Record 4060 View: Overview | Glossary HistCite Guide |
Author(s): MERCIER C; MEKENYAN O; DUBOIS JE; BONCHEV D
Title: DARC PELCO AND OASIS METHODS .1. METHODOLOGICAL COMPARISON - MODELING PURINE PKA AND ANTITUMOR-ACTIVITY
Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 26 (6): 575-592
Date: 1991 SEP
Document Type: Journal : Article
Language: English
Comment:
Address: HIGHLER SCH CHEM TECHNOL,BU-8010 BURGAS,BULGARIA.
Reprint: MERCIER, C, UNIV PARIS 07,INST TOPOL & DYNAM SYST,CNRS,1 RUE GUY
BROSSE,F-75221 PARIS 05,FRANCE. Abstract: Two QSAR approaches have been compared in detail. The DARC/PELCO method is based on the exhaustive generation of all topochromatic sites around the reference structure and the evaluation of their contribution to the property. The OASIS system is an optimized version of the extended Hansch type physicochemical method which makes use of a large set of molecular descriptors (topological, steric, quantum chemical, etc.). The DARC/PELCO models of a series of purine derivatives have a more specific area of reliable prediction and greater accuracy than OASIS models. The latter, in turn, provide more details concerning the possible biological mechanism. In spite of their differences, the two methods produce similar predictions for the properties under study. A conclusion is drawn about the complementarity of these QSAR approaches for optimizing the lead structure in congeneric series of biologically active molecules.
Cited References: ALBERT A, 1954, J CHEM SOC, P2060 ALBERT A, 1960, BIOCHEM J, V76, P621 ALBERT A, 1960, J CHEM SOC, P4705 ALBERT A, 1971, DETERMINATION IONIZA BALABAN AT, 1979, THEOR CHIM ACTA, V53, P355 BALABAN AT, 1982, CHEM PHYS LETT, V89, P399 BASAK SC, 1984, J PHARM SCI, V73, P429 BINGHAM RC, 1975, J AM CHEM SOC, V97, P1285 BONCHEV D, 1983, INFORMATION THEORETI CHRETIEN JR, 1985, EUR J MED CHEM, V20, P315 CONE WH, 1970, CHEMOTHERAPY CANCER, PCH1 CRAMER RD, 1988, QUANT STRUCT-ACT REL, V7, P18 DEWAR MJS, 1977, J AM CHEM SOC, V99, P4899 DONNAY RH, 1974, J CHIM PHYS, V11, P1418 DOUCET JP, 1983, J ORG CHEM, V48, P3174 DUBOIS JE, 1966, CR ACAD SCI C CHIM, V263, P764 DUBOIS JE, 1973, J CHIM PHYS, V70, P1608 DUBOIS JE, 1976, EUR J MED CHEM, V11, P225 DUBOIS JE, 1979, C R ACAD SCI SER P 2, V292, P783 DUBOIS JE, 1979, CR ACAD SCI C CHIM, V289, P89 DUBOIS JE, 1984, CR ACAD SCI B PHYS, V298, P525 DUBOIS JE, 1986, ACTA PHARM JUGOSL, V36, P135 DUBOIS JE, 1989, B SOC CHIM BELG, V98, P31 DUPERRAY B, 1976, EUR J MED CHEM, V11, P323 EXNER O, 1988, CORRELATION ANAL CHE, P173 FREE SM, 1964, J MED CHEM, V7, P395 FUJITA T, 1971, J MED CHEM, V14, P148 GINERSOROLLA A, 1958, J AM CHEM SOC, V80, P5744 GINERSOROLLA A, 1959, J AM CHEM SOC, V81, P2515 GOLUB GH, 1970, NUMER MATH, V14, P403 GUTMAN I, 1972, CHEM PHYS LETT, V17, P535 GUTMAN I, 1975, J CHEM PHYS, V62, P3399 HANSCH C, 1964, J AM CHEM SOC, V86, P1616 HANSCH C, 1973, J MED CHEM, V16, P1207 HANSCH C, 1976, J MED CHEM, V19, P1 HANSCH C, 1979, SUBSTITUENT CONSTANT HOSOYA H, 1971, B CHEM SOC JPN, V44, P2332 HOSOYA H, 1972, J CHEM DOCUM, V12, P181 KANETTI H, UNPUB QCPE VERSION KIER LB, 1976, MOL CONNECTIVITY CHE KIER LB, 1981, J PHARM SCI, V70, P930 KIER LB, 1986, MOL CONNECTIVITY CHE LEWIN S, 1962, J CHEM SOC, P1466 LISTER JH, 1971, PURINES, P9 MEKENYAN O, 1985, 3RD P INT C CHEM BIO, V3, P385 MEKENYAN O, 1986, ACTA PHARM JUGOSL, V36, P225 MEKENYAN O, 1986, DRUG DES, V36, P176 MEKENYAN O, 1986, DRUG RES, V36, P629 MEKENYAN O, 1988, J MATH CHEM, V2, P347 MEKENYAN O, 1988, QUANT STRUCT-ACT REL, V7, P240 MEKENYAN O, 1989, 3 P INT C MATH CHEM MEKENYAN O, 1990, COMPUT CHEM, V14, P193 MEKENYAN O, 1991, EUR J MED CHEM, V26, P305 MEKENYAN O, 1991, IN PRESS J MATH CHEM MERCIER C, 1979, EUR J MED CHEM, V14, P415 MERCIER C, 1981, EUR J MED CHEM, V16, P473 MERCIER C, 1989, QUANTITATIVE STRUCTU, P203 MERCIER C, 1990, QUANT STRUCT-ACT REL, V9, P88 MERCIER C, 1990, SYSTEMES INFORMATION, P28 MERCIER C, 1991, IN PRESS GORDON BREA, V2 MERCIER C, 1991, J MED CHEM, V34, P934 MOTOC I, 1982, MATCH-COMMUN MATH CO, V13, P369 NEIMAN Z, 1981, J PHARM SCI, V70, P425 NEIMAN Z, 1982, J PHARM SCI, V71, P618 PERRIN DD, 1965, J CHEM SOC, P5590 POALNSKY DE, 1986, MATCH-COMMUN MATH CH, V21, P133 POLANSKY OE, 1986, MATCH-COMMUN MATH CH, V21, P341 RANDIC M, 1975, J AM CHEM SOC, V97, P6609 RANDIC M, 1979, CHEM PHYS LETT, V63, P332 RAY SK, 1981, INDIAN J CHEM B, V20, P894 SOBEL Y, 1981, EUR J MED CHEM, V16, P477 STEWART JJP, 1989, J COMPUT CHEM, V10, P209 TAFT RW, 1952, J AM CHEM SOC, V74, P3120 THIEL W, 1981, J AM CHEM SOC, V103, P1413 TOMASIK P, 1979, CHEM ZVESTI, V33, P105 TOPLISS JG, 1979, J MED CHEM, V22, P1238 VERLOOP A, 1976, DRUG DESIGN, V7, P165 WIENER H, 1947, J AM CHEM SOC, V69, P17 WIENER H, 1948, J PHYS CHEM-US, V52, P1082 YEE WT, 1976, REP U ELECTR COMMUN, V27, P53 YEE WT, 1977, REP U ELECTR COMMUNU, V27, P53 |