#	Cited nodes	Nodes / Authors	GCS	LCS
10601	12	10601 1997 CANCER RESEARCH 57(21):4830-4837 Chen L; Li LJ; Waxman DJ Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene	27	7
10602	3	10602 1997 CANCER RESEARCH 57(21):4931-4939 Sun SY; Yue P; Dawson MI; Shroot B; Michel S; Lamph WW; Heyman RA; Teng M; Chandraratna RAS; Shudo K; Hong WK; Lotan R Differential effects of synthetic nuclear retinoid receptor- selective retinoids on the growth of human non-small cell lung carcinoma cells	76	0
10603	24	10603 1997 CANCER TREATMENT REVIEWS 23(5-6):321-339 Vermes A; Guchelaar HJ; Koopmans RP Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach	8	0
10604	13	10604 1997 CARCINOGENESIS 18(2):391-397 Hakkola J; Pasanen M; Pelkonen O; Hukkanen J; Evisalmi S; Anttila S; Rane A; Mantyla M; Purkunen R; Saarikoski S; Tooming M; Raunio H Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells	66	22
10605	14	10605 1997 CARCINOGENESIS 18(8):1491-1498 Beier K; Volkl A; Metzger C; Mayer D; Bannasch P; Fahimi HD Hepatic zonation of the induction of cytochrome P450 IVA, peroxisomal lipid beta-oxidation enzymes and peroxisome proliferation in rats treated with dehydroepiandrosterone (DHEA). Evidence of distinct zonal and sex-specific differences	21	3
10606	13	10606 1997 CARCINOGENESIS 18(9):1775-1783 Gardner I; Wakazono H; Bergin P; deWaziers I; Beaune P; Kenna JG; Caldwell J Cytochrome P450 mediated bioactivation of methylglyoxal to 1'- hydroxymethyleugenol in Fischer 344 rat and human liver microsomes	4	1
10607	12	10607 1997 CARCINOGENESIS 18(10):1985-1991 Sakuma T; Igarashi T; Hieda M; Ohgiya S; Isogai M; Ninomiya S; Nagata R; Nemoto N; Kamataki T Marmoset CYP1A2: primary structure and constitutive expression in livers	4	2
10608	11	10608 1997 CELL BIOLOGY AND TOXICOLOGY 13(3):185-192 Hoet PHM; Demedts M; Nemery B In vitro modulation of the P450 activities of hamster and human lung slices	5	2
10609	2	10609 1997 CHEMICAL & PHARMACEUTICAL BULLETIN 45(2):333-337 Okada M; Yoden T; Kawaminami E; Shimada Y; Kudoh M; Isomura Y Studies on aromatase inhibitors .2. Synthesis and biological evaluation of 1-amino-1H-1,2,4-triazole derivatives	8	1
10610	3	10610 1997 CHEMICAL & PHARMACEUTICAL BULLETIN 45(8):1293-1299 Okada M; Yoden T; Kawaminami E; Shimada Y; Kudoh M; Isomura Y Studies on aromatase inhibitors .4. Synthesis and biological evaluation of N,N-disubstituted-5-aminopyrimidine derivatives	3	0
10611	9	10611 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(1):41-48 deGroot MJ; Bijloo GJ; Martens BJ; vanAcker FAA; Vermeulen NPE A refilled substrate model for human cytochrome P450 2D6	30	12
10612	14	10612 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(1):91-102 Foroozesh M; Primrose G; Guo ZY; Bell LC; Alworth WL; Guengerich FP Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes	20	3
10613	15	10613 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(5):582-588 Anari MR; Josephy PD; Henry T; OBrien PJ Hydrogen peroxide supports human and rat cytochrome P450 1A2- catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: Significance of cytochrome P450 peroxygenase	11	0
10614	24	10614 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(5):589-599 Woodcroft KJ; Webb CD; Yao M; Weedon AC; Bend JR Metabolism of the cytochrome P450 mechanism-based inhibitor N- benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: Comparative study with 1-aminobenzotriazole	7	5
10615	23	10615 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(5):600-608 Kent UM; Bend JR; Chamberlin BA; Gage DA; Hollenberg PF Mechanism-based inactivation of cytochrome P450 2B1 by N- benzyl-1-aminobenzotriazole	12	7
10616	13	10616 1997 CHEMICAL REVIEWS 97(8):2879-2932 Shilov AE; Shul'pin GB Activation of C-H bonds by metal complexes	319	1
10617	10	10617 1997 CHEMICO-BIOLOGICAL INTERACTIONS 103(3):167-178 Le HT; Franklin MR Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines	7	0
10618	84	10618 1997 CHEMICO-BIOLOGICAL INTERACTIONS 106(3):161-182 Guengerich FP Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species	85	35
10619	7	10619 1997 CHEMICO-BIOLOGICAL INTERACTIONS 107(1-2):47-61 Mattes WB; Li AP Quantitative reverse transcriptase PCR assay for the measurement of induction in cultured hepatocytes	9	2
10620	7	10620 1997 CHEMISTRY & INDUSTRY (20):831-834 Lewis D Sex and drugs and P450	3	0
10621	5	10621 1997 CHEMOSPHERE 34(1):1-12 Poon R; Lecavalier P; Bergman A; Yagminas A; Chu I; Valli VE Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure	14	1
10622	17	10622 1997 CIRCULATION RESEARCH 81(2):258-267 Weintraub NL; Fang X; Kaduce TL; VanRollins M; Chatterjee P; Spector AA Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids	53	14
10623	15	10623 1997 CLINICA CHIMICA ACTA 257(1):59-84 Lieber CS Ethanol metabolism, cirrhosis and alcoholism	60	2
10624	25	10624 1997 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 24(7):465-470 Murray M Drug-mediated inactivation of cytochrome P450	11	3
10625	29	10625 1997 CLINICAL CHEMISTRY 43(2):254-266 Linder MW; Prough RA; Valdes R Pharmacogenetics: A laboratory tool for optimizing therapeutic efficiency	63	7
10626	10	10626 1997 CLINICAL CHEMISTRY 43(8):1512-1526 Sturgill MG; Lambert GH Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function	5	0
10627	2	10627 1997 CLINICAL ENDOCRINOLOGY 47(1):93-99 GillingSmith C; Story H; Rogers V; Franks S Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome	43	4
10628	16	10628 1997 CLINICAL PHARMACOKINETICS 32():1-21 Preskorn SH Clinically relevant pharmacology of selective serotonin reuptake inhibitors - An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism	125	9
10629	70	10629 1997 CLINICAL PHARMACOKINETICS 32(3):210-258 Bertz RJ; Granneman GR Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions	274	37
10630	17	10630 1997 CLINICAL PHARMACOKINETICS 33(6):454-471 Sproule BA; Naranjo CA; Bremner KE; Hassan PC Selective serotonin reuptake inhibitors and CNS drug interactions - A critical review of the evidence	80	9
10631	7	10631 1997 CNS DRUGS 7(4):273-312 Rudorfer MV; Potter WZ The role of metabolites of antidepressants in the treatment of depression	10	1
10632	7	10632 1997 CNS DRUGS 8(1):51-78 Naguib M; Magboul MMA; Jaroudi R Clinically significant drug interactions with general anaesthetics - Incidence, mechanisms and management	3	1
10633	17	10633 1997 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 116(1):61-75 Stegeman JJ; Woodin BR; Singh H; Oleksiak MF; Celander M Cytochromes p450 (CYP) in tropical fishes: Catalytic activities, expression of multiple CYP proteins and high levels of microsomal p450 in liver of fishes from Bermuda	10	2
10634	6	10634 1997 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 118(2):185-189 Adav SS; Govindwar SP Effects of aflatoxin B1 on liver microsomal enzymes in different strains of chickens	3	1
10635	12	10635 1997 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 118(3):397-404 Levine SL; Oris JT Induction of CYP1A mRNA and catalytic activity in gizzard shad (Dorosoma cepedianum) after waterborne exposure to benzo[a]pyrene	3	0
10636	40	10636 1997 CRITICAL REVIEWS IN TOXICOLOGY 27(2):199-222 Puga A; Nebert DW; McKinnon RA; Menon AG Genetic polymorphisms in human drug-metabolizing enzymes: Potential uses of reverse genetics to identify genes of toxicological relevance	29	2
10637	4	10637 1997 CRITICAL REVIEWS IN TOXICOLOGY 27(3):273-297 Das M; Khanna SK Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil	20	0
10638	11	10638 1997 CURRENT OPINION IN BIOTECHNOLOGY 8(3):274-278 Kellner DG; Maves SA; Sligar SG Engineering cytochrome P450s for bioremediation	28	4
10639	21	10639 1997 CURRENT OPINION IN BIOTECHNOLOGY 8(5):623-628 Guengerich FP; Parikh A Expression of drug-metabolizing enzymes	13	4
10640	9	10640 1997 CURRENT PHARMACEUTICAL DESIGN 3(2):177-208 Hartman PG; Sanglard D Inhibitors of ergosterol biosynthesis as antifungal agents	11	0
10641	10	10641 1997 DERMATOLOGIC SURGERY 23(12):1169-1174 Klein JA; Kassarjdian N Lidocaine toxicity with tumescent liposuction - A case report of probable drug interactions	19	0
10642	12	10642 1997 DNA AND CELL BIOLOGY 16(3):357-368 Cloutier M; Fleury A; Courtemanche J; Ducharme L; Mason JI; LeHoux JG Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis	11	2
10643	16	10643 1997 DNA AND CELL BIOLOGY 16(4):501-514 Zimmer T; Vogel F; Ohta A; Takagi M; Schunck WH Protein quality - A determinant of the intracellular fate of membrane-bound cytochromes P450 in yeast	10	2
10644	4	10644 1997 DNA AND CELL BIOLOGY 16(5):533-544 GonzalezManchon C; Butta N; Ferrer M; Ayuso MS; Parrilla R Molecular cloning and functional characterization of the human cytosolic malic enzyme promoter: Thyroid hormone responsiveness	4	1
10645	3	10645 1997 DNA AND CELL BIOLOGY 16(11):1373-1384 Snyder MJ; Maddison DR Molecular phylogeny of glutathione-S-transferases	22	1
10646	2	10646 1997 DRUG AND CHEMICAL TOXICOLOGY 20(1-2):45-61 Propst TL; Fort DJ; Stover EL; Schrock B; Bantle JA Evaluation of the developmental toxicity of benzo[alpha]pyrene and 2-acetylaminofluorene using Xenopus: Modes of biotransformation	7	0
10647	7	10647 1997 DRUG METABOLISM AND DISPOSITION 25(1):21-26 Zhang QY; Wikoff J; Dunbar D; Fasco M; Kaminsky L Regulation of cytochrome P4501A1 expression in rat small intestine	18	4
10648	15	10648 1997 DRUG METABOLISM AND DISPOSITION 25(1):110-115 Kumar GN; Dubberke E; Rodrigues AD; Roberts E; Dennisen JF Identification of cytochromes p450 involved in the human liver microsomal metabolism of the thromboxane a, inhibitor seratrodast (ABT-001)	7	3
10649	18	10649 1997 DRUG METABOLISM AND DISPOSITION 25(2):168-174 Yamazaki H; Inoue K; Turvy CG; Guengerich FP; Shimada T Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome p450 enzymes	29	12
10650	12	10650 1997 DRUG METABOLISM AND DISPOSITION 25(3):384-389 LehmanMcKeeman LD; Johnson DR; Caudill D; Stuard SB Mechanism-based inactivation of mouse hepatic cytochrome P4502B enzymes by amine metabolites of musk xylene	9	0
10651	10	10651 1997 DRUG METABOLISM AND DISPOSITION 25(4):437-441 McNamee JP; JurimaRomet M; Kobus SM; Marks GS cDNA-expressed human cytochrome P450 isozymes - Inactivation by porphyrinogenic xenobiotics	6	1
10652	12	10652 1997 DRUG METABOLISM AND DISPOSITION 25(4):502-507 Wang RW; Newton DJ; Scheri TD; Lu AYH Human cytochrome P450 3A4-catalyzed testosterone 6 beta- hydroxylation and erythromycin N-demethylation - Competition during catalysis	46	21
10653	17	10653 1997 DRUG METABOLISM AND DISPOSITION 25(5):557-563 Laurenzana EM; Owens SM Metabolism of phencyclidine by human liver microsomes	4	2
10654	25	10654 1997 DRUG METABOLISM AND DISPOSITION 25(5):617-622 Shimada T; Gillam EMJ; Sutter TR; Strickland PT; Guengerich FP; Yamazaki H Oxidation of xenobiotics by recombinant human cytochrome P450 1B1	51	16
10655	11	10655 1997 DRUG METABOLISM AND DISPOSITION 25(5):623-630 Rodrigues AD; Roberts EM; Mulford DJ; Yao Y; Ouellet D Oxidative metabolism of clarithromycin in the presence of human liver microsomes - Major role for the cytochrome P4503A (CYP3A) subfamily	35	5
10656	13	10656 1997 DRUG METABOLISM AND DISPOSITION 25(6):716-724 Kashiyama E; Yokoi T; Odomi M; Funae Y; Inoue K; Kamataki T Cytochrome P450 responsible for the stereoselective S-oxidation of flosequinan in hepatic microsomes from rats and humans	4	2
10657	1	10657 1997 DRUG METABOLISM AND DISPOSITION 25(8):932-939 Vincent SH; Painter SK; LufferAtlas D; Karanam BV; McGowan E; Cioffe C; Doss G; Chiu SHL Orally active inhibitors of human leukocyte elastase .2. Disposition of L-694,458 in rats and rhesus monkeys	10	1
10658	25	10658 1997 DRUG METABOLISM AND DISPOSITION 25(8):985-993 Code EL; Crespi CL; Penman BW; Gonzalez FJ; Chang TKH; Waxman DJ Human cytochrome P4502B6 - Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation	69	15
10659	16	10659 1997 DRUG METABOLISM AND DISPOSITION 25(8):994-1000 Chang TKH; Anderson MD; Bandiera SM; Bellward GD Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley rats	8	3
10660	15	10660 1997 DRUG METABOLISM AND DISPOSITION 25(8):1008-1012 Okita JR; Johnson SB; Castle PJ; Dezellem SC; Okita RT Improved separation and immunodetection of rat cytochrome P450 4A forms in liver and kidney	10	3
10661	12	10661 1997 DRUG METABOLISM AND DISPOSITION 25(10):1150-1156 Lee CA; Manyike PT; Thummel KE; Nelson SD; Slattery JT Mechanism of cytochrome P450 activation by caffeine and 7,8- benzoflavone in rat liver microsomes	8	3
10662	10	10662 1997 DRUG METABOLISM AND DISPOSITION 25(10):1176-1183 Buhler DR; Miranda CL; Deinzer ML; Griffin DA; Henderson MC The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450S	16	5
10663	25	10663 1997 DRUG METABOLISM AND DISPOSITION 25(11):1234-1241 Guengerich FP; Parikh A; Johnson EF; Richardson TH; VonWachenfeldt C; Cosme J; Jung F; Strassburg CP; Manns MP; Tukey RH; Pritchard M; FournelGigleux S; Burchell B Heterologous expression of human drug-metabolizing enzymes	18	4
10664	15	10664 1997 DRUG METABOLISM AND DISPOSITION 25(11):1242-1248 Roberts ES; Hopkins NE; Foroozesh M; Alworth WL; Halpert JR; Hollenberg PF Inactivation of cytochrome P450S 2B1, 2B4, 2B6, and 2B11 by arylalkynes	12	4
10665	7	10665 1997 DRUG METABOLISM AND DISPOSITION 25(11):1266-1271 Clement B; Demesmaeker M A formation of guanoxabenz from guanabenz in human liver - A new metabolic marker for CYP1A2	9	1
10666	6	10666 1997 DRUG METABOLISM AND DISPOSITION 25(11):1298-1303 Shet MS; Mcphaul M; Fisher CW; Stallings NR; Estabrook RW Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2	15	15
10667	9	10667 1997 DRUG METABOLISM AND DISPOSITION 25(12):1347-1353 Moody DE; Alburges ME; Parker RJ; Collins JM; Strong JM The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone	40	1
10668	115	10668 1997 DRUG METABOLISM REVIEWS 29(1-2):413-580 Rendic S; DiCarlo FJ Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors	271	82
10669	8	10669 1997 DRUG METABOLISM REVIEWS 29(3):589-650 Lewis DFV Quantitative structure-activity relationships in substrates, inducers, and inhibitors of cytochrome P4501 (CYP1)	28	3
10670	35	10670 1997 DRUG METABOLISM REVIEWS 29(3):747-799 DeGroot MJ; Vermeulen NPE Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes	19	8
10671	28	10671 1997 DRUG METABOLISM REVIEWS 29(4):1079-1105 Strobel HW; Geng J; Kawashima H; Wang HM Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue	15	3
10672	42	10672 1997 DRUG METABOLISM REVIEWS 29(4):1129-1188 Morgan ET Regulation of cytochromes P450 during inflammation and infection	98	10
10673	21	10673 1997 DRUG SAFETY 17(6):390-406 Mitchell PB Drug interactions of clinical significance with selective serotonin reuptake inhibitors	30	2
10674	4	10674 1997 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 36(2):118-122 Khatisashvili G; Gordeziani M; Kvesitadze G; Korte F Plant monooxygenases: Participation in xenobiotic oxidation	6	0
10675	2	10675 1997 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 38(3):286-291 Sinha S; Gupta M; Chandra P Oxidative stress induced by iron in Hydrilla verticillata (l.f.) Royle: Response of antioxidants	7	0
10676	4	10676 1997 EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY 2, PTS A AND B 400():439-445 Wilson MW; Leung LK; Hong JT; Glauert HP Effect of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on eicosanoid concentrations in rat liver	0	0
10677	6	10677 1997 EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY 3 407():255-260 Carroll MA; McGiff JC Renal cytochrome P450-dependent eicosanoids	5	2
10678	10	10678 1997 ENDOCRINE REVIEWS 18(3):361-377 Parker KL; Schimmer BP Steroidogenic factor 1: A key determinant of endocrine development and function	220	3
10679	16	10679 1997 ENDOCRINE-RELATED CANCER 4(4):407-422 Simpson ER; Zhao Y; Bulun SE; Mendelson CR; Agarwal VR Mesenchymal-epithelial interactions and breast cancer - role of local estrogen production	2	0
10680	18	10680 1997 ENDOCRINOLOGY 138(5):2011-2020 Borroni R; Liu Z; Simpson ER; Hinshelwood MM A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary	13	1
10681	13	10681 1997 ENDOCRINOLOGY 138(12):5125-5135 Shozu M; Zhao Y; Simpson ER Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene	20	1
10682	11	10682 1997 ENVIRONMENTAL HEALTH PERSPECTIVES 105():759-762 Hong JY; Yang CS Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity	25	3
10683	28	10683 1997 ENVIRONMENTAL HEALTH PERSPECTIVES 105():767-774 Pelkonen O; Raunio H Metabolic activation of toxins: Tissue-specific expression and metabolism in target organs	28	7
10684	5	10684 1997 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 4(4):229-234 Schalk M; Pierrel MA; Zimmerlin A; Batard Y; Durst F; WerckReichhart D Xenobiotics: Substrates and inhibitors of the plant cytochrome P450	3	0
10685	7	10685 1997 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 16(2):306-311 Levine SL; Czosnyka H; Oris JT Effect of the fungicide clotrimazole on the bioconcentration of benzo[a]pyrene in gizzard shad (Dorosoma cepedianum): In vivo and in vitro inhibition of cytochrome P4501A activity	3	2
10686	13	10686 1997 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 16(5):900-907 Celander M; Bremer J; Hahn ME; Stegeman JJ Glucocorticoid-xenobiotic interactions: Dexamethasone-mediated potentiation of cytochrome P4501A induction by beta- naphthoflavone in a fish hepatoma cell line (PLHC-1)	19	0
10687	12	10687 1997 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 16(6):1304-1310 Sanderson JT; Janz DM; Bellward GD; Giesy JP Effects of embryonic and adult exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in great blue herons (Ardea herodias)	13	1
10688	11	10688 1997 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 3(1):1-6 Maeda Y; Morita K; Tasaki T; Kazusaka A; Imaoka S; Funae Y; Fujita S Strain differences in age-associated change in testosterone 6 beta-hydroxylation in Wistar and Dark Agouti rats	8	0
10689	23	10689 1997 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 3(1):17-24 Natsuhori M; vanRaak M; Ligtenberg M; Kleij L; tenBerge D; ZweersZeilmaker WM; deGroene EM; vanMiert ASJPAM; Witkamp RF; Horbach GJ Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells	3	1
10690	2	10690 1997 EUROPEAN HEART JOURNAL 18(12):1865-1872 Harrington D; Coats AJS Skeletal muscle abnormalities and evidence for their role in symptom generation in chronic heart failure	19	0
10691	15	10691 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 244(2):361-370 Khan KK; Mazumdar S; Modi S; Sutcliffe M; Roberts GCK; Mitra S Steady-state and picosecond-time-resolved fluorenscence studies on the recombinant heme domain of Bacillus megaterium cytochrome P-450	7	3
10692	7	10692 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 245(1):17-24 RaffalliMathieu F; Geneste O; Lang MA Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA - Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene	8	2
10693	3	10693 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 245(2):349-354 Kelly GP; Muskett FW; Whitford D Analysis of backbone dynamics in cytochrome b(5) using N-15-NMR relaxation measurements	11	0
10694	2	10694 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 247(2):596-604 Lansink M; VanBennekum AM; Blaner WS; Kooistra T Differences in metabolism and isomerization of all-trans- retinoic acid and 9-cis-retinoic acid between human endothelial cells and hepatocytes	10	0
10695	31	10695 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 247(2):625-634 Lacroix D; Sonnier M; Moncion A; Cheron G; Cresteil T Expression of CYP3A in the human liver - Evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth	70	14
10696	5	10696 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 247(2):725-732 McCoubrey WK; Huang TJ; Maines MD Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3	241	3
10697	5	10697 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 248(3):707-716 Kayser H; Winkler T; SpindlerBarth M 26-hydroxylation of ecdysteroids is catalyzed by a typical cytochrome P-450-dependent oxidase and related to ecdysteroid resistance in an insect cell line	13	4
10698	12	10698 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 249(1):270-279 Banci L; Bertini I; Ferroni F; Rosato A Solution structure of reduced microsomal rat cytochrome b(5)	29	6
10699	1	10699 1997 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 52(1):49-54 Awni WM; Cavanaugh JH; Leese P; Kasier J; Cao GL; Locke CS; Dube LM The pharmacokinetic and pharmacodynamic interaction between zileuton and terfenadine	9	0
10700	2	10700 1997 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 22(2):165-171 Klinger W; Oelschlager H; Karge E; Rothley D Interaction of chlormezanone with rat liver microsomes and its degradation	5	2

#	Cited nodes	Nodes / Authors	GCS	LCS
10701	1	10701 1997 EXERCISE IMMUNOLOGY REVIEW 3():1-31 Konig D; Berg A; Weinstock C; Keul J; Northoff H Essential fatty acids, immune function, and exercise	17	0
10702	1	10702 1997 FASEB JOURNAL 11(1):3-14 Weinshilboum RM; Otterness DM; Aksoy IA; Wood TC; Her C; Raftogianis RB Sulfotransferase molecular biology: cDNAs and genes	174	6
10703	17	10703 1997 FASEB JOURNAL 11(1):29-36 Simpson ER; Michael MD; Agarwal VR; Hinshelwood MM; Bulun SE; Zhao Y Expression of the CYP19 (aromatase) gene: An unusual case of alternative promoter usage	77	11
10704	3	10704 1997 FASEB JOURNAL 11(4):234-247 Levy GN Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer	148	0
10705	19	10705 1997 FASEB JOURNAL 11(6):419-427 Waterman MR; Bischof LJ Cytochromes P450 .12. Diversity of ACTH (cAMP)-dependent transcription of bovine steroid hydroxylase genes	21	3
10706	0	10706 1997 FASEB JOURNAL 11(9):A784-A784 Estabrook RW Unanswered questions, unexplored opportunities, and uncertain directions for future research on P450s.	0	0
10707	3	10707 1997 FEBS LETTERS 406(1-2):216-219 Bolton RM; Curstedt L; Cederlund E; Hjelmqvist L; Mannervik B; Ahokas JT; Jornvall H Characterization of a marsupial glutathione transferase, a class alpha enzyme from brown Antechinus (Antechinus stuartii)	0	0
10708	4	10708 1997 FEBS LETTERS 412(1):233-235 Kelly SL; Lamb DC; Kelly DE Sterol 22-desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism	9	2
10709	1	10709 1997 FEBS LETTERS 414(3):571-575 Sparla F; Bagnaresi P; Scagliarini S; Trost P NADH:Fe(III)-chelate reductase of maize roots is an active cytochrome b(5) reductase	11	1
10710	5	10710 1997 FEBS LETTERS 415(3):253-257 Schlichting I; Jung C; Schulze H Crystal structure of cytochrome P-450cam complexed with the (1S)-camphor enantiomer	9	2
10711	1	10711 1997 FOOD AND CHEMICAL TOXICOLOGY 35(2):225-239 Poon R; Lecavalier P; Mueller R; Valli VE; Procter BG; Chu I Subchronic oral toxicity of Di-n-octyl phthalate and di(2- ethylhexyl) phthalate in the rat	36	0
10712	3	10712 1997 FREE RADICAL BIOLOGY AND MEDICINE 22(6):1047-1054 Nandi A; Mukhopadhyay CK; Ghosh MK; Chattopadhyay DJ; Chatterjee IB Evolutionary significance of vitamin C biosynthesis in terrestrial vertebrates	12	0
10713	13	10713 1997 FREE RADICAL BIOLOGY AND MEDICINE 23(7):963-971 Pahan K; Smith BT; Singh AK; Singh I Cytochrome P-450 2E1 in rat liver peroxisomes: Downregulation by ischemia/reperfusion-induced oxidative stress	8	1
10714	4	10714 1997 FUNDAMENTAL AND APPLIED TOXICOLOGY 38(1):64-74 Phillips JC; Price RJ; Cunninghame ME; Osimitz TG; Cockburn A; Gabriel KL; Preiss FJ; Butler WH; Lake BG Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats	5	0
10715	6	10715 1997 FUNDAMENTAL AND APPLIED TOXICOLOGY 39(1):67-75 Lake BG; Cunninghame ME; Price RJ Comparison of the hepatic and renal effects of 1,4- dichlorobenzene in the rat and mouse	10	0
10716	7	10716 1997 GENE 187(1):123-129 Nunez S; Trant JM Isolation of the putative cDNA encoding cholesterol side chain cleavage cytochrome P450 (CYP11A) of the southern stingray (Dasyatis americana)	6	1
10717	9	10717 1997 GENE 195(1):29-33 Delye C; Laigret F; CorioCostet MF Cloning and sequence analysis of the eburicol 14 alpha- demethylase gene of the obligate biotrophic grape powdery mildew fungus	10	3
10718	51	10718 1997 GENERAL PHARMACOLOGY 28(3):351-359 Simpson AECM The cytochrome P450 4 (CYP4) family	58	24
10719	9	10719 1997 GENERAL PHARMACOLOGY 28(4):577-582 Buzaleh AM; Vazquez ES; Nunez G; Batlle AMD Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation	3	1
10720	9	10720 1997 GENOMICS 45(3):519-528 Zhang LQ; Xiao H; Schultz RA; Shen RF Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene (Tbxas1)	13	1
10721	4	10721 1997 HEPATOLOGY 25(2):278-283 Krahenbuhl L; Reichen J; Talos C; Krahenbuhl S Benzoic acid metabolism reflects hepatic mitochondrial function in rats with long-term extrahepatic cholestasis	5	1
10722	16	10722 1997 HEPATOLOGY 25(5):1166-1175 Greuet J; Pichard L; Ourlin JC; Bonfils C; Domergue J; LeTreut P; Maurel P Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture	22	0
10723	7	10723 1997 HEPATOLOGY 26(2):386-391 Forestier M; Solioz M; Isbeki F; Talos C; Reichen J; Krahenbuhl S Hepatic mitochondrial proliferation in rats with secondary biliary cirrhosis: Time course and mechanisms	2	1
10724	2	10724 1997 HEPATOLOGY 26(6):1444-1457 Cable EE; Isom HC Exposure of primary rat hepatocytes in long-term DMSO culture to selected transition metals induces hepatocyte proliferation and formation of duct-like structures	13	0
10725	8	10725 1997 HUMAN & EXPERIMENTAL TOXICOLOGY 16(5):262-266 Stott I; Murthy A; Robinson A; Thomas NW; Fry JR Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat	6	0
10726	23	10726 1997 HUMAN & EXPERIMENTAL TOXICOLOGY 16(8):441-448 Hlavica P; Golly I; Lehnerer M; Schulze J Primary aromatic amines: their N-oxidative bioactivation	11	2
10727	2	10727 1997 HUMAN GENETICS 99(2):248-250 Jenkins MM; Prchal JT A high-frequency polymorphism of NADH-cytochrome b5 reductase in African-Americans	1	1
10728	6	10728 1997 HUMAN GENETICS 99(6):710-719 Ruppitsch W; Meisslitzer C; WeirichSchwaiger H; Klocker H; Scheidereit C; Schweiger M; HirschKauffmann M The role of oxygen metabolism for the pathological phenotype of Fanconi anemia	28	0
10729	3	10729 1997 HYPERTENSION 30(6):1598-1605 Bauersachs J; Fleming I; Scholz D; Popp R; Busse R Endothelium-derived hyperpolarizing factor, but not nitric oxide, is reversibly inhibited by brefeldin A	8	0
10730	3	10730 1997 IMMUNOLOGY LETTERS 58(2):113-120 Zhang B; Centra M; Cao GL; Ratych RE; Domachowske JB; Malech HL; Rosen GM Are free radicals responsible for endothelial cell killing of Staphylococcus aureus?	5	1
10731	4	10731 1997 INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 36(4):312-317 Chauhan SMS; Parkash S; Mohapatra PP Oxidation of geraniol and related volatile terpenoids with iodosylbenzene catalysed by 5,10,15,20-tetrakis(2',6'- dichlorophenyl)porphyrinatoiron(III) chloride in dichloromethane, aqueous SDS and CTAB micelles	0	0
10732	10	10732 1997 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 27(5):377-385 Hung CF; Berenbaum MR; Schuler MA Isolation and characterization of CYP6B4, a furanocoumarin- inducible cytochrome P450 from a Polyphagous caterpillar (Lepidoptera: Papilionidae)	18	7
10733	16	10733 1997 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 27(6):595-604 Danielson PB; Fogleman JC Isolation and sequence analysis of cytochrome P450 12B1: The first mitochondrial insect P450 with homology to 1 alpha,25 dihydroxy-D-3 24-hydroxylase	12	9
10734	9	10734 1997 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 27(6):605-615 Rose RL; Goh D; Thompson DM; Verma KD; Heckel DG; Gahan LJ; Roe RM; Hodgson E Cytochrome P450 (CYP)9A1 in Heliothis virescens: The first member of a new CYP family	22	12
10735	9	10735 1997 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 27(12):999-1006 Smith FF; Scott JG Functional expression of house fly (Musca domestica) cytochrome P450 CYP6D1 in yeast (Saccharomyces cerevisiae)	7	5
10736	9	10736 1997 INSECT MOLECULAR BIOLOGY 6(1):77-81 Liu N; Scott JG Phenobarbital induction of CYP6D1 is due to a trans acting factor on autosome 2 in house flies, Musca domestica	20	4
10737	3	10737 1997 INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 113(1-3):173-176 Merk HF; Baron J; Hertl M; Niederau D; Rubben A Lymphocyte activation in allergic reactions elicited by small- molecular-weight compounds	11	1
10738	11	10738 1997 INTERNATIONAL JOURNAL FOR PARASITOLOGY 27(1):33-40 Kotze AC Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda)	6	0
10739	2	10739 1997 INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH 27(1):55-59 Yucel G; Yesilkaya A; Aksu TA; Yegin A; Ahciguzel Y Increased resistance to oxidative stress in normal and glucose- 6-phosphate dehydrogenase-deficient hemolysates in the presence of enzyme substrates	0	0
10740	2	10740 1997 INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 78(1):49-56 Sarraf CE; Horgan M; Edwards RJ; Alison MR Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice	3	0
10741	1	10741 1997 INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES 160(1-3):269-281 Thiemt S; Spiteller G 1,4-dihydroxy fatty acids: Artifacts by reduction of di- and polyunsaturated fatty acids with sodium borohydride	0	0
10742	1	10742 1997 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 45(12):4826-4832 Sheets JJ; Schmidt A; Samaritoni JG; Gifford JM In vitro metabolism of the N-alkyl-N-(5-isothiazolyl)- and N- (alkylisothiazolin-5-ylidene)phenylacetamides. Evidence of proinsecticidal activity	1	0
10743	1	10743 1997 JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 14(5):270-276 BarAmi S; Regev A; GitayGoren H Effect of androgen substrates on the steroidogenic pattern of cumulus cells: Correlation with cumulus culture morphology	1	0
10744	12	10744 1997 JOURNAL OF BIOCHEMISTRY 122(6):1122-1128 Yoshida Y; Noshiro M; Aoyama Y; Kawamoto T; Horiuchi T; Gotoh O Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase .2. Evolutionary analysis of protein and gene structures	27	9
10745	12	10745 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(2):1127-1135 GrahamLorence S; Truan G; Peterson JA; Falck JR; Wei SZ; Helvig C; Capdevila JH An active site substitution, F87V, converts cytochrome p450 BM- 3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase	54	37
10746	7	10746 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(6):3238-3245 Xiao GH; Falkner KC; Xie YQ; Lindahl RG; Prough RA cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression	15	1
10747	11	10747 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(12):7915-7921 Govindaraj S; Poulos TL The domain architecture of cytochrome P450BM-3	16	9
10748	40	10748 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(19):12551-12559 Wu S; Chen WN; Murphy E; Gabel S; Tomer KB; Foley J; Steenbergen C; Falck JR; Moomaw CR; Zeldin DC Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.	53	26
10749	11	10749 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(23):14532-14541 Chen Q; Galleano M; Cederbaum AI Cytotoxicity and apoptosis produced by arachidonic acid in hep G2 cells overexpressing human cytochrome P4502E1	75	3
10750	8	10750 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(30):18702-18708 Ray WJ; Bain G; Yao M; Gottlieb DI CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family	88	13
10751	13	10751 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(31):19176-19186 Urban P; Mignotte C; Kazmaier M; Delorme F; Pompon D Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-Cytochrome P450 reductases with P450 CYP73A5	54	17
10752	19	10752 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(32):19725-19730 Yun CH; Song M; Kim H Conformational change of cytochrome P450 1A2 induced by phospholipids and detergents	18	9
10753	6	10753 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(34):21221-21226 Bhat R; Bresnick E Glycine N-methyltransferase is an example of functional diversity - Role as a polycyclic aromatic hydrocarbon-binding receptor	12	0
10754	9	10754 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(36):22509-22513 Jenkins CM; Genzor CG; Fillat MF; Waterman MR; GomezMoreno C Negatively charged Anabaena flavodoxin residues (Asp(144) and Glu(145)) are important for reconstitution of cytochrome P450 17 alpha-hydroxylase activity	13	5
10755	13	10755 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(36):22611-22616 Kuo CL; Vaz ADN; Coon MJ Metabolic activation of trans-4-hydroxy-2-nonenal, a toxic product of membrane lipid peroxidation and inhibitor of P450 cytochromes	10	1
10756	11	10756 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(36):22891-22897 Chen CD; Doray B; Kemper B Efficient assembly of functional cytochrome P450 2C2 requires a spacer sequence between the N-terminal signal anchor and catalytic domains	8	3
10757	5	10757 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(37):23057-23063 Andberg MB; Hamberg M; Haeggstrom JZ Mutation of tyrosine 383 in leukotriene A(4) hydrolase allows conversion of leukotriene A(4) into 5S,6S-dihydroxy-7,9-trans- 11,14-cis-eicosatetraenoic acid - Implications for the epoxide hydrolase mechanism	14	0
10758	5	10758 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(38):23995-24001 Schwarz M; Lund EG; Lathe R; Bjorkhem I; Russell DW Identification and characterization of a mouse oxysterol 7 alpha-hydroxylase cDNA	75	12
10759	8	10759 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(42):26702-26707 Wo YYP; Stewart J; Greenlee WF Functional analysis of the promoter for the human CYP1B1 gene	22	4
10760	4	10760 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(47):29546-29553 Graber MN; Alfonso A; Gill DL Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid	19	3
10761	2	10761 1997 JOURNAL OF BONE AND MINERAL RESEARCH 12(10):1552-1559 StArnaud R; Messerlian S; Moir JM; Omdahl JL; Glorieux FH The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D deficiency rickets (PDDR) disease locus	79	3
10762	7	10762 1997 JOURNAL OF CHEMICAL CRYSTALLOGRAPHY 27(3):183-189 Mague JT; Foroozesh M; Hopkins NE; Gan LLS; Alworth WL Aryl acetylene inhibitors for cytochrome P450-based monooxygenase isozymes	5	0
10763	1	10763 1997 JOURNAL OF CHEMICAL RESEARCH-S (11):381-+ Canfield LM; Crabb TA Microbiological transformations. Part 14. Microbiological transformations of derivatives and open-chain analogues of 1,2,3,4-tetrahydroisoquinoline with the fungus Cunninghamella elegans	1	0
10764	3	10764 1997 JOURNAL OF CLEAN TECHNOLOGY ENVIRONMENTAL TOXICOLOGY AND OCCUPATIONAL MEDICINE 6(3):299-317 Poon R; Chu I; Bjarnason S; Vincent R; Potvin M; Miller RB; Valli VE Short-term inhalation toxicity of methanol, gasoline, and methanol/gasoline in the rat	0	0
10765	11	10765 1997 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82(1):70-74 Agarwal VR; Ashanullah CI; Simpson ER; Bulun SE Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of women	21	5
10766	5	10766 1997 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82(6):1739-1745 Mullis PE; Yoshimura N; Kuhlmann B; Lippuner K; Jaeger P; Harada H Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450(arom) gene: Impact of estrogens on the hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood	49	5
10767	2	10767 1997 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82(9):2956-2961 Miller MM; James RA; Richer JK; Gordon DF; Wood WM; Horwitz KB Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: Implications for tamoxifen carcinogenicity	7	0
10768	8	10768 1997 JOURNAL OF CLINICAL PHARMACOLOGY 37(7):635-648 West WL; Knight EM; Pradhan S; Hinds TS Interpatient variability: Genetic predisposition and other genetic factors	16	1
10769	4	10769 1997 JOURNAL OF ENDOCRINOLOGY 154(2):201-209 Moraga PF; Llanos MN; Ronco AM Arachidonic acid release from rat Leydig cells depends on the presence of luteinizing hormone human chorionic gonadotrophin receptors	13	0
10770	4	10770 1997 JOURNAL OF ENDOCRINOLOGY 154(3):379-387 Beaudoin C; Blomquist CH; Bonenfant M; Tremblay Y Expression of the genes for 3 beta-hydroxysteroid dehydrogenase type 1 and cytochrome P450scc during syncytium formation by human placental cytotrophoblast cells in culture and the regulation by progesterone and estradiol	12	0
10771	4	10771 1997 JOURNAL OF ETHNOPHARMACOLOGY 56(2):159-164 Dhuley JN; Naik SR Protective effect of Rhinax, a herbal formulation, against CCl4-induced liver injury and survival in rats	1	0
10772	7	10772 1997 JOURNAL OF ETHNOPHARMACOLOGY 58(1):21-30 Ferreira R; Candeias F; Simoes F; Nascimento J; Morais JC Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat	3	0
10773	18	10773 1997 JOURNAL OF EXPERIMENTAL ZOOLOGY 277(4):313-325 Arukwe A; Goksoyr A Changes in three hepatic cytochrome P450 subfamilies during a reproductive cycle in Turbot (Scophthalmus maximus L)	11	3
10774	3	10774 1997 JOURNAL OF FERMENTATION AND BIOENGINEERING 84(4):324-329 Hara M; Ohkawa H; Narato M; Shirai M; Asada Y; Karube I; Miyake J Regeneration of NADPH by cactus chloroplasts: Coupling reaction with P450 monooxygenase	3	1
10775	8	10775 1997 JOURNAL OF HEPATOLOGY 26():12-21 Larrey D; Pageaux GP Genetic predisposition to drug-induced hepatotoxicity	18	1
10776	11	10776 1997 JOURNAL OF HEPATOLOGY 26():54-62 Ourlin JC; Jounaidi Y; Maurel P; Vilarem MJ Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7	10	3
10777	6	10777 1997 JOURNAL OF HEPATOLOGY 26():81-85 Pompon D; Gautier JC; Perret A; Truan G; Urban P Simulation of human xenobiotic metabolism in microorganisms - Yeast a good compromise between E-coli and human cells	2	0
10778	6	10778 1997 JOURNAL OF LIPID RESEARCH 38(6):1189-1203 Hawke RL; Chapman JM; Winegar DA; Salisbury JA; Welch RM; Brown A; Franzmann KW; Sigel C Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity	6	0
10779	6	10779 1997 JOURNAL OF MEMBRANE BIOLOGY 157(2):177-191 Rittenhouse AR; Vandorpe DH; Brugnara C; Alper SL The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells	26	3
10780	5	10780 1997 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 29(6):1605-1613 Scholz TD; Koppenhafer SL; TenEyck CJ; Schutte BC Developmental regulation of the alpha-glycerophosphate shuttle in porcine myocardium	8	0
10781	9	10781 1997 JOURNAL OF MOLECULAR ENDOCRINOLOGY 19(3):227-240 Miller WL Congenital lipoid adrenal hyperplasia: the human gene knockout for the steroidogenic acute regulatory protein	32	2
10782	4	10782 1997 JOURNAL OF NEUROCHEMISTRY 69(2):465-475 Kubick S; Strotmann J; Andreini I; Breer H Subfamily of olfactory receptors characterized by unique structural features and expression patterns	17	0
10783	5	10783 1997 JOURNAL OF NEUROSCIENCE RESEARCH 49(3):301-308 Vizuete ML; Merino M; Cano J; Machado A In vivo protection of striatal dopaminergic system against 1- methyl-4-phenylpyridinium neurotoxicity by phenobarbital	6	0
10784	6	10784 1997 JOURNAL OF NUTRITION 127():S907-S911 French SW; Morimoto M; Reitz RC; Koop D; Klopfenstein B; Estes K; Clot P; IngelmanSundberg M; Albano E Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats	26	5
10785	5	10785 1997 JOURNAL OF NUTRITION 127(11):2212-2216 Wang KS; Mock NI; Mock DM Biotin biotransformation to bisnorbiotin is accelerated by several peroxisome proliferators and steroid hormones in rats	6	0
10786	1	10786 1997 JOURNAL OF NUTRITION 127(12):2293-2301 Kim MJ; Aiken JM; Havighurst T; Hollander J; Ripple MO; Weindruch R Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells	17	0
10787	28	10787 1997 JOURNAL OF OCCUPATIONAL HEALTH 39(2):83-91 Nakajima T Cytochrome P450 isoforms and the metabolism of volatile hydrocarbons of low relative molecular mass	5	0
10788	7	10788 1997 JOURNAL OF ORGANIC CHEMISTRY 62(26):9114-9122 Toy PH; Dhanabalasingam B; Newcomb M; Hanna IH; Hollenberg PF A substituted hypersensitive radical probe for enzyme-catalyzed hydroxylations: Synthesis of racemic and enantiomerically enriched forms and application in a cytochrome P450-catalyzed oxidation	16	2
10789	7	10789 1997 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 15(9-10):1215-1222 Homma R; Kouyama T; Yamada M; Niimura Y; Krivosheev AV; Hara T; Kawato S Time-resolved study of effect of chlorpromazine on mobility of cytochrome P-450 and phospholipids in the inner membrane of adrenocortical mitochondria	2	0
10790	3	10790 1997 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 16(3):481-489 Corcoran O; Spraul M; Hofmann M; Ismail IM; Lindon JC; Nicholson JK 750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines	4	0
10791	11	10791 1997 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 37(2):67-73 Purdon MP; LehmanMcKeeman LD Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites	11	8
10792	16	10792 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 282(2):1122-1129 Sidhu JS; Omiecinski CJ An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures	31	7
10793	10	10793 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 282(3):1435-1441 Masubuchi Y; Iwasa T; Hosokawa S; Suzuki T; Horie T; Imaoka S; Funae Y; Narimatsu S Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes	6	4
10794	16	10794 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283(2):434-442 Yamazaki H; Inoue K; Shaw PM; Checovich WJ; Guengerich FP; Shimada T Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: Effects of contents of these two forms in individual human samples	44	10
10795	13	10795 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283(3):1168-1176 Zhao XJ; Ishizaki T The in vitro hepatic metabolism of quinine in mice, rats and dogs: Comparison with human liver microsomes	16	6
10796	13	10796 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283(3):1425-1432 Fraser DJ; Feyereisen R; Harlow GR; Halpert JR Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library	15	7
10797	10	10797 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283(3):1486-1494 Chen GF; Ronis MJJ; Thomas PE; Flint DJ; Badger TM Hormonal regulation of microsomal cytochrome P450 2C11 in rat liver and kidney	11	4
10798	15	10798 1997 JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH 56(6):311-334 Chauhan SMS Oxygenations of terpenoids, nitrogen heterocycles, phenolics and related compounds with chemical models for selected monooxygenases	4	0
10799	7	10799 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 61(3-6):167-174 Jakob F; Siggelkow H; Homann D; Kohrle J; Adamski J; Schutze N Local estradiol metabolism in osteoblast- and osteoclast-like cells	19	0
10800	15	10800 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 61(3-6):203-210 Zhao Y; Agarwal VR; Mendelson CR; Simpson ER Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture	18	0

#	Cited nodes	Nodes / Authors	GCS	LCS
10801	11	10801 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 61(3-6):211-217 Toda K; Fukata J; Onishi S; Hashimoto K; Sagara Y; Shizuta Y Cooperative regulation of the human aromatase cytochrome P450 gene transcription by placenta-specific cis-acting elements	1	0
10802	2	10802 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 61(3-6):359-364 Lauber ME; Sarasin A; Lichtensteiger W Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain	7	1
10803	12	10803 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 62(2-3):223-232 Spink DC; Spink BC; Cao JQ; Gierthy JF; Hayes CL; Li Y; Sutter TR Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells	27	4
10804	4	10804 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 62(4):277-286 Zhou MY; Vila MDC; GomezSanchez EP; GomezSanchez CE Cloning of two alternatively spliced 21-hydroxylase cDNAs from rat adrenal	1	0
10805	14	10805 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 62(4):345-352 Tomlinson ES; Maggs JL; Park BK; Back DJ Dexamethasone metabolism in vitro: Species differences	5	1
10806	6	10806 1997 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 63(4-6):345-350 Vitas M; Pajic T; Kelly SL; Komel R 11 beta-hydroxysteroid dehydrogenase activity in progesterone biotransformation by the filamentous fungus Cochliobolus lunatus	6	2
10807	11	10807 1997 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 119(17):4059-4069 Lee HI; Dexter AF; Fann YC; Lakner FJ; Hager LP; Hoffman BM Structure of the modified heme in allylbenzene-inactivated chloroperoxidase determined by Q-band CW and pulsed ENDOR	13	0
10808	11	10808 1997 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 119(24):5489-5498 DeVoss JJ; Sibbesen O; Zhang ZP; deMontellano PRO Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant	29	7
10809	6	10809 1997 JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS 93(9):1769-1774 Zhang Z; Nassar AEF; Lu ZQ; Schenkman JB; Rusling JF Direct electron injection from electrodes to cytochrome P450(cam) in biomembrane-like films	62	17
10810	13	10810 1997 JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 96(10):792-801 Wang PS; Lo MJ; Kau MM Glucocorticoids and aging	10	0
10811	5	10811 1997 JOURNAL OF THE WORLD AQUACULTURE SOCIETY 28(2):158-164 Perkins EJ; Schlenk D Comparisons of uptake and depuration of 2-methylisoborneol in male, female, juvenile, and 3MC-induced channel catfish Ictalurus punctatus	4	0
10812	2	10812 1997 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 50(1):53-65 Poon R; Davis HD; Lecavalier P; Liteplo R; Yagminas A; Chu I; Bihun C Effects of benzothiophene on male rats following short-term oral exposure	2	0
10813	4	10813 1997 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 51(3):265-277 Lecavalier P; Chu I; Yagminas A; Villeneuve DC; Poon R; Feeley M; Hakansson H; Ahlborg UG; Valli VE; Bergman A; Seegal RF; Kennedy SW Subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl in rats	5	0
10814	10	10814 1997 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 52(2):169-188 Gunasena GH; Kanz MF Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes	0	0
10815	2	10815 1997 LEUKEMIA & LYMPHOMA 25(5-6):427-& Kizaki M; Ueno H; Matsushita H; Takayama N; Muto A; Awaya N; Ikeda Y Retinoid resistance in leukemic cells	11	0
10816	25	10816 1997 LIFE SCIENCES 61(26):2507-2520 Szklarz GD; Halpert JR Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450	28	12
10817	16	10817 1997 MAYO CLINIC PROCEEDINGS 72(9):835-847 Richelson E Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs	57	7
10818	2	10818 1997 MEDICAL CLINICS OF NORTH AMERICA 81(5):1165-& Navar LG The kidney in blood pressure regulation and development of hypertension	21	0
10819	20	10819 1997 METAL SITES IN PROTEINS AND MODELS 88():39-70 Chapman SK; Daff S; Munro AW Heme: The most versatile redox centre in biology?	17	2
10820	34	10820 1997 METAL SITES IN PROTEINS AND MODELS 88():175-207 Wong LL; Westlake CG; Nickerson DP Protein engineering of cytochrome P450(cam)	20	7
10821	2	10821 1997 MICROBIOLOGY-UK 143():1993-2001 DeGroot PWJ; Schaap PJ; VanGriensven LJLD; Visser J Isolation of developmentally regulated genes from the edible mushroom Agaricus bisporus	15	2
10822	24	10822 1997 MICROSCOPY RESEARCH AND TECHNIQUE 39(5):424-435 Rich KJ; Boobis AR Expression and inducibility of P450 enzymes during liver ontogeny	9	5
10823	6	10823 1997 MOLECULAR & GENERAL GENETICS 256(2):115-120 Fujii T; Nakamura K; Shibuya K; Tanase S; Gotoh O; Ogawa T; Fukuda H Structural characterization of the gene and corresponding cDNA for the cytochrome P450rm from Rhodotorula minuta which catalyzes formation of isobutene and 4-hydroxylation of benzoate	7	2
10824	10	10824 1997 MOLECULAR AND CELLULAR BIOCHEMISTRY 167(1-2):1-29 Singh I Biochemistry of peroxisomes in health and disease	52	3
10825	11	10825 1997 MOLECULAR AND CELLULAR ENDOCRINOLOGY 131(1):39-49 Bassett MH; McCarthy JL; Waterman MR; Sliter TJ Sequence and developmental expression of Cyp18, a member of a new cytochrome P450 family from Drosophila	17	8
10826	9	10826 1997 MOLECULAR BIOLOGY 31(5):680-683 Mezentsev AN; Gulyaeva LF; Grishanova AY; Kovalenko SP; Lyakhovich VV Alternative splicing of cytochrome P4502B2 mRNA in rat liver	0	0
10827	11	10827 1997 MOLECULAR CARCINOGENESIS 20(2):224-230 Hukkanen J; Hakkola J; Anttila S; Piipari R; Karjalainen A; Pelkonen O; Raunio H Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes	40	11
10828	9	10828 1997 MOLECULAR CARCINOGENESIS 20(3):308-316 LehmanMcKeeman LD; Stuard SB; Caudill D; Johnson DR Induction of mouse cytochrome p450 2B enzymes by amine metabolites of musk xylene: Contribution of microsomal enzyme induction to the hepatocarcinogenicity of musk xylene	6	0
10829	10	10829 1997 MOLECULAR ENDOCRINOLOGY 11(2):127-137 Liu Z; Simpson ER Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells	71	2
10830	16	10830 1997 MOLECULAR PHARMACOLOGY 51(1):147-151 Guengerich FP; Vaz ADN; Raner GN; Pernecky SJ; Coon MJ Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes	11	5
10831	6	10831 1997 MOLECULAR PHARMACOLOGY 51(5):703-710 Dohr O; Sinning R; Vogel C; Munzel P; Abel J Effect of transforming growth factor-beta(1) on expression of aryl hydrocarbon receptor and genes of Ah gene battery: Clues for independent down-regulation in A549 cells	20	7
10832	19	10832 1997 MOLECULAR PHARMACOLOGY 51(5):741-754 SchmiedlinRen P; Thummel KE; Fisher JM; Paine MF; Lown KS; Watkins PB Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1 alpha,25-dihydroxyvitamin D-3	81	8
10833	25	10833 1997 MOLECULAR PHARMACOLOGY 51(6):931-943 Zeldin DC; Foley J; Goldsworthy SM; Cook ME; Boyle JE; Ma JX; Moomaw CR; Tomer KB; Steenbergen C; Wu S CYP2J subfamily cytochrome P450s in the gastrointestinal tract: Expression, localization, and potential functional significance	31	21
10834	5	10834 1997 MOLECULAR PHARMACOLOGY 52(1):46-53 OLeary KA; Li HC; Ram PA; McQuiddy P; Waxman DJ; Kasper CB Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: Identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene	9	3
10835	17	10835 1997 MOLECULAR PHARMACOLOGY 52(3):362-372 Kroetz DL; Huse LM; Thuresson A; Grillo MP Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney	24	7
10836	9	10836 1997 MOLECULAR PHARMACOLOGY 52(4):590-599 Sinal CJ; Bend JR Aryl hydrocarbon receptor-dependent induction of Cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells	56	7
10837	2	10837 1997 MOLECULAR PHARMACOLOGY 52(5):912-919 Zhong Z; Connor H; Stachlewitz RF; VonFrankenberg M; Mason RP; Lemasters JJ; Thurman RG Role of free radicals in primary nonfunction of marginal fatty grafts from rats treated acutely with ethanol	5	0
10838	2	10838 1997 MUSCLE & NERVE 20(10):1219-1224 HeimanPatterson TD; Argov Z; Chavin JM; Kalman B; Alder H; DiMauro S; Bank W; Tahmoush AJ Biochemical and genetic studies in a family with mitochondrial myopathy	2	0
10839	10	10839 1997 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 377(2):199-209 Bellec G; Dreano Y; Bail JP; Menez JF; Berthou F Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes	2	2
10840	22	10840 1997 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 380(1-2):43-59 ThorntonManning JR; Dahl AR Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes	25	1
10841	4	10841 1997 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 392(1-2):125-138 MullerTegethoff K; Kersten B; Kasper P; Muller L Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing	9	1
10842	13	10842 1997 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 386(1):1-23 Josephy PD; Gruz P; Nohmi T Recent advances in the construction of bacterial genotoxicity assays	30	7
10843	16	10843 1997 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 387(1):17-34 Paolini M; CantelliForti G On the metabolizing systems for short-term genotoxicity assays: a review	6	0
10844	18	10844 1997 NATURE BIOTECHNOLOGY 15(8):784-788 Parikh A; Gillam EMJ; Guengerich FP Drug metabolism by Escherichia coli expressing human cytochromes P450	83	42
10845	7	10845 1997 NATURE STRUCTURAL BIOLOGY 4(1):32-35 Curnow KM; Mulatero P; EmericBlanchouin N; AupetitFaisant B; Corvol P; Pascoe L The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme	33	6
10846	13	10846 1997 NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355(1):8-13 Salonpaa P; Kottari S; Pelkonen O; Raunio H Regulation of CYP 2A5 induction by porphyrinogenic agents in mouse primary hepatocytes	6	1
10847	18	10847 1997 NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355(3):309-318 Evert B; Eichelbaum M; Haubruck H; Zanger UM Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His(324)Pro) expressed by recombinant baculovirus in insect cells	12	4
10848	3	10848 1997 NEUROENDOCRINOLOGY 66(3):173-180 Lauber ME; Sarasin A; Lichtensteiger W Transient sex differences of aromatase (CYP19) mRNA expression in the developing rat brain	5	0
10849	3	10849 1997 NEUROLOGY 48(5):1238-1243 Sobreira C; Hirano M; Shanske S; Keller RK; Haller RG; Davidson E; Santorelli FM; Miranda AF; Bonilla E; Mojon DS; Barreira AA; King MP; DiMauro S Mitochondrial encephalomyopathy with coenzyme Q(10) deficiency	56	3
10850	12	10850 1997 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 28(1):63-73 Shao Y; Pardini L; Pardini RS Intervention of transplantable human mammary carcinoma MX-1 chemotherapy with dietary menhaden oil in athymic mice: Increased therapeutic effects and decreased toxicity of cyclophosphamide	7	0
10851	1	10851 1997 OIKOS 80(2):411-416 Forbes VE; Parker ED; Calow P Are there advantages of having sex in novel environments?	4	0
10852	25	10852 1997 PEDIATRIC CLINICS OF NORTH AMERICA 44(1):55-& Leeder JS; Kearns GL Pharmacogenetics in pediatrics - Implications for practice	46	2
10853	2	10853 1997 PESTICIDE SCIENCE 49(3):291-299 Swales NJ; Caldwell J Phase 1 and 2 metabolism in freshly isolated hepatocytes and subcellular fractions from rat, mouse, chicken and ox livers	0	0
10854	7	10854 1997 PHARMACEUTICAL RESEARCH 14(8):1019-1025 Raeissi SD; Guo ZY; Dobson GL; Artursson P; Hidalgo IJ Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine	16	2
10855	17	10855 1997 PHARMACOGENETICS 7(2):103-113 Inoue K; Yamazaki H; Imiya K; Akasaka S; Guengerich FP; Shimada T Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations	73	26
10856	7	10856 1997 PHARMACOGENETICS 7(2):115-119 Xie HG; Huang SL; Xu ZH; Xiao XS; He N; Zhou HH Evidence for the effect of gender on activity of (S)- mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population	14	1
10857	11	10857 1997 PHARMACOGENETICS 7(3):203-210 Crespi CL; Miller VP The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase	61	11
10858	24	10858 1997 PHARMACOGENETICS 7(3):211-221 Chang TKH; Yu L; Goldstein JA; Waxman DJ Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-K-m catalysts of cyclophosphamide and ifosfamide activation	38	5
10859	8	10859 1997 PHARMACOGENETICS 7(3):247-250 Gullsten H; Agundez JAG; Benitez J; Laara E; Ladero JM; DiazRubio M; FernandezSalguero P; Gonzalez F; Rautio A; Pelkonen O; Raunio H CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis	26	7
10860	8	10860 1997 PHARMACOGENETICS 7(4):255-269 Mackenzie PI; Owens IS; Burchell B; Bock KW; Bairoch A; Belanger A; FournelGigleux S; Green M; Hum DW; Iyanagi T; Lancet D; Louisot P; Magdalou J; Chowdhury JR; Ritter JK; Schachter H; Tephly TR; Tipton KF; Nebert DW The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence	277	16
10861	11	10861 1997 PHARMACOGENETICS 7(4):283-293 Casley WL; Menzies JA; Mousseau N; Girard M; Moon TW; Whitehouse LW Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen- induced hepatotoxicity	7	0
10862	20	10862 1997 PHARMACOGENETICS 7(6):441-452 Treluyer JM; Gueret G; Cheron G; Sonnier M; Cresteil T Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility	26	7
10863	5	10863 1997 PHARMACOLOGICAL RESEARCH 35(5):477-480 Watanabe M; Tanaka M; Tateishi T; Nakura H; Kumai T; Kobayashi S Effects of the estrous cycle and the gender difference on hepatic drug-metabolising enzyme activities	7	0
10864	4	10864 1997 PHARMACOLOGICAL RESEARCH 36(3):249-254 Ceppa L; Dacasto M; Carletti M; Montesissa C; Nebbia C 'In vitro' interactions of monensin with hepatic xenobiotic metabolizing enzymes	4	0
10865	42	10865 1997 PHARMACOLOGICAL REVIEWS 49(4):403-449 Lin JH; Lu AYH Role of pharmacokinetics and metabolism in drug discovery and development	90	11
10866	10	10866 1997 PHARMACOLOGY & THERAPEUTICS 73(1):67-74 Kaminsky LS; Zhang ZY Human P450 metabolism of warfarin	87	13
10867	84	10867 1997 PHYSIOLOGICAL REVIEWS 77(2):517-544 Lieber CS Cytochrome P-4502E1: Its physiological and pathological role	181	22
10868	3	10868 1997 PHYSIOLOGICAL REVIEWS 77(3):731-758 Rolfe DFS; Brown GC Cellular energy utilization and molecular origin of standard metabolic rate in mammals	144	0
10869	1	10869 1997 PHYTOCHEMICALS FOR PEST CONTROL 658():58-89 Gang DR; DinkovaKostova AT; Davin LB; Lewis NG Phylogenetic links in plant defense systems: Lignans, isoflavonoids, and their reductases	12	0
10870	4	10870 1997 PHYTOCHEMISTRY 44(5):865-867 Muhlenbeck U; Barz W Cytochrome-P450-dependent formation of alpha- hydroxyacetovanillone from acetovanillone in Solanum khasianum	1	0
10871	6	10871 1997 PHYTOCHEMISTRY 45(2):233-237 Winter J; Schneider B; Strack D; Adam G Role of a cytochrome P450-dependent monooxygenase in the hydroxylation of 24-epi-Brassinolide	10	0
10872	5	10872 1997 PHYTOCHEMISTRY 45(6):1165-1172 Petersen M Cytochrome P450-dependent hydroxylation in the biosynthesis of rosmarinic acid in Coleus	11	0
10873	14	10873 1997 PLANT JOURNAL 11(2):191-201 Bak S; Kahn RA; Olsen CE; Halkier BA Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals	36	13
10874	13	10874 1997 PLANT MOLECULAR BIOLOGY 33(5):875-885 Clark IM; Forde BG; Hallahan DL Spatially distinct expression of two new cytochrome P450s in leaves of Nepeta racemosa: Identification of a trichome- specific isoform	8	3
10875	7	10875 1997 PLANT PHYSIOLOGY 113(3):755-763 Mizutani M; Ohta D; Sato R Isolation of a cDNA and a genomic clone encoding cinnamate 4- hydroxylase from Arabidopsis and its expression manner in planta	33	10
10876	5	10876 1997 PLANT PHYSIOLOGY 114(4):1335-1346 Szczyglowski K; Hamburger D; Kapranov P; deBruijn FJ Construction of a Lotus japonicus late nodulin expressed sequence tag library and identification of novel nodule- specific genes	46	2
10877	15	10877 1997 PLANT SCIENCE 126(1):39-47 Akashi T; Aoki T; Takahashi T; Kameya N; Nakamura I; Ayabe S Cloning of cytochrome P450 cDNAs from cultured Glycyrrhiza echinata L cells and their transcriptional activation by elicitor-treatment	14	4
10878	7	10878 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(6):2133-2138 Oprea TI; Hummer G; Garcia AE Identification of a functional water channel in cytochrome P450 enzymes	33	8
10879	6	10879 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(16):8411-8416 Wang M; Roberts DL; Paschke R; Shea TM; Masters BSS; Kim JJP Three-dimensional structure of NADPH-cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes	152	33
10880	10	10880 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(20):10797-10802 Danielson PB; MacIntyre RJ; Fogleman JC Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome P450s: Evidence for involvement in host- plant allelochemical resistance	32	16
10881	7	10881 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(24):12920-12925 Shinki T; Shimada H; Wakino S; Anazawa H; Hayashi M; Saruta T; DeLuca HF; Suda T Cloning and expression of rat 25-hydroxyvitamin D-3-1 alpha- hydroxylase cDNA	64	7
10882	6	10882 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(25):13554-13558 Reipa V; Mayhew MP; Vilker VL A direct electrode-driven P450 cycle for biocatalysis	20	10
10883	5	10883 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(26):14954-14959 Koopmann E; Hahlbrock K Differentially regulated NADPH : cytochrome P450 oxidoreductases in parsley	9	6
10884	4	10884 1997 PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 216(2):201-210 Subbaramaiah K; Zakim D; Weksler BB; Dannenberg AJ Inhibition of cyclooxygenase: A novel approach to cancer prevention	109	1
10885	12	10885 1997 PROGRESS IN LIPID RESEARCH 36(2-3):197-226 Bach TJ; Benveniste P Cloning of cDNAs or genes encoding enzymes of sterol biosynthesis from plants and other eukaryotes: Heterologous expression and complementation analysis of mutations for functional characterization	22	0
10886	13	10886 1997 PROSTAGLANDINS & OTHER LIPID MEDIATORS 54(4):677-687 Schaefer WR; Werner K; Schweer H; Schneider J; Arbogast E; Zahradnik HP Cytochrome P450 metabolites of arachidonic acid in human placenta	6	2
10887	5	10887 1997 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 56(1):57-61 Gonzalez E; Jawerbaum A; Novaro V; Gimeno MAF Influence of epoxyeicosatrienoic acids on uterine function	3	2
10888	28	10888 1997 PROTEIN EXPRESSION AND PURIFICATION 9(3):346-354 Parikh A; Guengerich FP Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:Rat NADPH- cytochrome P450 reductase fusion protein	10	8
10889	1	10889 1997 PROTEIN EXPRESSION AND PURIFICATION 11(1):53-60 Grisshammer R; Tucker J Quantitative evaluation of neurotensin receptor purification by immobilized metal affinity chromatography	14	0
10890	6	10890 1997 PROTEINS-STRUCTURE FUNCTION AND GENETICS 28(3):388-404 Jean P; Pothier J; Dansette PM; Mansuy D; Viari A Automated multiple analysis of protein structures: Application to homology modeling of cytochromes P450	7	3
10891	9	10891 1997 PSYCHIATRIC ANNALS 27(4):244-& Ereshefsky L; Alfaro CL; Lam YWF Treating depression: Potential drug interactions	11	1
10892	10	10892 1997 PSYCHOPHARMAKOTHERAPIE 4(3):9-17 Eckert A; Mannheim JR; Muller WE The pharmacokinetics of sertraline	0	0
10893	29	10893 1997 RECENT PROGRESS IN HORMONE RESEARCH, PROCEEDINGS OF THE 1996 CONFERENCE, VOL 52 52():185-214 Simpson ER; Zhao Y; Agarwal VR; Michael MD; Bulun SE; Hinshelwood MM; Graham-Lorence S; Sun TJ; Fisher CR; Qin KN; Mendelson CR Aromatase expression in health and disease	99	8
10894	28	10894 1997 REPRODUCTIVE TOXICOLOGY 11(2-3):397-412 Gonzalez FJ The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility	13	2
10895	8	10895 1997 RESEARCH IN VETERINARY SCIENCE 63(3):269-272 Zweers-Zeilmaker WM; Wildschut S; Witkamp RF; Van Miert ASJPAM The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus)	0	0
10896	2	10896 1997 REVUE NEUROLOGIQUE 153(10):547-553 Debouverie M; Wagner M; Ducrocq X; Grignon Y; Mousson B; Weber M The MNGIE syndrome in two siblings	7	0
10897	6	10897 1997 SCIENCE 277(5333):1827-1830 Takeyama K; Kitanaka S; Sato T; Kobori M; Yanagisawa J; Kato S 25-hydroxyvitamin D-3 1 alpha-hydroxylase and vitamin D synthesis	136	12
10898	19	10898 1997 STEROIDS 62(1):117-123 Peterson JA; Sevrioukova I; Truan G; GrahamLorence SE P450BM-3: A tale of two domains - Or is it three?	5	4
10899	6	10899 1997 STEROIDS 62(1):124-127 Vickery LE Molecular recognition and electron transfer in mitochondrial steroid hydroxylase systems	31	7
10900	4	10900 1997 STEROIDS 62(1):197-206 Fitzpatrick SL; Carlone DL; Robker RL; Richards JS Expression of aromatase in the ovary: Down-regulation of mRNA by the ovulatory luteinizing hormone surge	34	1

#	Cited nodes	Nodes / Authors	GCS	LCS
10901	1	10901 1997 SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY 27(12):1144-1149 Adachi T; Takeuchi M; Uno S; Kato M; Miya K; Saji S Characterization of certain hepatocyte-proliferating and/or protective factors induced by the sensitization of freezing- thawing hepatic tissue	0	0
10902	15	10902 1997 THROMBOSIS RESEARCH 88(4):389-398 Zhang ZY; Kerr J; Wexler RS; Li HY; Robinson AJ; Harlow PP; Kaminsky LS Warfarin analog inhibition of human CYP2C9-catalyzed S-warfarin 7-hydroxylation	2	0
10903	15	10903 1997 TOXICOLOGY 117(1):13-23 Iribarne C; Dreano Y; Bardou LG; Menez JF; Berthou F Interaction of methadone with substrates of human hepatic cytochrome P450 3A4	35	3
10904	13	10904 1997 TOXICOLOGY 118(2-3):93-113 Lewis DFV; Bird MG; Parke DV Molecular modelling of CYP2E1 enzymes from rat, mouse and man: An explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity	21	11
10905	4	10905 1997 TOXICOLOGY 121(2):143-153 Badger DA; Kuester RK; Sauer JM; Sipes IG Gadolinium chloride reduces cytochrome p450: Relevance to chemical-induced hepatotoxicity	23	2
10906	12	10906 1997 TOXICOLOGY 122(1-2):11-21 Eliasson M; Brock S; Ahlberg MB Evidence for mitochondrial metabolism of 7,12- dimethylbenz(a)anthracene in porcine ovaries: comparison with microsomal metabolism	2	0
10907	18	10907 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 142(1):123-132 Miranda CL; Henderson MC; Williams DE; Buhler DR In vitro metabolism of 7,12-dimethylbenz[a]anthracene by rainbow trout liver microsomes and trout P450 isoforms	5	1
10908	11	10908 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 142(1):169-177 LehmanMcKeeman LD; Johnson DR; Caudill D Induction and inhibition of mouse cytochrome P-450 2B enzymes by musk xylene	23	3
10909	7	10909 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 144(2):396-400 Rasheed A; Hines RN; McCarverMay DG Variation in induction of human placental CYP2E1: Possible role in susceptibility to fetal alcohol syndrome?	12	2
10910	10	10910 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 145(1):54-60 Hammond DK; Zhu BT; Wang MY; Ricci MJ; Liehr JG Cytochrome P450 metabolism of estradiol in hamster liver and kidney	16	2
10911	12	10911 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 146(1):134-143 Gu J; Walker VE; Lipinskas TW; Walker DM; Ding XX Intraperitoneal administration of coumarin causes tissue- selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa	18	8
10912	5	10912 1997 TOXICOLOGY AND APPLIED PHARMACOLOGY 147(2):289-299 Franklin MR; Phillips JD; Kushner JP Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda	11	0
10913	12	10913 1997 TOXICOLOGY LETTERS 90(1):67-75 Moorthy B; Nguyen UTL; Gupta S; Stewart KD; Welty SE; Smith CV Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha	9	3
10914	11	10914 1997 TOXICOLOGY LETTERS 93(2-3):195-203 Murray M; Sefton RM; Martini R; Butler AM Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides	4	0
10915	1	10915 1997 TRANSPLANTATION PROCEEDINGS 29(4):1984-1985 Kwiatkowski P; Puc J; RotbartFiedor M; Oluwole SF; Rowinski W; Hardy MA; Fiedor P Effects of pefloxacin on rat pancreatic islet cell function after 24-hour cold preservation	1	0
10916	10	10916 1997 TRENDS IN ENDOCRINOLOGY AND METABOLISM 8(9):346-354 Boon WC; Coghlan JP; Curnow KM; McDougall JG Aldosterone secretion - A molecular perspective	7	0
10917	7	10917 1997 VETERINARY AND HUMAN TOXICOLOGY 39(3):141-146 Kodam KM; Govindwar SP In vivo and in vitro effect of sulfamethazine on hepatic mixed function oxidases in rats	0	0
10918	2	10918 1997 VETERINARY RESEARCH COMMUNICATIONS 21(5):317-323 Deoras DP; YoungCurtis P; Dalvi RR; Tippett FE Effect of gossypol on hepatic and serum gamma- glutamyltransferase activity in rats	0	0
10919	5	10919 1997 VITAMINS AND COENZYMES, PT L 282():186-199 Ohyama Y; Hayashi S; Usui E; Noshiro M; Okuda KI Assay of vitamin D derivatives and purification of vitamin D hydroxylases	1	0
10920	5	10920 1997 VITAMINS AND COENZYMES, PT L 282():213-223 Noshiro M; Ohyama Y; Usui E; AkiyoshiShibata M; Yabusaki Y; Okuda KI Molecular cloning of vitamin D-3 hydroxylases	0	0
10921	20	10921 1997 VOPROSY MEDITSINSKOI KHIMII 43(2):67-81 Shumyantseva VV; Avdeenko YL; Moskvitina TL; Archakov AI Naturally occurring and semisynthetic monocomponent flavocytochromes as catalytically self-sufficient monooxygenases.	4	0
10922	1	10922 1997 WATER RESEARCH 31(4):816-824 Schnabel WE; Dietz AC; Burken JG; Schnoor JL; Alvarez PJ Uptake and transformation of trichloroethylene by edible garden plants	16	0
10923	21	10923 1997 XENOBIOTICA 27(2):159-173 Beresford AP; Ellis WJ; Ayrton J; Johnson MA; Lewis DFV Cytochrome P4501A (CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan	3	2
10924	11	10924 1997 XENOBIOTICA 27(2):175-187 Gooneratne R; Miranda CL; Henderson MC; Buhler DR beta-Naphthoflavone induced CYP1A1 and 1A3 proteins in the liver of rainbow trout (Oncorhynchus mykiss)	19	15
10925	25	10925 1997 XENOBIOTICA 27(3):287-299 Tan YZ; White SP; Paranawithana SR; Yang CS A hypothetical model for the active site of human cytochrome P4502E1	16	9
10926	19	10926 1997 XENOBIOTICA 27(4):319-339 Lewis DFV; Eddershaw PJ; Goldfarb PS; Tarbit MH Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: Structural studies on specific CYP2D6 substrate metabolism	49	16
10927	17	10927 1997 XENOBIOTICA 27(4):341-355 Gokhale MS; Bunton TE; Zurlo J; Yager JD Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices	21	3
10928	11	10928 1997 XENOBIOTICA 27(4):357-368 DeGroot MJ; Bijloo GJ; VanAcker FAA; Guerra CF; Snijders JG; Vermeulen NPE Extension of a predictive substrate model for human cytochrome P4502D6	10	5
10929	5	10929 1997 XENOBIOTICA 27(5):413-421 Vargas M; Franklin MR Intestinal UDP-glucuronosyltransferase activities in rat and rabbit	11	1
10930	48	10930 1997 XENOBIOTICA 27(5):443-478 Lewis DFV; Lake BG Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners	33	13
10931	10	10931 1997 XENOBIOTICA 27(8):769-780 ZweersZeilmaker WM; Horbach GJ; Witkamp RF Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).	5	2
10932	7	10932 1997 XENOBIOTICA 27(8):853-864 Verschoyle RD; Martin J; Dinsdale D Selective inhibition and induction of CYP activity discriminates between the isoforms responsible for the activation of butylated hydroxytoluene and naphthalene in mouse lung	2	1
10933	12	10933 1997 XENOBIOTICA 27(10):1025-1037 Jones BC; Tyman CA; Smith DA Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes	8	4
10934	15	10934 1997 XENOBIOTICA 27(11):1165-1173 Lake BG; Ball SE; Renwick AB; Tredger JM; Kao J; Beamand JA; Price RJ Induction of CYP3A isoforms in cultured precision-cut human liver slices	23	5
10935	8	10935 1997 ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES 52(9-10):605-614 MullerEnoch D Blue light mediated photoreduction of the flavoprotein NADPH- cytochrome P450 reductase. A Forster-type energy transfer	0	0
10936	1	10936 1997 ZYGOTE 5(2):153-175 Ikegami R; RiveraBennetts AK; Brooker DL; Yager TD Effect of inhibitors of DNA replication on early zebrafish embryos: evidence for coordinate activation of multiple intrinsic cell-cycle checkpoints at the mid-blastula transition	8	0
10937	0	10937 1998 ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 215():U648-U648 Estabrook RW The discovery of cytochrome P450: Biology's solution to unique oxygenation chemistry.	0	0
10938	3	10938 1998 ACCOUNTS OF CHEMICAL RESEARCH 31(6):363-369 Rusling JF Enzyme bioelectrochemistry in cast biomembrane-like films	87	6
10939	5	10939 1998 ACTA ANAESTHESIOLOGICA SCANDINAVICA 42(9):1025-1027 Dale O; Olkkola KT Cytochrome P450, molecular biology and anaesthesia	4	1
10940	8	10940 1998 ADVANCES IN MICROBIAL PHYSIOLOGY, VOL 39 39():291-338 Lloyd D Circadian and ultradian clock-controlled rhythms in unicellular microorganisms	13	0
10941	24	10941 1998 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 22(2):455-462 Amet Y; Lucas D; Zhang-Gouillon ZQ; French SW P-450-dependent metabolism of lauric acid in alcoholic liver disease: Comparison between rat liver and kidney microsomes	7	2
10942	9	10942 1998 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 22(2):501-504 Kessova IG; DeCarli LM; Lieber CS Inducibility of cytochromes P-4502E1 and P-4501A1 in the rat pancreas	9	2
10943	15	10943 1998 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 22(7):1493-1500 Amet Y; Adas F; Nanji AA Fatty acid omega- and (omega-1)-hydroxylation in experimental alcoholic liver disease: Relationship to different dietary fatty acids	4	3
10944	17	10944 1998 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 22(9):2125-2132 Salmela KS; Kessova IG; Tsyrlov IB; Lieber CS Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system	27	5
10945	11	10945 1998 AMERICAN FAMILY PHYSICIAN 57(1):107-116 Cupp MJ; Tracy TS Cytochrome P450: New nomenclature and clinical implications	19	2
10946	8	10946 1998 AMERICAN JOURNAL OF HUMAN GENETICS 62(3):573-584 Stoilov I; Akarsu AN; Alozie I; Child A; Barsoum-Homsy M; Turacli ME; Or M; Lewis RA; Ozdemir N; Brice G; Aktan SG; Chevrette L; Coca-Prados M; Sarfarazi M Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1	66	14
10947	1	10947 1998 AMERICAN JOURNAL OF HUMAN GENETICS 63(1):29-36 Hanna MG; Nelson IP; Rahman S; Lane RJM; Land J; Heales S; Cooper MJ; Schapira AHV; Morgan-Hughes JA; Wood NW Cytochrome c oxidase deficiency associated with the first stop- codon point mutation in human mtDNA	44	1
10948	2	10948 1998 AMERICAN JOURNAL OF PATHOLOGY 153(2):515-525 Shi JL; Aisaki K; Ikawa Y; Wake K Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride	29	5
10949	5	10949 1998 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 44(3):C900-C909 French SA; Territo PR; Balaban RS Correction for inner filter effects in turbid samples: fluorescence assays of mitochondrial NADH	10	0
10950	18	10950 1998 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 44(1):H100-H109 Stephenson AH; Sprague RS; Lonigro AJ 5,6-epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog	7	0
10951	14	10951 1998 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 44(6):H2113-H2121 Fang X; Moore SA; Stoll LL; Rich G; Kaduce TL; Weintraub NL; Spector AA 14,15-epoxyeicosatrienoic acid inhibits prostaglandin E-2 production in vascular smooth muscle cells	12	0
10952	13	10952 1998 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 19(3):L423-L431 Dumoulin M; Salvail D; Gaudreault SB; Cadieux A; Rousseau E Epoxyeicosatrienoic acids relax airway smooth muscles and directly activate reconstituted K-Ca channels	19	0
10953	3	10953 1998 ANALYTICAL BIOCHEMISTRY 261(1):16-28 Kiss L; Bieniek E; Weissmann N; Schutte H; Sibelius U; Gunther A; Bier J; Mayer K; Henneking K; Padberg W; Grimm H; Seeger W; Grimminger F Simultaneous analysis of 4- and 5-series lipoxygenase and cytochrome P450 products from different biological sources by reversed-phase high-performance liquid chromatographic technique	11	1
10954	5	10954 1998 ANALYTICAL CHEMISTRY 70(12):519R-589R Anderson JL; Coury LA; Leddy J Dynamic electrochemistry: Methodology and application	21	0
10955	9	10955 1998 ANNALES D ENDOCRINOLOGIE 59(2):79-92 Carreau S; Balinski B; Levallet J Male germ cells: a new source of estrogens in the mammalian testis.	9	1
10956	6	10956 1998 ANNUAL REVIEW OF MEDICINE 49():311-328 New MI Diagnosis and management of congenital adrenal hyperplasia	25	1
10957	87	10957 1998 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 38():389-430 Thummel KE; Wilkinson GR In vitro and in vivo drug interactions involving human CYP3A	159	26
10958	47	10958 1998 ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY 49():311-343 Chapple C Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases	79	15
10959	1	10959 1998 ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY 49():557-583 Cunningham FX; Gantt E Genes and enzymes of carotenoid biosynthesis in plants	94	0
10960	28	10960 1998 ANTI-CANCER DRUG DESIGN 13(6):541-573 Patterson AV; Saunders MP; Chinje EC; Patterson LH; Stratford IJ Enzymology of tirapazamine metabolism: a review	35	0
10961	10	10961 1998 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 42(2):241-253 Sanglard D; Ischer F; Koymans L; Bille J Amino acid substitutions in the cytochrome P-450 lanosterol 14 alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents	96	4
10962	9	10962 1998 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 64(10):3784-3790 Schneider S; Wubbolts MG; Sanglard D; Witholt B Biocatalyst engineering by assembly of fatty acid transport and oxidation activities for in vivo application of cytochrome P- 450(BM-3) monooxygenase	9	8
10963	19	10963 1998 AQUATIC TOXICOLOGY 41(1-2):63-81 Novi S; Pretti C; Cognetti AM; Longo V; Marchetti S; Gervasi PG Biotransformation enzymes and their induction by beta- naphthoflavone in adult sea bass (Dicentrarchus labrax)	12	2
10964	9	10964 1998 AQUATIC TOXICOLOGY 43(1):41-50 Mattson M; Raunio H; Pelkonen O; Helle E Elevated levels of cytochrome P4501A (CYP1A) in ringed seals from the Baltic Sea	12	4
10965	26	10965 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 349(1):53-64 Truan G; Peterson JA Thr268 in substrate binding and catalysis in P450BM-3	9	5
10966	28	10966 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 349(1):95-104 Cvrk T; Strobel HW Photoaffinity labeling of cytochrome P4501A1 with azidocumene: Identification of cumene hydroperoxide binding region	11	3
10967	21	10967 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 349(2):329-340 Wang HF; Lanza DL; Yost GS Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene	23	4
10968	11	10968 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 349(2):349-355 Foussat J; Costet P; Galtier P; Pineau T; Lesca P The 4S benzo(a)pyrene-binding protein is not a transcriptional activator of Cyp1a1 gene in Ah receptor-deficient (AHR -/-) transgenic mice	6	0
10969	11	10969 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 350(2):233-238 Chen CD; Doray B; Kemper B A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2	4	1
10970	23	10970 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 350(2):324-332 Hanna IH; Teiber JF; Kokones KL; Hollenberg PF Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities	46	26
10971	22	10971 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 350(2):333-339 He YQ; Harlow GR; Szklarz GD; Halpert JR Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: The role of nonsubstrate recognition site residues	14	8
10972	14	10972 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 351(1):60-65 Kurose K; Tohkin N; Ushio F; Fukuhara M Cloning and characterization of Syrian hamster testosterone 7 alpha-hydroxylase, CYP2A9	8	5
10973	12	10973 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 352(2):271-280 Yang YH; Wang JL; Miranda CL; Buhler DR CYP2M1: Cloning, sequencing, and expression of a new cytochrome P450 from rainbow trout liver with fatty acid (omega-6)- hydroxylation activity	9	4
10974	24	10974 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 353(1):16-28 Lasker JM; Wester MR; Aramsombatdee E; Raucy JL Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations	41	10
10975	12	10975 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 353(1):109-115 Woods ST; Sadleir J; Downs T; Triantopoulos T; Headlam MJ; Tuckey RC Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462	9	3
10976	14	10976 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 353(2):365-373 Hosea NA; Guengerich FP Oxidation of nonionic detergents by cytochrome P450 enzymes	12	5
10977	8	10977 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 354(1):133-138 Shumyantseva VV; Uvarov VY; Byakova OE; Archakov AI Semisynthetic flavocytochromes based on cytochrome P450 2B4: Reductase and oxygenase activities	6	5
10978	15	10978 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 354(2):295-302 Roberts ES; Alworth WL; Hollenberg PF Mechanism-based inactivation of cytochromes P450 2E1 and 2B1 by 5-phenyl-1-pentyne	23	3
10979	12	10979 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 355(2):201-205 Kikuta Y; Kusunose E; Sumimoto H; Mizukami Y; Takeshige K; Sakaki T; Yabusaki Y; Kusunose M Purification and characterization of recombinant human neutrophil leukotriene B-4 omega-hydroxylase (cytochrome p450 4F3)	16	7
10980	19	10980 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 356(2):100-106 Bani MH; Tohkin M; Ushio F; Fukuhara M Evidence for involvement of cAMP-dependent pathway in the phenobarbital-induced expression of a novel hamster cytochrome P450, CYP3A31	6	3
10981	20	10981 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 356(2):229-238 Yun CH; Ahn T; Guengerich FP Conformational change and activation of cytochrome P450 2B1 induced by salt and phospholipid	8	3
10982	20	10982 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):27-36 Roussel F; Duignan DB; Lawton MP; Obach RS; Strick CA; Tweedie DJ Expression and characterization of canine cytochrome P450 2D15	14	0
10983	41	10983 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):45-57 Luo G; Zeldin DC; Blaisdell JA; Hodgson E; Goldstein JA Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid	22	13
10984	21	10984 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):111-120 Shimada T; Wunsch RM; Hanna IH; Sutter TR; Guengerich FP; Gillam EMJ Recombinant human cytochrome P450 1B1 expression in Escherichia coli	38	19
10985	9	10985 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):131-136 Stundl UM; Schmidt I; Scheller U; Schmid R; Schunck WH; Schauer F Purification and characterization of cytosolic cytochrome P450 forms from yeasts belonging to the genus Trichosporon	4	2
10986	5	10986 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):137-146 Andreou ER; Prokipcak RD Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction	7	1
10987	8	10987 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(2):310-316 Makovec T; Breskvar K Purification and characterization of NADPH-cytochrome P450 reductase from filamentous fungus Rhizopus nigricans	4	0
10988	14	10988 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 358(2):271-276 Snyder MJ Identification of a new cytochrome P450 family, CYP45, from the lobster, Homarus americanus, and expression following hormone and xenobiotic exposures	5	3
10989	24	10989 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 359(1):89-98 Jin RY; Koop DR; Raucy JL; Lasker JM Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4	14	7
10990	15	10990 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 359(2):231-240 Guzov VM; Unnithan GC; Chernogolov AA; Feyereisen R CYP12A1, a mitochondrial cytochrome P450 from the house fly	17	8
10991	16	10991 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 359(2):241-248 Fukuhara M; Kurose K; Aiba N; Matsunaga N; Omata W; Kato K; Kimura M A major phenobarbital-inducible P450 isozyme, CYP2A14, in the Chinese hamster liver: Purification, characterization, and cDNA cloning	5	3
10992	18	10992 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 360(1):53-61 Lee SJ; Wang-Buhler JL; Cok I; Yu TS; Yang YH; Miranda CL; Lech J; Buhler DR Cloning, sequencing, and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers	12	4
10993	13	10993 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 360(2):239-247 Louis CA; Wood SG; Walton HS; Sinclair PR; Sinclair JF Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: Comparison to glutethimide and relation to induction of 5-aminolevulinate synthase	3	0
10994	5	10994 1998 ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY 37(1):57-63 Korytko PJ; Scott JG CYP6D1 protects thoracic ganglia of houseflies from the neurotoxic insecticide cypermethrin	15	6
10995	12	10995 1998 ARCHIVES OF MICROBIOLOGY 170(3):147-154 George HL; Hirschi KD; VanEtten HD Biochemical properties of the products of cytochrome P450 genes (PDA) encoding pisatin demethylase activity in Nectria haematococca	7	3
10996	1	10996 1998 ARCHIVES OF NEUROLOGY 55(12):1591-1591 Riggs JE; Schochet SS Critical illness myopathy, steroids, and cytochrome P450	1	0
10997	4	10997 1998 ARCHIVES OF PHARMACAL RESEARCH 21(2):120-127 Hong JT; Yun YP Effects of the peroxisome proliferator ciprofibrate and prostaglandin F-2 alpha combination treatment on second messengers in cultured rat hepatocytes	0	0
10998	12	10998 1998 ARCHIVES OF PHARMACAL RESEARCH 21(3):305-309 Chun YJ Expression of recombinant human cytochrome P450 1A2 in Escherichia coli bacterial mutagenicity tester strain	1	0
10999	12	10999 1998 ARCHIVES OF TOXICOLOGY 72(6):336-341 Kojo A; Viitala P; Pasanen M; Pelkonen O; Raunio H; Juvonen R Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes	4	2
11000	13	11000 1998 ARCHIVES OF TOXICOLOGY 72(7):395-401 Chen RM; Chou MW; Ueng TH Induction of cytochrome P450 1A in hamster liver and lung by 6- nitrochrysene	5	0

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