| Record 7927 View: Standard | Glossary HistCite Guide |
|
Author(s): Lamont LB; Crittenden SL; Bernstein D; Wickens M; Kimble J
Title: FBF-1 and FBF-2 regulate the size of the mitotic region in the C-elegans germline
Source: DEVELOPMENTAL CELL 7 (5): 697-707
Date: 2004 NOV
Document Type: Journal : Article
DOI:
Language: English
Comment:
Address: Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USA. Reprint: Kimble, J, Univ Wisconsin, Dept Biochem, 420 Henry Mall, Madison, WI
53706 USA. E-mail: jekimble@facstaff.wisc.edu
Abstract: In the C. elegans germline, GLIP-1/Notch signaling and two nearly identical RNA binding proteins, FBF-1 and FBF-2, promote proliferation. Here, we show that the fbf-1 and fbf-2 genes are largely redundant for promoting mitosis but that they have opposite roles in fine-tuning the size of the mitotic region. The mitotic region is smaller than normal in fbf-1 mutants but larger than normal in fbf-2 mutants. Consistent with gene-specific roles, fbf-2 expression is limited to the distal germline, while fbf-1 expression is broader. The fbf-2 gene, but apparently not fbf-1, is controlled by GLP-1/Notch signaling, and the abundance of FBF-1 and FBF-2 proteins is limited by reciprocal 3'UTR repression. We propose that the divergent fbf genes and their regulatory subnetwork enable a precise control over size of the mitotic region. Therefore, fbf-1 and fbf-2 provide a paradigm for how recently duplicated genes can diverge to fine-tune patterning during animal development.
Cited References: AUSTIN J, 1987, CELL, V51, P589 BARDONI B, 1994, NAT GENET, V7, P497 BERNSTEIN DS, 2002, METHODS, V26, P123 BERSET T, 2001, SCIENCE, V291, P1055 BRENNER S, 1974, GENETICS, V77, P71 CARLES CC, 2003, TRENDS PLANT SCI, V8, P394 CARROLL S, 2001, DNA DIVERSITY MOL GE CHIAL HJ, 1999, P NATL ACAD SCI USA, V96, P10200 CHRISTENSEN S, 1996, DEVELOPMENT, V122, P1373 CRITTENDEN S, 1998, METHOD MOL BIOL, V122, P141 CRITTENDEN SL, 1994, DEVELOPMENT, V120, P2901 CRITTENDEN SL, 2002, NATURE, V417, P660 CRITTENDEN SL, 2003, PHILOS T ROY SOC B, V358, P1359 DERNBURG AF, 1998, CELL, V94, P387 ECKMANN CR, 2002, DEV CELL, V3, P697 ECKMANN CR, 2004, IN PRESS GENETICS EPSTEIN HF, 1995, MODERN BIOL ANAL ORG FUCHS E, 2004, CELL, V116, P769 HANSEN D, 2004, DEVELOPMENT, V131, P93 HENDZEL MJ, 1997, CHROMOSOMA, V106, P348 HODGKIN J, 1991, P ROY SOC LOND B BIO, V246, P19 HUANG B, 1999, AM J MED GENET, V87, P349 JONES AR, 1996, DEV BIOL, V180, P165 JORDAN BK, 2001, AM J HUM GENET, V68, P1102 KADYK LC, 1998, DEVELOPMENT, V125, P1803 KRAEMER B, 1999, CURR BIOL, V9, P1009 LYNCH M, 2000, GENETICS, V154, P459 MURATA Y, 1995, CELL, V80, P747 OHNO S, 1970, EVOLUTION GENE DUPLI OHTA T, 2003, GENETICA, V118, P209 PAPP B, 2003, NATURE, V424, P194 PASIERBEK P, 2001, GENE DEV, V15, P1349 PERRIERE G, 1996, BIOCHIMIE, V78, P364 POURQUIE O, 2003, INT J DEV BIOL, V47, P597 RUDEL D, 2001, GENETICS, V157, P639 SCHEDL A, 1996, CELL, V86, P71 SCHWARZ M, 2000, DEVELOPMENT, V127, P4325 SENGUPTA DJ, 1996, P NATL ACAD SCI USA, V93, P8496 SIBLEY MH, 1993, J CELL BIOL, V123, P255 TADAUCHI T, 2001, EMBO J, V20, P552 TICKLE C, 2003, DEV CELL, V4, P449 WICKENS M, 2002, TRENDS GENET, V18, P150 YOO AS, 2004, SCIENCE, V303, P663 YU H, 2004, BIOINFORMATICS, V20, P1198 ZETKA MC, 1999, GENE DEV, V13, P2258 ZHANG BL, 1997, NATURE, V390, P477 ZIMBERSTROBL U, 1994, EMBO J, V13, P4973 |