#	Cited nodes	Nodes / Authors	GCS	LCS
11601	6	11601 1999 DRUG METABOLISM AND DISPOSITION 27(1):98-101 Huang JD; Guo WC; Lai MD; Guo YL; Lambert GH Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese	18	3
11602	9	11602 1999 DRUG METABOLISM AND DISPOSITION 27(1):102-109 Yang TJ; Krausz KW; Sai Y; Gonzalez FJ; Gelboin HV Eight inhibitory monoclonal antibodies define the role of individual P-450S in human liver microsomal diazepam, 7- ethoxycoumarin, and imipramine metabolism	18	9
11603	6	11603 1999 DRUG METABOLISM AND DISPOSITION 27(2):193-200 Singleton DW; Lei XD; Webb SJ; Prough RA; Geoghegan TE Cytochrome P-450 mRNAs are modulated by dehydroepiandrosterone, nafenopin, and triiodothyronine	6	4
11604	7	11604 1999 DRUG METABOLISM AND DISPOSITION 27(2):250-254 Nicolas JM; Collart P; Gerin B; Mather G; Trager W; Levy R; Roba J In vitro evaluation of potential drug interactions with levetiracetam, a new antiepileptic agent	26	2
11605	16	11605 1999 DRUG METABOLISM AND DISPOSITION 27(2):288-296 Bourrie M; Meunier V; Berger Y; Fabre G Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes	22	1
11606	7	11606 1999 DRUG METABOLISM AND DISPOSITION 27(4):533-541 Granvil CP; Madan A; Sharkawi M; Parkinson A; Wainer IW Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes	22	4
11607	18	11607 1999 DRUG METABOLISM AND DISPOSITION 27(4):542-548 Cummings BS; Zangar RC; Novak RF; Lash LH Cellular distribution of cytochromes P-450 in the rat kidney	11	3
11608	9	11608 1999 DRUG METABOLISM AND DISPOSITION 27(5):600-604 Yanev S; Kent UM; Pandova B; Hollenberg PF Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates	13	3
11609	16	11609 1999 DRUG METABOLISM AND DISPOSITION 27(7):792-797 Nakajima M; Ohyama K; Nakamura S; Shimada N; Yamazaki H; Yokoi T Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes	9	4
11610	5	11610 1999 DRUG METABOLISM AND DISPOSITION 27(7):804-809 Zhang QY; Dunbar D; Ostrowska A; Zeisloft S; Yang J; Kaminsky LS Characterization of human small intestinal cytochromes P-450	41	10
11611	7	11611 1999 DRUG METABOLISM AND DISPOSITION 27(8):860-865 Kobayashi K; Nakajima M; Oshima K; Shimada N; Yokoi T; Chiba K Involvement of CYP2E1 as a low-affinity enzyme in phenacetin O- deethylation in human liver microsomes	10	3
11612	21	11612 1999 DRUG METABOLISM AND DISPOSITION 27(9):999-1004 Yamazaki H; Nakajima M; Nakamura M; Asahi S; Shimada N; Gillam EMJ; Guengerich FP; Shimada T; Yokoi T Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes	19	11
11613	26	11613 1999 DRUG METABOLISM AND DISPOSITION 27(9):1017-1023 McGinnity DF; Griffin SJ; Moody GC; Voice M; Hanlon S; Friedberg T; Riley RJ Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli	16	2
11614	9	11614 1999 DRUG METABOLISM AND DISPOSITION 27(9):1068-1073 Becquemont L; Mouajjah S; Escaffre O; Beaune P; Funck-Brentano C; Jaillon P Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism	9	3
11615	16	11615 1999 DRUG METABOLISM AND DISPOSITION 27(10):1117-1122 Masimirembwa CM; Otter C; Berg M; Jonsson M; Leidvik B; Jonsson E; Johansson T; Backman A; Edlund A; Andersson TB Heterologous expression and kinetic characterization of human cytochromes P-450: Validation of a pharmaceutical tool for drug metabolism research	23	2
11616	15	11616 1999 DRUG METABOLISM AND DISPOSITION 27(12):1381-1391 Nakajima M; Nakamura S; Tokudome S; Shimada N; Yamazaki H; Yokoi T Azelastine N-demethylation by cytochrome P-450 (CYP) 3A4, CYP2D6, and CYP1A2 in human liver microsomes: Evaluation of approach to predict the contribution of multiple CYPS	19	4
11617	11	11617 1999 DRUG METABOLISM AND DISPOSITION 27(12):1429-1433 Kobayashi K; Abe S; Nakajima M; Shimada N; Tani M; Chiba K; Yamamoto T Role of human CYP2B6 in S-mephobarbital N-demethylation	9	3
11618	12	11618 1999 DRUG METABOLISM AND DISPOSITION 27(12):1512-1518 Hosagrahara VP; Hansen LK; Remmel RP Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: Preliminary evidence for CYP3A isoforms in pigs	5	1
11619	3	11619 1999 DRUG METABOLISM REVIEWS 31(1):15-28 Wrighton SA; Ring BJ Predicting drug interactions and pharmacokinetic variability with in vitro methods: The olanzapine experience	10	2
11620	21	11620 1999 DRUG METABOLISM REVIEWS 31(1):159-174 Porter TD; Chang SY Strategies to enhance the coexpression of cytochrome P450 2E1 and reductase in bacteria	3	3
11621	13	11621 1999 DRUG METABOLISM REVIEWS 31(1):195-203 Jenkins CM; Waterman MR Flavodoxin as a model for the P450-interacting domain of NADPH cytochrome P450 reductase	0	0
11622	49	11622 1999 DRUG METABOLISM REVIEWS 31(1):205-234 Scarborough PE; Ma JX; Qu W; Zeldin DC P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues	23	11
11623	0	11623 1999 DRUG METABOLISM REVIEWS 31(2):297-302 Estabrook RW A tribute to Alfred Goerge Hildebrandt	0	0
11624	22	11624 1999 DRUG METABOLISM REVIEWS 31(2):317-331 Estabrook RW Discovering the functions of cytochrome P450 in drug metabolism: The role of Alfred Hildebrandt	0	0
11625	11	11625 1999 DRUG METABOLISM REVIEWS 31(2):333-342 Kagawa N; Bischof LJ; Cheng PY; Anwar A; Waterman MR Biochemical diversity of peptide-hormone-dependent regulation of steroidogenic P450s	3	0
11626	37	11626 1999 DRUG METABOLISM REVIEWS 31(2):351-364 Schenkman JB; Jansson I Interactions between cytochrome P450 and cytochrome b(5)	17	8
11627	16	11627 1999 DRUG METABOLISM REVIEWS 31(2):503-522 Waxman DJ; Chen L; Hecht JED; Jounaidi Y Cytochrome P450-based cancer gene therapy: Recent advances and future prospects	24	1
11628	23	11628 1999 DRUG METABOLISM REVIEWS 31(2):523-544 Friedberg T; Pritchard MP; Bandera M; Hanlon SP; Yao D; McLaughlin LA; Ding S; Burchell B; Wolf CR Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: An intralaboratory comparison	15	3
11629	75	11629 1999 DRUG METABOLISM REVIEWS 31(3):719-754 Ekins S; Wrighton SA The role of CYP2B6 in human xenobiotic metabolism	36	8
11630	7	11630 1999 DRUG METABOLISM REVIEWS 31(4):971-997 Baliga R; Ueda N; Walker PD; Shah SV Oxidant mechanisms in toxic acute renal failure	36	1
11631	8	11631 1999 DRUGS 58(2):233-255 Njar VCO; Brodie AMH Comprehensive pharmacology and clinical efficacy of aromatase inhibitors	18	0
11632	5	11632 1999 DRUGS & AGING 14(2):75-90 Patterson A; Harris AL Molecular chemotherapy for breast cancer	13	0
11633	7	11633 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 43(1):74-82 van Dam RA; Ahokas JT; Holdway DA Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis): Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity	1	0
11634	13	11634 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 43(3):252-260 Scholz S; Segner H Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: Concentration-response relationships of four model substances	11	1
11635	8	11635 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 44(1):118-128 Bols NC; Schirmer K; Joyce EM; Dixon DG; Greenberg BM; Whyte JJ Ability of polycyclic aromatic hydrocarbons to induce 7- ethoxyresorufin-o-deethylase activity in a trout liver cell line	27	1
11636	1	11636 1999 ENDOCRINOLOGY 140(10):4732-4738 Teixeira J; Fynn-Thompson E; Payne AH; Donahoe PK Mullerian-inhibiting substance regulates androgen synthesis at the transcriptional level	28	0
11637	16	11637 1999 ENDOCRINOLOGY 140(12):5609-5618 Hu MC; Chou SJ; Huang YY; Hsu NC; Li H; Chung BC Tissue-specific, hormonal, and developmental regulation of SCC- LacZ expression in transgenic mice leads to adrenocortical zone characterization	14	1
11638	12	11638 1999 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 28(2):265-+ Rosenfield RL Ovarian and adrenal function in polycystic ovary syndrome	17	0
11639	23	11639 1999 ENVIRONMENTAL HEALTH PERSPECTIVES 107():37-47 Hirvonen A Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer	27	1
11640	6	11640 1999 ENVIRONMENTAL SCIENCE & TECHNOLOGY 33(10):1671-1674 Uchimura M; Sandeaux R; Larroque C The enzymatic detoxifying system of a native Mediterranean Scorpio fish is affected by Caulerpa taxifolia in its environment	2	0
11641	10	11641 1999 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 18(11):2565-2573 Levine SL; Oris JT; Denison MS Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propiconazole	3	0
11642	4	11642 1999 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 7(2):95-107 Pinelli E; El Adlouni C; Pipy B; Quartulli F; Pfohl-Leszkowicz A Roles of cyclooxygenase and lipoxygenases in ochratoxin A genotoxicity in human epithelial lung cells	6	0
11643	1	11643 1999 ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 7 463():255-263 Ziegler TL; Vasiliou V Aldehyde dehydrogenase gene superfamily - The 1998 update	5	0
11644	3	11644 1999 ESSAYS IN BIOCHEMISTRY, VOL 34, 1999 34():71-83 Sligar SG Nature's universal oxygenases: the cytochromes P450	6	0
11645	5	11645 1999 EUROPEAN HEART JOURNAL SUPPLEMENTS 1(T):T7-T12 Horsmans Y Differential metabolism of statins: importance in drug-drug interactions	5	0
11646	5	11646 1999 EUROPEAN HEART JOURNAL SUPPLEMENTS 1(T):T13-T18 Weissberg PL Atherosclerosis involves more than just lipids: plaque dynamics	6	0
11647	1	11647 1999 EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY 80(1):22-27 Wang H; Hiatt WR; Barstow TJ; Brass EP Relationships between muscle mitochondrial DNA content, mitochondrial enzyme activity and oxidative capacity in man: alterations with disease	15	1
11648	11	11648 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 259(3):731-738 Sakaki T; Sawada N; Takeyama KI; Kato S; Inouye K Enzymatic properties of mouse 25-hydroxyvitamin D-3 1 alpha- hydroxylase expressed in Escherichia coli	13	3
11649	8	11649 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 260(2):347-354 Arnesano F; Banci L; Bertini I; Felli IC; Koulougliotis D Solution structure of the B form of oxidized rat microsomal cytochrome b(5) and backbone dynamics via N-15 rotating-frame NMR-relaxation measurements - Biological implications	19	3
11650	7	11650 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 260(3):768-773 Kisselev P; Tuckey RC; Woods ST; Triantopoulos T; Schwarz D Enzymatic properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) - Differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin	2	0
11651	6	11651 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 262(1):43-48 Sakaki T; Sawada N; Nonaka Y; Ohyama Y; Inouye K Metabolic studies using recombinant Escherichia coli cells producing rat mitochondrial CYP24 - CYP24 can convert 1 alpha,25-dihydroxyvitamin D-3 to calcitroic acid	16	3
11652	21	11652 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 262(2):435-446 Cabello-Hurtado F; Taton M; Forthoffer N; Kahn R; Bak S; Rahier A; Werck-Reichhart D Optimized expression and catalytic properties of a wheat obtusifoliol 14 alpha-demethylase (CYP51) expressed in yeast - Complementation of erg11 Delta yeast mutants by plant CYP51	8	0
11653	19	11653 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 264(1):19-26 Posti K; Leinonen S; Tetri S; Kottari S; Viitala P; Pelkonen O; Raunio H Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases	4	1
11654	11	11654 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 265(3):950-956 Sawada N; Sakaki T; Kitanaka S; Takeyama K; Kato S; Inouye K Enzymatic properties of human 25-hydroxyvitamin D-3 1 alpha- hydroxylase - Coexpression with adrenodoxin and NADPH- adrenodoxin reductase in Escherichia coli	14	3
11655	4	11655 1999 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 55(5):341-347 Bonnabry P; Sievering J; Leemann T; Dayer P Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions	6	1
11656	3	11656 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(1):63-68 Klinger W; Oelschlager H; Rothley D; Karge E; Seeling A Interaction of chlormezanone enantiomers with rat liver microsomes	1	0
11657	8	11657 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(2):141-147 Zhang W; Parentau H; Greenly RL; Metz CA; Aggarwal S; Wainer IW; Tracy TS Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase	5	1
11658	14	11658 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(3):243-248 Czekaj P; Nowaczyk-Dura G Inhibiting effect of ethinylestradiol/levonorgestrel combination on microsomal enzymatic activities in rat liver and kidney	1	1
11659	7	11659 1999 EUROPEAN JOURNAL OF ENDOCRINOLOGY 141(1):35-39 Gallo M; Aragno M; Gatto V; Tamagno E; Brignardello E; Manti R; Danni O; Boccuzzi G Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line	4	0
11660	17	11660 1999 EUROPEAN NEUROPSYCHOPHARMACOLOGY 9(4):301-309 Prior TI; Chue PS; Tibbo P; Baker GB Drug metabolism and atypical antipsychotics	24	2
11661	11	11661 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):369-374 Lewis DFV Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity	11	2
11662	8	11662 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):392-396 Meneguz A; Fortuna S; Lorenzini P; Volpe MT Influence of urethane and ketamine on rat hepatic cytochrome P450 in vivo	2	0
11663	12	11663 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):412-417 Raunio H; Hakkola J; Hukkanen J; Lassila A; Paivarinta K; Pelkonen O; Anttila S; Piipari R; Boobis A; Edwards RJ Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue	19	6
11664	5	11664 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):455-457 Zviarynski IU; Zavodnik LB The effect of folic acid on the drug metabolizing liver function in man with viral hepatitis	1	0
11665	4	11665 1999 EXPERIMENTAL CELL RESEARCH 250(2):284-297 Sonneveld E; van den Brink CE; van der Leede BJM; Maden M; van der Saag PT Embryonal carcinoma cell lines stably transfected with mRAR beta 2-lacZ: Sensitive system for measuring levels of active retinoids	7	0
11666	0	11666 1999 FASEB JOURNAL 13(7):A1345-A1345 Guryev OL; Gilep A; Usanov SA; Estabrook RW Cytochrome P4503A4-cytochrome bs interactions: Biological relevance of heme transfer	0	0
11667	1	11667 1999 FEBS LETTERS 456(1):85-88 Jornvall H Motifer, a search tool for finding amino acid sequence patterns from nucleotide sequence databases	0	0
11668	8	11668 1999 FEBS LETTERS 458(2):97-102 Schroder G; Unterbusch E; Kaltenbach M; Schmidt J; Strack D; De Luca V; Schroder J Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase	19	3
11669	5	11669 1999 FEBS LETTERS 460(2):309-314 Neve EPA; Ingelman-Sundberg M A soluble NH2-terminally truncated catalytically active form of rat cytochrome P450 2E1 targeted to liver mitochondria	10	4
11670	13	11670 1999 FEBS LETTERS 462(3):283-288 Lamb DC; Kelly DE; Manning NJ; Kaderbhai MA; Kelly SL Biodiversity of the P450 catalytic cycle: yeast cytochrome b(5)/NADH cytochrome b(5) reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction	12	5
11671	6	11671 1999 FERTILITY AND STERILITY 71(2):328-333 Nagamani M; Urban R Increased expression of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage and P450 17 alpha-hydroxylase enzymes in ovarian hyperthecosis	4	0
11672	4	11672 1999 FERTILITY AND STERILITY 71(3):528-535 Jose M; Puche C; Cabero A; Cabero L; Meseguer A Expression of P450c17 messenger ribonucleic acid in postmenopausal human ovary tissues	5	0
11673	35	11673 1999 FOOD AND CHEMICAL TOXICOLOGY 37(4):423-453 Lake BG Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment	17	0
11674	6	11674 1999 FOOD AND CHEMICAL TOXICOLOGY 37(5):503-508 Ng HP; Wang YF; Lee CY; Hu ML Toxicological and antioxidant effects of short-term dehydroepiandrosterone injection in young rats fed diets deficient or adequate in vitamin E	2	0
11675	17	11675 1999 FOOD AND CHEMICAL TOXICOLOGY 37(6):609-618 Renwick AB; Mistry H; Barton PT; Mallet F; Price RJ; Beamand JA; Lake BG Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices	9	2
11676	11	11676 1999 FREE RADICAL BIOLOGY AND MEDICINE 27(11-12):1267-1275 Nguyen NSD; Cottet-Maire F; Buetler TM; Lo Russo A; Krauskopf AS; Armstrong JM; Vickers AEM; Mace K; Ruegg UT Metabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells	7	1
11677	13	11677 1999 GASTROENTEROLOGY CLINICS OF NORTH AMERICA 28(1):1-+ Vlahcevic ZR; Pandak WM; Stravitz RT Regulation of bile acid biosynthesis	41	0
11678	4	11678 1999 GENE 226(2):327-338 Lundqvist E; Johansson I; Ingelman-Sundberg M Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes	25	1
11679	9	11679 1999 GENERAL PHARMACOLOGY 33(4):325-336 Yang ZW; Zhang AM; Altura BT; Altura BM Hydrogen peroxide-induced endothelium-dependent relaxation of rat aorta - Involvement of Ca2+ and other cellular metabolites	14	0
11680	1	11680 1999 GENETIC EPIDEMIOLOGY 17(4):253-273 Yang P; Schwartz AG; McAllister AE; Swanson GM; Aston CE Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis	7	0
11681	4	11681 1999 GENOMICS 56(2):184-196 Gafvels M; Olin M; Chowdhary BP; Raudsepp T; Andersson U; Persson B; Jansson M; Bjorkhem I; Eggertsen G Structure and chromosomal assignment of the sterol 12 alpha- hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns	15	2
11682	1	11682 1999 HEPATO-GASTROENTEROLOGY 46():1406-1408 Suematsu M Recent developments in hepatic circulatory physiology	1	0
11683	11	11683 1999 HISTOLOGY AND HISTOPATHOLOGY 14(2):407-415 Sarasquete C; Munoz-Cueto JA; Ortiz JB; Rodriguez-Gomez FJ; Dinis MT; Segner H Immunocytochemical distribution of cytochrome P4501A (CYP1A) in developing gilthead seabream, Sparus aurata	7	3
11684	15	11684 1999 HORMONE RESEARCH 51(5):211-222 Peter M; Dubuis JM; Sippell WG Disorders of the aldosterone synthase and steroid 11 beta- hydroxylase deficiencies	6	0
11685	9	11685 1999 INDUSTRIAL HEALTH 37(4):440-448 Wang RS; Nakajima T; Honma T Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat	1	0
11686	10	11686 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(2):145-151 Ranasinghe C; Hobbs AA Isolation and characterisation of a cytochrome b5 cDNA clone from Helicoverpa armigera (Hubner): possible involvement of cytochrome b5 in cytochrome P450 CYP6B7 activity towards pyrethroids	1	0
11687	11	11687 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(4):377-384 Crampton AL; Baxter GD; Barker SC Identification and characterisation of a cytochrome P450 gene and processed pseudogene from an arachnid: the cattle tick, Boophilus microplus	3	3
11688	6	11688 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(8):667-673 Lu KH; Bradfield JY; Keeley LL Juvenile hormone inhibition of gene expression for cytochrome P4504C1 in adult females of the cockroach, Blaberus discoidalis	2	1
11689	45	11689 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(9):757-777 Scott JG Cytochromes P450 and insecticide resistance	30	6
11690	10	11690 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(9):829-834 Crampton AL; Baxter CD; Barker SC A new family of cytochrome P450 genes (CYP41) from the cattle tick, Boophilus microplus	0	0
11691	15	11691 1999 INSECT MOLECULAR BIOLOGY 8(2):149-159 Danielson PB; Foster JLM; Cooper SK; Fogleman JC Diversity of expressed cytochrome P450 genes in the adult Mediterranean Fruit Fly, Ceratitis capitata	4	4
11692	6	11692 1999 INTERNATIONAL BIODETERIORATION & BIODEGRADATION 44(1):49-54 Gordeziani M; Khatisashvili G; Ananiashvili T; Varazashvili T; Kurashvili M; Kvesitadze G; Tkhelidze P Energetic significance of plant monooxygenase individual components participating in xenobiotics degradation	3	0
11693	8	11693 1999 INTERNATIONAL JOURNAL OF ANDROLOGY 22(4):211-223 Carreau S; Genissel C; Bilinska B; Levallet J Sources of oestrogen in the testis and reproductive tract in the male	41	0
11694	6	11694 1999 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 31(2):345-362 Arinc E; Cakir D Simultaneous purification and characterization of cytochrome b5 reductase and cytochrome b5 from sheep liver	1	0
11695	1	11695 1999 INTERNATIONAL JOURNAL OF CANCER 83(5):679-684 Bhisey RA; Ramchandani AG; D'Souza AV; Borges AM; Notani PN Long-term carcinogenicity of pan masala in Swiss mice	3	0
11696	2	11696 1999 INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 21(7):455-462 Rezzani R; Rodella L; Bianchi R Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A	1	0
11697	10	11697 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 3(1):33-39 Beurton F; Gueret G; Horisberger M; Cheron G; Cresteil T Transcriptional activation of CYP2C, MxA and Fas in sudden infant death syndrome	8	2
11698	43	11698 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 3(3):227-238 Murray M Mechanisms and significance of inhibitory drug interactions involving cytochrome P450 enzymes (Review)	11	3
11699	5	11699 1999 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 75(9):1189-1199 Yukawa O; Nakajima T; Yukawa M; Ozawa T; Yamada T Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low- dose irradiation	7	0
11700	9	11700 1999 JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS 38(1A):298-301 Suzuki-Tomii K; Ohta Y; Kawato S; Mitaku S Comparative experiments of protein denaturation for studying structural difference of homologous membrane proteins: P- 450(scc) and P-450(11 beta)	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
11701	11	11701 1999 JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 5(3):143-150 Feldweg AM; Leddy JP Drug interactions affecting the efficacy of corticosteroid therapy - A brief review with an illustrative case	0	0
11702	9	11702 1999 JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE 15(4-5):96-98 Agradi E; Brevini TAL; Bolla M; Baga R; Favetta LA Cytochrome P-450 levels and EROD activity in the Adriatic sturgeon (Acipenser naccarii, Chondrostei) and its induction by beta-Naphthoflavone	1	0
11703	12	11703 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(1):1-9 Sidhu JS; Omiecinski CJ Insulin-mediated modulation of cytochrome p450 gene induction profiles in primary rat hepatocyte cultures	4	1
11704	13	11704 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(2):77-82 Carr BA; Franklin MR Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness	3	0
11705	7	11705 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(6):307-315 Hu K; Bunce NJ Metabolism of polychlorinated dibenzo-p-dioxins by rat liver microsomes	8	0
11706	7	11706 1999 JOURNAL OF BIOCHEMISTRY 125(6):1094-1103 Kobayashi M; Sakuradani E; Shimizu S Genetic analysis of cytochrome b(5) from arachidonic acid- producing fungus, Mortierella alpina 1S-4: Cloning, RNA editing and expression of the gene in Escherichia coli, and purification and characterization of the gene product	8	0
11707	8	11707 1999 JOURNAL OF BIOCHEMISTRY 126(1):19-25 Ishida H; Kuruta Y; Gotoh O; Yamashita C; Yoshida Y; Noshiro M Structure, evolution, and liver-specific expression of sterol 12 alpha-hydroxylase P450 (CYP8B)	8	3
11708	11	11708 1999 JOURNAL OF BIOCHEMISTRY 126(2):402-407 Nunoya K; Yokoi T; Takahashi Y; Kimura K; Kinoshita M; Kamataki T Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metabolizer phenotype	26	4
11709	7	11709 1999 JOURNAL OF BIOCHEMISTRY 126(5):927-933 Nitahara Y; Aoyama Y; Horiuchi T; Noshiro M; Yoshida Y Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli	6	0
11710	11	11710 1999 JOURNAL OF BIOCHEMISTRY 126(6):1080-1089 Zimmer T; Ogura A; Ohta A; Takagi M Misfolded membrane-bound cytochrome P450 activates KAR2 induction through two distinct mechanisms	2	0
11711	25	11711 1999 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):226-231 Moon JY; Bin Lim H; Sohn HO; Lee YG; Lee DW Acetone enhancement of cumene hydroperoxide-supported microsomal cytochrome P450-dependent benzo(a)pyrene hydroxylation	1	0
11712	7	11712 1999 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):232-238 Kim KW; Kim HY; Park SS; Jeong HS; Park SH; Lee JY; Jeong JH; Moon YH Gender differences in activity and induction of hepatic microsomal cytochrome P-450 by 1-bromopropane in Sprague-Dawley rats	1	0
11713	9	11713 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(4):2045-2052 Pikuleva IA; Cao C; Waterman MR An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and P450scc (CYP11A1)	17	9
11714	11	11714 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(8):4764-4769 Chen JK; Wang DW; Falck JR; Capdevila J; Harris RC Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor	37	13
11715	2	11715 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(8):4985-4994 Houston M; Estevez A; Chumley P; Aslan M; Marklund S; Parks DA; Freeman BA Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide- dependent signaling	43	0
11716	9	11716 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(11):7421-7430 Park SH; Liu XW; Hennighausen L; Davey HW; Waxman DJ Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression - Impact of Stat5a gene disruption	40	3
11717	4	11717 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(14):9573-9580 Pou S; Keaton L; Surichamorn W; Rosen GM Mechanism of superoxide generation by neuronal nitric-oxide synthase	46	3
11718	6	11718 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(21):14545-14550 Mingot JM; Penalva MA; Fernandez-Canon JM Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2- hydroxylation, results in penicillin overproduction	8	2
11719	47	11719 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(25):17777-17788 Ma JX; Qu W; Scarborough PE; Tomer KB; Moomaw CR; Maronpot R; Davis LS; Breyer MD; Zeldin DC Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome p450 highly expressed in Kidney	20	13
11720	7	11720 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(45):32279-32286 Yamada K; Ogawa H; Honda S; Harada N; Okazaki T A GCM motif protein is involved in placenta-specific expression of human aromatase gene	16	0
11721	18	11721 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(51):36097-36106 Sevrioukova IF; Hazzard JT; Tollin G; Poulos TL The FMN to heme electron transfer in cytochrome P450BM-3 - Effect of chemical modification of cysteines engineered at the FMN-heme domain interaction site	5	3
11722	4	11722 1999 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 33(1):12-18 Reilly MP; Moran N; Meagher E; Delanty N; Cucchiara AE; Lawson JA; Catella-Lawson F A randomized, placebo-controlled, crossover study of E5510 and aspirin in healthy volunteers	1	0
11723	7	11723 1999 JOURNAL OF CELL SCIENCE 112(4):515-523 McLaughlin L; Burchell B; Pritchard M; Wolf CR; Friedberg T Treatment of mammalian cells with the endoplasmic reticulum- proliferator compactin strongly induces recombinant and endogenous xenobiotic metabolizing enzymes and 3-hydroxy-3- methylglutaryl-CoA reductase in vitro	2	0
11724	4	11724 1999 JOURNAL OF CHEMICAL ECOLOGY 25(3):537-548 Rey D; Cuany A; Pautou MP; Meyran JC Differential sensitivity of mosquito taxa to vegetable tannins	16	0
11725	1	11725 1999 JOURNAL OF CHEMICAL RESEARCH-S (1):32-33 Lerestif JM; Feuillet S; Bazureau JP; Hamelin J Novel synthesis of protected methyl 4-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxylate via cleavage of functionalized dihydrooxazoles (oxazolines)	3	0
11726	8	11726 1999 JOURNAL OF CHROMATOGRAPHY A 848(1-2):149-159 Schwaneberg U; Sprauer A; Schmidt-Dannert C; Schmid RD P450 monooxygenase in biotechnology - I. Single-step, large- scale purification method for cytochrome P450BM-3 by anion- exchange chromatography	10	8
11727	7	11727 1999 JOURNAL OF CHROMATOGRAPHY B 721(1):13-19 Yamazaki H; Tanaka M; Shimada T Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O- deethylation by human liver cytochrome P450 enzymes	18	7
11728	7	11728 1999 JOURNAL OF CHROMATOGRAPHY B 734(1):23-29 Soucek P Novel sensitive high-performance liquid chromatographic method for assay of coumarin 7-hydroxylation	2	0
11729	7	11729 1999 JOURNAL OF CHROMATOGRAPHY B 734(1):73-81 Testino SA; Ozarowski J; Thurston AW; Arrendale RF; Patonay G Determination of testosterone and 6 beta-hydroxytestosterone by gas chromatography-selected ion monitoring-mass spectrometry for the characterization of cytochrome p450 3A activity	3	1
11730	2	11730 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(1):220-227 Feneberg R; Sparber M; Veldhuis JD; Mehls O; Ritz E; Schaefer F Synchronous fluctuations of blood insulin and lactate concentrations in humans	1	0
11731	11	11731 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(9):3382-3385 Mapes S; Corbin CJ; Tarantal A; Conley A The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17 alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3 beta-hydroxysteroid dehydrogenase/Delta 5-4 isomerase (3 beta-HSD)	14	4
11732	6	11732 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(11):4050-4054 Deladoey J; Fluck C; Bex M; Yoshimura N; Harada N; Mullis PE Aromatase deficiency caused by a novel P450(arom) gene mutation: Impact of absent estrogen production on serum gonadotropin concentration in a boy	21	2
11733	25	11733 1999 JOURNAL OF CLINICAL INVESTIGATION 104(6):751-760 Holla VR; Makita K; Zaphiropoulos PG; Capdevila JH The kidney cytochrome P-4502C23 arachidonic acid epoxygenase is upregulated during dietary salt loading	21	6
11734	10	11734 1999 JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 24(2):87-92 Tanaka E Clinically significant pharmacokinetic drug interactions between antiepileptic drugs	22	2
11735	9	11735 1999 JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 24(5):323-329 Tanaka E Update: genetic polymorphism of drug metabolizing enzymes in humans	19	5
11736	40	11736 1999 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 19(5):23S-35S Greenblatt DJ; Von Moltke LL; Harmatz JS; Shader RI Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions	13	0
11737	13	11737 1999 JOURNAL OF ENZYME INHIBITION 14(3):175-+ Lewis DFV; Wiseman A; Tarbit MH Molecular modelling of lanosterol 14 alpha-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: Quantitative structure-activity relationships (QSARs) within two related series of antifungal azole derivatives	9	1
11738	6	11738 1999 JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY 233(2):285-300 Schroder HC; Batel R; Lauenroth S; Hassanein HMA; Lacorn M; Simat T; Steinhart H; Muller WEG Induction of DNA damage and expression of heat shock protein HSP70 by polychlorinated biphenyls in the marine sponge Suberites domuncula Olivi	10	1
11739	7	11739 1999 JOURNAL OF HEPATOLOGY 30(6):1035-1044 Takemura S; Minamiyama Y; Imaoka S; Funae Y; Hirohashi K; Inoue M; Kinoshita H Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia	29	2
11740	11	11740 1999 JOURNAL OF HEPATOLOGY 31(2):263-270 Tanaka M; Nakura H; Tateishi T; Watanabe M; Nakaya S; Kumai T; Kobayashi S Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury	4	0
11741	3	11741 1999 JOURNAL OF HEPATOLOGY 31(3):550-555 Krahenbuhl S; Kleinle S; Henz S; Leibundgut K; Liechti S; Zimmermann A; Wiesmann U Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson's syndrome	7	0
11742	10	11742 1999 JOURNAL OF LABORATORY AND CLINICAL MEDICINE 134(2):133-140 Finnstrom N; Bjelfman C; Thorn M; Loof L; Rane A Quantitation of cytochrome P450 mRNAs in patients with suspected liver diseases as assessed by reverse transcriptase- polymerase chain reaction	4	1
11743	25	11743 1999 JOURNAL OF LIPID RESEARCH 40(11):1990-1997 Adas F; Salaun JP; Berthou F; Picart D; Simon B; Amet Y Requirement for omega and (omega-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11	4	1
11744	4	11744 1999 JOURNAL OF LIPID RESEARCH 40(12):2195-2203 Wu ZL; Martin KO; Javitt NB; Chiang JYL Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1	22	3
11745	16	11745 1999 JOURNAL OF MEDICINAL CHEMISTRY 42(9):1515-1524 de Groot MJ; Ackland MJ; Horne VA; Alex AA; Jones BC Novel approach to predicting P450-mediated drug metabolism: Development of a combined protein and pharmacophore model for CYP2D6	54	0
11746	16	11746 1999 JOURNAL OF MEDICINAL CHEMISTRY 42(20):4062-4070 de Groot MJ; Ackland MJ; Horne VA; Alex AA; Jones BC A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6	42	0
11747	16	11747 1999 JOURNAL OF MOLECULAR BIOLOGY 289(4):981-990 Ziegler GA; Vonrhein C; Hanukoglu I; Schulz GE The structure of adrenodoxin reductase of mitochondrial P450 systems: Electron transfer for steroid biosynthesis	24	3
11748	15	11748 1999 JOURNAL OF NEUROENDOCRINOLOGY 11(8):597-604 Rosenbrock H; Hagemeyer CE; Singec I; Knoth R; Volk B Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms	10	4
11749	2	11749 1999 JOURNAL OF NEUROSCIENCE 19(24):10843-10855 de la Houssaye BA; Mikule K; Nikolic D; Pfenninger KH Thrombin-induced growth cone collapse: Involvement of phospholipase A(2) and eicosanoid generation	6	0
11750	7	11750 1999 JOURNAL OF PATHOLOGY 188(2):197-200 Hutson JL; Wickramasinghe SN Expression of CYP2E1 by human monocyte-derived macrophages	2	1
11751	19	11751 1999 JOURNAL OF PESTICIDE SCIENCE 24(2):197-203 Ohkawa H; Tsujii H; Shimoji M; Imajuku Y; Imaishi H Cytochrome P450 biodiversity and plant protection	5	0
11752	11	11752 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 288(2):463-471 Zhuo XL; Gu J; Zhang QY; Spink DC; Kaminsky LS; Ding XX Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice	18	5
11753	14	11753 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 288(3):928-937 Yu LJ; Drewes P; Gustafsson K; Brain EGC; Hecht JED; Waxman DJ In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: Impact on pharmacokinetics and antitumor activity	20	1
11754	7	11754 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 289(2):641-648 Dowsley TF; Reid K; Petsikas D; Ulreich JB; Fisher RL; Forkert PG Cytochrome P-450-dependent bioactivation of 1,1 - dichloroethylene to a reactive epoxide in human lung and liver microsomes	7	2
11755	18	11755 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 289(2):661-667 Li DN; Pritchard MP; Hanlon SP; Burchell B; Wolf CR; Friedberg T Competition between cytochrome P-450 isozymes for NADPH- cytochrome P-450 oxidoreductase affects drug metabolism	8	2
11756	24	11756 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 289(3):1611-1619 Mastyugin V; Aversa E; Bonazzi A; Vafaes C; Mieyal P; Schwartzman ML Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: Involvement of a cytochrome P-4504B1 isoform	12	6
11757	8	11757 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 290(3):1250-1257 Barclay TB; Peters JM; Sewer MB; Ferrari L; Gonzalez FJ; Morgan ET Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent	26	2
11758	14	11758 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 290(3):1270-1277 Galisteo M; Marc N; Fautrel A; Guillouzo A; Corcos L; Lagadic-Gossmann D Involvement of cyclic nucleotide- and calcium-regulated pathways in phenobarbital-induced cytochrome P-450 3A expression in mouse primary hepatocytes	6	2
11759	20	11759 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 291(1):424-433 Ekins S; Bravi G; Wikel JH; Wrighton SA Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates	38	3
11760	17	11760 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 291(2):749-759 Mei Q; Tang CY; Assang C; Lin Y; Slaughter D; Rodrigues AD; Baillie TA; Rushmore TH; Shou MG Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism	23	4
11761	6	11761 1999 JOURNAL OF PHARMACY AND PHARMACOLOGY 51(10):1167-1174 Zhao XJ; Ishizaki T An in-vitro study on the metabolism of rokitamycin and possible interactions of the drug with rat liver microsomes	0	0
11762	2	11762 1999 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 69(1-6):205-210 Brodie A; Lu Q; Long B Aromatase and its inhibitors	14	0
11763	10	11763 1999 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 41(2):237-249 Gupta AK; Katz HI; Shear NH Drug interactions with itraconazole, fluconazole, and terbinafine and their management	32	0
11764	4	11764 1999 JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 76(11):1283-1289 Vilker VL; Reipa V; Mayhew M; Holden MJ Challenges in capturing oxygenase activity in vitro	5	2
11765	2	11765 1999 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2):297-300 Rosen GM; Pou S; Cohen MS; Hassett DJ; Britigan BE; Barber MJ; Cao GL; Cosby K; Sturgeon BE; Halpern HJ N-14-spin trapping of free radicals in the presence of N-15- spin labeled Neisseria gonorrhoeae	0	0
11766	2	11766 1999 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (8):1759-1763 Tsai P; Pou S; Straus R; Rosen GM Evaluation of various spin traps for the in vivo in situ detection of hydroxyl radical	5	2
11767	3	11767 1999 JOURNAL OF THE NATIONAL CANCER INSTITUTE 91(3):215-225 Hursting SD; Slaga TJ; Fischer SM; DiGiovanni J; Phang JM Mechanism-based cancer prevention approaches: Targets, examples, and the use of transgenic mice	36	0
11768	8	11768 1999 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 56(6):433-447 Nebbia C; Ceppa L; Dacasto M; Carletti M Triphenyltin acetate-mediated in vitro inactivation of rat liver cytochrome P-450	6	2
11769	23	11769 1999 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS 2(2):183-210 Hu KK; Bunce NJ Metabolism of polychlorinated dibenzo-p-dioxins and related dioxin-like compounds	14	0
11770	4	11770 1999 JOURNAL OF VOICE 13(3):424-446 Abitbol J; Abitbol P; Abitbol B Sex hormones and the female voice	10	0
11771	2	11771 1999 LANGMUIR 15(20):6829-6836 Yeung C; Purves T; Kloss AA; Kuhl TL; Sligar S; Leckband D Cytochrome c recognition of immobilized, orientational variants of cytochrome b(5): Direct force and equilibrium binding measurements	12	1
11772	11	11772 1999 LIFE SCIENCES 64(8):643-653 Starkel P; Sempoux C; Van den Berge V; Stevens M; De Saeger C; Desager JP; Horsmans Y CYP 3A proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin	11	3
11773	6	11773 1999 LIFE SCIENCES 64(10):827-835 Mesdjian E; Seree E; Charvet B; Mirrione A; Bourgarel-Rey V; Desobry A; Barra Y Metabolism of carbamazepine by CYP3A6: A model for in vitro drug interactions studies	3	0
11774	6	11774 1999 LIFE SCIENCES 65(12):1257-1264 Jiang HB; Ichikawa Y Neuronal nitric oxide synthase catalyzes the reduction of 7- ethoxyresorufin	4	0
11775	5	11775 1999 LIFE SCIENCES 65(17):1747-1756 Kitamura T; Tanaka K; Morita K; Saito S; Kiba T; Numata K; Sekihara H Dehydroepiandrosterone (DHEA) facilitates liver regeneration after partial hepatectomy in rats	2	0
11776	10	11776 1999 MARINE BIOTECHNOLOGY 1(2):155-166 Carvan MJ; Ponomareva LV; Solis WA; Matlib RS; Puga A; Nebert DW Trout CYP1A3 gene: Recognition of fish DNA motifs by mouse regulatory proteins	6	2
11777	9	11777 1999 MARINE BIOTECHNOLOGY 1(4):342-345 Ogino Y; Itakura T; Mitsuo R; Sato M Induction of two forms of eel cytochrome P450 1A genes by 3- methylcholanthrene	2	1
11778	10	11778 1999 MARINE BIOTECHNOLOGY 1(4):353-358 Mitsuo R; Itakura T; Sato M Cloning and sequencing of cytochrome P450 1A complementary DNA in eel (Anguilla japonica)	2	2
11779	10	11779 1999 MARINE BIOTECHNOLOGY 1(4):364-370 Ogino Y; Itakura T; Kato H; Aoki J; Sato M Functional analysis of promoter region from eel cytochrome P450 1A1 gene in transgenic medaka	2	1
11780	10	11780 1999 MARINE BIOTECHNOLOGY 1(4):371-375 Aoki J; Itakura T; Kato H; Sato M Isolation and sequence analysis of the eel cytochrome P450 1A1 gene	1	1
11781	3	11781 1999 MARINE ECOLOGY-PROGRESS SERIES 178():205-219 Muller WEG; Wiens M; Batel R; Steffen R; Schroder HC; Borojevic R; Custodio MR Establishment of a primary cell culture from a sponge: primmorphs from Suberites domuncula	36	0
11782	2	11782 1999 MEDICAL SCIENCE RESEARCH 27(9):617-620 Kalapos MP Influence of acetone on the hepatotoxicity of methylglyoxal	1	0
11783	10	11783 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 192(1-2):53-61 Engels W; van Bilsen M; Wolffenbuttel BHR; van der Vusse GJ; Glatz JFC Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid binding protein content in liver, heart and kidney of the diabetic rat	9	1
11784	16	11784 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 198(1-2):79-88 Ramana KV; Kohli KK Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey	1	0
11785	11	11785 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 198(1-2):89-100 Ikegwuonu FI; Jefcoate CR Evidence for the involvement of the fatty acid and peroxisomal beta-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and benz(a) anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells)	5	0
11786	9	11786 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 200(1-2):169-176 Dhawan A; Parmar D; Dayal M; Seth PK Cytochrome P450 (P450) isoenzyme specific dealkylation of alkoxyresorufins in rat brain microsomes	7	0
11787	9	11787 1999 MOLECULAR AND CELLULAR ENDOCRINOLOGY 153(1-2):183-196 Liu Z; Simpson ER Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression	18	1
11788	11	11788 1999 MOLECULAR BIOLOGY 33(4):618-621 Matushkin YG; Morozova IN; Morozov PS Theoretical analysis of mutation spectra of cytochrome P450	0	0
11789	11	11789 1999 MOLECULAR DIAGNOSIS 4(4):365-379 Linder MW; Valdes R Pharmacogenetics in the practice of laboratory medicine	9	0
11790	16	11790 1999 MOLECULAR ENDOCRINOLOGY 13(1):167-175 Geller DH; Auchus RJ; Miller WL P450c17 mutations R347H and R358Q selectively disrupt 17,20- lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b(5)	33	8
11791	7	11791 1999 MOLECULAR ENDOCRINOLOGY 13(6):946-957 Nelson VL; Legro RS; Strauss JF; McAllister JM Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries	34	1
11792	30	11792 1999 MOLECULAR ENDOCRINOLOGY 13(7):1169-1182 Auchus RJ; Miller WL Molecular modeling of human P450c17 (17 alpha- hydroxylase/17,20-lyase): Insights into reaction mechanisms and effects of mutations	35	10
11793	14	11793 1999 MOLECULAR PHARMACOLOGY 55(2):279-287 Kurose K; Tohkin M; Fukuhara M A novel positive regulatory element that enhances hamster CYP2A8 gene expression mediated by xenobiotic responsive element	4	2
11794	13	11794 1999 MOLECULAR PHARMACOLOGY 56(3):588-597 Schlezinger JJ; White RD; Stegeman JJ Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3 ',4,4 '-tetrachlorobiphenyl: Production of reactive oxygen by vertebrate CYP1As	51	7
11795	10	11795 1999 MOLECULAR PHARMACOLOGY 56(6):1329-1339 Goodwin B; Hodgson E; Liddle C The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module	97	27
11796	7	11796 1999 MOLECULAR PLANT-MICROBE INTERACTIONS 12(12):1044-1052 Oh BJ; Ko MK; Kim YS; Kim KS; Kostenyuk I; Kee HK A cytochrome P450 gene is differentially expressed in compatible and incompatible interactions between pepper (Capsicum annuum) and the anthracnose fungus, Colletotrichum gloeosporioides	3	0
11797	16	11797 1999 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 428(1-2):115-124 Guengerich FP; Parikh A; Turesky RJ; Josephy PD Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype	9	4
11798	13	11798 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 439(2):287-300 Kranendonk M; Fisher CW; Roda R; Carreira F; Theisen P; Laires A; Rueff J; Vermeulen NPE; Estabrook RW Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems	6	6
11799	8	11799 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 440(1):91-100 Lake BG; Beamand JA; Tredger JM; Barton PT; Renwick AB; Price RJ Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices	10	1
11800	26	11800 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 441(1):73-83 Kranendonk M; Carreira F; Theisen P; Laires A; Fisher CW; Rueff J; Estabrook RW; Vermeulen NPE Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies	9	9

#	Cited nodes	Nodes / Authors	GCS	LCS
11801	12	11801 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 442(2):113-120 Aryal P; Yoshikawa K; Terashita T; Guengerich FP; Shimada T; Oda Y Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase	11	7
11802	5	11802 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 443(1-2):235-249 Hursting SD; Kari FW The anti-carcinogenic effects of dietary restriction: mechanisms and future directions	15	1
11803	9	11803 1999 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 436(3):227-261 Taningher M; Malacarne D; Izzotti A; Ugolini D; Parodi S Drug metabolism polymorphisms as modulators of cancer susceptibility	40	2
11804	4	11804 1999 MYCOLOGICAL RESEARCH 103():1009-1018 Gramss G; Kirsche B; Voigt KD; Gunther T; Fritsche W Conversion rates of five polycyclic aromatic hydrocarbons in liquid cultures of fifty-eight fungi and the concomitant production of oxidative enzymes	11	0
11805	7	11805 1999 NATURE 399(6737):670-673 Joo H; Lin ZL; Arnold FH Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation	99	20
11806	11	11806 1999 NEOPLASMA 46(6):363-367 Iscan M; Eke BC; Aygormez S; Coban T; Bulbul D 7-Ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue	0	0
11807	2	11807 1999 NEUROMUSCULAR DISORDERS 9(4):208-214 Weller B; Carpenter S; Lochmuller H; Karpati G Myopathy with trabecular muscle fibers	3	0
11808	4	11808 1999 NEUROPHARMACOLOGY 38(7):979-989 Wu SN; Li HF; Jan CR; Shen AY Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH(3) cells	18	1
11809	14	11809 1999 ONCOLOGY RESEARCH 11(11-12):523-528 Knupfer H; Knupfer MM; Hotfilder M; Preiss R P450-expression in brain tumors	2	0
11810	5	11810 1999 ORAL ONCOLOGY 35(2):191-196 Tanimoto K; Hayashi S; Yoshiga K; Ichikawa T Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose	17	1
11811	7	11811 1999 PEDIATRIC RESEARCH 45(3):384-388 Dardis A; Saraco N; Rivarola MA; Belgorosky A Decrease in the expression of the 3 beta-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: Implications for the mechanism of adrenarche	8	2
11812	5	11812 1999 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 64(1):33-46 Inui H; Ueyama Y; Shiota N; Okhawa Y; Ohkawa H Herbicide metabolism and cross-tolerance in transgenic potato plants expressing human CYP1A1	15	2
11813	5	11813 1999 PESTICIDE SCIENCE 55(11):1043-1058 Davies J; Caseley JC Herbicide safeners: a review	11	0
11814	5	11814 1999 PHARMACEUTICAL RESEARCH 16(6):790-798 Kong ANT; Mandlekar S; Yu R; Lei W; Fasanmande A Pharmacodynamics and toxicodynamics of drug action: Signaling in cell survival and cell death	9	1
11815	3	11815 1999 PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY 2(3):119-120 Crespi CL Assessing the potential for drug-drug interactions in an accelerated throughput mode	6	0
11816	30	11816 1999 PHARMACOGENETICS 9(1):61-70 Louerat-Oriou B; Flinois JP; Beaune PH; Pompon D High yield purification and characterization of engineered human P450 1A2 and generation of immuno-inhibitor antibodies	0	0
11817	7	11817 1999 PHARMACOGENETICS 9(2):131-144 Tantcheva-Poor I; Zaigler M; Rietbrock S; Fuhr U Estimation of cytochrome P-450CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test	28	0
11818	9	11818 1999 PHARMACOGENETICS 9(2):239-250 Lovell DP; van Iersel M; Walters DG; Price RJ; Lake BG Genetic variation in the metabolism of coumarin in mouse liver	3	0
11819	2	11819 1999 PHARMACOGENETICS 9(2):263-265 Sempoux C; Starkel P; Stevens M; Van Den Berge V; Horsmans Y Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes	9	3
11820	8	11820 1999 PHARMACOGENETICS 9(3):327-332 Chen GF; Tang YM; Green B; Lin DX; Guengerich FP; Daly AK; Caporaso NE; Kadlubar FF Low frequency of CYP2A6 gene polymorphism as revealed by a one- step polymerase chain reaction method	27	3
11821	19	11821 1999 PHARMACOGENETICS 9(3):357-366 Schulz-Utermoehl T; Bennett AJ; Ellis SW; Tucker GT; Boobis AR; Edwards RJ Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression	11	0
11822	9	11822 1999 PHARMACOGENETICS 9(4):421-434 Vasiliou V; Bairoch A; Tipton KF; Nebert DW Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping	36	3
11823	14	11823 1999 PHARMACOLOGICAL REVIEWS 51(1):63-81 Mensah-Nyagan AG; Do-Rego JL; Beaujean D; Luu-The V; Pelletier G; Vaudry H Neurosteroids: Expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system	49	0
11824	20	11824 1999 PHARMACOLOGICAL REVIEWS 51(2):135-157 Lin JH; Chiba M; Baillie TA Is the role of the small intestine in first-pass metabolism overemphasized?	50	4
11825	24	11825 1999 PHARMACOLOGY & THERAPEUTICS 84(2):121-131 Crespi CL; Miller VP The use of heterologously expressed drug metabolizing enzymes - state of the art and prospects for the future	20	3
11826	10	11826 1999 PHARMACOLOGY & TOXICOLOGY 85(2):65-73 Eltom SE; Schwark WS CYP1A1 and CYP1B1, two hydrocarbon-inducible cytochromes P450, are constitutively expressed in neonate and adult goat liver, lung and kidney	4	2
11827	9	11827 1999 PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY 55(6):317-326 Delserone LM; McCluskey K; Matthews DE; Vanetten HD Pisatin demethylation by fungal pathogens and nonpathogens of pea: association with pisatin tolerance and virulence	8	2
11828	4	11828 1999 PHYTOCHEMISTRY 50(2):243-248 Bouwmeester HJ; Konings MCJM; Gershenzon J; Karp F; Croteau R Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum carvi)	7	1
11829	5	11829 1999 PHYTOCHEMISTRY 52(7):1195-1202 Friederich S; Rueffer M; Asakawa Y; Zenk MH Cytochromes P-450 catalyze the formation of marchantins A and C in Marchantia polymorpha	7	0
11830	7	11830 1999 PLANT AND CELL PHYSIOLOGY 40(11):1182-1186 Akashi T; Fukuchi-Mizutani M; Aoki T; Ueyama Y; Yonekura-Sakakibara K; Tanaka Y; Kusumi T; Ayabe S Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones	12	1
11831	15	11831 1999 PLANT AND CELL PHYSIOLOGY 40(12):1232-1242 Takemoto D; Hayashi M; Doke N; Nishimura M; Kawakita K Molecular cloning of a defense-response-related cytochrome P450 gene from tobacco	2	0
11832	10	11832 1999 PLANT JOURNAL 19(2):183-193 Kaltenbach M; Schroder G; Schmelzer E; Lutz V; Schroder J Flavonoid hydroxylase from Catharanthus roseus: cDNA, heterologous expression, enzyme properties and cell-type specific expression in plants	13	2
11833	5	11833 1999 PLANT JOURNAL 19(4):441-451 Brugliera F; Barri-Rewell G; Holton TA; Mason JG Isolation and characterization of a flavonoid 3 '-hydroxylase cDNA clone corresponding to the Ht1 locus of Petunia hybrida	24	0
11834	3	11834 1999 PLANT MOLECULAR BIOLOGY 40(2):237-248 Panavas T; Pikula A; Reid PD; Rubinstein B; Walker EL Identification of senescence-associated genes from daylily petals	19	1
11835	4	11835 1999 PLANT MOLECULAR BIOLOGY REPORTER 17(4):355-361 Shimada Y; Ohbayashi M; Nakano-Shimada R; Okinaka Y; Kiyokawa S; Kikuchi Y A novel method to clone P450s with modified single-specific- primer PCR	1	0
11836	6	11836 1999 PLANT PHYSIOLOGY 121(3):821-828 Akashi T; Aoki T; Ayabe S Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in licorice	27	2
11837	8	11837 1999 PLANT SCIENCE 149(2):105-113 Oudin A; Hamdi S; Ouelhazi L; Chenieux JC; Rideau M; Clastre M Induction of a novel cytochrome P450 (CYP96 family) in periwinkle (Catharanthus roseus) cells induced for terpenoid indole alkaloid production	4	0
11838	3	11838 1999 POSTGRADUATE MEDICINE 105(2):193-+ Johnson MD; Newkirk G; White JR Clinically significant drug interactions - What you need to know before writing prescriptions	15	4
11839	9	11839 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(4):1750-1755 Siminszky B; Corbin FT; Ward ER; Fleischmann TJ; Dewey RE Expression of a soybean cytochrome P450 monooxygenase cDNA in yeast and tobacco enhances the metabolism of phenylurea herbicides	19	6
11840	27	11840 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):1863-1868 Sevrioukova IF; Li HY; Zhang H; Peterson JA; Poulos TL Structure of a cytochrome P450-redox partner electron-transfer complex	73	23
11841	9	11841 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):1977-1982 Buters JTM; Sakai S; Richter T; Pineau T; Alexander DL; Savas U; Doehmer J; Ward JM; Jefcoate CR; Gonzalez FJ Cytochrome P450 CYP1B1 determines susceptibility to 7,12- dimethylbenz[a]anthracene-induced lymphomas	62	10
11842	3	11842 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(13):7238-7243 Lund EG; Guileyardo JM; Russell DW cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain	58	10
11843	3	11843 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(22):12790-12797 New MI; Wilson RC Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess	20	0
11844	6	11844 1999 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 266(1414):1-12 von Schantz T; Bensch S; Grahn M; Hasselquist D; Wittzell H Good genes, oxidative stress and condition-dependent sexual signals	48	0
11845	22	11845 1999 PROTEINS-STRUCTURE FUNCTION AND GENETICS 34(3):403-415 Chang YT; Loew GH Homology modeling and substrate binding study of human CYP4A11 enzyme	19	8
11846	31	11846 1999 PROTEINS-STRUCTURE FUNCTION AND GENETICS 37(2):176-190 Payne VA; Chang YT; Loew GH Homology modeling and substrate binding study of human CYP2C9 enzyme	17	3
11847	18	11847 1999 PROTEINS-STRUCTURE FUNCTION AND GENETICS 37(2):204-217 Payne VA; Chang YT; Loew GH Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes	5	0
11848	10	11848 1999 REVUE DES MALADIES RESPIRATOIRES 16(6BIS):1236-1243 Pairon JC; Housset B Biomarkers and exposure to asbestos.	3	1
11849	2	11849 1999 RUSSIAN JOURNAL OF GENERAL CHEMISTRY 69(6):936-953 Shugalei IV; Tselinskii IV Nitroalkanes as initiators of radical chain processes in chemistry and biology	1	0
11850	6	11850 1999 SCIENCE 285(5431):1276-1279 Node K; Huo YQ; Ruan XL; Yang BC; Spiecker M; Ley K; Zeldin DC; Liao JK Anti-inflammatory properties of cytochrome P450 epoxygenase- derived eicosanoids	85	27
11851	1	11851 1999 SCIENCE 286(5447):2179-2184 White KP; Rifkin SA; Hurban P; Hogness DS Microarray analysis of Drosophila development during metamorphosis	122	2
11852	2	11852 1999 SCIENCES DES ALIMENTS 19(5):515-542 Aurousseau B The origin of ovine carcass discoloration: a review.	1	0
11853	9	11853 1999 STEROIDS 64(3):178-186 Holland HL Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts	8	1
11854	9	11854 1999 TOXICOLOGICAL SCIENCES 47(1):52-61 Korytko PJ; Casey AC; Bush B; Quimby FW Induction of hepatic cytochromes P450 in dogs exposed to a chronic low dose of polychlorinated biphenyls	4	0
11855	13	11855 1999 TOXICOLOGICAL SCIENCES 48(2):151-156 Omiecinski CJ; Remmel RP; Hosagrahara VP Concise review of the cytochrome P450s and their roles in toxicology	27	8
11856	2	11856 1999 TOXICOLOGICAL SCIENCES 49(1):15-28 Collins AS; Sumner SCJ; Borghoff SJ; Medinsky MA A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures	7	0
11857	7	11857 1999 TOXICOLOGICAL SCIENCES 52(1):130-139 Inder RE; Bray BJ; Sipes IG; Rosengren RJ Role of cytochrome P4502E1 in retinol's attenuation of carbon tetrachloride-induced hepatotoxicity in the Swiss Webster mouse	3	0
11858	27	11858 1999 TOXICOLOGY 133(1):1-33 Lewis DFV; Dickens M; Lake BG; Eddershaw PJ; Tarbit MH; Goldfarb PS Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity	15	5
11859	38	11859 1999 TOXICOLOGY 139(1-2):53-79 Lewis DFV; Lake BG; George SG; Dickins M; Eddershaw PJ; Tarbit MH; Beresford AP; Goldfarb PS; Guengerich FP Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102	16	5
11860	0	11860 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 154(2):126-134 Metosh-Dickey CA; Mason RP; Winston GW Nitroarene reduction and generation of free radicals by cell- free extracts of wild-type, and nitroreductase-deficient and - enriched Salmonella typhimurium strains used in the umu gene induction assay	1	0
11861	20	11861 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 155(1):96-106 Mahajan SS; Rifkind AB Transcriptional activation of avian CYP1A4 and CYP1A5 by 2,3,7,8-tetrachlorodibenzo-p-dioxin: Differences in gene expression and regulation compared to mammalian CYP1A1 and CYP1A2	10	4
11862	19	11862 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 156(3):231-240 Bhagwat SV; Mullick J; Raza H; Avadhani NG Constitutive and inducible cytochromes P450 in rat lung mitochondria: Xenobiotic induction, relative abundance, and catalytic properties	10	1
11863	9	11863 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 157(3):157-165 Ertl RP; Bandiera SM; Buhler DR; Stegeman JJ; Winston GW Immunochemical analysis of liver microsomal cytochromes P450 of the American alligator, Alligator mississippiensis	1	0
11864	14	11864 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 158(2):197-205 You L; Chan SK; Brace JM; Archibeque-Engle S; Casanova M; Corton JC; Heck HD Modulation of testosterone-metabolizing hepatic cytochrome P- 450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p '-DDE	13	4
11865	5	11865 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 160(1):10-20 Letcher RJ; van Holsteijn I; Drenth HJ; Norstrom RJ; Bergman A; Safe S; Pieters R; van den Berg M Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells	12	1
11866	5	11866 1999 TOXICOLOGY IN VITRO 13(4-5):633-638 Bort R; Castell JV; Pfeifer A; Gomez-Lechon MJ; Mace K High expression of human CYP2C in immortalized human liver epithelial cells	3	1
11867	36	11867 1999 TOXICOLOGY LETTERS 110(1-2):43-55 Adas F; Berthou F; Salaun JP; Dreano Y; Amet Y Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A	6	3
11868	14	11868 1999 USPEKHI KHIMII 68(10):967-975 Shumyantseva VV; Bulko TV; Archakov AI Regulation of cytochrome P450S catalytic activities by means of physico-chemical methods	0	0
11869	7	11869 1999 VETERINARY AND HUMAN TOXICOLOGY 41(4):210-212 Govindwar SP; Adav SS Effects of aflatoxin B-1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens	0	0
11870	14	11870 1999 VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 434(5):401-411 Yokose T; Doy M; Taniguchi T; Shimada T; Kakiki M; Horie T; Matsuzaki Y; Mukai K Immunohistochemical study of cytochrome P4502C and 3A in human non-neoplastic and neoplastic tissues	21	10
11871	6	11871 1999 VOPROSY MEDITSINSKOI KHIMII 45(1):30-36 Schwartz EI; Gulyaeva LF; Lyakhovich VV The interstrain differences in the enzymatic activity of CYP2B1 and expression of its gene in rat liver during induction with phenobarbital and triphenyldioxane	0	0
11872	4	11872 1999 WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 15(2):259-263 Salokhe MD; Govindwar SP Effect of carbon source on the biotransformation enzymes in Serratia marcescens	0	0
11873	9	11873 1999 WORLD JOURNAL OF SURGERY 23(1):6-11 Izuishi K; Wakabayashi H; Kokudo Y; Maeba T; Ryu M; Maeta H Microsomal cytochrome P-450 monooxygenase system and its drug- metabolizing activity after partial portal vein ligation in the rat	1	0
11874	12	11874 1999 XENOBIOTICA 29(3):217-229 Shiraga T; Kaneko H; Iwasaki K; Tozuka Z; Suzuki A; Hata T Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes	9	1
11875	25	11875 1999 XENOBIOTICA 29(3):231-241 Yamazaki H; Shimada T Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes	15	5
11876	19	11876 1999 XENOBIOTICA 29(3):269-279 Ogg MS; Williams JM; Tarbit M; Goldfarb PS; Gray TJB; Gibson GG A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro	32	10
11877	54	11877 1999 XENOBIOTICA 29(4):361-393 Lewis DFV; Lake BG; Dickins M; Eddershaw PJ; Tarbit MH; Goldfarb PS Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b(5) binding site and comparisons with CYP2B1 and CYP2B4	26	10
11878	13	11878 1999 XENOBIOTICA 29(5):437-451 Chen GF; Ronis MJJ; Ingelman-Sundberg M; Badger TM Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney	16	2
11879	14	11879 1999 XENOBIOTICA 29(6):629-640 Roos PH Common multiple interactions of tricyclic antidepressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat	0	0
11880	2	11880 1999 XENOBIOTICA 29(7):655-691 Rockett JC; Esdaile DJ; Gibson GG Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential	4	0
11881	13	11881 1999 XENOBIOTICA 29(7):703-717 Grace JM; Skanchy DJ; Aguilar AJ Metabolism of artelinic acid to dihydroqinghaosu by human liver cytochrome P4503A	7	1
11882	26	11882 1999 XENOBIOTICA 29(8):763-781 Lewis DFV; Lake BG Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102	9	5
11883	7	11883 1999 XENOBIOTICA 29(8):815-826 Kashiyama E; Yokoi T; Odomi M; Kamataki T Stereoselective S-oxidation and reduction of flosequinan in rat	0	0
11884	6	11884 1999 XENOBIOTICA 29(9):873-883 Hanioka N; Jinno H; Chung YS; Tanaka-Kagawa T; Nishimura T; Ando M Inhibition of rat hepatic cytochrome P450 activities by biodegradation products of 4-tert-octylphenol ethoxylate	7	1
11885	15	11885 1999 XENOBIOTICA 29(9):885-898 Nakajima M; Kobayashi K; Oshima K; Shimada N; Tokudome S; Chiba K; Yokoi T Activation of phenacetin O-deethylase activity by alpha- naphthoflavone in human liver microsomes	12	7
11886	16	11886 1999 XENOBIOTICA 29(12):1191-1202 Nakajima M; Suzuki M; Yamaji R; Takashina H; Shimada N; Yamazaki H; Yokoi T Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds	3	1
11887	11	11887 1999 XENOBIOTICA 29(12):1213-1226 Hanioka N; Jinno H; Tanaka-Kagawa T; Nishimura T; Ando M In vitro metabolism of simazine, atrazine and propazine by hepatic cytochrome P450 enzymes of rat, mouse and guinea pig, and oestrogenic activity of chlorotriazines and their main metabolites	4	0
11888	2	11888 1999 ZEITSCHRIFT FUR GASTROENTEROLOGIE 37(5):367-378 Strohmeyer G; Weik C Drug-induced liver disease	2	0
11889	7	11889 2000 ACCOUNTS OF CHEMICAL RESEARCH 33(7):449-455 Newcomb M; Toy PH Hypersensitive radical probes and the mechanisms of cytochrome P450-catalyzed hydroxylation reactions	48	1
11890	16	11890 2000 ACTA BIOCHIMICA POLONICA 47(4):1093-1105 Czekaj P Phenobarbital-induced expression of cytochrome P450 genes	0	0
11891	6	11891 2000 ACTA PHARMACOLOGICA SINICA 21(8):673-679 Han XM; Zhou HH Polymorphism of CYP450 and cancer susceptibility	4	0
11892	6	11892 2000 ACTA PHYSIOLOGICA SCANDINAVICA 168(4):543-549 Harder DR; Roman RJ; Gebremedhin D Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes	6	1
11893	8	11893 2000 ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 55 55():175-263 El Khadem HS; Fatiadi AJ Hydrazine derivatives of carbohydrates and related compounds	1	0
11894	3	11894 2000 AMERICAN JOURNAL OF CLINICAL NUTRITION 72(2):670S-674S Jenkins RR Exercise and oxidative stress methodology: a critique	4	0
11895	17	11895 2000 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 279(2):H857-H862 Nithipatikom K; Pratt PF; Campbell WB Determination of EETs using microbore liquid chromatography with fluorescence detection	18	5
11896	5	11896 2000 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 279(6):L1005-L1028 Thannickal VJ; Fanburg BL Reactive oxygen species in cell signaling	108	0
11897	19	11897 2000 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 279(6):F965-F981 Imig JD Eicosanoid regulation of the renal vasculature	27	3
11898	10	11898 2000 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 161(6):1917-1923 Kiss L; Schutte H; Mayer K; Grimm H; Padberg W; Seeger W; Grimminger F Synthesis of arachidonic acid-derived lipoxygenase end cytochrome P450 products in the intact human lung vasculature	9	3
11899	19	11899 2000 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 22(3):360-366 Hukkanen J; Lassila A; Paivarinta K; Valanne S; Sarpo S; Hakkola J; Pelkonen O; Raunio H Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line	19	7
11900	8	11900 2000 ANAESTHESIA 55(6):540-544 Chimbira W; Sweeney BP The effect of smoking on postoperative nausea and vomiting	6	0

#	Cited nodes	Nodes / Authors	GCS	LCS
11901	11	11901 2000 ANDROLOGIA 32(4-5):255-262 Schuppe HC; Wieneke P; Donat S; Fritsche E; Kohn FM; Abel J Xenobiotic metabolism, genetic polymorphisms and male infertility	2	0
11902	4	11902 2000 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 40():159-176 Nagata K; Yamazoe Y Pharmacogenetics of sulfotransferase	39	2
11903	9	11903 2000 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 40():581-616 Tukey RH; Strassburg CP Human UDP-glucuronosyltransferases: Metabolism, expression, and disease	111	6
11904	45	11904 2000 AQUATIC TOXICOLOGY 48(4):529-547 Snyder MJ Cytochrome P450 enzymes in aquatic invertebrates: recent advances and future directions	14	3
11905	14	11905 2000 AQUATIC TOXICOLOGY 49(1-2):101-109 Cao ZJ; Hong J; Peterson RE; Aiken JM Characterization of CYP1A1 and CYP1A3 gene expression in rainbow trout (Oncorhynchus mykiss)	6	2
11906	2	11906 2000 AQUATIC TOXICOLOGY 50(4):403-415 van Schanke A; Boon JP; Aardoom Y; van Leest A; van Schooten FJ; Maas L; van den Berg M; Everaarts JM Effect of a dioxin-like PCB (CB 126) on the biotransformation and genotoxicity of benzo[a]pyrene in the marine flatfish dab (Limanda limanda)	8	0
11907	10	11907 2000 AQUATIC TOXICOLOGY 51(2):145-153 Teramitsu I; Yamamoto Y; Chiba I; Iwata H; Tanabe S; Fujise Y; Kazusaka A; Akahori F; Fujita S Identification of novel cytochrome P450 1A genes from five marine mammal species	4	1
11908	10	11908 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 373(1):44-55 Pikuleva IA; Tesh K; Waterman MR; Kim YC The tertiary structure of full-length bovine adrenodoxin suggests functional dimers	23	7
11909	16	11909 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 373(2):335-345 Khan KK; Halpert JR Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes	16	3
11910	18	11910 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 373(2):375-384 Ourlin JC; Baader M; Fraser D; Halpert JR; Meyer UA Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37)	10	5
11911	29	11911 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 374(2):269-278 Roussel F; Khan KK; Halpert JR The importance of SRS-1 residues in catalytic specificity of human cytochrome p450 3A4	20	6
11912	6	11912 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 375(1):145-153 Kneer N; Lardy H Thyroid hormone and dehydroepiandrosterone permit gluconeogenic hormone responses in hepatocytes	1	0
11913	9	11913 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 377(1):43-48 Shumyantseva VV; Bulko TV; Bachmann TT; Bilitewski U; Schmid RD; Archakov AI Electrochemical reduction of flavocytochromes 2B4 and 1A2 and their catalytic activity	6	5
11914	16	11914 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 378(2):333-339 Kawashima H; Naganuma T; Kusunose E; Kono T; Yasumoto R; Sugimura K; Kishimoto T Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein	8	3
11915	14	11915 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 378(2):364-376 Zhang XL; Chen LP; Hardwick JP Promoter activity and regulation of the CYP4F2 leukotriene B-4 omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells	4	2
11916	13	11916 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 379(1):97-108 O'Leary KA; Kasper CB Molecular basis for cell-specific regulation of the NADPH- cytochrome P450 oxidoreductase gene	4	0
11917	14	11917 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 379(1):127-136 Haudenschild C; Schalk M; Karp F; Croteau R Functional expression of regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha spp.) in Escherichia coli and Saccharomyces cerevisiae	14	3
11918	23	11918 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 380(1):29-38 Kullman SW; Hamm JT; Hinton DE Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes)	4	2
11919	19	11919 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 380(1):117-125 Parimoo B; Thomas PE Epitope mapping of rat cytochrome P4502B1 using glutathione S- transferase-2B1 fusion constructs	1	0
11920	10	11920 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 380(2):367-372 Bobyleva V; Pazienza L; Muscatello U; Kneer N; Lardy H Short-term hypothermia activates hepatic mitochondrial sn- glycerol-3-phosphate dehydrogenase and thermogenic systems	2	0
11921	16	11921 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 381(1):164-170 Hayashi K; Sakaki T; Kominami S; Inouye K; Yabusaki Y Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b(5) in yeast	9	4
11922	19	11922 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 381(2):191-204 Blume N; Leonard J; Xu ZJ; Watanabe O; Remotti H; Fishman J Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells	1	0
11923	19	11923 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 383(1):70-78 Hudecek J; Anzenbacherova E; Anzenbacher P; Munro AW; Hildebrandt P Structural similarities and differences of the heme pockets of various P450 isoforms as revealed by resonance Raman spectroscopy	2	0
11924	9	11924 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 383(1):119-127 Hsu PY; Tsai AL; Wang LH Identification of thromboxane synthase amino acid residues involved in heme-propionate binding	2	0
11925	16	11925 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 383(2):225-232 Kikuta Y; Kasyu H; Kusunose E; Kusunose M Expression and catalytic activity of mouse leukotriene B-4 omega-hydroxylase, CYP4F14	6	4
11926	7	11926 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 384(1):143-153 MacDonald MJ; Marshall LK Mouse lacking NAD(+)-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle	5	1
11927	17	11927 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 384(2):311-318 Lekas P; Tin KL; Lee C; Prokipcak RD The human cytochrome P450 1A1 mRNA is rapidly degraded in HepG2 cells	13	2
11928	10	11928 2000 ARCHIVES OF PHARMACAL RESEARCH 23(1):1-16 Kong ANT; Yu R; Chen C; Mandlekar S; Primiano T Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis	34	1
11929	11	11929 2000 ARCHIVES OF TOXICOLOGY 73(12):625-631 Hanioka N; Jinno H; Chung YS; Nishimura T; Tanaka-Kagawa T; Ando M Effect of 4-tert-octylphenol on cytochrome P450 enzymes in rat liver	3	1
11930	3	11930 2000 ARCHIVES OF TOXICOLOGY 74(7):379-387 Laube B; Winkler S; Ladstetter B; Scheller T; Schwarz LR Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora	0	0
11931	7	11931 2000 ARCHIVES OF TOXICOLOGY 74(7):397-403 Pons F; Haag M; Corcos L; Bonnet P; Guillouzo A; Lugnier A; Frossard N Inhalation of toluene diisocyanate affects cytochrome P4502B1 expression in rat lung	5	3
11932	3	11932 2000 ARCHIVES OF TOXICOLOGY 74(7):415-420 Bertini S; Del Carratore R; Giorgi M; Bronzetti G; Della Croce C Genotoxic and mono-oxygenase system effects of the fungicide maneb	0	0
11933	3	11933 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 267(1):184-189 Dalton TP; Dieter MZ; Matlib RS; Childs NL; Shertzer HG; Genter MB; Nebert DW Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery	15	5
11934	9	11934 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 267(2):572-576 Guigal N; Seree E; Bourgarel-Rey V; Barra Y Induction of CYP1A1 by serum independent of AhR pathway	7	0
11935	7	11935 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(3):677-682 Tares S; Berge JB; Amichot M Cloning and expression of cytochrome P450 genes belonging to the CYP4 family and to a novel family, CYP48, in two hymenopteran insects, Trichogramma cacoeciae and Apis mellifera	1	1
11936	7	11936 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(3):740-744 Lei CH; Wollenberger U; Jung C; Scheller FW Clay-bridged electron transfer between cytochrome P450(cam) and electrode	8	2
11937	7	11937 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(2):393-396 Mushiroda T; Ariyoshi N; Kimura K; Takahara E; Nagata O; Kato H; Kamataki T A high-level expression of CYP2A in the lung of the suncus (Suncus murinus) and its role in the activation of 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone	0	0
11938	12	11938 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(2):623-627 Inoue E; Takahashi Y; Imai Y; Kamataki T Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450	2	2
11939	10	11939 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(3):737-742 Simgen B; Contzen J; Schwarzer R; Bernhardt R; Jung C Substrate binding to 15 beta-hydroxylase (CYP106A2) probed by FT infrared spectroscopic studies of the iron ligand CO stretch vibration	4	1
11940	2	11940 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 271(3):788-795 Lee PL; Halloran C; Cross AR; Beutler E NADH-ferric reductase activity associated with dihydropteridine reductase	5	0
11941	12	11941 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(3):799-804 Yoshida Y; Aoyama Y; Noshiro M; Gotoh O Sterol 14-demethylase P450 (CYP51) provides a breakthrough for the discussion on the evolution of cytochrome P450 gene superfamily	13	4
11942	23	11942 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(3):1132-1137 Maibeche-Coisne M; Monti-Dedieu L; Aragon S; Dauphin-Villemant C A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system	3	0
11943	9	11943 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(2):762-766 LeLean JE; Moon N; Dunham WR; Coon MJ EPR spectrometry of cytochrome P4502B4: Effects of mutations and substrate binding	3	1
11944	8	11944 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 277(3):594-598 Jeong HG; Kim JY; Choi CY Down-regulation of murine Cyp1a-1 in mouse hepatoma Hepa-1c1c7 cells by bisphenol A	2	0
11945	7	11945 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279(1):288-292 Jarukamjorn K; Sakuma T; Nemoto N Discriminating activation of CYP2B9 expression in male C57BL/6 mouse liver by beta-estradiol	4	0
11946	7	11946 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279(2):708-711 Taylor M; Lamb DC; Cannell RJP; Dawson MJ; Kelly SL Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1)	1	1
11947	71	11947 2000 BIOCHEMICAL JOURNAL 347():321-337 Honkakoski P; Negishi M Regulation of cytochrome P450 (CYP) genes by nuclear receptors	68	14
11948	21	11948 2000 BIOCHEMICAL PHARMACOLOGY 59(1):65-85 Nebert DW; Roe AL; Dieter MZ; Solis WA; Yang Y; Dalton TP Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis	95	7
11949	9	11949 2000 BIOCHEMICAL PHARMACOLOGY 59(5):583-589 Oinonen T; Ronis M; Wigell T; Tohmo K; Badger T; Lindros KO Growth hormone-regulated periportal expression of CYP2C7 in rat liver	1	0
11950	10	11950 2000 BIOCHEMICAL PHARMACOLOGY 59(8):997-1005 Puga A; Barnes SJ; Chang CY; Zhu H; Nephew KP; Khan SA; Shertzer HG Activation of transcription factors activator protein-1 and nuclear factor-kappa B by 2,3,7,8-tetrachlorodibenzo-p-dioxin	23	0
11951	28	11951 2000 BIOCHEMICAL PHARMACOLOGY 59(10):1277-1287 Kawai M; Bandiera SM; Chang TKH; Bellward GD Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2	7	0
11952	15	11952 2000 BIOCHEMICAL PHARMACOLOGY 60(3):293-306 Lewis DFV On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics - Towards the prediction of human P450 substrate specificity and metabolism	32	7
11953	10	11953 2000 BIOCHEMICAL PHARMACOLOGY 60(6):857-863 Ueno T; Tamura S; Frels WI; Shou M; Gonzalez FJ; Kimura S A transgenic mouse expressing human CYP1A2 in the pancreas	3	0
11954	7	11954 2000 BIOCHEMISTRY 39(10):2484-2498 Chang YT; Loew G Homology modeling, molecular dynamics simulations, and analysis of CYP119, a P450 enzyme from extreme acidothermophilic archaeon Sulfolobus solfataricus	11	2
11955	31	11955 2000 BIOCHEMISTRY 39(17):5196-5205 Helvig C; Capdevila JH Biochemical characterization of rat P4502C11 fused to rat or bacterial NADPH-P450 reductase domains	3	3
11956	16	11956 2000 BIOCHEMISTRY 39(19):5731-5737 Smith SV; Koley AP; Dai RK; Robinson RC; Leong H; Markowitz A; Friedman FK Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: A CO flash photolysis study	6	1
11957	26	11957 2000 BIOCHEMISTRY 39(20):5929-5939 Hosea NA; Miller GP; Guengerich FP Elucidation of distinct ligand binding sites for cytochrome P450 3A4	53	17
11958	6	11958 2000 BIOCHEMISTRY 39(20):5961-5970 Ihara M; Takahashi S; Ishimori K; Morishima I Functions of fluctuation in the heme-binding loops of cytochrome b(5) revealed in the process of heme incorporation	6	0
11959	34	11959 2000 BIOCHEMISTRY 39(21):6489-6497 Davydov DR; Kariakin AA; Petushkova NA; Peterson JA Association of cytochromes P450 with their reductases: Opposite sign of the electrostatic interactions in P450BM-3 as compared with the microsomal 2B4 system	6	3
11960	9	11960 2000 BIOCHEMISTRY 39(24):7117-7130 Arnesano F; Banci L; Bertini I; Koulougliotis D; Monti A Monitoring mobility in the early steps of unfolding: The case of oxidized cytochrome b(5) in the presence of 2 M guanidinium chloride	7	0
11961	4	11961 2000 BIOCHEMISTRY 39(30):8859-8869 Reynolds CM; Poole LB Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity	12	0
11962	12	11962 2000 BIOCHEMISTRY 39(31):9419-9429 Haines DC; Sevrioukova IF; Peterson JA The FMN-binding domain of cytochrome P450BM-3: Resolution, reconstitution, and flavin analogue substitution	3	2
11963	9	11963 2000 BIOCHEMISTRY 39(36):10986-10995 Ziegler GA; Schulz GE Crystal structures of adrenodoxin reductase in complex with NADP(+) and NADPH suggesting a mechanism for the electron transfer of an enzyme family	16	2
11964	11	11964 2000 BIOCHEMISTRY 39(41):12699-12707 Murataliev MB; Feyereisen R Functional interactions in cytochrome P450(BM3). Evidence that NADP(H) binding controls redox potentials of the flavin cofactors	2	0
11965	11	11965 2000 BIOCHEMISTRY 39(45):13817-13824 Gillam EMJ; Notley LM; Cai HL; De Voss JJ; Guengerich FP Oxidation of indole by cytochrome P450 enzymes	14	4
11966	23	11966 2000 BIOCHEMISTRY 39(49):15110-15120 Loughran PA; Roman LJ; Aitken AE; Miller RT; Masters BSS Identification of unique amino acids that modulate CYP4A7 activity	6	3
11967	2	11967 2000 BIOCHEMISTRY-MOSCOW 65(8):972-975 Sumbayev VV In vitro effects of corticosteroids, DDT, and 4,9- dichlorodibenzodioxin on rat liver xanthine oxidase activity. Interactions between xanthine oxidase and cytochrome P450 in rat liver in vivo	1	0
11968	5	11968 2000 BIOCHEMISTRY-MOSCOW 65(10):1206-1211 Kovaleva IE; Grivennikov SI; Luzikov VN On the effect of cholesterol on the fate of CYP11A1 imported into yeast mitochondria in vivo	0	0
11969	13	11969 2000 BIOCHEMISTRY-MOSCOW 65(12):1362-1366 Novikova LA; Nazarov PA; Saveliev AS; Drutsa VL; Sergeev VN; Miller WL; Luzikov VN Interaction of catalytic domains in cytochrome P450scc- adrenodoxin reductase-adrenodoxin fusion protein imported into yeast mitochondria	1	1
11970	50	11970 2000 BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1460(2-3):353-374 Lewis DFV; Hlavica P Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects	8	3
11971	1	11971 2000 BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1465(1-2):79-103 Theodoulou FL Plant ABC transporters	32	0
11972	9	11972 2000 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1529(1-3):126-135 Russell DW Oxysterol biosynthetic enzymes	27	0
11973	17	11973 2000 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1476(2):253-264 Cao PR; Bulow H; Dumas B; Bernhardt R Construction and characterization of a catalytic fusion protein system: P-45011(beta)-adrenodoxin reductase-adrenodoxin	4	3
11974	74	11974 2000 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1543(2):383-407 Miles CS; Ost TWB; Noble MA; Munro AW; Chapman SK Protein engineering of cytochromes P-450	21	9
11975	7	11975 2000 BIOFIZIKA 45(6):1013-1018 Shumyantseva VV; Bulko TV; Schmid RD; Archakov AI Photoreduction of flavocytochrome P4502B4	1	0
11976	10	11976 2000 BIOLOGICAL CHEMISTRY 381(7):611-614 Weitzel JM; Grott S; Radtke C; Kutz S; Seitz HJ Multiple promoters direct the tissue-specific expression of rat mitochondrial glycerol-3-phosphate dehydrogenase	4	1
11977	2	11977 2000 BIOMARKERS 5(2):81-107 Neghab M; Stacey NH Serum bile acids as a sensitive biological marker for evaluating hepatic effects of organic solvents	2	0
11978	2	11978 2000 BIOMETALS 13(1):23-28 Sugimori D; Ichimata T; Ikeda A; Nakamura S Purification and characterization of a ferredoxin from Haloarcula japonica strain TR-1	1	1
11979	2	11979 2000 BIOORGANICHESKAYA KHIMIYA 26(2):97-111 Preobrazhenskaya MN; Korolev AM Indole derivatives in vegetables of the Cruciferae family	1	0
11980	6	11980 2000 BIOTECHNOLOGY LETTERS 22(1):3-8 Engler KH; Kelly SL; Coker RD; Evans IH Toxin-binding properties of cytochrome P450 in Saccharomyces cerevisiae and Kluyveromyces marxianus	1	0
11981	9	11981 2000 BIOTECHNOLOGY PROGRESS 16(4):610-616 Mayhew MP; Reipa V; Holden MJ; Vilker VL Improving the cytochrome P450 enzyme system for electrode- driven biocatalysis of styrene epoxidation	14	3
11982	6	11982 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 49():35S-42S Prakash C; Kamel A; Cui D; Whalen RD; Miceli JJ; Tweedie D Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions	26	0
11983	10	11983 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 49(2):145-151 Ou-Yang DS; Huang SL; Wang W; Xie HG; Xu ZH; Shu Y; Zhou HH Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population	15	0
11984	8	11984 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 49(3):244-253 Ohyama K; Nakajima M; Suzuki M; Shimada N; Yamazaki H; Yokoi T Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions	13	2
11985	15	11985 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 50(6):573-580 Ong CE; Coulter S; Birkett DJ; Bhasker CR; Miners JO The xenobiotic inhibitor profile of cytochrome P4502C8	9	1
11986	9	11986 2000 BRITISH JOURNAL OF PHARMACOLOGY 129(3):547-554 Fearon IM; Ball SG; Peers C Clotrimazole inhibits the recombinant human cardiac L-type Ca2+ channel alpha(1C) subunit	4	0
11987	9	11987 2000 BRITISH JOURNAL OF PHARMACOLOGY 130(8):1745-1752 Thum T; Borlak J Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat	7	1
11988	16	11988 2000 CANCER RESEARCH 60(6):1604-1608 Rubin GL; Zhao Y; Kalus AM; Simpson ER Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible implications for breast cancer therapy	37	2
11989	10	11989 2000 CANCER RESEARCH 60(12):3232-3238 Quintieri L; Rosato A; Napoli E; Sola F; Geroni C; Floreani M; Zanovello P In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: Role of cytochrome P450 3A	9	3
11990	16	11990 2000 CANCER RESEARCH 60(17):4667-4677 Williams JA; Phillips DH Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer	27	2
11991	15	11991 2000 CARCINOGENESIS 21(3):345-351 Guengerich FP Metabolism of chemical carcinogens	24	2
11992	3	11992 2000 CARCINOGENESIS 21(4):669-676 Alexandrie AK; Warholm M; Carstensen U; Axmon A; Hagmar L; Levin JO; Ostman C; Rannug A CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure	21	0
11993	3	11993 2000 CARCINOGENESIS 21(6):1163-1166 Schabath MB; Spitz MR; Zhang XM; Delclos GL; Wu XF Genetic variants of myeloperoxidase and lung cancer risk	28	0
11994	13	11994 2000 CARCINOGENESIS 21(6):1227-1232 Kushida H; Fujita K; Suzuki A; Yamada M; Endo T; Nohmi T; Kamataki T Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase	19	9
11995	10	11995 2000 CARCINOGENESIS 21(8):1559-1566 Teiber JF; Hollenberg PF Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine	3	3
11996	2	11996 2000 CELL BIOLOGY INTERNATIONAL 24(8):569-580 Gilbert D; Lloyd D The living cell: A complex autodynamic multi-oscillator system?	3	0
11997	2	11997 2000 CELLULAR AND MOLECULAR BIOLOGY 46(7):1191-1212 Krieg R; Halbhuber KJ; Oehring H Novel chromogenic substrates with metal chelating properties for the histochemical detection of peroxidasic activity, derived from 3-amino-9-ethylcarbazole (AEC) and 3,6-diamino-9- ethylcarbazole	0	0
11998	30	11998 2000 CELLULAR AND MOLECULAR LIFE SCIENCES 57(3):487-499 Dai R; Pincus MR; Friedman FK Molecular modeling of mammalian cytochrome P450s	13	3
11999	18	11999 2000 CHEMICAL RESEARCH IN TOXICOLOGY 13(12):1349-1359 Goosen TC; Kent UM; Brand L; Hollenberg PF Inactivation of cytochrome P4502B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables	4	1
12000	3	12000 2000 CHEMICO-BIOLOGICAL INTERACTIONS 126(1):45-61 Soucek P; Ivan G; Pavel S Effect of the microsomal system on interconversions between hydroquinone, benzoquinone, oxygen activation, and lipid peroxidation	3	0

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