| Record 403 View: Standard | Glossary HistCite Guide |
|
Author(s): Reddien PW; Horvitz HR
Title: The engulfment process of programmed cell death in Caenorhabditis elegans
Source: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY 20: 193-221
Date: 2004
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Univ Utah, Sch Med, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA.
MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA. Reprint: Reddien, PW, Univ Utah, Sch Med, Dept Neurobiol & Anat, Salt Lake City,
UT 84132 USA. E-mail: reddien@neuro.utah.edu
horvitz@MIT.EDU Author Keywords: phagocytosis; apoptosis; migration; Rac; signaling
KeyWords Plus: RECEPTOR-MEDIATED PHAGOCYTOSIS; MACROPHAGE SCAVENGER RECEPTOR; ACTIN
STRESS FIBERS; APOPTOTIC CELLS; C-ELEGANS; CORPSE ENGULFMENT;
PHOSPHATIDYLSERINE RECEPTOR; BINDING PROTEIN; IN-VIVO; MEMBRANE
PHOSPHATIDYLSERINE
Abstract: Programmed cell death involves the removal of cell corpses by other cells in a process termed engulfment. Genetic studies of the nematode Caenorhabditis elegans have led to a framework not only for the killing step of programmed cell death but also for the process of cell-corpse engulfment. This work has defined two signal transduction pathways that act redundantly to control engulfment. Signals expressed by dying cells probably regulate these C. elegans pathways. Components of the cell-corpse recognition system of one of the C. elegans pathways include the CED-7 ABC transporter, which likely presents a death ligand on the surface of the dying cell; the CED-1 transmembrane receptor, which recognizes this signal; and the CED-6 adaptor protein, which may transduce a signal from CED-1. The second C. elegans pathway acts in parallel and involves a novel Rac GTPase signaling pathway, with the components CED-2 CrkII, CED-5 DOCK 180, CED-12 ELMO, and CED-10 Rac. The cell-corpse recognition system that activates this pathway remains to be characterized. In C. elegans, and possibly in mammals, the process of cell-corpse engulfment promotes the death process itself. The known mechanisms for cell-corpse engulfment leave much to be discovered concerning this fundamental aspect of metazoan biology.
Cited References: ADAMS JM, 2003, GENE DEV, V17, P2481 ALBERT ML, 1998, J EXP MED, V188, P1359 ALBERT ML, 2000, NAT CELL BIOL, V2, P899 ALBINA JE, 1993, J IMMUNOL, V150, P5080 ARUR S, 2003, DEV CELL, V4, P587 AVERY L, 1987, CELL, V51, P1071 BARNES H, 2001, J BIOL CHEM, V276, P19119 BERGER AJ, 1998, J NEUROSCI, V18, P2871 BOTTO M, 1998, NAT GENET, V19, P56 BOURNE HR, 1991, NATURE, V349, P117 BRUGNERA E, 2002, NAT CELL BIOL, V4, P574 CALLAHAN MK, 2000, CELL DEATH DIFFER, V7, P645 CALLEBAUT I, 2003, BIOCHEM BIOPH RES CO, V300, P619 CARON E, 1998, SCIENCE, V282, P1717 CHALFIE M, 1981, DEV BIOL, V82, P538 CHENG EHYA, 2001, MOL CELL, V8, P705 CHIMINI G, 2000, NAT CELL BIOL, V2, PE191 CHUNG SB, 2000, NAT CELL BIOL, V2, P931 CLISSOLD PM, 2001, TRENDS BIOCHEM SCI, V26, P7 COHEN PL, 2002, J EXP MED, V196, P135 CONRADT B, 1998, CELL, V93, P519 CUI P, 2004, EXP CELL RES, V293, P154 CUI SJ, 1994, CANCER RES, V54, P2462 DEVITT A, 1998, NATURE, V392, P505 DIEZROUX G, 1997, DEVELOPMENT, V124, P3633 DRISCOLL M, 1991, NATURE, V349, P588 DUFFIELD JS, 2003, CLIN SCI, V404, P27 ELLIS HM, 1986, CELL, V44, P817 ELLIS RE, 1991, ANNU REV CELL BIOL, V7, P663 ELLIS RE, 1991, DEVELOPMENT, V112, P591 ELLIS RE, 1991, GENETICS, V129, P79 ERICKSON MRS, 1997, J CELL BIOL, V138, P589 FADOK VA, 1992, J IMMUNOL, V148, P2207 FADOK VA, 2000, NATURE, V405, P85 FADOK VA, 2001, J BIOL CHEM, V276, P1071 FERGUSON EL, 1985, GENETICS, V110, P17 FERGUSON EL, 1987, NATURE, V326, P259 FIRE A, 1998, NATURE, V391, P806 FRANC NC, 1996, IMMUNITY, V4, P431 FRANC NC, 1999, SCIENCE, V284, P1991 GAVRIELI Y, 1992, J CELL BIOL, V119, P493 GLUCKSMANN A, 1951, BIOL REV, V26, P59 GOTTHARDT M, 2000, J BIOL CHEM, V275, P25616 GRIMSLEY CM, 2004, J BIOL CHEM, V279, P6087 GUMIENNY TL, 1999, DEVELOPMENT, V126, P1011 GUMIENNY TL, 2001, CELL, V107, P27 HALL DH, 1997, J NEUROSCI, V17, P1033 HAMON Y, 2000, NAT CELL BIOL, V2, P399 HASEGAWA H, 1996, MOL CELL BIOL, V16, P1770 HEDGECOCK EM, 1983, SCIENCE, V220, P1277 HEEMELS MT, 2000, NATURE, V407, P769 HENGARTNER MO, 1994, CELL, V76, P665 HENGARTNER MO, 2001, CELL, V104, P325 HERRMANN M, 1998, ARTHRITIS RHEUM, V41, P1241 HIGGINS CF, 1992, ANNU REV CELL BIOL, V8, P67 HOEPPNER DJ, 2001, NATURE, V412, P202 HOWELL BW, 1999, MOL CELL BIOL, V19, P5179 HUGHES DA, 1995, EUR J IMMUNOL, V25, P466 JACOBSON MD, 1997, CELL, V88, P347 JANSEN G, 1997, NAT GENET, V17, P119 KAIBUCHI K, 1999, ANNU REV BIOCHEM, V68, P459 KATOH H, 2003, NATURE, V424, P461 KAVANAUGH WM, 1995, SCIENCE, V268, P1177 KERR JFR, 1972, BRIT J CANCER, V26, P239 KIYOKAWA E, 1998, J BIOL CHEM, V273, P24479 KLEMKE RL, 1998, J CELL BIOL, V140, P961 KOCH CA, 1991, SCIENCE, V252, P668 KORSWAGEN HC, 1997, GENE DEV, V11, P1493 KRIEGER M, 1994, ANNU REV BIOCHEM, V63, P601 LANG R, 1994, DEVELOPMENT, V120, P3395 LANG RA, 1993, CELL, V74, P453 LAUBER K, 2003, CELL, V113, P717 LEVERRIER Y, 2001, CURR BIOL, V11, P195 LI MO, 2003, SCIENCE, V302, P1560 LIU QA, 1998, CELL, V93, P961 LIU QA, 1999, CURR BIOL, V9, P1347 LUCIANI MF, 1996, EMBO J, V15, P226 LUNDQUIST EA, 2001, DEVELOPMENT, V128, P4475 MARGUET D, 1999, NAT CELL BIOL, V1, P454 MARTIN SJ, 1995, J EXP MED, V182, P1545 MASSOL P, 1998, EMBO J, V17, P6219 MATSUDA M, 1992, MOL CELL BIOL, V12, P3482 MEIER P, 2000, NATURE, V407, P796 METZSTEIN MM, 1998, TRENDS GENET, V14, P410 NAGATA K, 1996, J BIOL CHEM, V271, P30022 NAKANO T, 1997, J BIOL CHEM, V272, P29411 NOBES CD, 1995, CELL, V81, P53 OGDEN CA, 2001, J EXP MED, V194, P781 ORSO E, 2000, NAT GENET, V24, P192 PAWSON T, 1997, SCIENCE, V278, P2075 PLATT N, 1996, P NATL ACAD SCI USA, V93, P12456 PLATT N, 1998, TRENDS CELL BIOL, V8, P365 POTTER PK, 2003, J IMMUNOL, V170, P3223 PRADHAN D, 1997, MOL BIOL CELL, V8, P767 RABINOVITCH M, 1995, TRENDS CELL BIOL, V5, P85 REDDIEN PW, 2000, NAT CELL BIOL, V2, P131 REDDIEN PW, 2001, NATURE, V412, P198 REN Y, 1998, CELL DEATH DIFFER, V5, P563 RIDLEY AJ, 1992, CELL, V70, P389 RIDLEY AJ, 1992, CELL, V70, P401 RING GH, 1999, SEMIN NEPHROL, V19, P25 ROBERTSON AMG, 1982, J EMBRYOL EXP MORPH, V67, P89 RUDIN CM, 1997, ANNU REV MED, V48, P267 RUETZ S, 1994, CELL, V77, P1 SAUTER B, 2000, J EXP MED, V191, P423 SAVILL J, 1990, NATURE, V343, P170 SAVILL J, 1992, J CLIN INVEST, V90, P1513 SAVILL J, 1997, J LEUKOCYTE BIOL, V61, P375 SAVILL J, 2003, SCIENCE, V302, P1516 SAVILL JS, 1989, J CLIN INVEST, V84, P1518 SCOTT RS, 2001, NATURE, V411, P207 SHAH A, 1999, AGING MENT HEALTH, V3, P153 SHAHAM S, 1996, GENE DEV, V10, P578 SHAHAM S, 1998, J BIOL CHEM, V273, P35109 SHAW G, 1996, BIOESSAYS, V18, P35 SHI YG, 2002, MOL CELL, V9, P459 SMIT JJM, 1993, CELL, V75, P451 SMITS E, 1999, CURR BIOL, V9, P1351 STEVEN R, 1998, CELL, V92, P785 SU HP, 2000, J BIOL CHEM, V275, P9542 SU HP, 2002, J BIOL CHEM, V277, P11772 SULSTON JE, 1977, DEV BIOL, V56, P110 SULSTON JE, 1983, DEV BIOL, V100, P64 TAYLOR PR, 2000, J EXP MED, V192, P359 THOMPSON CB, 1995, SCIENCE, V267, P1456 THORNBERRY NA, 1998, SCIENCE, V281, P1312 TOSELLOTRAMPONT AC, 2001, J BIOL CHEM, V276, P13797 TURNER C, 2003, CELL DEATH DIFFER, V10, P302 VAN AL, 1997, GENE DEV, V11, P2295 VANDELOOSDRECHT AA, 1993, EXP HEMATOL, V21, P1628 VANDENEIJNDE SM, 1998, APOPTOSIS, V3, P9 WANG XC, 2003, SCIENCE, V302, P1563 WHITE JG, 1991, PHILOS T R SOC B, V331, P263 WOO M, 1998, GENE DEV, V12, P806 WU YC, 1998, CELL, V93, P951 WU YC, 1998, NATURE, V392, P501 WU YC, 2000, GENE DEV, V14, P536 WU YC, 2001, DEV CELL, V1, P491 WYLLIE AH, 1980, INT REV CYTOL, V68, P251 WYLLIE AH, 1980, NATURE, V284, P555 YAJNIK V, 2003, CELL, V112, P673 YUAN JY, 1992, DEVELOPMENT, V116, P309 YUAN JY, 1993, CELL, V75, P641 ZHOU Z, 2001, CELL, V104, P43 ZHOU Z, 2001, DEV CELL, V1, P477 ZIPKIN ID, 1997, CELL, V90, P883 ZOU H, 1997, CELL, V90, P405 |