| Record 287 View: Standard | Glossary HistCite Guide |
|
Author(s): Baccala R (Baccala, Roberto); Hoebe K (Hoebe, Kasper); Kono DH (Kono, Dwight H.); Beutler B (Beutler, Bruce); Theofilopoulos AN (Theofilopoulos, Argyrios N.)
Title: TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Source: NATURE MEDICINE 13 (5): 543-551
Date: 2007 MAY
Document Type: Journal : Review
DOI: 10.1038/nm1590
Language: English
Comment:
Address: Scripps Res Inst, Dept Immunol, La Jolla, CA 93037 USA.
Reprint: Baccala, R, Scripps Res Inst, Dept Immunol, La Jolla, CA 93037 USA.
E-mail: argyrio@scripps.edu
Author Keywords:
KeyWords Plus: TOLL-LIKE RECEPTORS; PATTERN-RECOGNITION RECEPTORS; DENDRITIC CELL
ACTIVATION; ANTIGEN-PRESENTING CELLS; LUPUS-ERYTHEMATOSUS; MURINE
LUPUS; RIG-I; IMMUNE-RESPONSES; APOPTOTIC CELLS; MAMMALIAN DNA
Abstract: We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phase serves an amplification function and is mediated by uptake of TLR ligands derived from self-antigens (principally nucleic acids) complexed with autoantibodies. Both phases depend on elaboration of type I interferons (IFNs), and therapeutic interruption of induction or activity of these cytokines in predisposed individuals might have a substantial mitigating effect in lupus and other autoimmune diseases.
Cited References: ALBERT ML, 1998, NATURE, V392, P86 ANDRADE F, 2000, RHEUM DIS CLIN N AM, V26, P215 AVRAMEAS S, 1991, IMMUNOL TODAY, V12, P154 BACCALA R, 2005, IMMUNOL REV, V204, P9 BAGAVANT H, 2004, SCAND J IMMUNOL, V60, P52 BANCHEREAU J, 2006, IMMUNITY, V25, P383, DOI 10.1016/j.immuni.2006.08.010 BARRAT FJ, 2005, J EXP MED, V202, P1131, DOI 10.1084/jem.20050914 BEKEREDJIANDING IB, 2005, J IMMUNOL, V174, P4043 BERLAND R, 2006, IMMUNITY, V25, P429, DOI 10.1016/j.immuni.2006.07.014 BEUTLER B, 2006, ANNU REV IMMUNOL, V24, P353, DOI 10.1146/annurev.immunol.24.021605.090552 BODANO A, 2004, ARTHRITIS RHEUM, V50, P4070, DOI 10.1002/art.20721 BOTTO M, 1998, NAT GENET, V19, P56 BOULE MW, 2004, J EXP MED, V199, P1631, DOI 10.1084/jem.20031942 BRAUN D, 2003, J AUTOIMMUN, V20, P15, DOI 10.1016/S0896-8411(02)00109-9 CHEN M, 2006, SCIENCE, V311, P1160, DOI 10.1126/science.1122545 CHRISTENSEN SR, 2005, J EXP MED, V202, P321, DOI 10.1084/jem.20050338 CHRISTENSEN SR, 2006, IMMUNITY, V25, P417, DOI 10.1016/j.immuni.2006.07.013 CORTEZGONZALEZ X, 2006, DNA CELL BIOL, V25, P253 DECKER P, 2005, J IMMUNOL, V174, P3326 DENNY MF, 2006, J IMMUNOL, V176, P2095 DONG L, 2005, ARTHRITIS RHEUM, V52, P651, DOI 10.1002/art.20810 EHLERS M, 2006, J EXP MED, V203, P553, DOI 10.1084/jem.20052438 ERIKSSON U, 2003, NAT MED, V9, P1484, DOI 10.1038/nm960 FITZGERALD KA, 2006, CELL, V125, P834, DOI 10.1016/j.cell.2006.05.014 FRITZ JH, 2006, NAT IMMUNOL, V7, P1250, DOI 10.1038/ni1412 GAIPL US, 2006, CURR TOP MICROBIOL, V305, P161 GALLUCCI S, 1999, NAT MED, V5, P1249 GITLIN L, 2006, P NATL ACAD SCI USA, V103, P8459, DOI 10.1073/pnas.0603082103 GOODNOW CC, 2005, NATURE, V435, P590, DOI 10.1038/nature03724 GRAHAM RR, 2006, NAT GENET, V38, P550, DOI 10.1038/ng1782 HANG L, 1983, J EXP MED, V157, P874 HONDA K, 2006, NAT REV IMMUNOL, V6, P644, DOI 10.1038/nri1900 HORNUNG V, 2006, SCIENCE, V314, P994, DOI 10.1126/science.1132505 HRON JD, 2004, J IMMUNOL, V173, P2134 ISHII KJ, 2006, CURR PHARM DESIGN, V12, P4135 ISHII KJ, 2006, NAT IMMUNOL, V7, P40, DOI 10.1038/ni1282 IWASAKI A, 2004, NAT IMMUNOL, V5, P987, DOI 10.1038/ni1112 JANSSEN E, 2006, IMMUNITY, V24, P787, DOI 10.1016/j.immuni.2006.03.024 KATO H, 2006, NATURE, V441, P101, DOI 10.1038/nature04734 KAWAI T, 2006, CELL DEATH DIFFER, V13, P816, DOI 10.1038/sj.cdd.4401850 KAWANE K, 2006, NATURE, V443, P998, DOI 10.1038/nature05245 KONO DH, 2004, SYSTEMIC LUPUS ERYTH, P225 KRIEG AM, 2002, ANNU REV IMMUNOL, V20, P709 LANG KS, 2005, NAT MED, V11, P138, DOI 10.1038/nm1176 LANG KS, 2006, J CLIN INVEST, V116, P2456, DOI 10.1172/JCI28349 LARTIGUE A, 2006, J IMMUNOL, V177, P1349 LAU CM, 2005, J EXP MED, V202, P1171, DOI 10.1084/jem.20050630 LEBON A, 2006, J IMMUNOL, V176, P2074 LIEW FY, 2005, NAT REV IMMUNOL, V5, P446, DOI 10.1038/nri1630 LIN Q, 1998, J EXP MED, V187, P79 LIU YJ, 2005, ANNU REV IMMUNOL, V23, P275, DOI 10.1146/annurev.immunol.23.021704.115633 LU QX, 2001, SCIENCE, V293, P306 MALDONADO MA, 1999, J IMMUNOL, V162, P6322 MARSHAKROTHSTEIN A, 2006, NAT REV IMMUNOL, V6, P823, DOI 10.1038/nri1957 MARTIN DA, 2005, J EXP MED, V202, P1465, DOI 10.1084/jem.20052228 MARTIN DA, 2006, ARTHRITIS RHEUM, V54, P951, DOI 10.1002/art.21677 MATHIAN A, 2005, J IMMUNOL, V174, P2499 MEANS TK, 2005, J CLIN INVEST, V115, P407, DOI 10.1172/JCI200523025 MEVORACH D, 1998, J EXP MED, V188, P387 MEYLAN E, 2006, MOL CELL, V22, P561 MOHTY M, 2003, J IMMUNOL, V171, P3385 NAPIREI M, 2000, NAT GENET, V25, P177 NESTLE FO, 2005, J EXP MED, V202, P135, DOI 10.1081/jem.20050500 NORDMARK G, 2006, NAT CLIN PRACT RHEUM, V2, P262, DOI 10.1038/ncprheum0173 OBEID M, 2007, NAT MED, V13, P54, DOI 10.1038/nm1523 OGDEN CA, 2006, CURR DIRECT AUTOIMMU, V9, P120 OKABE Y, 2005, J EXP MED, V202, P1333 ONEILL LAJ, 2006, NAT IMMUNOL, V7, P1023, DOI 10.1038/ni1006-1023 PAWAR RD, 2006, AM J PHYSIOL-RENAL, V291, F509, DOI 10.1152/ajprenal.00453.2005 PICHLMAIR A, 2006, SCIENCE, V314, P997, DOI 10.1126/science.1132998 PISITKUN P, 2006, SCIENCE, V312, P1669, DOI 10.1126/science.1124978 PLATANIAS LC, 2005, NAT REV IMMUNOL, V5, P375, DOI 10.1038/nri1604 POOLE BD, 2006, AUTOIMMUNITY, V39, P63, DOI 10.1080/08016930500484849 REZAEI N, 2006, INT IMMUNOPHARMACOL, V6, P863, DOI 10.1016/j.intimp.2006.02.005 RONNBLOM L, 2006, ARTHRITIS RHEUM, V54, P408, DOI 10.1002/art.21571 ROTHENFUSSER S, 2005, J IMMUNOL, V175, P5260 SANO H, 1982, J IMMUNOL, V128, P1341 SAVARESE E, 2006, BLOOD, V107, P3229, DOI 10.1182/blood-2005-07-2650 SCHWARTING A, 2005, J AM SOC NEPHROL, V16, P3264, DOI 10.1681/ASN.2004111014 SEYA T, 2003, ANTICANCER RES, V23, P4369 SIGURDSSON S, 2005, AM J HUM GENET, V76, P528 STETSON DB, 2006, IMMUNITY, V24, P93 STEWART TA, 2003, CYTOKINE GROWTH F R, V14, P139, DOI 10.1016/S1359-6101(02)00088-6 SUBRAMANIAN S, 2006, P NATL ACAD SCI USA, V103, P9970, DOI 10.1073/pnas.0603912103 SUN QM, 2006, IMMUNITY, V24, P633, DOI 10.1016/j.immuni.2006.04.004 TABETA K, 2006, NAT IMMUNOL, V7, P156, DOI 10.1038/ni1297 TAKEMURA Y, 2007, J CLIN INVEST, V117, P375, DOI 10.1172/JCI29709 THEOFILOPOULOS AN, 2005, ANNU REV IMMUNOL, V23, P307, DOI 10.1146/annurev.immunol.23.021704.115843 TSUKUMO SI, 2004, CLIN IMMUNOL, V113, P14, DOI 10.1016/j.clim.2004.05.009 VOLLMER J, 2005, J EXP MED, V202, P1575, DOI 10.1084/jem.20051696 WAGNER H, 2006, ADV IMMUNOL, V91, P159, DOI 10.1016/S0065-2776(06)91004-9 WALDNER H, 2004, J CLIN INVEST, V113, P990, DOI 10.1172/JCI200419388 WENZEL J, 2006, CLIN EXP DERMATOL, V31, P576, DOI 10.1111/j.1365-2230.2006.02150.x WINAU F, 2006, IMMUNITY, V24, P105 WU XB, 2006, ARTHRITIS RHEUM, V54, P336, DOI 10.1002/art.21553 YONEYAMA M, 2005, J IMMUNOL, V175, P2851 YOSHIDA H, 2005, NAT IMMUNOL, V6, P49, DOI 10.1038/ni1146 YU P, 2006, INT IMMUNOL, V18, P1211, DOI 10.1093/intimm/dxl067 ZHU JK, 2005, J CLIN INVEST, V115, P1869, DOI 10.1172/JCI123049 ZHUANG HY, 2006, ARTHRITIS RHEUM, V54, P1573, DOI 10.1002/art.21800 |