#	Cited nodes	Nodes / Authors	GCS	LCS
11101	3	11101 1998 CARCINOGENESIS 19(1):133-139 Butterworth M; Lau SS; Monks TJ 2-hydroxy-4-glutathion-S-yl-17 beta-estradiol and 2-hydroxy-1- glutathion-S-yl-17 beta-estradiol produce oxidative stress and renal toxicity in an animal model of 17 beta-estradiol-mediated nephrocarcinogenicity	11	0
11102	5	11102 1998 CARCINOGENESIS 19(1):161-167 Orner GA; Hendricks JD; Arbogast D; Williams DE Modulation of aflatoxin-B-1 hepatocarcinogenesis in trout by dehydroepiandrosterone: Initiation/post-initiation and latency effects	4	0
11103	10	11103 1998 CARCINOGENESIS 19(5):771-780 Piechocki MP; Hines RN Functional characterization of the human CYP1A1 negative regulatory element: Modulation of Ah receptor mediated transcriptional activity	17	4
11104	9	11104 1998 CARCINOGENESIS 19(5):867-872 Huang ZQ; Guengerich FP; Kaminsky LS 16 alpha-hydroxylation of estrone by human cytochrome P4503A4/5	17	5
11105	5	11105 1998 CARCINOGENESIS 19(10):1867-1871 Crawford EL; Weaver DA; DeMuth JP; Jackson DM; Khuder SA; Frampton MW; Utell MJ; Thilly WG; Willey JC Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells	11	3
11106	1	11106 1998 CELL BIOCHEMISTRY AND FUNCTION 16(2):139-147 Odajima T; Onishi M Inactivation of urate oxidase by a system composed of lactoperoxidase, hydrogen peroxide and bromide	0	0
11107	4	11107 1998 CELL GROWTH & DIFFERENTIATION 9(8):629-637 Sonneveld E; van den Brink CE; van der Leede BJM; Schulkes RKAM; Petkovich M; van der Burg B; van der Saag PT Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells	43	3
11108	3	11108 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(1):54-63 Mordente A; Martorana GE; Minotti G; Giardina B Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10- hydroxydecyl)-1,4-benzoquinone (idebenone)	13	0
11109	22	11109 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(6):659-665 Yamazaki H; Shaw PM; Guengerich FP; Shimada T Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes	36	12
11110	26	11110 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(9):1048-1056 Shimada T; Yamazaki H; Foroozesh M; Hopkins NE; Alworth WL; Guengerich FP Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1	47	12
11111	8	11111 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(9):1067-1074 Roberts ES; Lin HL; Crowley JR; Vuletich JL; Osawa Y; Hollenberg PF Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1	43	2
11112	20	11112 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(10):1154-1161 Kent UM; Roberts ES; Chun J; Hodge K; Juncaj J; Hollenberg PF Inactivation of cytochrome P450 2E1 by tert-butylisothiocyanate	14	9
11113	4	11113 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(11):1274-1282 Roberts JC; Phaneuf HL; Szakacs JG; Zera RT; Lamb JG; Franklin MR Differential chemoprotection against acetaminophen-induced hepatotoxicity by latentiated L-cysteines	4	0
11114	17	11114 1998 CHEMICO-BIOLOGICAL INTERACTIONS 110(1-2):103-121 Guan XM; Fisher MB; Lang DH; Zheng YM; Koop DR; Rettie AE Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecanoic acid	12	2
11115	9	11115 1998 CHEMICO-BIOLOGICAL INTERACTIONS 113(1):1-14 Chung WG; Roh HK; Kim HM; Cha YN Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine: identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns	19	2
11116	19	11116 1998 CHEMICO-BIOLOGICAL INTERACTIONS 115(3):175-199 Lewis DFV; Eddershaw PJ; Dickens M; Tarbit MH; Goldfarb PS Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate	20	7
11117	14	11117 1998 CHEMICO-BIOLOGICAL INTERACTIONS 116(1-2):123-141 Eliasson E; Gardner I; Hume-Smith H; de Waziers I; Beaune P; Kenna JG Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis	9	1
11118	12	11118 1998 CHEMICO-BIOLOGICAL INTERACTIONS 116(3):181-198 Hanioka N; Jinno H; Kitazawa K; Tanaka-Kagawa T; Nishimura T; Ando M; Ogawa K In vitro biotransformation of atrazine by rat liver microsomal cytochrome P450 enzymes	11	2
11119	6	11119 1998 CHEMOSPHERE 36(14):2933-2940 Masaphy S; Krinfeld B; Levanon D Induction of linoleic acid-supported benzo(a)pyrene hydroxylase activity by manganese in the white rot fungus Pleurotus pulmonarius	1	0
11120	16	11120 1998 CIRCULATION RESEARCH 83(9):932-939 Oltman CL; Weintraub NL; VanRollins M; Dellsperger KC Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation	58	16
11121	13	11121 1998 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 25(10):783-787 McKinnon RA; Nebert DW Cytochrome P450 knockout mice: New toxicological models	6	2
11122	45	11122 1998 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 25(11):877-886 Gillam EMJ Human cytochrome P450 enzymes expressed in bacteria: Reagents to probe molecular interactions in toxicology	4	2
11123	2	11123 1998 CLINICAL CANCER RESEARCH 4(10):2293-2297 van Asperen J; van Tellingen O; van der Valk MA; Rozenhart M; Beijnen JH Enhanced oral absorption and decreased elimination of paclitaxel in mice cotreated with cyclosporin A	46	0
11124	3	11124 1998 CLINICAL CHEMISTRY 44(5):1110-1123 White S; Wong SHY Standards of laboratory practice: analgesic drug monitoring	2	0
11125	2	11125 1998 CLINICAL ENDOCRINOLOGY 48(6):707-711 Rumsby G; Avey CJ; Conway GS; Honour JW Genotype-phenotype analysis in late onset 21-hydroxylase deficiency in comparison to the classical forms	20	1
11126	45	11126 1998 CLINICAL PHARMACOKINETICS 35(5):361-390 Lin JH; Lu AYH Inhibition and induction of cytochrome P450 and the clinical implications	122	31
11127	11	11127 1998 CLINICAL PHARMACOLOGY & THERAPEUTICS 64(1):8-17 Adedoyin A; Arns PA; Richards WO; Wilkinson GR; Branch RA Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6	17	1
11128	17	11128 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 121(4):407-416 Orellana M; Rodrigo R; Thielemann L; Jimenez P; Valdes E Modulation of peroxisomal and microsomal fatty acid oxidation by acetone. A comparative study between liver and kidney	0	0
11129	14	11129 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 119(2):143-148 Bani MH; Fukuhara M; Kimura M; Ushio F Modulation of snake hepatic cytochrome P450 by 3- methylcholanthrene and phenobarbital	2	0
11130	13	11130 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 120(1):67-75 Hahn ME; Woodin BR; Stegeman JJ; Tillitt DE Aryl hydrocarbon receptor function in early vertebrates: Inducibility of cytochrome P450 1A in agnathan and elasmobranch fish	16	5
11131	5	11131 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):1-3 Stegeman JJ; Livingstone DR Forms and functions of cytochrome P450	9	0
11132	9	11132 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):5-14 Mansuy D The great diversity of reactions catalyzed by cytochromes P450	30	14
11133	2	11133 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):15-22 Nelson DR Metazoan cytochrome P450 evolution	24	12
11134	26	11134 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):23-53 Hahn ME The aryl hydrocarbon receptor: A comparative perspective	81	9
11135	7	11135 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):65-72 Walker CH Avian forms of cytochrome P450	15	5
11136	19	11136 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):73-83 Gupta RP; Abou-Donia MB Cytochrome P450 enzymes in chickens: characteristics and induction by xenobiotics	6	0
11137	14	11137 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):85-105 Ertl RP; Winston GW The microsomal mixed function oxidase system of amphibians and reptiles: components, activities and induction	8	3
11138	51	11138 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):107-137 Buhler DR; Wang-Buhler JL Rainbow trout cytochrome P450s: purification, molecular aspects, metabolic activity, induction and role in environmental monitoring	40	12
11139	10	11139 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):139-146 den Besten PJ Cytochrome P450 monooxygenase system in echinoderms	13	0
11140	14	11140 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):157-172 James MO; Boyle SM Cytochromes P450 in crustacea	10	2
11141	9	11141 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):173-179 Lee RF Annelid cytochrome P-450	9	1
11142	19	11142 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):231-240 Morrison HG; Weil EJ; Karchner SI; Sogin ML; Stegeman JJ Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences	21	12
11143	11	11143 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):241-248 Stien X; Amichot M; Berge JB; Lafaurie M Molecular cloning of a CYP1A cDNA from the teleost fish Dicentrarchus labrax	2	2
11144	14	11144 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):249-265 Sen A; Arinc E Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunochemical properties	6	5
11145	9	11145 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):289-296 Ronisz D; Forlin L Interaction of isosafrole, beta-naphthoflavone and other CYP1A inducers in liver of rainbow trout (Oncorhynchus mykiss) and eelpout (Zoarces viviparus)	5	3
11146	6	11146 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):305-310 Perkins EJ; Schlenk D Immunochemical characterization of hepatic cytochrome P450 isozymes in the channel catfish: assessment of sexual, developmental and treatment-related effects	8	1
11147	17	11147 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):351-360 Brown DJ; Clark GC; Van Beneden RJ A new cytochrome P450 (CYP30) family identified in the clam, Mercenaria mercenaria	8	6
11148	10	11148 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):361-369 Peters LD; Nasci C; Livingstone DR Immunochemical investigations of cytochrome P450 forms/epitopes (CYP1A, 2B, 2E, 3A and 4A) in digestive gland of Mytilus sp	14	1
11149	7	11149 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):405-412 Gorman N; Walton HS; Sinclair JF; Sinclair PR CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator)	4	0
11150	8	11150 1998 COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES 321(6):485-494 Parant M Xenobiotic metabolism in bivalves	5	0
11151	2	11151 1998 CONTRACEPTION FERTILITE SEXUALITE 26(9):649-655 Abitbol J; Abitbol B The diva twilight: female voice at menopause	4	0
11152	19	11152 1998 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 33(5):375-405 Johnston JO Aromatase inhibitors	5	0
11153	25	11153 1998 CRITICAL REVIEWS IN TOXICOLOGY 28(1):1-33 Youssef J; Badr M Extraperoxisomal targets of peroxisome proliferators: Mitochondrial, microsomal, and cytosolic effects. Implications for health and disease	19	0
11154	86	11154 1998 CRITICAL REVIEWS IN TOXICOLOGY 28(1):35-72 Hakkola J; Pelkonen O; Pasanen M; Raunio H Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: Role in intrauterine toxicity	41	11
11155	11	11155 1998 CURRENT GENETICS 34(5):399-403 Delye C; Bousset L; Corio-Costet MF PCR cloning and detection of point mutations in the eburicol 14 alpha-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a "recalcitrant" fungus	16	2
11156	18	11156 1998 CURRENT OPINION IN CHEMICAL BIOLOGY 2(2):263-268 Wong LL Cytochrome P450 monooxygenases	22	7
11157	8	11157 1998 CURRENT OPINION IN LIPIDOLOGY 9(2):113-118 Schwarz M; Lund EG; Russell DW Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis	34	0
11158	7	11158 1998 DERMATOLOGY 196(1):171-175 Paraskevaidis A; Drakoulis N; Roots I; Orfanos CE; Zouboulis CC Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne	3	0
11159	2	11159 1998 DIABETES-METABOLISM REVIEWS 14(3):241-249 Honing MLH; Morrison PJ; Banga JD; Stroes ESG; Rabelink TJ Nitric oxide availability in diabetes mellitus	39	0
11160	15	11160 1998 DNA AND CELL BIOLOGY 17(3):221-230 Kikuta Y; Kato M; Yamashita Y; Miyauchi Y; Tanaka K; Kamada N; Kusunose M Human leukotriene B-4 omega-hydroxylase (CYP4F3) gene: Molecular cloning and chromosomal localization	21	10
11161	11	11161 1998 DNA AND CELL BIOLOGY 17(3):231-238 Andersen MR; Farin FM; Omiecinski CJ Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR	21	5
11162	13	11162 1998 DNA AND CELL BIOLOGY 17(3):301-309 Gong DW; Bi S; Weintraub BD; Reitman M Rat mitochondrial glycerol-3-phosphate dehydrogenase gene: Multiple promoters, high levels in brown adipose tissue, and tissue-specific regulation by thyroid hormone	14	4
11163	8	11163 1998 DNA AND CELL BIOLOGY 17(5):461-470 Liu SQ; Park Y; Rivera-Rivera I; Li H; Kemper B Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1/2	19	5
11164	6	11164 1998 DNA SEQUENCE 8(6):357-374 Anwar A; Coghlan JP; Jeyaseelan K Structure of an ovine CYP11B1 gene	0	0
11165	13	11165 1998 DRUG METABOLISM AND DISPOSITION 26(2):91-97 Vargas M; Lamb JG; Franklin MR Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3- thione], 1,7-phenanthroline, and 2,2 '-dypyridyl in rats is not accompanied by induction of intestinal enzymes	16	2
11166	21	11166 1998 DRUG METABOLISM AND DISPOSITION 26(3):207-215 Hickman D; Wang JP; Wang Y; Unadkat JD Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities	62	11
11167	11	11167 1998 DRUG METABOLISM AND DISPOSITION 26(3):261-266 Nakajima M; Inoue T; Shimada N; Tokudome S; Yamamoto T; Kuroiwa Y Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes	20	3
11168	12	11168 1998 DRUG METABOLISM AND DISPOSITION 26(4):299-304 Draper AJ; Madan A; Smith K; Parkinson A Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes	14	3
11169	3	11169 1998 DRUG METABOLISM AND DISPOSITION 26(4):313-317 Grace JM; Aguilar AJ; Trotman KM; Brewer TG Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450	24	4
11170	6	11170 1998 DRUG METABOLISM AND DISPOSITION 26(4):318-323 Takedomi S; Matsuo H; Yamano K; Yamamoto K; Iga T; Sawada Y Quantitative prediction of the interaction of midazolam and histamine H-2 receptor antagonists in rats	10	1
11171	12	11171 1998 DRUG METABOLISM AND DISPOSITION 26(5):396-400 Lee CH; Watt KC; Chang AM; Plopper CG; Buckpitt AR; Pinkerton KE Site-selective differences in cytochrome P450 isoform activities - Comparison of expression in rat and rhesus monkey lung and induction in rats	7	0
11172	28	11172 1998 DRUG METABOLISM AND DISPOSITION 26(5):483-489 Amato G; Longo V; Mazzaccaro A; Gervasi PG Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver	9	1
11173	12	11173 1998 DRUG METABOLISM AND DISPOSITION 26(6):566-571 Hashizume T; Mise M; Terauchi Y; O L; Fujii T; Miyazaki H; Inaba T N-dealkylation and hydroxylation of ebastine by human liver cytochrome P450	17	3
11174	17	11174 1998 DRUG METABOLISM AND DISPOSITION 26(7):681-688 Sinal CJ; Hirst M; Webb CD; Bend JR Enantioselective, mechanism-based inactivation of guinea pig hepatic cytochrome P450 by N-(alpha-methylbenzyl)-1- aminobenzotriazole	1	0
11175	11	11175 1998 DRUG METABOLISM AND DISPOSITION 26(8):822-824 Su T; He WL; Gu J; Lipinskas TW; Ding XX Differential xenobiotic induction of CYP2A5 in mouse liver, kidney, lung, and olfactory mucosa	10	3
11176	7	11176 1998 DRUG METABOLISM AND DISPOSITION 26(9):875-882 Jones BC; Hyland R; Ackland M; Tyman CA; Smith DA Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6	9	3
11177	8	11177 1998 DRUG METABOLISM AND DISPOSITION 26(10):970-976 Machinist JM; Mayer MD; Roberts EM; Surber BW; Rodrigues AD Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor	2	1
11178	18	11178 1998 DRUG METABOLISM AND DISPOSITION 26(10):1031-1038 Anderson MD; Bandiera SM; Chang TKH; Bellward GD Effect of androgen administration during puberty on hepatic CYP2C11, CYP3A, and CYP2A1 expression in adult female rats	11	3
11179	16	11179 1998 DRUG METABOLISM AND DISPOSITION 26(12):1175-1178 Guengerich FP; Hosea NA; Parikh A; Bell-Parikh LC; Johnson WW; Gillam EMJ; Shimada T Twenty years of biochemistry of human P450s - Purification, expression, mechanism, and relevance to drugs	15	9
11180	6	11180 1998 DRUG METABOLISM AND DISPOSITION 26(12):1179-1184 Szklarz GD; Halpert JR Molecular basis of P450 inhibition and activation - Implications for drug development and drug therapy	19	4
11181	16	11181 1998 DRUG METABOLISM AND DISPOSITION 26(12):1202-1212 Lin JH Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics	25	2
11182	33	11182 1998 DRUG METABOLISM REVIEWS 30(3):441-498 Mugford CA; Kedderis GL Sex-dependent metabolism of xenobiotics	25	5
11183	28	11183 1998 DRUG METABOLISM REVIEWS 30(3):541-568 Juchau MR; Boutelet-Bochan H; Huang Y Cytochrome-P450-dependent biotransformation of xenobiotics in human and rodent embryonic tissues	19	4
11184	3	11184 1998 DRUG METABOLISM REVIEWS 30(4):645-674 Miller JA The metabolism of xenobiotics to reactive electrophiles in chemical carcinogenesis and mutagenesis: A collaboration with Elizabeth Cavert Miller and our associates	5	1
11185	29	11185 1998 DRUG METABOLISM REVIEWS 30(4):739-786 Lewis DFV; Pratt JM The P450 catalytic cycle and oxygenation mechanism	22	9
11186	4	11186 1998 DRUG RESISTANCE UPDATES 1(4):255-265 Sanglard D; Ischer F; Calabrese D; de Micheli M; Bille J Multiple resistance mechanisms to azole antifungals in yeast clinical isolates	28	0
11187	11	11187 1998 DRUG SAFETY 18(2):83-97 Albengres E; Le Louet H; Tillement JP Systemic antifungal agents - Drug interactions of clinical significance	52	3
11188	1	11188 1998 ENDOCRINE RESEARCH 24(2):113-126 Parker CR; Conway-Myers BA The effects of dehydroepiandrosterone (DHEA) on the thymus, spleen, and adrenals of prepubertal and adult female rats	0	0
11189	13	11189 1998 ENDOCRINOLOGY 139(4):1684-1691 Sun TJ; Zhao Y; Mangelsdorf DJ; Simpson ER Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells	24	2
11190	10	11190 1998 ENDOCRINOLOGY 139(4):2179-2189 Tchoudakova A; Callard GV Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary	42	2
11191	11	11191 1998 ENDOCRINOLOGY 139(5):2314-2321 Stromstedt M; Waterman MR; Haugen TB; Tasken K; Parvinen M; Rozman D Elevated expression of lanosterol 14 alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats	28	3
11192	10	11192 1998 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 32(4):314-324 Taras-Valero D; Perin-Roussel O; Plessis MJ; Perin F Inhibition of 5,9-dimethyldibenzo[c,g]carbazole-DNA adduct formation in mouse liver by pretreatment with cytochrome P4501A inducers in vivo	5	0
11193	10	11193 1998 ENVIRONMENTAL HEALTH PERSPECTIVES 106():593-611 Lagadic L; Caquet T Invertebrates in testing of environmental chemicals: Are they alternatives?	6	0
11194	11	11194 1998 ENVIRONMENTAL HEALTH PERSPECTIVES 106(10):633-641 Lewis DFV; Ioannides C; Parke DV Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen	23	3
11195	12	11195 1998 ENVIRONMENTAL HEALTH PERSPECTIVES 106():983-988 Zhou YC; Waxman DJ Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids	10	0
11196	13	11196 1998 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 17(3):439-445 Lin S; Bullock PL; Addison RF; Bandiera SM Detection of cytochrome P4501A in several species using antibody against a synthetic peptide derived from rainbow trout cytochrome P4501A1	9	1
11197	2	11197 1998 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 17(12):2395-2407 Tietge JE; Johnson RD; Jensen KM; Cook PM; Elonen GE; Fernandez JD; Holcombe GW; Lothenbach DB; Nichols JW Reproductive toxicity and disposition of 2,3,7,8- tetrachlorodibenzo-p-dioxin in adult brook trout (Salvelinus fontinalis) following a dietary exposure	14	1
11198	7	11198 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 5(1):29-34 Eke BC; Coban T; Vural N; Iscan M Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats	1	1
11199	12	11199 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 5(3):179-196 Seidel A; Soballa VJ; Raab G; Frank H; Greim H; Grimmer G; Jacob J; Doehmer J Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450	11	1
11200	15	11200 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 5(3):205-213 Gupta M; Miggens J; Parrish A; Womack J; Ramos KS; Rodriguez LV; Goldstein LS; Holtzapple C; Stanker L; Safe SH Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice	2	0

#	Cited nodes	Nodes / Authors	GCS	LCS
11201	20	11201 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 6(1):13-25 Yawetz A; Zilberman B; Woodin B; Stegeman JJ Cytochromes P-4501A, P-4503A and P-4502B in liver and heart of Mugil capito treated with CYP1A inducers	0	0
11202	16	11202 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 251(3):893-898 Sonnier M; Cresteil T Delayed ontogenesis of CYP1A2 in the human liver	35	5
11203	16	11203 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 252(3):458-466 Bottner B; Denner K; Bernhardt R Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2-specific ones	10	3
11204	4	11204 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 253(3):743-750 Arteel GE; Thurman RG; Raleigh JA Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state	17	0
11205	19	11205 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 256(2):398-403 Zimmer T; Scheller U; Takagi M; Schunck WH Mutual conversion of fatty-acid substrate specificity by a single amino-acid exchange at position 527 in P-450Cm2 and P- 450Alk3A	6	2
11206	16	11206 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 258(2):869-878 Nonaka Y; Fujii T; Kagawa N; Waterman MR; Takemori H; Okamoto M Structure/function relationship of CYP11B1 associated with Dahl's salt-resistant rats - Expression of rat CYP11B1 and CYP11B2 in Escherichia coli	7	3
11207	24	11207 1998 EUROPEAN JOURNAL OF BIOCHEMISTRY 258(3):1040-1049 Louerat-Oriou B; Perret A; Pompon D Differential redox and electron-transfer properties of purified yeast, plant and human NADPH-cytochrome P-450 reductases highly modulate cytochrome P-450 activities	7	0
11208	11	11208 1998 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 54(1):7-12 Klotz U; Ammon E Clinical and toxicological consequences of the inductive potential of ethanol	19	2
11209	3	11209 1998 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 23(4):497-500 Iscan M; Coban T; Bulbul D; Eke BC; Aygormez S; Berberoglu U Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue	3	0
11210	2	11210 1998 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 10(6):503-507 Yurdaydin C; Swain MG; Mininberg ED; Vergalla J; Kleiner D; Paul SM; Jones EA Effect of inhibition of ornithine decarboxylase activity in a model of acute hepatocellular necrosis	0	0
11211	5	11211 1998 EUROPEAN NEUROLOGY 39(2):65-71 Argov Z Functional evaluation techniques in mitochondrial disorders	7	1
11212	2	11212 1998 EUROPEAN RESPIRATORY JOURNAL 12(3):742-744 O'Brien A; Blaivas M; Albers J; Wald J; Watts C A case of respiratory muscle weakness due to cytochrome c oxidase enzyme deficiency	1	0
11213	45	11213 1998 EVOLUTIONARY BIOLOGY, VOL 30 30():15-77 Fogleman JC; Danielson PB; MacIntyre RJ The molecular basis of adaptation in Drosophila - The role of cytochrome P450s	15	9
11214	3	11214 1998 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 50(4-6):323-329 Oelschlager H; Rothley D; Klinger W; Karge E; Vogelsang H Chromatographic resolution of ciprofibrate and interaction of the racemate and both enantiomers with rat liver microsomes in vitro	0	0
11215	6	11215 1998 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 50(4-6):425-431 Farker K; Lehmann MH; Oelschlagel B; Haerting J; Hoffmann A; Janitzky V; Schubert J Impact of CYP2E1 genotype in renal cell and urothelial cancer patients	6	0
11216	1	11216 1998 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 50(4-6):501-506 Lupp A; Kerst S; Karge E; Quack G; Klinger W Investigation on possible antioxidative properties of the NMDA- receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro	2	0
11217	18	11217 1998 EXPERIMENTAL CELL RESEARCH 242(1):294-302 Oesch-Bartlomowicz B; Padma PR; Becker R; Richter B; Hengstler JG; Freeman JE; Wolf CR; Oesch F Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser(129) replacement	10	0
11218	0	11218 1998 FASEB JOURNAL 12(8):A1397-A1397 Guryev OL; Kiselyova OI; Krivosheev AV; Yaminsky IV; Usanov SA; Estabrook RW Atomic force microscopy imaging of cytochrome P450-containing Langmuir-Blodgett films	0	0
11219	0	11219 1998 FASEB JOURNAL 12(8):A1436-A1436 Usanov SA; Lepesheva GI; Gilep A; Estabrook RW Conformational dynamics and molecular recognition reactions of the recombinant cytochrome P450scc (CYP11A1) detected by fluorescence energy transfer	0	0
11220	0	11220 1998 FASEB JOURNAL 12(8):A1442-A1442 Gilep A; Guryev O; Usanov S; Estabrook RW Engineering, expression, and purification of a recombinant fusion protein containing cytochrome b5 and NADPH-P450 reductase.	0	0
11221	5	11221 1998 FEBS LETTERS 430(3):348-352 Tampo Y; Tsukamoto M; Yonaha M The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7- dihydroimidazo[1,2-alpha]pyrazin-3-one (MCLA), a chemiluminescence probe to detect superoxide anions	10	0
11222	6	11222 1998 FEBS LETTERS 431(2):227-230 Jover R; Bort R; Gomez-Lechon MJ; Castell JV Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells	16	3
11223	8	11223 1998 FEBS LETTERS 431(3):343-346 Lamb SB; Lamb DC; Kelly SL; Stuckey DC Cytochrome P450 immobilisation as a route to bioremediation/biocatalysis	14	6
11224	14	11224 1998 FEBS LETTERS 438(3):245-249 Godiard L; Sauviac L; Dalbin N; Liaubet L; Callard D; Czernic P; Marco Y CYP76C2, an Arabidopsis thaliana cytochrome P450 gene expressed during hypersensitive and developmental cell death	3	0
11225	6	11225 1998 FISH PHYSIOLOGY AND BIOCHEMISTRY 18(1):49-57 Wang WD; Chen YM; Hu CH Detection of Ah receptor and Ah receptor nuclear translocator mRNAs in the oocytes and developing embryos of zebrafish (Danio rerio)	24	1
11226	14	11226 1998 FISH PHYSIOLOGY AND BIOCHEMISTRY 18(1):97-106 Moutou KA; Burke MD; Houlihan DF Hepatic P450 monooxygenase response in rainbow trout (Oncorhynchus mykiss (Walbaum)) administered aquaculture antibiotics	1	0
11227	8	11227 1998 FOOD ADDITIVES AND CONTAMINANTS 15():45-51 Cresteil T Onset of xenobiotic metabolism in children: toxicological implications	25	2
11228	11	11228 1998 FREE RADICAL BIOLOGY AND MEDICINE 24(7-8):1168-1175 Klimek J; Wozniak M; Szymanska G; Zelewski L Inhibitory effect of free radicals derived from organic hydroperoxide on progesterone synthesis in human term placental mitochondria	10	0
11229	1	11229 1998 FREE RADICAL BIOLOGY AND MEDICINE 25(8):979-988 Xie CS; Lovell MA; Markesbery WR Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity	21	0
11230	14	11230 1998 FUNDAMENTAL & CLINICAL PHARMACOLOGY 12(5):553-558 Lucas D; Farez C; Bardou LG; Vaisse J; Attali JR; Valensi P Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation	25	6
11231	46	11231 1998 FUNGAL GENETICS AND BIOLOGY 23(1):1-17 van den Brink HJM; van Gorcom RFM; van den Hondel CAMJJ; Punt PJ Cytochrome P450 enzyme systems in fungi	28	0
11232	6	11232 1998 FUNGAL GENETICS AND BIOLOGY 25(3):157-170 Tudzynski B; Holter K Gibberellin biosynthetic pathway in Gibberella fujikuroi: Evidence for a gene cluster	27	2
11233	6	11233 1998 GENE 209(1-2):123-129 Xiang SH; Parsons HK; Murray M Identification of a novel transcriptional silencer in the protein-coding region of the human CYP2C9 gene	7	3
11234	5	11234 1998 GENERAL AND COMPARATIVE ENDOCRINOLOGY 111(2):141-155 Ponthier JL; Shackleton CHL; Trant JM Seasonal changes in the production of two novel and abundant ovarian steroids in the channel catfish (Ictalurus punctatus)	6	1
11235	9	11235 1998 GENES & DEVELOPMENT 12(15):2381-2391 Kim GT; Tsukaya H; Uchimiya H The ROTUNDIFOLIA3 gene of Arabidopsis thaliana encodes a new member of the cytochrome P-450 family that is required for the regulated polar elongation of leaf cells	34	5
11236	4	11236 1998 GENOME RESEARCH 8(10):1007-1021 Mazzarella R; Schlessinger D Pathological consequences of sequence duplications in the human genome	42	0
11237	11	11237 1998 GENOMICS 49(1):152-155 Ma JX; Ramachandran S; Fiedorek FT; Zeldin DC Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4	5	3
11238	2	11238 1998 HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA 12(5):943-+ Steele VE; Boone CW; Lubet RA; Crowell JA; Holmes CA; Sigman CC; Kelloff GJ Preclinical drug development paradigms for chemopreventives	11	0
11239	15	11239 1998 HEPATOLOGY 27(2):427-432 Raunio H; Juvonen R; Pasanen M; Pelkonen O; Paakko P; Soini Y Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma	11	4
11240	7	11240 1998 HEPATOLOGY 28(6):1655-1662 Maheo K; Morel F; Antras-Ferry J; Langouet S; Desmots F; Corcos L; Guillouzo A Endotoxin suppresses the oltipraz-mediated induction of major hepatic glutathione transferases and cytochromes P450 in the rat	7	0
11241	1	11241 1998 INHALATION TOXICOLOGY 10(5):531-553 Robledo RF; Witten ML Acute pulmonary response to inhaled JP-8 jet fuel aerosol in mice	11	0
11242	9	11242 1998 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 28(1):1-9 Scharf ME; Neal JJ; Marcus CB; Bennett GW Cytochrome P450 purification and immunological detection in an insecticide resistant strain of German cockroach (Blattella germanica, L.)	9	1
11243	13	11243 1998 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 28(8):571-580 Ranasinghe C; Hobbs AA Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance	12	3
11244	7	11244 1998 INSECT MOLECULAR BIOLOGY 7(2):185-190 Kasai S; Shono T; Yamakawa M Molecular cloning and nucleotide sequence of a cytochrome P450 cDNA from a pyrethroid-resistant mosquito, Culex quinquefasciatus Say	6	2
11245	4	11245 1998 INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 68(6):404-410 Sonneveld E; van der Saag PT Metabolism of retinoic acid: Implications for development and cancer	8	0
11246	6	11246 1998 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 36(9):463-468 Farker K; Lehmann MH; Kastner R; Hoffmann A; Janitzky V; Schubert J; Matz U; Hofmann W CYP2E1 genotyping in renal cell urothelial cancer patients in comparison with control populations	5	0
11247	9	11247 1998 IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE 15(3):96-99 O'Donohoe A; Gill M Pharmacogenetics of the hepatic cytochrome P450 enzyme system: Its relevance for prescribing in psychiatry	0	0
11248	7	11248 1998 JAPANESE JOURNAL OF CANCER RESEARCH 89(10):1028-1032 Yokose T; Doy M; Kakiki M; Horie T; Matsuzaki Y; Mukai K Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach	3	1
11249	8	11249 1998 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 46(7):2707-2713 Kuilman MEM; Maas RFM; Judah DJ; Fink-Gremmels J Bovine hepatic metabolism of aflatoxin B-1	5	1
11250	6	11250 1998 JOURNAL OF APPLIED TOXICOLOGY 18(4):285-292 Chu I; Poon R; Yagminas A; Lecavalier P; Hakansson H; Valli VE; Kennedy SW; Bergman A; Seegal RF; Feeley M Subchronic toxicity of PCB 105 (2,3,3 ',4,4 '- entachlorobiphenyl) in rats	8	0
11251	16	11251 1998 JOURNAL OF BIOCHEMISTRY 123(1):162-168 Tasaki T; Nakamura A; Itoh S; Ohashi K; Yamamoto Y; Masuda M; Iwata H; Kazusaka A; Kamataki T; Fujita S Expression and characterization of dog CYP2D15 using Baculovirus expression system	4	2
11252	4	11252 1998 JOURNAL OF BIOCHEMISTRY 123(4):747-751 Tasaki T; Iwata H; Kazusaka A; Fujita S Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and the expressed dog CYP2D15	1	0
11253	10	11253 1998 JOURNAL OF BIOCHEMISTRY 124(3):503-508 Yamamoto Y; Ishizuka M; Takada A; Fujita S Cloning, tissue distribution, and functional expression of two novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24	4	1
11254	22	11254 1998 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 31(4):391-398 Lee DW; Lim HB; Moon JY; Park KH In vitro enhancement of microsomal cytochrome P450-dependent monooxygenases by organic solvents in rat liver	1	0
11255	29	11255 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(6):3158-3165 Auchus RJ; Lee TC; Miller WL Cytochrome b(5) augments the 17,20-lyase activity of human P450c17 without direct electron transfer	89	37
11256	11	11256 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(7):3948-3953 Ohkuma M; Zimmer T; Iida T; Schunck WH; Ohta A; Takagi M Isozyme function of n-alkane-inducible cytochromes P450 in Candida maltosa revealed by sequential gene disruption	14	5
11257	14	11257 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(9):5174-5183 Zhang LY; Savas U; Alexander DL; Jefcoate CR Characterization of the mouse Cyp1B1 gene - Identification of an enhancer region that directs aryl hydrocarbon receptor- mediated constitutive and induced expression	29	4
11258	1	11258 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(11):6041-6045 Aleryani S; Milo E; Rose Y; Kostka P Superoxide-mediated decomposition of biological S-nitrosothiols	33	0
11259	6	11259 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(11):6163-6165 Nikoshkov A; Lajic S; Vlamis-Gardikas A; Tranebjaerg L; Holst M; Wedell A; Luthman H Naturally occurring mutants of human steroid 21-hydroxylase (P450c21) pinpoint residues important for enzyme activity and stability	15	1
11260	13	11260 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(13):7260-7267 Cabello-Hurtado F; Batard Y; Salaun JP; Durst F; Pinot F; Werck-Reichhart D Cloning, expression in yeast, and functional characterization of CYP81B1, a plant cytochrome P450 that catalyzes in-chain hydroxylation of fatty acids	27	0
11261	9	11261 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(15):8882-8889 Babu BR; Griffith OW N-5-(1-imino-5-butenyl)-L-ornithine - A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase	37	0
11262	17	11262 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(26):16155-16162 Huss JM; Kasper CB Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression	29	12
11263	31	11263 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(27):17036-17049 Bridges A; Gruenke L; Chang YT; Vakser IA; Loew G; Waskell L Identification of the binding site on cytochrome P450 2B4 for cytochrome b(5) and cytochrome P450 reductase	44	20
11264	11	11264 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(28):17917-17925 Zhang WQ; Shields JM; Sogawa K; Fujii-Kuriyama Y; Yang VW The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion	38	2
11265	8	11265 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(29):18153-18160 Pikuleva IA; Babiker A; Waterman MR; Bjorkhem I Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways	24	4
11266	21	11266 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(36):23055-23061 Dierks EA; Zhang ZP; Johnson EF; de Montellano PRO The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant	11	2
11267	18	11267 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(36):23454-23462 Zhang JH; Ding XX Identification and characterization of a novel tissue-specific transcriptional activating element in the 5 '-flanking region of the CYP2A3 gene predominantly expressed in rat olfactory mucosa	10	4
11268	6	11268 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(43):27988-27997 Hsu MH; Palmer CNA; Song W; Griffin KJ; Johnson EF A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding	25	3
11269	4	11269 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(43):28032-28039 Snajdrova L; Xu AD; Narayanan N Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle	16	3
11270	10	11270 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(47):30879-30887 Pfister SL; Spitzbarth N; Nithipatikom K; Edgemond WS; Falck JR; Campbell WB Identification of the 11,14,15- and 11,12,15- trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta	17	4
11271	24	11271 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(47):31581-31589 Kroetz DL; Yook P; Costet P; Bianchi P; Pineau T Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes	65	8
11272	20	11272 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(49):32528-32534 Scheller U; Zimmer T; Becher D; Schauer F; Schunck WH Oxygenation cascade in conversion of n-alkanes to alpha,omega- dioic acids catalyzed by cytochrome p450 52A3	8	2
11273	10	11273 1998 JOURNAL OF BIOMEDICAL SCIENCE 5(3):153-172 Shen RF; Tai HH Thromboxanes: Synthase and receptors	8	0
11274	3	11274 1998 JOURNAL OF CELL BIOLOGY 140(5):1091-1099 Kuznetsov AV; Mayboroda O; Kunz D; Winkler K; Schubert W; Kunz WS Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers	22	1
11275	2	11275 1998 JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 18(2):215-221 Perez-Pinzon MA; Mumford PL; Carranza V; Sick TJ Calcium influx from the extracellular space promotes NADH hyperoxidation and electrical dysfunction after anoxia in hippocampal slices	8	0
11276	4	11276 1998 JOURNAL OF CHROMATOGRAPHY B 706(2):201-207 Baltes MRH; Dubois JG; Hanocq M Ethyl acetate extraction procedure and isocratic high- performance liquid chromatographic assay for testosterone metabolites in cell microsomes	10	5
11277	10	11277 1998 JOURNAL OF CHROMATOGRAPHY B 714(2):133-144 Adas F; Picart D; Berthou F; Simon B; Amet Y Liquid chromatography mass spectrometry and gas chromatography mass spectrometry of omega- and (omega-1)-hydroxylated metabolites of elaidic and oleic acids in human and rat liver microsomes	8	3
11278	6	11278 1998 JOURNAL OF CHROMATOGRAPHY B 717(1-2):201-245 Tsikas D Application of gas chromatography mass spectrometry and gas chromatography tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans	21	1
11279	1	11279 1998 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83(2):448-452 Erden HF; Zwain IH; Asakura H; Yen SSC Corticotropin-releasing factor inhibits luteinizing hormone- stimulated P450c17 gene expression and androgen production by isolated thecal cells of human ovarian follicles	8	1
11280	22	11280 1998 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83(3):886-895 Hellmold H; Rylander T; Magnusson M; Reihner E; Warner M; Gustafsson JA Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties	22	7
11281	5	11281 1998 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83(3):1033-1036 Taymans SE; Pack S; Pak E; Torpy DJ; Zhuang ZP; Stratakis CA Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3	33	5
11282	13	11282 1998 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 51(3):138-142 Rieder CRM; Ramsden DB; Williams AC Cytochrome P450 1B1 mRNA in the human central nervous system	10	2
11283	40	11283 1998 JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 23(6):403-416 Tanaka E Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes	23	3
11284	8	11284 1998 JOURNAL OF CLINICAL PSYCHIATRY 59():22-26 Richelson E Pharmacokinetic interactions of antidepressants	9	0
11285	14	11285 1998 JOURNAL OF CLINICAL PSYCHIATRY 59():31-39 Jefferson JW Drug and diet interactions: Avoiding therapeutic paralysis	10	0
11286	16	11286 1998 JOURNAL OF CLINICAL PSYCHIATRY 59():37-47 Jefferson JW Drug interactions - Friend or foe?	17	2
11287	9	11287 1998 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 12(2):183-193 de Groot MJ; Havenith RWA; Vinkers HM; Zwaans R; Vermeulen NPE; van Lenthe JH Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s	9	0
11288	15	11288 1998 JOURNAL OF EXPERIMENTAL ZOOLOGY 280(1):1-7 Herman CA; Oliw EH Liver microsomes from the yellow aat snake (Elaphe obsoleta) and American bullfrog (Rana catesbeiana) oxidize polyunsaturated fatty acids by NADPH-dependent hydroxylation and epoxidation	0	0
11289	2	11289 1998 JOURNAL OF HEART AND LUNG TRANSPLANTATION 17(11):1104-1112 Oelberg DA; Systrom DM; Markowitz DH; Zorb SL; Wright C; Wain JC; Ginns LC Exercise performance in cystic fibrosis before and after bilateral lung transplantation	6	0
11290	4	11290 1998 JOURNAL OF HEART AND LUNG TRANSPLANTATION 17(12):1231-1237 Tirdel GB; Girgis R; Fishman RS; Theodore J Metabolic myopathy as a cause of the exercise limitation in lung transplant recipients	12	1
11291	2	11291 1998 JOURNAL OF LEUKOCYTE BIOLOGY 64(3):322-330 Huang YI; Surichamorn W; Cao GL; Meng M; Pou S; Rosen GM; Salcedo TW; Strimpler A; Veale C; Bernstein PR; Bonuccelli CM Effect of trifluoromethyl ketone-based elastase inhibitors on neutrophil function in vitro	5	0
11292	31	11292 1998 JOURNAL OF LIPID RESEARCH 39(6):1210-1219 Adas F; Berthou F; Picart D; Lozac'h P; Beauge F; Amet Y Involvement of cytochrome P450 2E1 in the (omega-1)- hydroxylation of oleic acid in human and rat liver microsomes	14	8
11293	6	11293 1998 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 5(1-4):371-377 Jezequel SG Microbial models of mammalian metabolism: uses and misuses (clarification of some misconceptions)	1	0
11294	1	11294 1998 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 5(1-4):379-384 Gilder V; Bunch AW The synthesis of 17 alpha-ethynylestradiol glucuronides by mammalian microsomes immobilised in hollow-fibres	2	0
11295	2	11295 1998 JOURNAL OF MOLECULAR MODELING 4(7):234-238 Archakov AI; Lisitsa AV; Zgoda VG; Ivanova MS; Koymans L Clusterization of P450 superfamily using the objective pair alignment method and the UPGMA program	1	1
11296	6	11296 1998 JOURNAL OF NEUROCHEMISTRY 71(2):844-852 Vogel R; Jennemann G; Seitz J; Wiesinger H; Hamprecht B Mitochondrial malic enzyme: Purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain	15	1
11297	10	11297 1998 JOURNAL OF NEUROSCIENCE RESEARCH 54(3):402-411 Ibach B; Appel K; Gebicke-Haerter P; Meyer RP; Friedberg T; Knoth R; Volk B Effect of phenytoin on cytochrome P450 2B mRNA expression in primary rat astrocyte cultures	7	2
11298	3	11298 1998 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 17(6-7):1101-1110 Iwuoha EI; Joseph S; Zhang Z; Smyth MR; Fuhr U; de Montellano PRO Drug metabolism biosensors: electrochemical reactivities of cytochrome P450(cam) immobilised in synthetic vesicular systems	7	5
11299	31	11299 1998 JOURNAL OF PHARMACEUTICAL SCIENCES 87(11):1322-1330 Wacher VJ; Silverman JA; Zhang YC; Benet LZ Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics	104	7
11300	23	11300 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 284(1):51-60 Bylund J; Kunz T; Valmsen K; Oliw EH Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes	19	4

#	Cited nodes	Nodes / Authors	GCS	LCS
11301	8	11301 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 284(2):437-442 Nakamura K; Yokoi T; Kodama T; Inoue K; Nagashima K; Shimada N; Shimizu T; Kamataki T Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes	7	4
11302	3	11302 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 285(3):1233-1238 Ross AD; Dey I; Janes N; Israel Y Effect of antithyroid drugs on hydroxyl radical formation and alpha-1-proteinase inhibitor inactivation by neutrophils: Therapeutic implications	5	0
11303	16	11303 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 285(3):1287-1295 Gu J; Zhang QY; Genter MB; Lipinskas TW; Negishi M; Nebert DW; Ding XX Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: Role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes	17	8
11304	32	11304 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 285(3):1327-1336 Powell PK; Wolf I; Jin RY; Lasker JM Metabolism of arachidonic acid to 20-hydroxy-5,8,11,14- eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11	33	15
11305	25	11305 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 286(2):772-779 Pascual JMS; McKenzie A; Yankaskas JR; Falck JR; Zeldin DC Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells	6	6
11306	18	11306 1998 JOURNAL OF PHYSIOLOGY-LONDON 508(3):777-792 Xiao YF; Huang L; Morgan JP Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells	30	7
11307	15	11307 1998 JOURNAL OF PROTEIN CHEMISTRY 17(2):121-129 Dai RK; Pincus MR; Friedman FK Molecular modeling of cytochrome P450 2B1: Mode of membrane insertion and substrate specificity	15	8
11308	13	11308 1998 JOURNAL OF PROTEIN CHEMISTRY 17(7):643-650 Dai RK; Zhai SP; Wei XX; Pincus MR; Vestal RE; Friedman FK Inhibition of human cytochrome P450 1A2 by flavones: A molecular modeling study	16	5
11309	13	11309 1998 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 64(1-2):121-128 Katagiri M; Tatsuta K; Imaoka S; Funae Y; Honma K; Matsuo N; Yokoi H; Ishimura K; Ishibashi F; Kagawa N Evidence that immature rat liver is capable of participating in steroidogenesis by expressing 17 alpha-hydroxylase/17,20-lyase P450c17	2	1
11310	7	11310 1998 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 66(1-2):1-10 Brodie AMH; Njar VCO Aromatase inhibitors in advanced breast cancer: Mechanism of action and clinical implications	28	0
11311	25	11311 1998 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 66(4):217-233 Lewis DFV; Lee-Robichaud P Molecular modelling of steroidogenic cytochromes P450 from families CYP11, CYP17, CYP19 and CYP21 based on the CYP102 crystal structure	13	3
11312	9	11312 1998 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120(30):7404-7410 Tschirret-Guth RA; Medzihradszky KF; de Montellano PRO Specific azidophenyldiazene hemoprotein active site probes. Cross-linking of the heme to His-64 in myoglobin	7	0
11313	5	11313 1998 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120(31):7719-7729 Toy PH; Newcomb M; Hollenberg PF Hypersensitive mechanistic probe studies of cytochrome P450- catalyzed hydroxylation reactions. Implications for the cationic pathway	51	4
11314	3	11314 1998 JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 75(8):939-943 Piazza GJ; Foglia TA; Nunez A Enantioselective conversion of linoleate hydroperoxide to an alpha,beta-epoxy alcohol by niobium ethoxide	0	0
11315	11	11315 1998 JOURNAL OF THE INDIAN CHEMICAL SOCIETY 75(10-12):795-803 Chandra R; Aneja R Cytochrome P450 enzymes: Significance, multiplicity of isoforms, substrates, catalytic and regulatory mechanisms, physiological functions and clinical correlations	0	0
11316	7	11316 1998 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 53(4):313-325 Foster EP; Vrolijk NH; Chen TT; Curtis LR Interaction of 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl with hepatic cytochrome P-4501A in rainbow trout (Oncorhynchus mykiss)	5	4
11317	13	11317 1998 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 54(7):509-527 Ueng TH; Hwang WP; Chen RM; Wang HW; Kuo ML; Park SS; Guengerich FP Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues	12	1
11318	10	11318 1998 KIDNEY INTERNATIONAL 54(1):216-223 Brunner LJ; Bennett WM; Koop DR Cyclosporine suppresses rat hepatic cytochrome P450 in a time- dependent manner	12	1
11319	2	11319 1998 MARINE ENVIRONMENTAL RESEARCH 46(1-5):21-24 Boyle SM; Greenberg RM; James MO Isolation of CYP2L2 and two other cytochrome P450 sequences from a spiny lobster, Panulirus argus, hepatopancreas cDNA library	0	0
11320	1	11320 1998 MEDIATORS OF INFLAMMATION 7(2):85-91 Longo WE; Damore LJ; Mazuski JE; Smith GS; Panesar N; Kaminski DL The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation	10	0
11321	6	11321 1998 MEDICAL SCIENCE RESEARCH 26(10):691-693 Ahmed RS; Pawar SS Effect of inducers on the hepatic microsomal mixed function oxidase system of female rats during food restriction	1	0
11322	11	11322 1998 MEDICINA CLINICA 111(12):465-470 Ladero JM; Garcia-Agundez JA; Benitez J Enzymatic polymorphisms and lung cancer	0	0
11323	1	11323 1998 MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS 62(3):807-+ Crickmore N; Zeigler DR; Feitelson J; Schnepf E; Van Rie J; Lereclus D; Baum J; Dean DH Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins	134	0
11324	4	11324 1998 MOLECULAR AND CELLULAR ENDOCRINOLOGY 137(1):13-19 Endoh A; Yang L; Hornsby PJ CYP21 pseudogene transcripts are much less abundant than those from the active gene in normal human adrenocortical cells under various conditions in culture	3	1
11325	10	11325 1998 MOLECULAR AND CELLULAR ENDOCRINOLOGY 139(1-2):117-129 Shozu M; Simpson ER Aromatase expression of human osteoblast-like cells	37	5
11326	27	11326 1998 MOLECULAR AND CELLULAR ENDOCRINOLOGY 145(1-2):111-121 Qin KN; Rosenfield RL Role of cytochrome P450c17 in polycystic ovary syndrome	13	1
11327	3	11327 1998 MOLECULAR AND GENERAL GENETICS 259(3):299-308 Olano C; Rodriguez AM; Michel JM; Mendez C; Raynal MC; Salas JA Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring	31	0
11328	23	11328 1998 MOLECULAR ASPECTS OF MEDICINE 19(3):155-+ Biason-Lauber A Molecular medicine of steroid hormone biosynthesis - Introduction	2	0
11329	4	11329 1998 MOLECULAR BIOLOGY 32(3):471-474 Sharipova GA; Gulyaeva LF; Lyakhovich VV Cytochromes P-4501A activity and mRNA level in liver and lungs of rats induced with various xenobiotics	0	0
11330	3	11330 1998 MOLECULAR BIOLOGY AND EVOLUTION 15(11):1447-1459 Gotoh O Divergent structures of Caenorhabditis elegans cytochrome P450 genes suggest the frequent loss and gain of introns during the evolution of nematodes	15	3
11331	4	11331 1998 MOLECULAR CARCINOGENESIS 23(2):76-85 Pfohl-Leszkowicz A; Pinelli E; Bartsch H; Mohr U; Castegnaro M Sex- and strain-specific expression of cytochrome P450s in ochratoxin A-induced genotoxicity and carcinogenicity in rats	11	0
11332	4	11332 1998 MOLECULAR PHARMACOLOGY 53(3):438-445 Reiners JJ; Lee JY; Clift RE; Dudley DT; Myrand SP PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase	36	1
11333	9	11333 1998 MOLECULAR PHARMACOLOGY 53(3):475-482 Hellmold H; Magnusson M; Pelto-Huikko M; Rylander T; Gustafsson JA; Warner M Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast	4	1
11334	25	11334 1998 MOLECULAR PHARMACOLOGY 54(3):504-513 Qu W; Rippe RA; Ma JX; Scarborough P; Biagini C; Fiedorek FT; Travlos GS; Parker C; Zeldin DC Nutritional status modulates rat liver cytochrome P450 arachidonic acid metabolism	9	6
11335	6	11335 1998 MOLECULAR PHARMACOLOGY 54(6):1113-1117 Schuetz EG; Brimer C; Schuetz JD Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element	31	9
11336	12	11336 1998 MUTAGENESIS 13(3):263-269 Kranendonk M; Mesquita P; Laires A; Vermeulen NPE; Rueff J Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens	14	9
11337	30	11337 1998 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 400(1-2):201-213 Guengerich FP; Shimada T Activation of procarcinogens by human cytochrome P450 enzymes	55	9
11338	1	11338 1998 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 402(1-2):321-329 von Borstel RC; Higgins JA Janus carcinogens and mutagens	8	0
11339	36	11339 1998 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 410(3):245-270 Lewis DFV; Watson E; Lake BG Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics	25	14
11340	55	11340 1998 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 411(1):19-43 Sawada M; Kamataki T Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays	8	3
11341	8	11341 1998 MYCOSES 41():32-38 Vanden Bossche H; Koymans L Cytochromes P450 in fungi	9	0
11342	98	11342 1998 NATURAL PRODUCT REPORTS 15(6):653-696 Brown GD The biosynthesis of steroids and triterpenoids	6	0
11343	17	11343 1998 NERVENARZT 69(11):944-955 Normann C; Hesslinger B; Bauer J; Berger M; Walden J The role of the hepatic cytochrome P450 enzymes in psychopharmacology	7	1
11344	9	11344 1998 NEUROCHEMICAL RESEARCH 23(2):227-233 Alexander JJ; Snyder A; Tonsgard JH Omega-oxidation of monocarboxylic acids in rat brain	3	0
11345	2	11345 1998 NEUROLOGY 50(4):1055-1060 Taivassalo T; De Stefano N; Argov Z; Matthews PM; Chen J; Genge A; Karpati G; Arnold DL Effects of aerobic training in patients with mitochondrial myopathies	28	6
11346	3	11346 1998 NEUROLOGY 51(6):1562-1566 Lovell MA; Xie C; Markesbery WR Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease	40	0
11347	20	11347 1998 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 22(2):325-333 Baker GB; Fang J; Sinha S; Coutts RT Metabolic drug interactions with selective serotonin reuptake inhibitor (SSRI) antidepressants	17	2
11348	4	11348 1998 NEUROSCIENCE LETTERS 247(2-3):123-126 Vogel R; Hamprecht B; Wiesinger H Malic enzyme isoforms in astrocytes: comparative study on activities in rat brain tissue and astroglia-rich primary cultures	5	1
11349	8	11349 1998 NEW ENGLAND JOURNAL OF MEDICINE 338(10):653-661 Kitanaka S; Takeyama K; Murayama A; Sato T; Okumura K; Nogami M; Hasegawa Y; Niimi H; Yanagisawa J; Tanaka T; Kato S Inactivating mutations in the 25-hydroxyvitamin D-3 1 alpha- hydroxylase gene in patients with pseudovitamin D-deficiency rickets	79	5
11350	1	11350 1998 NEW ZEALAND MEDICAL JOURNAL 111(1065):175-175 Brown S Recreational use of oxygen	0	0
11351	7	11351 1998 NUCLEIC ACIDS RESEARCH 26(8):1959-1964 Chin KK; Chang SF The (-104)G nucleotide of the human CYP21 gene is important for CYP21 transcription activity and protein interaction	3	1
11352	1	11352 1998 ONCOLOGY RESEARCH 10(10):491-498 Di Padova M; Barbieri R; Fanciulli M; Arcuri E; Floridi A Effect of local anesthetic ropivacaine on the energy metabolism of Ehrlich ascites tumor cells	1	0
11353	10	11353 1998 PANCREAS 16(4):521-528 Wacke R; Kirchner A; Prall F; Nizze H; Schmidt W; Fischer U; Nitschke FP; Adam U; Fritz P; Belloc C; Drewelow B Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis	19	3
11354	1	11354 1998 PANMINERVA MEDICA 40(4):343-344 Fierro G; Sanfilippo M; Cavalletti MV; Biancari F; Vilardi V Laparoscopic cholecystectomy in a patient with mitochondrial myopathy	0	0
11355	2	11355 1998 PESTICIDE SCIENCE 54(1):43-51 Vicente JAF; Santos MS; Vercesi AE; Madeira VMC Comparative effects of the herbicide dinitro-o-cresol on mitochondrial bioenergetics	1	0
11356	12	11356 1998 PHARMACEUTICAL RESEARCH 15(4):517-524 Yokoi T; Kamataki T Genetic polymorphism of drug metabolizing enzymes: New mutations in CYP2D6 and CYP2A6 genes in Japanese	31	3
11357	3	11357 1998 PHARMACEUTICAL RESEARCH 15(8):1189-1195 Joshi R; Arora V; Desjardins JP; Robinson D; Himmelstein KJ; Iversen PL In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs	6	1
11358	2	11358 1998 PHARMACOGENETICS 8(1):49-53 Durocher F; Morissette J; Simard J Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region	5	0
11359	13	11359 1998 PHARMACOGENETICS 8(1):73-82 Yamamoto Y; Tasaki T; Nakamura A; Iwata H; Kazusaka A; Gonzalez FJ; Fujita S Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2	20	9
11360	20	11360 1998 PHARMACOGENETICS 8(2):137-155 Maenpaa J; Hall SD; Ring BJ; Strom SC; Wrighton SA Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone	47	17
11361	16	11361 1998 PHARMACOGENETICS 8(3):211-225 Leeder JS; Lu XL; Timsit Y; Gaedigk A Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions	9	1
11362	11	11362 1998 PHARMACOGENETICS 8(3):239-249 Nunoya K; Yokoi T; Kimura K; Inoue K; Kodama T; Funayama M; Nagashima K; Funae Y; Green C; Kinoshita M; Kamataki T A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4- one hydrochloride (SM-12502)	51	10
11363	8	11363 1998 PHARMACOGENETICS 8(5):375-382 Yang TJ; Sai Y; Krausz KW; Gonzalez FJ; Gelboin HV Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver	11	2
11364	13	11364 1998 PHARMACOGENETICS 8(5):391-401 Shou MG; Martinet M; Korzekwa KR; Krausz KW; Gonzalez FJ; Gelboin HV Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver	16	2
11365	9	11365 1998 PHARMACOGENETICS 8(5):411-421 Powell H; Kitteringham NR; Pirmohamed M; Smith DA; Park BK Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype	26	5
11366	5	11366 1998 PHARMACOLOGICAL RESEARCH 38(3):215-219 Janbaz KH; Saeed SA; Gilani AH An assessment of the potential of protopine to inhibit microsomal drug metabolising enzymes and prevent chemical- induced hepatotoxicity in rodents	0	0
11367	43	11367 1998 PHARMACOLOGICAL REVIEWS 50(1):107-141 Lohr JW; Willsky GR; Acara MA Renal drug metabolism	22	3
11368	14	11368 1998 PHARMACOLOGY 56(2):71-79 Sharma MC; Sharma MR; Shapiro BH A comparison of cytochrome P-450-dependent testosterone 2 alpha-hydroxylase in rat (P-450 2C11) and mouse (P-4502 alpha)	1	0
11369	14	11369 1998 PHARMACOLOGY 56(3):150-157 Jang GR; Benet LZ Antiprogestin-mediated inactivation of cytochrome P450 3A4	6	2
11370	2	11370 1998 PHARMACOLOGY 57(6):286-294 Yoshimura T; Itoh S; Tsujikawa K; Yamada E; Ishii T; Iemura O; Kameda Y; Mimura T; Kohama Y Effect of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D- 3 on the expression of vitamin-D-responsive genes in vitamin-D- deficient mice	1	0
11371	11	11371 1998 PHARMACOLOGY & TOXICOLOGY 82(2):74-79 Villard PH; Herber R; Seree EM; Attolini L; Magdalou J; Lacarelle B Effect of cigarette smoke on UDP-glucuronosyltransferase activity and cytochrome P450 content in liver, lung and kidney microsomes in mice	11	1
11372	7	11372 1998 PHARMACOLOGY & TOXICOLOGY 82(2):93-97 Hukkanen J; Mantyla M; Kangas L; Wirta P; Hakkola J; Paakki P; Evisalmi S; Pelkonen O; Raunio H Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium	13	1
11373	30	11373 1998 PHARMACOLOGY & TOXICOLOGY 82(5):209-217 Hakkola J; Tanaka E; Pelkonen O Developmental expression of cytochrome P450 enzymes in human liver	22	4
11374	2	11374 1998 PHARMACOLOGY & TOXICOLOGY 83(6):231-239 Johnston DE; Kroening C Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes	9	3
11375	13	11375 1998 PHARMACOTHERAPY 18(1):84-112 Michalets EL Update: Clinically significant cytochrome P-450 drug interactions	209	21
11376	8	11376 1998 PHARMACOTHERAPY 18(2):381-385 Thomas AR; Chan LN; Bauman JL; Olopade CO Prolongation of the QT interval related to cisapride-diltiazem interaction	27	1
11377	13	11377 1998 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 353(1376):1701-1705 Berge JB; Feyereisen R; Amichot M Cytochrome P450 monooxygenases and insecticide resistance in insects	20	2
11378	3	11378 1998 PHYTOCHEMISTRY 49(2):387-394 Jiao Y; Davin LB; Lewis NG Furanofuran lignan metabolism as a function of seed maturation in Sesamum indicum: Methylenedioxy bridge formation	3	0
11379	6	11379 1998 PHYTOTHERAPY RESEARCH 12(2):89-93 Teel RW; Huynh H Effect of phytochemicals on cytochrome P450-linked alkoxyresorufin O-dealkylase activity	5	0
11380	13	11380 1998 PLANT JOURNAL 14(1):111-120 Batard Y; LeRet M; Schalk M; Robineau T; Durst F; Werck-Reichhart D Molecular cloning and functional expression in yeast of CYP76B1, a xenobiotic-inducible 7-ethoxycoumarin O-de-ethylase from Helianthus tuberosus	8	3
11381	12	11381 1998 PLANT MOLECULAR BIOLOGY 36(3):393-405 Bak S; Kahn RA; Nielsen HL; Moller BL; Halkier BA Cloning of three A-type cytochromes p450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome p450 in the biosynthesis of the cyanogenic glucoside dhurrin	30	5
11382	23	11382 1998 PLANT MOLECULAR BIOLOGY 37(1):39-52 Mizutani M; Ward E; Ohta D Cytochrome p450 superfamily in Arabidopsis thaliana: isolation of cDNAs, differential expression, and RFLP mapping of multiple cytochromes p450	23	6
11383	10	11383 1998 PLANT PHYSIOLOGY 116(1):357-367 Mizutani M; Ohta D Two isoforms of NADPH : cytochrome P450 reductase in Arabidopsis thaliana - Gene structure, heterologous expression in insect cells, and differential regulation	17	3
11384	7	11384 1998 PLANT PHYSIOLOGY 118(3):743-749 Winkler RG; Frank MR; Galbraith DW; Feyereisen R; Feldmann KA Systematic reverse genetics of transfer-DNA-tagged lines of Arabidopsis - Isolation of mutations in the cytochrome P450 gene superfamily	44	2
11385	4	11385 1998 PLANTA 204(1):64-69 Peters S; Schmidt W; Beerhues L Regioselective oxidative phenol couplings of 2,3 ',4,6- tetrahydroxybenzophenone in cell cultures of Centaurium erythraea RAFN and Hypericum androsaemum L.	15	1
11386	8	11386 1998 POLYMERS FOR ADVANCED TECHNOLOGIES 9(5):307-313 Sugihara N; Ogoma Y; Abe K; Kondo Y; Akaike T Immobilization of cytochrome P-450 and electrochemical control of its activity	7	4
11387	6	11387 1998 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95(12):6965-6970 Fisher CR; Graves KH; Parlow AF; Simpson ER Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene	188	8
11388	2	11388 1998 PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 217(1):23-29 Subbiah MTR Mechanisms of cardioprotection by estrogens	34	0
11389	20	11389 1998 PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 61 61():25-64 Kemper B Regulation of cytochrome P450 gene transcription by phenobarbital	6	2
11390	14	11390 1998 PSYCHOPHARMAKOTHERAPIE 5(1):8-18 Eckert A; Reiff J; Muller WE Drug interactions with antidepressants. Advantages of the selective serotonin reuptake inhibitor citalopram	6	0
11391	1	11391 1998 RECENT PROGRESS IN HORMONE RESEARCH, VOL 53 53():341-350 Glorieux FH; St-Arnaud R Molecular cloning of (25-OH D)-1 alpha-hydroxylase: An approach to the understanding of vitamin D pseudo-deficiency	4	0
11392	9	11392 1998 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 99(1):17-22 Ohmori S; Sakamoto Y; Nakasa H; Kitada M Nucleotide and amino acid sequences of the monkey P450 2B gene subfamily	3	0
11393	13	11393 1998 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 100(1):15-28 Ohmori S; Fujiki N; Nakasa H; Nakamura H; Ishii I; Itahashi K; Kitada M Steroid hydroxylation by human fetal CYP3A7 and human NADPH- cytochrome P450 reductase coexpressed in insect cells using baculovirus	6	5
11394	5	11394 1998 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 100(3):265-271 Doi H; Masubuchi Y; Narimatsu S; Nishigaki R; Horie T Salicylic acid-induced lipid peroxidation in rat liver microsomes	3	0
11395	7	11395 1998 SARSIA 83(3):225-241 Arukwe A; Goksoyr A Xenobiotics, xenoestrogens and reproduction disturbances in fish	9	0
11396	2	11396 1998 SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE 25():45-56 Witkamp RF; Monshouwer M Pharmacokinetics in vivo and in vitro in swine	3	0
11397	9	11397 1998 SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY 11(2):61-69 Friedberg T Molecular biological methods for characterizing drug- metabolizing enzymes in hepatic and extrahepatic tissues	1	1
11398	3	11398 1998 SOUTH AFRICAN JOURNAL OF SCIENCE 94(6):303-304 Farombi EO; Emerole GO Interference of common antimalarial drugs with some hepatic microsomal components and drug metabolism: potential implications for toxicity	5	0
11399	8	11399 1998 STROKE 29(1):229-234 Harder DR; Alkayed NJ; Lange AR; Gebremedhin D; Roman RJ Functional hyperemia in the brain - Hypothesis for astrocyte- derived vasodilator metabolites	34	6
11400	12	11400 1998 STRUCTURE WITH FOLDING & DESIGN 6(9):1079-1085 Peterson JA; Graham SE A close family resemblance: the importance of structure in understanding cytochromes P450	28	12

#	Cited nodes	Nodes / Authors	GCS	LCS
11401	1	11401 1998 TETRAHEDRON 54(16):3971-3982 Mozhaev VV; Budde CL; Rich JO; Usyatinsky AY; Michels PC; Khmelnitsky YL; Clark DS; Dordick JS Regioselective enzymatic acylation as a tool for producing solution-phase combinatorial libraries	24	0
11402	2	11402 1998 TETRAHEDRON-ASYMMETRY 9(16):2833-2844 Schneider S; Wubbolts MG; Sanglard D; Witholt B Production of chiral hydroxy long chain fatty acids by whole cell biocatalysis of pentadecanoic acid with an E-coli recombinant containing cytochrome P450(BM-3) monooxygenase	8	6
11403	4	11403 1998 TOXICOLOGICAL SCIENCES 46(1):185-196 Ratra GS; Cottrell S; Powell CJ Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene	3	0
11404	14	11404 1998 TOXICOLOGY 126(3):179-193 Irizar A; Ioannides C Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits	5	1
11405	8	11405 1998 TOXICOLOGY 130(2-3):79-93 Ratra GS; Morgan WA; Mullervy J; Powell CJ; Wright MC Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil	9	1
11406	11	11406 1998 TOXICOLOGY 131(1):9-20 Lake BG; Renwick AB; Cunninghame ME; Price RJ; Surry D; Evans DC Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver	14	5
11407	4	11407 1998 TOXICOLOGY 131(2-3):99-107 Hong JT; Glauert HP Stimulation of the DNA binding activity of AP-1 by the peroxisome proliferator ciprofibrate and eicosanoids in cultured rat hepatocytes	7	0
11408	8	11408 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 148(1):50-55 Drenth HJ; Bouwman CA; Seinen W; Van den Berg M Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3	18	3
11409	17	11409 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 148(2):195-204 Villard PH; Seree EM; Re JL; De Meo M; Barra Y; Attolini L; Dumenil G; Catalin J; Durand A; Lacarelle B Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: Relation to single strand breaks of DNA	25	8
11410	9	11410 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 149(2):195-202 Watt KC; Plopper CG; Weir AJ; Tarkington B; Buckpitt AR Cytochrome P450 2E1 in rat tracheobronchial airways: Response to ozone exposure	7	1
11411	5	11411 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 149(2):217-225 Ammann P; Laethem CL; Kedderis GL Chloroform-induced cytolethality in freshly isolated male B6C3F(1) mouse and F-344 rat hepatocytes	5	0
11412	24	11412 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 150(1):106-116 Gilday D; Bellward GD; Sanderson JT; Janz DM; Rifkind AB 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic cytochrome P450-dependent arachidonic acid epoxygenation in diverse avian orders: Regioisomer selectivity and immunochemical comparison of the TCDD-induced P450s to CYP1A4 and 1A5	12	6
11413	15	11413 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 151(1):166-173 Bentivegna CS; Ihnat MA; Baptiste NS; Hamilton JW Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo	7	1
11414	27	11414 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 153(1):1-11 Lee CA; Lawrence BP; Kerkvliet NI; Rifkind AB 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome p450-dependent arachidonic acid metabolism in mouse liver microsomes: Evidence for species-specific differences in responses	7	2
11415	2	11415 1998 TOXICOLOGY IN VITRO 12(4):431-444 Fahrig R; Rupp M; Steinkamp-Zucht A; Bader A Use of primary rat and human hepatocyte sandwich cultures for activation of indirect carcinogens: Monitoring of DNA strand breaks and gene mutations in co-cultured cells	4	0
11416	16	11416 1998 TOXICOLOGY IN VITRO 12(6):715-723 Monshouwer M; van't Klooster GAE; Nijmeijer SM; Witkamp RF; van Miert ASJPAM Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes	10	1
11417	16	11417 1998 TOXICOLOGY LETTERS 94(2):115-125 Amacher DE; Schomaker SJ Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes	5	0
11418	13	11418 1998 TOXICOLOGY LETTERS 103():161-166 Gonzalez FJ The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption	0	0
11419	6	11419 1998 VETERINARY AND HUMAN TOXICOLOGY 40(2):70-76 Olkowski A; Gooneratne R; Eason C Cytochrome p450 enzyme activities in the Australian brushtail possum Trichosurus vulpesula: A comparison with the rat, rabbit, sheep and chicken	3	2
11420	9	11420 1998 VETERINARY AND HUMAN TOXICOLOGY 40(4):208-212 Olkowski A; Gooneratne R; Eason C Inhibition of cytochrome P450 enzymes in the Australian brushtail possum, Trichosurus vulpecula: Comparison with that of the rat, rabbit, sheep and chicken	3	2
11421	12	11421 1998 VOPROSY MEDITSINSKOI KHIMII 44(1):3-27 Archakov AI; Zgoda VG; Karuzina II Oxidative modification of cytochrome P450 and other macromolecules during turnover	1	0
11422	7	11422 1998 VOPROSY MEDITSINSKOI KHIMII 44(5):423-436 Shumyantseva VV; Moskvitina TL; Bulko TV; Archakov AI Alternative electron sources in cytochrome P450-catalyzed reactions.	1	0
11423	18	11423 1998 XENOBIOTICA 28(2):103-115 Yamazaki H; Inoue K; Shimada T Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes	22	9
11424	8	11424 1998 XENOBIOTICA 28(2):117-126 Moon JY; Lee DW; Park KH Inhibition of 7-ethoxycoumarin O-deethylase activity in rat liver microsomes by naturally occurring flavonoids: structure- activity relationships	17	2
11425	21	11425 1998 XENOBIOTICA 28(2):137-152 Ong CE; Miners JO; Birkett DJ; Bhasker CR Baculovirus-mediated expression of cytochrome P4502C8 and human NADPH-cytochrome P450 reductase: optimization of protein expression	2	1
11426	27	11426 1998 XENOBIOTICA 28(3):235-268 Lewis DFV; Dickins M; Weaver RJ; Eddershaw PJ; Goldfarb PS; Tarbit MH Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site- directed mutagenesis experiments in the CYP2C subfamily	29	8
11427	10	11427 1998 XENOBIOTICA 28(3):293-301 Tassaneeyakul W; Birkett DL; Miners JO Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and nonsteroidal anti- inflammatory agents	7	4
11428	12	11428 1998 XENOBIOTICA 28(3):303-312 Bergeron RM; Serron SC; Rinehart JJ; Cawley GF; Backes WL Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11	7	1
11429	13	11429 1998 XENOBIOTICA 28(4):337-348 Renwick AB; Mistry H; Ball SE; Walters DG; Kao J; Lake BG Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms	16	5
11430	11	11430 1998 XENOBIOTICA 28(4):403-411 Inoue K; Yamazaki H; Shimada T Linkage between the distribution of mutations in the CYP2C18 and CYP2C19 genes in the Japanese and Caucasian	6	0
11431	17	11431 1998 XENOBIOTICA 28(6):549-557 Nishibe Y; Wakabayashi M; Harauchi T; Ohno K Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver	5	1
11432	76	11432 1998 XENOBIOTICA 28(7):617-661 Lewis DFV The CYP2 family: models, mutants and interactions	39	13
11433	6	11433 1998 XENOBIOTICA 28(8):759-766 Mae T; Hosoe K; Yamamoto T; Hidaka T; Ohashi T; Kleeman JM; Adams PE Effect of a new rifamycin derivative, rifalazil, on liver microsomal enzyme induction in rat and dog	4	0
11434	14	11434 1998 XENOBIOTICA 28(8):803-811 Lake BG; Tredger JM; Renwick AB; Barton PT; Price RJ 3,3 '-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices	18	5
11435	6	11435 1998 XENOBIOTICA 28(9):845-853 McKillop D; Wild MJ; Butters CJ; Simcock C Effects of propofol on human hepatic microsomal cytochrome P450 activities	13	1
11436	16	11436 1998 XENOBIOTICA 28(10):923-935 Marini S; Longo V; Mazzaccaro A; Gervasi PG Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues	9	4
11437	4	11437 1998 XENOBIOTICA 28(10):937-948 Swales NJ; Utesch D Metabolic activity of fresh and cryopreserved dog hepatocyte suspensions	10	1
11438	11	11438 1998 XENOBIOTICA 28(10):949-956 Carr BA; Franklin MR Drug-metabolizing enzyme induction by 2,2 '-dipyridyl, 1,7- phenanthroline, 7,8-benzoquinoline and oltipraz in mouse	1	0
11439	7	11439 1998 XENOBIOTICA 28(10):995-1004 Yamazaki H; Shimada T Formation in vitro of an inhibitory cytochrome P450 center dot Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes	3	0
11440	81	11440 1998 XENOBIOTICA 28(12):1129-1165 Smith G; Stubbins MJ; Harries LW; Wolf CR Molecular genetics of the human cytochrome P450 monooxygenase superfamily	25	7
11441	101	11441 1998 XENOBIOTICA 28(12):1167-1202 Clarke SE In vitro assessment of human cytochrome P450	42	16
11442	7	11442 1999 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 55():1209-1211 Ito S; Matsuoka T; Watanabe I; Kagasaki T; Serizawa N; Hata T Crystallization and preliminary X-ray diffraction analysis of cytochrome P450(sca-2) from Streptomyces carbophilus involved in production of pravastatin sodium, a tissue-selective inhibitor of HMG-CoA reductase	3	2
11443	31	11443 1999 ADDICTION BIOLOGY 4(3):283-301 Cho AK; Narimatsu S; Kumagai Y Metabolism of drugs of abuse by cytochromes P450	1	0
11444	37	11444 1999 ADVANCED DRUG DELIVERY REVIEWS 38(1):81-97 Pasanen M The expression and regulation of drug metabolism in human placenta	7	1
11445	5	11445 1999 ADVANCES IN INORGANIC CHEMISTRY, VOL 47 47():83-157 Link TA The structures of Rieske and Rieske-type proteins	15	0
11446	48	11446 1999 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 23(6):991-1007 Lieber CS Microsomal ethanol-oxidizing system (MEOS): The first 30 years (1968-1998) - A review	60	4
11447	5	11447 1999 AMERICAN JOURNAL OF MEDICINE 106(2):227-237 Gregg CR Drug interactions and anti-infective therapies	8	0
11448	1	11448 1999 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 277(6):E976-E983 Kashiwagi A; Shinozaki K; Nishio Y; Maegawa H; Maeno Y; Kanazawa A; Kojima H; Haneda M; Hidaka H; Yasuda H; Kikkawa R Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats	17	0
11449	3	11449 1999 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 277(5):G1048-G1054 Qu W; Graves LM; Thurman RG PGE(2) stimulates O-2 uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase	7	1
11450	18	11450 1999 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 277(5):H2098-H2108 Weintraub NL; Fang X; Kaduce TL; VanRollins M; Chatterjee P; Spector AA Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids	19	8
11451	8	11451 1999 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 276(2):L280-L288 Jacobs ER; Effros RM; Falck JR; Reddy KM; Campbell WB; Zhu DL Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator	0	5
11452	10	11452 1999 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 276(3):R766-R775 Oyekan AO; McAward K; Conetta J; Rosenfeld L; McGiff JC Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension	0	7
11453	1	11453 1999 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 276(4):R1087-R1094 Kozma F; Johnson RA; Zhang F; Yu CH; Tong XG; Nasjletti A Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels	0	3
11454	6	11454 1999 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 276(6):R1749-R1757 Ito O; Roman RJ Regulation of P-450 4A activity in the glomerulus of the rat	0	3
11455	20	11455 1999 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 277(3):R607-R623 McGiff JC; Quilley J 20-HETE and the kidney: resolution of old problems and new beginnings	1	13
11456	7	11456 1999 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 277(5):F790-F796 Alonso-Galicia M; Falck JR; Reddy KM; Roman RJ 20-HETE agonists and antagonists in the renal circulation	24	0
11457	3	11457 1999 AMERICAN JOURNAL OF PREVENTIVE MEDICINE 16(2):122-133 Ellsworth DL; Sholinsky P; Jaquish C; Fabsitz RR; Manolio TA Coronary heart disease - At the interface of molecular genetics and preventive medicine	11	0
11458	19	11458 1999 ANAESTHESIA 54(1):42-50 Chang GWM; Kam PCA The physiological and pharmacological roles of cytochrome P450 isoenzymes	18	4
11459	8	11459 1999 ANALYTICAL BIOCHEMISTRY 267(2):319-330 Grigoryev DN; Kato K; Njar VCO; Long BJ; Ling YZ; Wang X; Mohler J; Brodie AMH Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17 alpha-hydroxylase-C-17,C-20-lyase inhibitors	9	4
11460	17	11460 1999 ANALYTICAL BIOCHEMISTRY 269(2):359-366 Schwaneberg U; Schmidt-Dannert C; Schmitt J; Schmid RD A continuous spectrophotometric assay for P450 BM-3, a fatty acid hydroxylating enzyme, and its mutant F87A	21	17
11461	15	11461 1999 ANALYTICAL BIOCHEMISTRY 276(1):18-26 Bournique B; Petry M; Gonsset G Usefulness of statistic experimental designs in enzymology: Example with recombinant hCYP3A4 and 1A2	3	1
11462	2	11462 1999 ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION 18(7):725-747 Laudenbach V; Mantz J; Desmonts JM To understand molecular biology	0	0
11463	4	11463 1999 ANNALS OF CLINICAL AND LABORATORY SCIENCE 29(2):140-149 Linder MW; Valdes R Fundamentals and applications of pharmacogenetics for the clinical laboratory	8	2
11464	12	11464 1999 ANNALS OF CLINICAL BIOCHEMISTRY 36():722-729 van der Weide J; Steijns LSW Cytochrome P450 enzyme system: genetic polymorphisms and impact on clinical pharmacology	20	0
11465	40	11465 1999 ANNUAL REVIEW OF ENTOMOLOGY 44():507-533 Feyereisen R Insect P450 enzymes	66	20
11466	54	11466 1999 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 39():1-17 Guengrich FP Cytochrome P-450 3A4: Regulation and role in drug metabolism	124	33
11467	3	11467 1999 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 39():19-52 Weinshilboum RM; Otterness DM; Szumlanski CL Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase	43	2
11468	18	11468 1999 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 39():103-125 Whitlock JP Induction of cytochrome P4501A1	169	14
11469	2	11469 1999 ANTICANCER RESEARCH 19(3A):2095-2099 Huynh HT; Teel RW Effects of intragastrically administered Pycnogenol (R) on NNK metabolism in F344 rats	4	0
11470	26	11470 1999 AQUATIC TOXICOLOGY 47(1):43-69 Courtenay SC; Grunwald CM; Kreamer GL; Fairchild WL; Arsenault JT; Ikonomou M; Wirgin II A comparison of the dose and time response of CYP1A1 mRNA induction in chemically treated Atlantic tomcod from two populations	8	1
11471	7	11471 1999 AQUATIC TOXICOLOGY 47(2):117-128 Carlsson C; Part P; Brunstrom B 7-Ethoxyresorufin O-deethylase induction in cultured gill epithelial cells from rainbow trout	6	1
11472	11	11472 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 361(2):309-314 Biagini CP; Philpot RM; Celier CM Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11	9	1
11473	13	11473 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 362(1):32-37 Ogino M; Nagata K; Miyata M; Yamazoe Y Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3	17	8
11474	14	11474 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 362(2):242-253 Nagata K; Ogino M; Shimada M; Miyata M; Gonzalez FJ; Yamazoe Y Structure and expression of the rat CYP3A1 gene: Isolation of the gene (P450/6 beta B) and characterization of the recombinant protein	8	2
11475	1	11475 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 363(2):202-212 Xu G; Goodridge AG Function of a C-rich sequence in the polypyrimidine/polypurine tract of the promoter of the chicken malic enzyme gene depends on promoter context	4	0
11476	18	11476 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 366(1):116-124 Voice MW; Zhang Y; Wolf CR; Burchell B; Friedberg T Effects of human cytochrome b(5) on CYP3A4 activity and stability in vivo	14	10
11477	13	11477 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 366(2):192-198 Truan G; Komandla MR; Falck JR; Peterson JA P450BM-3: Absolute configuration of the primary metabolites of palmitic acid	6	2
11478	21	11478 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 366(2):199-206 Hosny G; Roman LJ; Mostafa MH; Masters BSS Unique properties of purified, Escherichia coli-expressed constitutive cytochrome P4504A5	7	3
11479	12	11479 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 367(1):129-136 Kusano K; Waterman MR; Sakaguchi M; Omura T; Kagawa N Protein synthesis inhibitors and ethanol selectively enhance heterologous expression of P450s and related proteins in Escherichia coli	20	8
11480	7	11480 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 367(2):322-332 Ripp SL; Itagaki K; Philpot RM; Elfarra AA Methionine S-oxidation in human and rabbit liver microsomes: Evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3	7	0
11481	19	11481 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 368(1):181-192 Lupien S; Karp F; Wildung M; Croteau R Regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha) species: cDNA isolation, characterization, and functional expression of (-)-4S-limonene-3-hydroxylase and (-)- 4S-limonene-6-hydroxylase	23	4
11482	23	11482 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):1-10 Nelson DR Cytochrome P450 and the individuality of species	99	33
11483	27	11483 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):11-23 Waxman DJ P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR	194	46
11484	19	11484 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):24-29 Graham SE; Peterson JA How similar are P450s and what can their differences teach us?	39	20
11485	16	11485 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):89-99 Jarukamjorn K; Sakuma T; Miyaura JI; Nemoto N Different regulation of the expression of mouse hepatic cytochrome P4502B enzymes by glucocorticoid and phenobarbital	10	3
11486	14	11486 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(2):193-196 Kikuta Y; Kusunose E; Ito M; Kusunose M Purification and characterization of recombinant rat hepatic CYP4F1	19	8
11487	22	11487 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 370(2):190-200 Soucek P Expression of cytochrome P450 2A6 in Escherichia coli: Purification, spectral and catalytic characterization, and preparation of polyclonal antibodies	5	3
11488	13	11488 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 371(2):270-276 Kurose K; Isozaki E; Tohkin M; Fukuhara M Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7 alpha-hydroxylase	4	1
11489	18	11489 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 372(1):189-196 Mankowski DC; Laddison KJ; Christopherson PA; Ekins S; Tweedie DJ; Lawton MP Molecular cloning, expression, and characterization of CYP2D17 from cynomolgus monkey liver	3	0
11490	4	11490 1999 ARCHIVES OF DERMATOLOGICAL RESEARCH 291(1):54-58 Baroni A; Ruocco V; De Paolis P; Cicatiello L; Esumi H; Tufano MA Ketoconazole inhibits lipopolysaccharide-induced activation of the nitric oxide synthase gene in the murine macrophage cell line J774	5	0
11491	13	11491 1999 ARCHIVES OF TOXICOLOGY 73(1):33-40 Nedelcheva V; Gut I; Soucek P; Tichavska B; Tynkova L; Mraz J; Guengerich FP; Ingelman-Sundberg M Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression	12	2
11492	17	11492 1999 ARCHIVES OF TOXICOLOGY 73(4-5):208-216 Iba MM; Fung J; Thomas PE; Park Y Constitutive and induced expression by pyridine and beta- naphthoflavone of rat CYP1A is sexually dimorphic	4	0
11493	8	11493 1999 ARCHIVES OF TOXICOLOGY 73(8-9):427-430 Bruning T; Abel J; Koch B; Lorenzen K; Harth V; Donat S; Sachinidis A; Vetter H; Bolt HM; Ko Y Real-time PCR-analysis of the cytochrome P4501B1 codon 432- polymorphism	4	0
11494	10	11494 1999 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 49(5):470-475 Muller-Enoch D Investigations on the role of cytochrome b(5) and divalent cations in the maximal nifedipine oxidase activity of human liver	1	0
11495	7	11495 1999 ATHEROSCLEROSIS 143(2):253-260 Aviram M; Kent UM; Hollenberg PF Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein	12	0
11496	5	11496 1999 BIOCATALYSIS AND BIOTRANSFORMATION 17(3):163-178 Schneider S; Wubbolts MG; Sanglard D; Witholt B Production of alkanedioic acids by cytochrome P450(BM-3) monooxygenase: Oxidation of 16-hydroxyhexadecanoic acid to hexadecane-1,16-dioic acid	2	2
11497	4	11497 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 254(1):120-123 Lardy H; Henwood SM; Weeks CE An acute oral gavage study of 3 beta-acetoxyandrost-5-ene-7,17- dione (7-oxo-DHEA-acetate) in rats	4	0
11498	20	11498 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255(2):300-306 Enriquez A; Leclercq I; Farrell GC; Robertson G Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats	17	1
11499	9	11499 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255(2):394-398 Gushchin GV; Gushchin MI; Gerber N; Boyd RT A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes	9	1
11500	8	11500 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 257(2):384-390 Lajic S; Nikoshkov A; Holst M; Wedell A Effects of missense mutations and deletions on membrane anchoring and enzyme function of human steroid 21-hydroxylase (P450c21)	5	1

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