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Author(s): York LW; Puthalapattu S; Wu GY
Title: Nonalcoholic Fatty Liver Disease and Low-Carbohydrate Diets
Source: ANNUAL REVIEW OF NUTRITION 29: 365-379
Date: 2009
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Univ Connecticut, Ctr Hlth, Dept Nutr, Farmington, CT 06030 USA.
Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA. Univ Connecticut, Ctr Hlth, Div Gastroenterol Hepatol, Farmington, CT 06030 USA. Reprint: York, LW, Univ Connecticut, Ctr Hlth, Dept Nutr, Farmington, CT 06030
USA. E-mail: lyork@uchc.edu
sputhalapattu@residen.uchc.edu wu@nso.uchc.edu Author Keywords: metabolic syndrome; insulin resistance; weight loss
KeyWords Plus: ALANINE AMINOTRANSFERASE ACTIVITY; INSULIN-RESISTANT ADULTS; METABOLIC
SYNDROME; WEIGHT-LOSS; CRYPTOGENIC CIRRHOSIS; HEPATIC STEATOSIS;
RANDOMIZED-TRIAL; NATURAL-HISTORY; UNITED-STATES; RISK-FACTORS
Abstract: Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance, obesity, and other features of metabolic syndrome and is known to be the most common cause for abnormal liver enzymes. The recent surge in the number of patients with NAFLD has been accompanied by an increase in research on potential treatment options, particularly weight loss and dietary interventions. Given the growing interest on the role of carbohydrates in the prevention and treatment of NAFLD, this review discusses the relationship between the amount of carbohydrates in the diet and effects on NAFLD, with special emphasis on a low-carbohydrate diet. We discuss the role of insulin resistance in the pathophysiology of NAFLD and provide an overview of various popular diets and their role as a treatment option for NAFLD. Additional large, longer-duration trials studying the efficacy of a low-carbohydrate diet in the treatment and prevention of NAFLD are eagerly awaited.
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