicarslan T; Nolte H; Tyndale RF; Sellers EM Inhibition of cytochromes P450 by antifungal imidazole derivatives	3	1
12775	24	12775 2002 DRUG METABOLISM AND DISPOSITION 30(4):355-362 Hutzler JM; Tracy TS Atypical kinetic profiles in drug metabolism reactions	5	2
12776	8	12776 2002 DRUG METABOLISM AND DISPOSITION 30(4):391-396 Hanioka N; Ozawa S; Jinno H; Tanaka-Kagawa T; Nishimura T; Ando M; Sawada JI Interaction of irinotecan (CPT-11) and its active metabolite 7- ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes	0	0
12777	9	12777 2002 DRUG METABOLISM AND DISPOSITION 30(5):570-575 Ripp SL; Fitzpatrick JL; Peters JM; Prough RA Induction of CYP3A expression by dehydroepiandrosterone: Involvement of the pregnane X receptor	3	3
12778	10	12778 2002 DRUG METABOLISM AND DISPOSITION 30(6):701-708 Mei Q; Tang CY; Lin Y; Rushmore TH; Shou MG Inhibition kinetics of monoclonal antibodies against cytochromes P450	3	0
12779	16	12779 2002 DRUG METABOLISM AND DISPOSITION 30(8):883-891 Williams JA; Ring BJ; Cantrell VE; Jones DR; Eckstein J; Ruterbories K; Hamman MA; Hall SD; Wrighton SA Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7	10	4
12780	6	12780 2002 DRUG METABOLISM AND DISPOSITION 30(8):904-910 Ishigami M; Takasaki W; Ikeda T; Komai T; Ito K; Sugiyama Y Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in rat liver microsomes	0	0
12781	18	12781 2002 DRUG METABOLISM AND DISPOSITION 30(9):970-976 Hiroi T; Chow T; Imaoka S; Funae Y Catalytic specificity of CYP2D isoforms in rat and human	1	1
12782	15	12782 2002 DRUG METABOLISM AND DISPOSITION 30(9):1022-1028 Kalsotra A; Anakk S; Boehme CL; Strobel HW Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats	3	0
12783	8	12783 2002 DRUG METABOLISM AND DISPOSITION 30(9):1029-1034 El-Sankary W; Bombail V; Gibson GG; Plant N Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element	4	0
12784	29	12784 2002 DRUG METABOLISM AND DISPOSITION 30(12):1406-1412 Lee SJ; Buhler DR Functional properties of a rainbow trout CYP3A27 expressed by recombinant baculovirus in insect cells	1	1
12785	16	12785 2002 DRUG METABOLISM AND DISPOSITION 30(12):1491-1496 Shih PS; Huang JD Pharmacokinetics of midazolam and 1 '-hydroxymidazolam in Chinese with different CYP3A5 genotypes	1	0
12786	15	12786 2002 DRUG METABOLISM REVIEWS 34(1-2):69-82 Lewis DFV; Modi S; Dickins M Structure-activity relationship for human cytochrome P450 substrates and inhibitors	5	0
12787	306	12787 2002 DRUG METABOLISM REVIEWS 34(1-2):83-448 Rendic S Summary of information on human CYP enzymes: Human P450 metabolism data	9	1
12788	55	12788 2002 DRUG METABOLISM REVIEWS 34(3):451-477 Hlavica P N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication	0	0
12789	15	12789 2002 DRUG METABOLISM REVIEWS 34(3):667-676 Kamataki T; Fujita K; Nakayama K; Yamazaki Y; Miyamoto M; Ariyoshi N Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: Application of genetically engineered Salmonella expressing human CYP	0	0
12790	8	12790 2002 DRUGS & AGING 19(4):299-320 Spina E; Scordo MG Clinically significant drug interactions with antidepressants in the elderly	2	0
12791	5	12791 2002 ENDOCRINE RESEARCH 28(4):435-441 Johnson EF; Wester MR; Stout CD The structure of microsomal cytochrome p450 2C5: A steroid and drug metabolizing enzyme	1	0
12792	33	12792 2002 ENDOCRINE REVIEWS 23(5):687-702 Kliewer SA; Goodwin B; Willson TM The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism	2	0
12793	19	12793 2002 ENDOCRINOLOGY 143(9):3361-3369 Moran FM; Ford JJ; Corbin CJ; Mapes SM; Njar VC; Brodie AM; Conley AJ Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig	1	1
12794	11	12794 2002 ENDOCRINOLOGY 143(12):4665-4672 Arlt W; Martens JWM; Song MS; Wang JT; Auchus RJ; Miller WL Molecular evolution of adrenarche: Structural and functional analysis of P450c17 from four primate species	1	0
12795	5	12795 2002 ENVIRONMENTAL HEALTH PERSPECTIVES 110():451-488 Bostrom CE; Gerde P; Hanberg A; Jernstrom B; Johansson C; Kyrklund T; Rannug A; Tornqvist M; Victorin K; Westerholm R Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air	5	0
12796	2	12796 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(3):527-531 Tavera-Mendoza L; Ruby S; Brousseau P; Fournier M; Cyr D; Marcogliese D Response of the amphibian tadpole (Xenopus laevis) to atrazine during sexual differentiation of the testis	4	0
12797	10	12797 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(9):1845-1853 Hawkins SA; Billiard SM; Tabash SP; Brown RS; Hodson PV Altering cytochrome p4501a activity affects polycyclic aromatic hydrocarbon metabolism and toxicity in rainbow trout (Oncorhynchus mykiss)	0	0
12798	6	12798 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(10):2027-2033 Ziccardi MH; Gardner IA; Denison MS Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons	1	0
12799	5	12799 2002 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 11(1):1-7 Ikeda M; Inukai N; Mitsui T; Sone H; Yonemoto J; Tohyama C; Tomita T Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats	0	0
12800	5	12800 2002 EPILEPSIA 43():37-44 Spina E; Perucca E Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12801	11	12801 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(7):1799-1805 Kisselev P; Schwarz D; Platt KL; Schunck WH; Roots I Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes	1	0
12802	20	12802 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(8):2075-2082 Kitazume T; Tanaka A; Takaya N; Nakamura A; Matsuyama S; Suzuki T; Shoun H Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system	0	0
12803	11	12803 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(15):3838-3846 Bulow HE; Bernhardt R Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity	1	1
12804	15	12804 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(22):5608-5616 Swart AC; Kolar NW; Lombard N; Mason JI; Swart P Baboon cytochrome P450 17 alpha-hydroxylase/17,20-lyase (CYP17) - Characterization of the adrenal microsomal and cloned enzymes	1	0
12805	6	12805 2002 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 58(5):333-337 Xu P; Huang SL; Zhu RH; Han XM; Zhou HH Phenotypic polymorphism of CYP2A6 activity in a Chinese population	0	0
12806	18	12806 2002 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 58(5):357-365 Sy SKB; Ciaccia A; Li W; Roberts EA; Okey A; Kalow W; Tang BK Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression	1	0
12807	2	12807 2002 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 27(2):107-111 Cui ZF; He P; Luo M; Xia SQ; Wu MC Phenacetin O-deethylation in extrahepatic tissues of rats	0	0
12808	5	12808 2002 EUROPEAN JOURNAL OF ENDOCRINOLOGY 147(6):717-725 Xita N; Georgiou I; Tsatsoulis A The genetic basis of polycystic ovary syndrome	0	0
12809	8	12809 2002 EUROPEAN JOURNAL OF PHARMACOLOGY 449(1-2):61-69 Costa B; Parolaro D; Colleoni M Chronic treatment with the endocannabinoid anandamide increases cytochrome P450 metabolizing system in the rat	0	0
12810	1	12810 2002 EXPERIMENTAL BIOLOGY AND MEDICINE 227(8):561-569 Dmitrieva RI; Doris PA Cardiotonic steroids: Potential endogenous sodium pump ligands with diverse function	1	0
12811	14	12811 2002 FASEB JOURNAL 16(12):1537-1549 Thum T; Borlak J Testosterone, cytochrome P450, and cardiac hypertrophy	2	0
12812	6	12812 2002 FEBS LETTERS 512(1-3):121-124 Rastogi S; Das M; Khanna SK A novel approach to study the activity and stoichiometry simultaneously for microsomal pentoxyresorufin-O-dealkylase reaction	0	0
12813	6	12813 2002 FEBS LETTERS 528(1-3):90-94 Matsunaga I; Sumimoto T; Ayata M; Ogura H Functional modulation of a peroxygenase cytochrome P450: novel insight into the mechanisms of peroxygenase and peroxidase enzymes	0	0
12814	1	12814 2002 FEMS YEAST RESEARCH 2(2):123-135 Gurvitz A; Hartig A; Ruis H; Hamilton B; de Couet HG Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster	0	0
12815	7	12815 2002 FOOD AND CHEMICAL TOXICOLOGY 40(1):53-63 Laurenzana EM; Weis CC; Bryant CW; Newbold R; Delclos KB Effect of dietary administration of genistein, nonylphenol or ethinyl estradiol on hepatic testosterone metabolism, cytochrome P-450 enzymes, and estrogen receptor alpha expression	1	0
12816	9	12816 2002 FOOD AND CHEMICAL TOXICOLOGY 40(11):1685-1692 Jeong HG; Kim JY Effects of o,p '-DDT on the 2,3,7,8-tetrachlorodibenzo-p- dioxin-inducible CYP1A1 expression in murine Hepa-lc1c7 cells	0	0
12817	2	12817 2002 FREE RADICAL BIOLOGY AND MEDICINE 32(8):702-711 Navarro-Antolin J; Lopez-Munoz MJ; Soria J; Lamas S Superoxide limits cyclosporine-A-induced formation of peroxynitrite in endothelial cells	2	0
12818	7	12818 2002 FUNGAL GENETICS AND BIOLOGY 35(2):135-146 Fraser JA; Davis MA; Hynes MJ The genes gmdA, encoding an amidase, and bzuA, encoding a cytochrome P450, are required for benzamide utilization in Aspergillus nidulans	0	0
12819	14	12819 2002 GENE 297(1-2):179-187 Cui XM; Strobel HW Cloning and characterization of the rat cytochrome P4504F5 (CYP4F5) gene	0	0
12820	3	12820 2002 GENE 299(1-2):235-243 Carre W; Bourneuf E; Douaire M; Diot C Differential expression and genetic variation of hepatic messenger RNAs from genetically lean and fat chickens	1	0
12821	1	12821 2002 GENE THERAPY 9(3):183-191 Zhong Z; Froh M; Wheeler MD; Smutney O; Lehmann TG; Thurman RG Viral gene delivery of superoxide dismutase attenuates experimental cholestasis-induced liver fibrosis in the rat	2	1
12822	5	12822 2002 GENERAL AND COMPARATIVE ENDOCRINOLOGY 126(3):279-286 Vilchis F; Chavez B; Larrea F; Timossi C; Montiel F The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus)	0	0
12823	2	12823 2002 GENOMICS 79(4):464-470 Wain HM; Bruford EA; Lovering RC; Lush MJ; Wright MW; Povey S Guidelines for human gene nomenclature	15	1
12824	1	12824 2002 HAEMOPHILIA 8(3):221-229 Evatt BL; Farrugia A; Shapiro AD; Wilde JT Haemophilia 2002: emerging risks of treatment	2	0
12825	1	12825 2002 HEPATOLOGY 35(3):732-733 Kullak-Ublick GA; Jung D; Hagenbuch B; Meier PJ Organic anion transporting polypeptides, cholestasis, and nuclear receptors	0	0
12826	2	12826 2002 HEPATOLOGY 35(6):1351-1359 Kamiya A; Kojima N; Kinoshita T; Sakai Y; Miyaijma A Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: Induction of tryptophan oxygenase	2	0
12827	11	12827 2002 HORMONE RESEARCH 57(5-6):145-152 Meinhardt U; Mullis PE The aromatase cytochrome P-450 and its clinical impact	3	0
12828	9	12828 2002 HUMAN & EXPERIMENTAL TOXICOLOGY 21(1):17-23 Eke BC; Iscan M Effects of cigarette smoke with different tar contents on hepatic and xenobiotic metabolizing pulmonary enzymes in rats	0	0
12829	5	12829 2002 HUMAN MUTATION 20(6):463-472 Nebert DW Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes	0	0
12830	11	12830 2002 HYPERTENSION 39(2):690-694 Imig JD; Zhao XY; Capdevila JH; Morisseau C; Hammock BD Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension	9	3
12831	9	12831 2002 INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 39(3):191-196 Rastogi S; Khanna SK; Das M A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450IIB 1/2: Comparison with fluorometric assay	1	0
12832	12	12832 2002 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):303-309 He H; Chen AC; Davey RB; Ivie GW Molecular cloning and nucleotide sequence of a new P450 gene, CYP319A1, from the cattle tick, Boophilus microplus	0	0
12833	7	12833 2002 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):311-320 Li XC; Berenbaum MR; Schuler MA Cytochrome P450 and actin genes expressed in Helicoverpa zea and Helicoverpa armigera: paralogy/orthology identification, gene conversion and evolution	4	0
12834	12	12834 2002 INSECT MOLECULAR BIOLOGY 11(3):273-281 Maibeche-Coisne M; Jacquin-Joly E; Francois MC; Nagnan-Le Meillour P cDNA cloning of biotransformation enzymes belonging to the cytochrome P450 family in the antennae of the noctuid moth Mamestra brassicae	0	0
12835	12	12835 2002 INSECT MOLECULAR BIOLOGY 11(5):409-418 Ranson H; Nikou D; Hutchinson M; Wang X; Roth CW; Hemingway J; Collins FH Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae	2	0
12836	1	12836 2002 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 31(2):250-251 Tesiorowski AM; Harris M; Chan KJ; Thompson CR; Montaner JSG Anaerobic threshold and random venous lactate levels among HIV- positive patients on antiretroviral therapy	1	0
12837	1	12837 2002 JOURNAL OF ADVERTISING RESEARCH 42(2):80-92 Nelson MR Recall of brand placements in computer/video games	0	0
12838	4	12838 2002 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50(2):378-383 Wu CC; Sheen LY; Chen HW; Kuo WW; Tsai SJ; Lii CK Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats	4	0
12839	3	12839 2002 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50(12):3533-3539 Kubo I; Masuoka N; Xiao P; Haraguchi H Antioxidant activity of dodecyl gallate	0	0
12840	20	12840 2002 JOURNAL OF APPLIED PHYSIOLOGY 93(1):330-337 Zhu DL; Zhang CY; Medhora M; Jacobs ER CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium	2	1
12841	3	12841 2002 JOURNAL OF BACTERIOLOGY 184(11):2963-2968 Kumon Y; Sasaki Y; Kato I; Takaya N; Shoun H; Beppu T Codenitrification and denitrification are dual metabolic pathways through which dinitrogen evolves from nitrate in Streptomyces antibioticus	1	0
12842	10	12842 2002 JOURNAL OF BACTERIOLOGY 184(14):3898-3908 Roberts GA; Grogan G; Greter A; Flitsch SL; Turner NJ Identification of a new class of cytochrome P450 from a Rhodococcus sp.	3	0
12843	10	12843 2002 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 16(2):84-95 Seubert JM; Sinal CJ; Bend JR Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat	0	0
12844	36	12844 2002 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 16(6):311-316 Porter TD The roles of cytochrome b(5) in cytochrome P450 reactions	2	2
12845	16	12845 2002 JOURNAL OF BIOCHEMISTRY 131(1):71-78 Furukawa M; Okubo T; Ogino M; Yamazaki T; Shimada M; Nagata K; Yamazoe Y Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation	0	0
12846	8	12846 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):5882-5890 Finta C; Zaphiropoulos PG Intergenic mRNA molecules resulting from trans-splicing	11	2
12847	15	12847 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(18):15647-15653 Baader M; Gnerre C; Stegeman JJ; Meyer UA Transcriptional activation of cytochrome P450CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit	2	1
12848	8	12848 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(27):24000-24005 Lamb DC; Skaug T; Song HL; Jackson CJ; Podust LM; Waterman MR; Kell DB; Kelly DE; Kelly SL The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2)	6	0
12849	3	12849 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26356-26363 Min GS; Kemper JK; Kemper B Glucocorticoid receptor-interacting protein 1 mediates ligand- independent nuclear translocation and activation of constitutive androstane receptor in vivo	1	0
12850	17	12850 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(31):27725-27732 Hawkes DB; Adams GW; Burlingame AL; de Montellano PRO; De Voss JJ Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization	2	0
12851	23	12851 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(32):28351-28363 Coon MJ Enzyme ingenuity in biological oxidations: A trail leading to cytochrome P450	0	0
12852	26	12852 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(37):33711-33719 Guengerich FP; Miller GP; Hanna IH; Sato H; Martin MV Oxidation of methoxyphenethylamines by cytochrome p450 2D6 - Analysis of rate-limiting steps	3	1
12853	11	12853 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(37):33842-33847 Zhang L; Kudo T; Takaya N; Shoun H The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH	1	0
12854	7	12854 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(43):40275-40280 Rosen GM; Tsai P; Weaver J; Porasuphatana S; Roman LJ; Starkov AA; Fiskum G; Pou S The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide	7	1
12855	15	12855 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(49):46959-46965 Jackson CJ; Lamb DC; Marezylo TH; Warrilow AGS; Manning NJ; Lowe DJ; Kelly DE; Kelly SL A novel sterol 14 alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily	0	0
12856	7	12856 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(50):48960-48964 Elmore CL; Porter TD Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in vivo	2	1
12857	8	12857 2002 JOURNAL OF BIOTECHNOLOGY 95(3):257-268 Jose J; Bernhardt R; Hannemann F Cellular surface display of dimeric Adx and whole cell P450- mediated steroid synthesis on E-coli	2	0
12858	8	12858 2002 JOURNAL OF CELLULAR BIOCHEMISTRY 86(3):440-450 Sterling KA; Cutroneo KR Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: Basement membrane-mediated apoptosis	0	0
12859	9	12859 2002 JOURNAL OF CELLULAR BIOCHEMISTRY 87(2):147-159 Wang YJ; Yu CF; Chen LC; Chen CH; Lin JK; Liang YC; Lin CH; Lin SY; Chen CF; Ho YS Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity	2	2
12860	12	12860 2002 JOURNAL OF CHILD NEUROLOGY 17():S85-S93 Glauser TA Advancing the medical management of epilepsy: Disease modification and pharmacogenetics	0	0
12861	14	12861 2002 JOURNAL OF CHROMATOGRAPHIC SCIENCE 40(7):397-402 Li HX; Letcher RJ A high-performance-liquid-chromatography-based method for the determination of hydroxylated testosterone metabolites formed in vitro in liver microsomes from gray seal (Halichoerus grypus)	1	1
12862	1	12862 2002 JOURNAL OF CLINICAL PERIODONTOLOGY 29(3):189-194 Battino M; Ferreiro MS; Gallardo I; Newman HN; Bullon P The antioxidant capacity of saliva	1	1
12863	12	12863 2002 JOURNAL OF ENDOCRINOLOGY 175(3):779-792 Depreter M; Vandesompele J; Espeel M; Speleman F; Roels F Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications	1	0
12864	7	12864 2002 JOURNAL OF HEALTH SCIENCE 48(2):118-125 Hirano Y; Uehara M; Saeki K; Kato T; Takahashi K; Mizutani T The influence of quinolines on coumarin 7-hydroxylation in bovine liver microsomes and human CYP2A6	1	0
12865	3	12865 2002 JOURNAL OF HEALTH SCIENCE 48(4):346-349 Tanaka H; Hirayama I; Takehana M; Kobayashi S; Tamura H Cytochrome P450 expression in rat ocular tissues and its induction by phenobarbital	0	0
12866	4	12866 2002 JOURNAL OF HEPATOLOGY 36(1):72-77 Seo MY; Lee SM Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats	2	0
12867	24	12867 2002 JOURNAL OF HUMAN GENETICS 47(8):419-444 Saito S; Iida A; Sekine A; Ogawa C; Kawauchi S; Higuchi S; Ohno M; Nakamura Y 906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population	1	0
12868	30	12868 2002 JOURNAL OF INORGANIC BIOCHEMISTRY 91(4):502-514 Lewis DFV Modelling human cytochromes P450 involved in drug metabolism from the CYP2C5 crystallographic template	2	0
12869	17	12869 2002 JOURNAL OF INORGANIC BIOCHEMISTRY 91(4):515-526 Fuziwara S; Sagami I; Rozhkova E; Craig D; Noble MA; Munro AW; Chapman SK; Shimizu T Catalytically functional flavocytochrome chimeras of P450BM3 and nitric oxide synthase	1	0
12870	14	12870 2002 JOURNAL OF INORGANIC BIOCHEMISTRY 91(4):527-541 McLean KJ; Cheesman MR; Rivers SL; Richmond A; Leys D; Chapman SK; Reid GA; Price NC; Kelly SM; Clarkson J; Smith WE; Munro AW Expression, purification and spectroscopic characterization of the cytochrome P450CYP121 from Mycobacterium tuberculosis	3	2
12871	1	12871 2002 JOURNAL OF INVERTEBRATE PATHOLOGY 79(1):51-58 Ranasinghe C; Akhurst RJ Matrix assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for detecting novel Bt toxins	1	0
12872	2	12872 2002 JOURNAL OF LIPID RESEARCH 43(1):2-12 Edwards PA; Kast HR; Anisfeld AM BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis	50	1
12873	6	12873 2002 JOURNAL OF LIPID RESEARCH 43(3):359-364 Kliewer SA; Willson TM Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor	9	1
12874	14	12874 2002 JOURNAL OF LIPID RESEARCH 43(9):1563-1578 Newman JW; Watanabe T; Hammock BD The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS	0	0
12875	20	12875 2002 JOURNAL OF MEDICINAL CHEMISTRY 45(10):1983-1993 de Groot MJ; Alex AA; Jones BC Development of a combined protein and pharmacophore model for cytochrome P4502C9	6	0
12876	4	12876 2002 JOURNAL OF NEUROCHEMISTRY 82(5):1252-1261 Sergeeva M; Strokin M; Wang H; Ubl JJ; Reiser G Arachidonic acid and docosahexaenoic acid suppress thrombin- evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation	2	1
12877	18	12877 2002 JOURNAL OF NEUROCHEMISTRY 82(6):1376-1387 Miksys S; Rao Y; Hoffmann E; Mash DC; Tyndale RF Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics	5	0
12878	4	12878 2002 JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 23(3):256-265 Cheng C; Roemer-Becuwe C; Pereira J When midazolam fails	0	0
12879	4	12879 2002 JOURNAL OF PARASITOLOGY 88(1):163-170 Lyddiard JRA; Whitfield PJ; Bartlett A Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae)	0	0
12880	13	12880 2002 JOURNAL OF PHARMACEUTICAL SCIENCES 91(4):952-963 Nakajima M; Tane K; Nakamura S; Shimada N; Yamazaki H; Yokoi T Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: Effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities	3	0
12881	12	12881 2002 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 47(3):143-151 Cui X; Palamanda J; Norton L; Thomas A; Lau YY; White RE; Cheng KC A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction	0	0
12882	13	12882 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 300(1):298-304 Hashizume T; Imaoka S; Mise M; Terauchi Y; Fujii T; Miyazaki H; Kamataki T; Funae Y Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal Microsomes	3	1
12883	11	12883 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 300(2):417-420 Chen CP; Thakker DR The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome P450-mediated metabolism of xenobiotics	0	0
12884	12	12884 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 303(3):945-951 Kondraganti SR; Jiang WW; Moorthy B Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CP1A2 gene	0	0
12885	1	12885 2002 JOURNAL OF PROTEIN CHEMISTRY 21(2):97-104 Lorrai A; Padiglia A; Medda R; Bellelli A; Arcovito A; Floris G Aminoglycosides as substrates and inhibitors of peroxidases: A possible role of these antibiotics against myeloperoxidase- dependent cytotoxicity	0	0
12886	13	12886 2002 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 80(3):273-290 Morfin R Involvement of steroids and cytochromes P-450 species in the triggering of immune defenses	1	0
12887	3	12887 2002 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 82(2-3):209-216 Satoh T; Itoh S; Seki T; Itoh S; Nomura N; Yoshizawa I On the inhibitory action of 29 drugs having side effect gynecomastia on estrogen production	1	1
12888	6	12888 2002 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124(7):1430-1437 Guallar V; Harris DL; Batista VS; Miller WH Proton-transfer dynamics in the activation of cytochrome P450eryF	7	0
12889	15	12889 2002 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124(20):5684-5691 Koo LS; Immoos CE; Cohen MS; Farmer PJ; de Montellano PRO Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119	4	2
12890	3	12890 2002 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124(43):12682-12683 Puchkaev AV; Wakagi T; de Montellano PRO CYP119 plus a Sultolobus tokodaii strain 7 ferredoxin and 2- oxoacid : ferredoxin oxidoreductase constitute a high- temperature cytochrome P450 catalytic system	0	0
12891	1	12891 2002 JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS (3):449-457 Perry CB; Chick T; Ntlokwana A; Davies G; Marques HM The co-ordination of ligands by iron porphyrins: a comparison of ligand binding by myoglobin from sperm whale and the haem undecapeptide from cytochrome c	1	0
12892	3	12892 2002 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 65(17):1247-1260 Ma JYC; Yang HM; Barger MW; Siegel PD; Zhong BZ; Kriech AJ; Castranova V Alteration of pulmonary cytochrome P-450 system: Effects of asphalt fume condensate exposure	1	0
12893	2	12893 2002 JOURNAL OF VECTOR ECOLOGY 27(2):222-229 Chareonviriyaphap T; Rongnoparut P; Juntarumporn P Selection for pyrethroid resistance in a colony of Anopheles minimus species A, a malaria vector in Thailand	1	1
12894	10	12894 2002 KIDNEY INTERNATIONAL 62(3):868-876 Liu H; Bigler SA; Henegar JR; Baliga R Cytochrome P4502B1 mediates oxidant injury in puromycin-induced nephrotic syndrome	1	1
12895	2	12895 2002 KOREAN JOURNAL OF GENETICS 24(4):335-342 Park KS; Park MJ; Mok JW Genetic polymorphisms of CYPB1, COMT and GSTs genes in Koreans	0	0
12896	24	12896 2002 LANCET 360(9340):1155-1162 Nebert DW; Russell DW Clinical importance of the cytochromes P450	8	1
12897	5	12897 2002 LEUKEMIA 16(10):1940-1958 Gallagher RE Retinoic acid resistance in acute promyelocytic leukemia	3	0
12898	3	12898 2002 LIPIDS 37(12):1163-1170 Gibbons GF The role of cytochrome P450 in the regulation of cholesterol biosynthesis	0	0
12899	4	12899 2002 LIPIDS 37(12):1187-1191 Lardy H; Marwah A; Marwah P Transformations of DHEA and its metabolites by rat liver	0	0
12900	2	12900 2002 MAGNETIC RESONANCE IN MEDICINE 48(6):965-972 Winalski CS; Shortkroff S; Mulkern RV; Schneider E; Rosen GM Magnetic resonance relaxivity of dendrimer-linked nitroxides	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12901	2	12901 2002 MAMMALIAN GENOME 13(9):515-523 Narayanan RA; Rink A; Beattie CW; Hu WS Differential gene expression analysis during porcine hepatocyte spheroid formation	0	0
12902	8	12902 2002 MICROBIOLOGY-SGM 148():2937-2949 McLean KJ; Marshall KR; Richmond A; Hunter IS; Fowler K; Kieser T; Gurcha SS; Besra GS; Munro AW Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes	5	2
12903	14	12903 2002 MOLECULAR ENDOCRINOLOGY 16(8):1864-1880 Ben-Zimra M; Koler M; Orly J Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: Activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element	1	0
12904	7	12904 2002 MOLECULAR PHARMACOLOGY 61(4):795-799 Raffalli-Mathieu F; Glisovic T; Ben-David Y; Lang MA Heterogeneous nuclear ribonucleoprotein A1 and regulation of the xenobiotic-inducible gene Cyp2a5	4	0
12905	31	12905 2002 MOLECULAR PHARMACOLOGY 61(4):840-852 King LM; Ma JX; Srettabunjong S; Graves J; Bradbury JA; Li LP; Spiecker M; Liao JK; Mohrenweiser H; Zeldin DC Cloning of CYP2J2 gene and identification of functional polymorphisms	1	0
12906	13	12906 2002 MOLECULAR PHARMACOLOGY 61(4):892-904 Zangar RC; Kimzey AL; Okita JR; Wunschel DS; Edwards RJ; Kim H; Okita RT Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway	4	0
12907	12	12907 2002 MOLECULAR PHARMACOLOGY 62(2):359-365 Goodwin B; Hodgson E; D'Costa DJ; Robertson GR; Liddle C Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor	10	2
12908	9	12908 2002 MOLECULAR PHARMACOLOGY 62(3):737-746 Ferguson SS; Lecluyse EL; Negishi M; Goldstein JA Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site	3	0
12909	10	12909 2002 MOLECULAR PHARMACOLOGY 62(5):1061-1067 Meyer RP; Podvinec M; Meyer UA Cytochrome P450CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme	0	0
12910	9	12910 2002 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 499(2):155-161 Chen N; Whitehead SE; Caillat AW; Gavit K; Isphording DR; Kovacevic D; McCreary MB; Hoffman SMG Identification and cross-species comparisons of CYP2F subfamily genes in mammals	1	0
12911	13	12911 2002 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 500(1-2):103-110 Hamzeiy H; Vahdati-Mashhadian N; Edwards HJ; Goldfarb PS Mutation analysis of the human CYP3A4 gene 5 ' regulatory region: population screening using non-radioactive SSCP	2	1
12912	6	12912 2002 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 517(1-2):135-145 Gabelova A; Farakasova T; Bacova G; Robichova S Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450	0	0
12913	2	12913 2002 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 519(1-2):163-170 Vian L; Yusuf AT; Guyomard C; Cano JP The Liverbeads (R) as a tool for the comet assay	0	0
12914	5	12914 2002 MYCOLOGICAL RESEARCH 106():1171-1178 Albertini C; Thebaud G; Fournier E; Leroux P Eburicol 14 alpha-demethylase gene (CYP51) polymorphism and speciation in Botrytis cinerea	0	0
12915	27	12915 2002 NATURAL PRODUCT REPORTS 19(4):477-493 de Montellano PRO; De Voss JJ Oxidizing species in the mechanism of cytochrome P450	6	0
12916	16	12916 2002 NATURE BIOTECHNOLOGY 20(11):1135-1139 Glieder A; Farinas ET; Arnold FH Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase	6	2
12917	19	12917 2002 NATURE REVIEWS DRUG DISCOVERY 1(4):259-266 Willson TM; Kliewer SA PXR, CAR and drug metabolism	7	0
12918	3	12918 2002 NEUROLOGY 58(10):1525-1532 Parkinson RB; Hopkins RO; Cleavinger HB; Weaver LK; Victoroff J; Foley JF; Bigler ED White matter hyperintensities and neuropsychological outcome following carbon monoxide poisoning	0	0
12919	6	12919 2002 NITRIC OXIDE, PT D 359():379-389 Daiber A; Ullrich V Peroxynitrite reactions with heme and heme-thiolate (P450) proteins	1	0
12920	15	12920 2002 ONCOLOGIST 7(6):516-530 Kruijtzer CMF; Beijnen JH; Schellens JHM Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: An overview	0	0
12921	4	12921 2002 ONCOLOGY REPORTS 9(2):327-329 Liu TC; Lin SF; Chen TP; Chang JG Polymorphism analysis of CYP3A5 in myeloid leukemia	1	1
12922	1	12922 2002 ORAL ONCOLOGY 38(5):486-490 Hahn M; Hagedorn G; Kuhlisch E; Schackert HK; Eckelt U Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer	0	0
12923	7	12923 2002 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 73(2):74-86 Yoon KS; Nelson JO; Clark JM Selective induction of abamectin metabolism by dexamethasone, 3-methylcholanthrene, and phenobarbital in Colorado potato beetle, Leptinotarsa decemlineata (Say)	2	0
12924	10	12924 2002 PHARMACEUTICAL RESEARCH 19(12):1788-1800 Ekins S; Mirny L; Schuetz EG A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXR alpha, and LXR beta	2	0
12925	15	12925 2002 PHARMACOGENETICS 12(5):367-374 Lo-Guidice JM; Allorge D; Cauffiez C; Chevalier D; Lafitte JJ; Lhermitte M; Broly F Genetic polymorphism of the human cytochrome P450CYP4B1: evidence for a non-functional allelic variant	3	0
12926	3	12926 2002 PHARMACOGENETICS 12(6):459-463 Gemignani F; Landi S; Vivant F; Zienolddiny S; Brennan P; Canzian F A catalogue of polymorphisms related to xenobiotic metabolism and cancer susceptibility	1	0
12927	141	12927 2002 PHYSIOLOGICAL REVIEWS 82(1):131-185 Roman RJ P-450 metabolites of arachidonic acid in the control of cardiovascular function	38	7
12928	5	12928 2002 PLANT JOURNAL 32(4):495-508 Hong Z; Ueguchi-Tanaka M; Shimizu-Sato S; Inukai Y; Fujioka S; Shimada Y; Takatsuto S; Agetsuma M; Yoshida S; Watanabe Y; Uozu S; Kitano H; Ashikari M; Matsuoka M Loss-of-function of a rice brassinosteroid biosynthetic enzyme, C-6 oxidase, prevents the organized arrangement and polar elongation of cells in the leaves and stem	1	0
12929	15	12929 2002 PLANT PHYSIOLOGY 130(1):179-189 Didierjean L; Gondet L; Perkins R; Lau SMC; Schaller H; O'Keefe DP; Werck-Reichhart D Engineering herbicide metabolism in tobacco and Arabidopsis with CYP76B1, a cytochrome P450 enzyme from Jerusalem artichoke	1	0
12930	6	12930 2002 PLANT PHYSIOLOGY 130(1):504-513 Bancos S; Nomura T; Sato T; Molnar G; Bishop GJ; Koncz C; Yokota T; Nagy F; Szekeres M Regulation of transcript levels of the Arabidopsis cytochrome P450 genes involved in brassinosteroid biosynthesis	2	1
12931	4	12931 2002 PLANT PHYSIOLOGY 130(3):1152-1161 Mori M; Nomura T; Ooka H; Ishizaka M; Yokota T; Sugimoto K; Okabe K; Kajiwara H; Satoh K; Yamamoto K; Hirochika H; Kikuchi S Isolation and characterization of a rice dwarf mutant with a defect in brassinosteroid biosynthesis	1	0
12932	19	12932 2002 PLANT PHYSIOLOGY 130(4):1837-1851 Ro DK; Ehlting J; Douglas CJ Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar	0	0
12933	7	12933 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(4):2222-2227 Davis BB; Thompson DA; Howard LL; Morisseau C; Hammock BD; Weiss RH Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation	3	0
12934	1	12934 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(11):7484-7489 Alesci S; Ramsey WJ; Bornstein SR; Chrousos GP; Hornsby PJ; Benvenga S; Trimarchi F; Ehrhart-Bornstein M Adenoviral vectors can impair adrenocortical steroidogenesis: Clinical implications for natural infections and gene therapy	2	0
12935	7	12935 2002 PROGRESS IN NATURAL SCIENCE 12(8):598-602 Wang H; Lin L; Lu ZY; Wang DW Up-regulation of endothelial nitric oxide synthase by cytochrome P450 arachidonic acid epoxygenase BM(3)F87V	0	0
12936	39	12936 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9():345-362 Kikuta Y; Kusunose E; Kusunose M Prostaglandin and leukotriene omega-hydroxylases	2	0
12937	1	12937 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9():471-482 Murphy RC; Zarini S Glutathione adducts of oxyeicosanoids	0	0
12938	4	12938 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 70(1-2):31-37 Chevalier D; Allorge D; Lo-Guidice JM; Cauffiez C; Lepetit C; Migot-Nabias F; Kenani A; Lhermitte M; Broly F Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5 '-untranslated region of the human prostacyclin synthase gene (CYP8A1)	0	0
12939	23	12939 2002 PROTEIN EXPRESSION AND PURIFICATION 24(3):329-337 Yamazaki H; Nakamura M; Komatsu T; Ohyama K; Hatanaka N; Asahi S; Shimada N; Guengerich FP; Shimada T; Nakajima M; Yokoi T Roles of NADPH-P450 reductase and apo- and holo-cytochrome b(5) on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli	7	4
12940	7	12940 2002 PROTEOMICS 2(6):713-722 Galeva N; Altermann M Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: Cytochromes P450 and other membrane proteins	6	0
12941	10	12941 2002 RECENT PROGRESS IN HORMONE RESEARCH, VOL 57 57():317-338 Simpson ER; Dowsett M Aromatase and its inhibitors: Significance for breast cancer therapy	3	0
12942	2	12942 2002 SCIENCE IN CHINA SERIES C-LIFE SCIENCES 45(5):512-517 Zhong L; Wang K; Tan J; Li W; Li SG Putative cytochrome P450 genes in rice genome (Oryza sativa L. ssp indica) and their EST evidence	0	0
12943	6	12943 2002 SCIENCE OF THE TOTAL ENVIRONMENT 300(1-3):37-49 Binet S; Pfohl-Leszkowicz A; Brandt H; Lafontaine M; Castegnaro M Bitumen fumes: review of work on the potential risk to workers and the present knowledge on its origin	0	0
12944	2	12944 2002 SEIKAGAKU 74(11):1317-1328 Suematsu M Gas biology: How do the gases conduct protein function in vivo?	0	0
12945	5	12945 2002 SEMINARS IN LIVER DISEASE 22(2):109-113 Farrell GC; Liddle C Drugs and the liver updated, 2002 - Foreword	1	0
12946	21	12946 2002 SEMINARS IN LIVER DISEASE 22(2):115-122 Liddle C; Goodwin B Regulation of hepatic drug metabolism: Role of the nuclear receptors PXR and CAR	5	0
12947	10	12947 2002 SEMINARS IN REPRODUCTIVE MEDICINE 20(3):249-254 Peter M Congenital adrenal hyperplasia: 11 beta-hydroxylase deficiency	0	0
12948	11	12948 2002 SEMINARS IN REPRODUCTIVE MEDICINE 20(3):277-283 Meinhardt U; Mullis PE The essential role of the aromatase/P450arom	0	0
12949	2	12949 2002 TETRAHEDRON 58(9):1667-1671 Tsukamoto S; Cha BC; Ohta T Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity	3	1
12950	4	12950 2002 TOXICOLOGIC PATHOLOGY 30(6):620-650 Nyska A; Kohen R Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification	1	0
12951	6	12951 2002 TOXICOLOGY 175(1-3):15-25 Fadhel Z; Lu ZJ; Robertson LW; Glauert HP Effect of 3,3 ',4,5 '-tetrachlorobiphenyl and 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats	0	0
12952	0	12952 2002 TOXICOLOGY 178(1):6-7 Estabrook RW The cytochrome P450s and "reactive metabolites"	0	0
12953	8	12953 2002 TOXICOLOGY 181():255-260 Josephy PD Genetically-engineered bacteria expressing human enzymes and their use in the study of mutagens and mutagenesis	0	0
12954	8	12954 2002 TOXICOLOGY AND APPLIED PHARMACOLOGY 179(1):1-12 Andersen HR; Vinggaard AM; Rasmussen TH; Gjermandsen IM; Bonefeld-Jorgensen EC Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro	7	0
12955	5	12955 2002 TOXICOLOGY LETTERS 128(1-3):129-144 Klinger W; Lupp A; Karge E; Baumbach H; Eichhorn F; Feix A; Fuldner F; Gernhardt S; Knels L; Kost B; Mertens G; Werner F; Oettel M; Romer W; Schwarz S; Elger W; Schneider B Estradiol, testosterone,, dehydroepiandrosterone and androstenedione: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro	2	0
12956	2	12956 2002 TRANSPLANT IMMUNOLOGY 10(4):255-258 Durak I; Kacmaz M; Cimen MYB; Buyukkocak S; Elgun S; Ozturk HS The effects of cyclosporine on antioxidant enzyme activities and malondialdehyde levels in rabbit hepatic tissues	0	0
12957	11	12957 2002 TRENDS IN ENDOCRINOLOGY AND METABOLISM 13(6):234-239 Rainey WE; Carr BR; Sasano H; Suzuki T; Mason JI Dissecting human adrenal androgen production	2	1
12958	6	12958 2002 WORLD JOURNAL OF SURGERY 26(8):950-957 Musholt TJ; Klebs SHG; Musholt PB; Ellerkamp V; Klempnauer J; Hoffmann MW Transplantation of adrenal tissue fragments in a murine model: Functional capacities of syngeneic and allogeneic grafts	1	0
12959	61	12959 2002 XENOBIOTICA 32(3):165-206 Gibson GG; Plant NJ; Swales KE; Ayrton A; El-Sankary W Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man	8	3
12960	8	12960 2002 XENOBIOTICA 32(6):521-534 Subrahmanyam V; Renwick AB; Walters DG; Price RJ; Tonelli AP; Lake BG Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms	0	0
12961	8	12961 2002 XENOBIOTICA 32(7):595-604 Johnson TN; Tanner MS; Tucker GT Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat	0	0
12962	8	12962 2002 XENOBIOTICA 32(9):739-747 Pan J; Xiang Q; Renwick AB; Price RJ; Ball SE; Kao J; Scatina JA; Lake BG Use of a quantitative real-time reverse transcription- polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices	1	1
12963	5	12963 2002 XENOBIOTICA 32(11):985-996 Granhall C; Floby E; Nordmark A; Orzechowski A; Thorne A; Tybring G; Sohlenius-Sternbeck AK Characterization of testosterone metabolism and 7- hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months	0	0
12964	13	12964 2002 XENOBIOTICA 32(12):1063-1077 Lesigiarska I; Pajeva I; Yanev S Quantitative structure-activity relationship (QSAR) and three- dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome P4502B1	0	0
12965	11	12965 2003 ACTA BIOCHIMICA POLONICA 50(2):405-413 Rauchova H; Drahota Z; Rauch P; Fato R; Lenaz G Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase	0	0
12966	15	12966 2003 ADVANCED SYNTHESIS & CATALYSIS 345(6-7):802-810 Maurer SC; Schulze H; Schmid RD; Urlacher V Immobilisation of P450BM-3 and an NADP(+) cofactor recycling system: Towards a technical application of heme-containing monooxygenases in fine chemical synthesis	0	0
12967	6	12967 2003 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 284(4):R1053-R1054 Skott O Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation	0	0
12968	3	12968 2003 ANALYTICAL LETTERS 36(8):1475-1491 Asai R; Nakamura C; Ikebukuro K; Karube I; Miyake J A Bioassay to detect contaminant-induced messenger RNA using a transcriptomic approach: Detection of RT-PCR-amplified single- stranded DNA based on the SPR sensor in cyanobacteria	0	0
12969	26	12969 2003 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 43():1-30 Conney AH Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450	0	0
12970	48	12970 2003 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 43():149-173 Ding XX; Kaminsky LS Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts	3	0
12971	6	12971 2003 ANTIOXIDANTS & REDOX SIGNALING 5(2):195-203 O'Donnell VB Free radicals and lipid signaling in endothelial cells	1	0
12972	15	12972 2003 AQUATIC TOXICOLOGY 62(1):67-78 Rees CB; McCormick SD; Vanden Heuvel JP; Li WM Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar)	0	0
12973	5	12973 2003 AQUATIC TOXICOLOGY 63(3):271-282 Cao ZJ; Tanguay RL; McKenzie D; Peterson RE; Aiken JM Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout	0	0
12974	7	12974 2003 ARCHIV DER PHARMAZIE 335(11-12):526-534 Haidar S; Hartmann RW C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17 alpha-hydroxylase-C17,20- lyase: Synthesis and biological evaluation	0	0
12975	10	12975 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):59-71 Guengerich FP Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions	0	0
12976	23	12976 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):113-126 Xue LL; Zgoda VG; Arison B; Correia MA Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase	0	0
12977	11	12977 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):134-144 Auchus RJ; Kumar AS; Boswell CA; Gupta MK; Bruce K; Rath NP; Covey DF The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21	1	0
12978	14	12978 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):145-152 Swart P; Lombard N; Swart AC; van der Merwe T; Murry BA; Nicol M; Mason JI Ovine steroid 17 alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme	0	0
12979	17	12979 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):197-206 Baldwin A; Huang ZQ; Jounaidi Y; Waxman DJ Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer	0	0
12980	15	12980 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):221-227 Bellamine A; Wang YR; Waterman MR; Dawson EP; Brown NJ; Capdevila JH Characterization of the CYNA11 gene, a second CYP4A gene in humans	1	0
12981	27	12981 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 411(2):223-234 Oleksiak MF; Wu S; Parker C; Qu W; Cox R; Zeldin DC; Stegeman JJ Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase	0	0
12982	1	12982 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):2-2 Klingenberg M The dragging emergence of the P450 cytochrome	0	0
12983	22	12983 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):77-89 Lee SJ; Buhler DR Cloning, tissue distribution, and functional studies of a new cytochrome P450 3A subfamily member, CYP3A45, from rainbow trout (Oncorhynchus mykiss) intestinal ceca	0	0
12984	21	12984 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):147-152 Mokashi V; Li L; Porter TD Cytochrome b5 reductase and cytochrome b5 support the CYP2E1- mediated activation of nitrosamines in a recombinant Ames test	0	0
12985	2	12985 2003 ARCHIVES OF MICROBIOLOGY 179(5):329-338 Mazoy R; Osorio CR; Toranzo AE; Lemos ML Isolation of mutants of Vibrio anguillarum defective in haeme utilisation and cloning of huvA, a gene coding for an outer membrane protein involved in the use of haeme as iron source	0	0
12986	6	12986 2003 ARCHIVES OF PHARMACAL RESEARCH 26(1):47-52 Lee WY; Lee SM The roles of Kupffer cells in hepatocellular dysfunction after femur fracture trauma in rats	0	0
12987	4	12987 2003 ARCHIVES OF TOXICOLOGY 77(3):138-144 Ohhira S; Watanabe M; Matsui H Metabolism of tributyltin and triphenyltin by rat, hamster and human hepatic microsomes	0	0
12988	15	12988 2003 ARCHIVES OF TOXICOLOGY 77(3):145-149 Haag M; Fautrel A; Guillouzo A; Frossard N; Pons F Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16 alpha-carbonitrile	0	0
12989	4	12989 2003 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 53(1):26-33 Washio T; Kohsaka K; Arisawa H; Masunaga H Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs	1	0
12990	15	12990 2003 BIOCHEMICAL JOURNAL 370():763-769 Marek CJ; Cameron GA; Elrick LJ; Hawksworth GM; Wright MC Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro	0	0
12991	21	12991 2003 BIOCHEMICAL JOURNAL 370():921-926 Flanagan JU; McLaughlin LA; Paine MJI; Sutcliffe MJ; Roberts GCK; Wolf CR Role of conserved Asp(293) of cytochrome P4502C9 in substrate recognition and catalytic activity	0	0
12992	15	12992 2003 BIOCHEMICAL JOURNAL 372():317-327 McLean KJ; Scrutton NS; Munro AW Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA	1	0
12993	8	12993 2003 BIOCHEMICAL PHARMACOLOGY 65(6):949-959 Fan LQ; Coley J; Miller RT; Cattley RC; Corton JC Opposing mechanisms of NADPH-cytochrome P450 oxidoreductase regulation by peroxisome proliferators	0	0
12994	4	12994 2003 BIOCHEMICAL PHARMACOLOGY 65(10):1583-1591 Imai K; Kudo N; Koyama M; Kawashima Y Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver	0	0
12995	6	12995 2003 BIOCHEMICAL PHARMACOLOGY 65(10):1653-1661 Glisovic T; Soderberg M; Christian K; Lang M; Raffalli-Mathieu F Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression	0	0
12996	17	12996 2003 BIOCHEMICAL PHARMACOLOGY 65(11):1817-1826 Joseph S; Rusling JF; Lvov YM; Friedberg T; Fuhr U An amperometric biosensor with human CYP3A4 as a novel drug screening tool	0	0
12997	10	12997 2003 BIOCHEMICAL PHARMACOLOGY 65(11):1889-1896 Zhang WS; Purchio A; Chen K; Burns SM; Contag CH; Contag PR In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors	0	0
12998	24	12998 2003 BIOCHEMISTRY 42(5):1245-1253 Guengerich FP; Hanna IH; Martin MV; Gillam EMJ Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis	0	0
12999	5	12999 2003 BIOCHEMISTRY 42(21):6363-6369 Marques-Soares C; Dijols S; Macherey AC; Wester MR; Johnson EF; Dansette PM; Mansuy D Sulfaphenazole derivatives as tools for comparing cytochrome P4502C5 and human cytochromes P4502Cs: Identification of a new high affinity substrate common to those enzymes	1	0
13000	5	13000 2003 BIOCHEMISTRY 42(21):6370-6379 Wester MR; Johnson EF; Marques-Soares C; Dansette PM; Mansuy D; Stout CD Structure of a substrate complex of mammalian cytochrome P4502C5 at 2.3 angstrom resolution: Evidence for multiple substrate binding modes	1	1

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