| Record 1522 View: Standard | Glossary HistCite Guide |
|
Author(s): Shaywitz AJ; Greenberg ME
Title: CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
Source: ANNUAL REVIEW OF BIOCHEMISTRY 68: 821-861
Date: 1999
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Childrens Hosp, Dept Neurol, Div Neurosci, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Neurobiol, Program Biol & Biomed Sci, Boston, MA 02115 USA. Reprint: Shaywitz, AJ, Childrens Hosp, Dept Neurol, Div Neurosci, Boston, MA
02115 USA. E-mail:
Author Keywords: CREB; CBP; PKA; CaMK; RSK; phosphorylation
KeyWords Plus: ELEMENT-BINDING-PROTEIN; CAMP-RESPONSIVE-ELEMENT; PHOSPHOENOLPYRUVATE
CARBOXYKINASE GENE; NERVE GROWTH-FACTOR; GLYCOGEN-SYNTHASE KINASE-3; C-
FOS TRANSCRIPTION; RNA-POLYMERASE-II; RUBINSTEIN-TAYBI SYNDROME;
NUCLEAR FACTOR CREB; P38 MAP KINASE
Abstract: Extracellular stimuli elicit changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate transcription factors within the nucleus. One of the best characterized stimulus-induced transcription factors, cyclic AMP response element (CRE)-binding protein (CREB), activates transcription of target genes in response to a diverse array of stimuli, including peptide hormones, growth factors, and neuronal activity, that activate a variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs). These kinases all phosphorylate CREB at a particular residue, serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB-mediated transcription. Despite this common feature, the mechanism by which CREB activates transcription varies depending on the stimulus. In some cases, signaling pathways target additional sites on CREB or proteins associated with CREB, permitting CREB to regulate distinct programs of gene expression under different conditions of stimulation. This review discusses the molecular mechanisms by which Ser133-phosphorylated CREB activates transcription, intracellular signaling pathways that lead to phosphorylation of CREB at Ser133, and features of each signaling pathway that impart specificity at the level of CREB activation.
Cited References: AHN S, 1998, MOL CELL BIOL, V18, P967 ALBERTS AS, 1994, J BIOL CHEM, V269, P7623 ANDERSON MG, 1994, NUCLEIC ACIDS RES, V22, P3194 ARANY Z, 1994, CELL, V77, P799 ARIAS J, 1994, NATURE, V370, P226 ARMSTRONG R, 1995, MOL CELL BIOL, V15, P1826 BADING H, 1991, SCIENCE, V253, P912 BADING H, 1993, SCIENCE, V260, P181 BANNISTER AJ, 1996, NATURE, V384, P641 BARLEV NA, 1995, J BIOL CHEM, V270, P19337 BARTON K, 1996, NATURE, V379, P81 BENBROOK DM, 1990, ONCOGENE, V5, P295 BERGER SL, 1992, CELL, V70, P251 BERKOWITZ LA, 1990, P NATL ACAD SCI USA, V87, P5258 BITO H, 1996, CELL, V87, P1203 BLENDY JA, 1996, EMBO J, V15, P1098 BLENDY JA, 1998, J MOL MED-JMM, V76, P104 BLENIS J, 1991, CELL GROWTH DIFFER, V2, P279 BLENIS J, 1993, P NATL ACAD SCI USA, V90, P5889 BONNI A, 1995, MOL CELL NEUROSCI, V6, P168 BRAUN AP, 1995, ANNU REV PHYSIOL, V57, P417 BRINDLE P, 1993, NATURE, V364, P821 BRINDLE P, 1995, P NATL ACAD SCI USA, V92, P10521 BROCKE L, 1995, J NEUROSCI, V15, P6796 BULLOCK BP, 1998, BIOCHEMISTRY-US, V37, P3795 CARRION AM, 1999, NATURE, V398, P80 CHAWLA S, 1998, SCIENCE, V281, P1505 CHEN RH, 1992, MOL CELL BIOL, V12, P915 CHIBA H, 1994, NUCLEIC ACIDS RES, V22, P1815 CHO H, 1998, MOL CELL BIOL, V18, P5355 CHRIVIA JC, 1993, NATURE, V365, P855 COHEN P, 1989, ANNU REV BIOCHEM, V58, P453 COLE TJ, 1992, GENOMICS, V13, P974 CRINO P, 1998, P NATL ACAD SCI USA, V95, P2313 CUENDA A, 1995, FEBS LETT, V364, P229 DASH PK, 1991, P NATL ACAD SCI USA, V88, P5061 DEAK M, 1998, EMBO J, V17, P4426 DECESARE D, 1998, P NATL ACAD SCI USA, V95, P12202 DEGROOT RP, 1993, EMBO J, V12, P3903 DEGROOT RP, 1993, MOL ENDOCRINOL, V7, P1495 DEGROOT RP, 1994, CELL, V79, P81 DEISSEROTH K, 1996, NEURON, V16, P89 DEISSEROTH K, 1998, NATURE, V392, P198 DELMAS V, 1992, P NATL ACAD SCI USA, V89, P4226 DOLMETSCH RE, 1997, NATURE, V386, P855 DOLMETSCH RE, 1998, NATURE, V392, P933 DUDLEY DT, 1995, P NATL ACAD SCI USA, V92, P7686 DWARKI VJ, 1990, EMBO J, V9, P225 ECKNER R, 1994, GENE DEV, V8, P869 ELLIS MJC, 1995, MOL ENDOCRINOL, V9, P255 ENSLEN H, 1994, J BIOL CHEM, V269, P15520 FARNSWORTH CL, 1995, NATURE, V376, P524 FENTZKE RC, 1998, J CLIN INVEST, V101, P2415 FERRERI K, 1994, P NATL ACAD SCI USA, V91, P1210 FIELDS RD, 1997, J NEUROSCI, V17, P7252 FINKBEINER S, 1996, NEURON, V16, P233 FINKBEINER S, 1997, NEURON, V19, P1031 FIOL CJ, 1994, J BIOL CHEM, V269, P32187 FISCH TM, 1987, MOL CELL BIOL, V7, P3490 FISCH TM, 1989, GENE DEV, V3, P198 FOULKES NS, 1991, CELL, V64, P739 FOULKES NS, 1992, NATURE, V355, P80 FOULKES NS, 1993, NATURE, V362, P264 FRANK DA, 1994, CELL, V79, P5 FRANKLIN JL, 1992, TRENDS NEUROSCI, V15, P501 GABBAY RA, 1996, J BIOL CHEM, V271, P1890 GALLIN WJ, 1995, CURR OPIN NEUROBIOL, V5, P367 GHOSH A, 1994, SCIENCE, V263, P1618 GHOSH A, 1995, SCIENCE, V268, P239 GILL G, 1994, P NATL ACAD SCI USA, V91, P192 GILMAN AG, 1987, ANNU REV BIOCHEM, V56, P615 GILMAN MZ, 1986, MOL CELL BIOL, V6, P4305 GINTY DD, 1993, SCIENCE, V260, P238 GINTY DD, 1994, CELL, V77, P713 GONZALEZ GA, 1989, CELL, V59, P675 GONZALEZ GA, 1989, NATURE, V337, P749 GONZALEZ GA, 1991, MOL CELL BIOL, V11, P1306 GOODMAN RH, 1990, ANNU REV NEUROSCI, V13, P111 GRAY PC, 1997, J BIOL CHEM, V272, P6297 GREENBERG ME, 1985, J BIOL CHEM, V260, P14101 GREENBERG ME, 1986, SCIENCE, V234, P80 HAGIWARA M, 1992, CELL, V70, P105 HAGIWARA M, 1993, MOL CELL BIOL, V13, P4852 HALAZONETIS TD, 1988, CELL, V55, P917 HAN JH, 1996, J BIOL CHEM, V271, P2886 HANSON RW, 1997, ANNU REV BIOCHEM, V66, P581 HARDINGHAM GE, 1997, NATURE, V385, P260 HAYNES SR, 1992, NUCLEIC ACIDS RES, V20, P2603 HEIST EK, 1998, J BIOL CHEM, V273, P19763 HERMANSEN K, 1985, ENDOCRINOLOGY, V116, P2251 HOEFFLER JP, 1988, SCIENCE, V242, P1430 HOEFFLER JP, 1990, MOL ENDOCRINOL, V4, P920 HURST HC, 1987, GENE DEV, V1, P1132 HURST HC, 1990, MOL CELL BIOL, V10, P6192 HURST HC, 1991, NUCLEIC ACIDS RES, V19, P4601 IMPEY S, 1998, NEURON, V21, P869 JANKNECHT R, 1996, NATURE, V383, P22 JANKNECHT R, 1996, ONCOGENE, V12, P1961 KAFFMAN A, 1998, GENE DEV, V12, P2673 KANG HJ, 1995, J PHYSIOLOGY-PARIS, V89, P11 KANG HJ, 1995, SCIENCE, V267, P1658 KARIN M, 1995, CURR BIOL, V5, P747 KAWASAKI H, 1998, NATURE, V393, P284 KEE BL, 1996, J BIOL CHEM, V271, P2373 KOBAYASHI M, 1995, NUCLEIC ACIDS RES, V23, P2848 KORZUS E, 1998, SCIENCE, V279, P703 KVIETIKOVA I, 1995, NUCLEIC ACIDS RES, V23, P4542 KWOK RPS, 1994, NATURE, V370, P223 LAMAS M, 1997, MOL ENDOCRINOL, V11, P1415 LAOIDE BM, 1993, EMBO J, V12, P1179 LEE KAW, 1987, P NATL ACAD SCI USA, V84, P8355 LEE KAW, 1989, MOL CELL BIOL, V9, P4390 LEE KAW, 1993, BIOCHIM BIOPHYS ACTA, V1174, P221 LEV S, 1995, NATURE, V376, P737 LEWIN GR, 1996, ANNU REV NEUROSCI, V19, P289 LIU F, 1993, J BIOL CHEM, V268, P6714 LIU FC, 1996, NEURON, V17, P1133 LORIAUX MM, 1994, J BIOL CHEM, V269, P28839 LUNDBLAD JR, 1995, NATURE, V374, P85 MATTHEWS RP, 1994, MOL CELL BIOL, V14, P6107 MCLAUGHLIN MM, 1996, J BIOL CHEM, V271, P8488 METALLO SJ, 1997, NAT STRUCT BIOL, V4, P115 MEYER TE, 1993, ENDOCR REV, V14, P269 MOLINA CA, 1993, CELL, V75, P875 MONTMINY M, 1997, ANNU REV BIOCHEM, V66, P807 MONTMINY MR, 1986, P NATL ACAD SCI USA, V83, P6682 MONTMINY MR, 1987, NATURE, V328, P175 MORGAN JI, 1986, NATURE, V322, P552 MUSTI AM, 1997, SCIENCE, V275, P400 MUTHUSAMY N, 1998, J BIOL CHEM, V273, P22841 NAKAJIMA T, 1996, CELL, V86, P465 NAKAJIMA T, 1997, CELL, V90, P1107 NAKAJIMA T, 1997, GENE DEV, V11, P738 NAKAMURA Y, 1995, NEUROSCIENCE, V68, P181 NGUYEN TV, 1990, J NEUROSCI, V10, P2825 NICHOLS M, 1992, EMBO J, V11, P3337 OGRYZKO VV, 1996, CELL, V87, P953 ONEILL EM, 1996, SCIENCE, V271, P209 PARKER D, 1996, MOL CELL BIOL, V16, P694 PARKER D, 1998, MOL CELL, V2, P353 PENDE M, 1997, J NEUROSCI, V17, P1291 PETRIJ F, 1995, NATURE, V376, P348 PICCIOTTO MR, 1995, SYNAPSE, V20, P75 QUINN PG, 1993, J BIOL CHEM, V268, P16999 QUINN PG, 1994, J BIOL CHEM, V269, P14375 RADHAKRISHNAN I, 1997, CELL, V91, P741 REHFUSS RP, 1991, J BIOL CHEM, V266, P18431 REUSCH JEB, 1994, ENDOCRINOLOGY, V135, P2418 RICHARDS JP, 1996, J BIOL CHEM, V271, P13716 ROBBINS RJ, 1982, BRAIN RES, V234, P377 ROESLER WJ, 1995, J BIOL CHEM, V270, P8225 ROSEN LB, 1994, NEURON, V12, P1207 ROSEN LB, 1996, P NATL ACAD SCI USA, V93, P1113 ROUSE J, 1994, CELL, V78, P1027 RUPPERT S, 1992, EMBO J, V11, P1503 RUSANESCU G, 1995, NEURON, V15, P1415 SASAKI K, 1984, J BIOL CHEM, V259, P15242 SASSONECORSI P, 1988, GENE DEV, V2, P1529 SCOTT BS, 1970, EXP NEUROL, V27, P16 SEAMON KB, 1981, P NATL ACAD SCI USA, V78, P3363 SHENG M, 1988, MOL CELL BIOL, V8, P2787 SHENG M, 1990, NEURON, V4, P477 SHENG M, 1990, NEURON, V4, P571 SHENG M, 1991, SCIENCE, V252, P1427 SHIEH PB, 1998, NEURON, V20, P727 SHIH HM, 1996, P NATL ACAD SCI USA, V93, P13896 SHIMOMURA A, 1996, J BIOL CHEM, V271, P17957 SILVA AJ, 1998, ANNU REV NEUROSCI, V21, P127 STEHLE JH, 1993, NATURE, V365, P314 STEMMER PM, 1995, FEBS LETT, V374, P237 STEWART AA, 1982, FEBS LETT, V137, P80 STRADER CD, 1994, ANNU REV BIOCHEM, V63, P101 STRUHL K, 1989, TRENDS BIOCHEM SCI, V14, P137 STRUHL K, 1998, GENE DEV, V12, P599 STRUTHERS RS, 1991, NATURE, V350, P622 SUN P, 1994, GENE DEV, V8, P2527 SUN PQ, 1996, J BIOL CHEM, V271, P3066 SUTHERLAND C, 1998, J BIOL CHEM, V273, P3198 SUTHERLAND EW, 1968, CIRCULATION, V37, P279 TAN Y, 1996, EMBO J, V15, P4629 TANAKA Y, 1997, P NATL ACAD SCI USA, V94, P10215 TAO X, 1998, NEURON, V20, P709 TAYLOR SS, 1990, ANNU REV BIOCHEM, V59, P971 THOMPSON MA, 1995, J BIOL CHEM, V270, P4224 TOKUMITSU H, 1995, J BIOL CHEM, V270, P19320 TRIVIER E, 1996, NATURE, V384, P567 TSUKADA J, 1994, MOL CELL BIOL, V14, P7285 VANDROMME M, 1996, TRENDS BIOCHEM SCI, V21, P59 VINSON CR, 1989, SCIENCE, V246, P911 WADZINSKI BE, 1993, MOL CELL BIOL, V13, P2822 WAEBER G, 1991, MOL ENDOCRINOL, V5, P1418 WAEBER G, 1991, MOL ENDOCRINOL, V5, P1431 WAEBER G, 1992, ENDOCRINOLOGY, V131, P2010 WALTON KM, 1992, MOL ENDOCRINOL, V6, P647 WANG XT, 1996, NATURE, V383, P434 WEGNER M, 1992, SCIENCE, V256, P370 WEIH F, 1990, GENE DEV, V4, P1437 WOODGETT JR, 1994, SEMIN CANCER BIOL, V5, P269 WU XL, 1998, J BIOL CHEM, V273, P20820 XIA Z, 1996, REGULATORY PROPERTIE XIE HJ, 1995, J IMMUNOL, V154, P1717 XIE HJ, 1996, CELL IMMUNOL, V169, P264 XING J, 1996, SCIENCE, V273, P959 XING J, 1998, MOL CELL BIOL, V18, P1946 XING LP, 1994, J BIOL CHEM, V269, P28732 XING LP, 1995, J BIOL CHEM, V270, P17488 YAMAMOTO KK, 1988, NATURE, V334, P494 YAMAMOTO KK, 1990, CELL, V60, P611 YANG LM, 1997, J IMMUNOL, V158, P2522 YANG XJ, 1996, NATURE, V382, P319 YAO H, 1998, J BIOL CHEM, V273, P8240 YAO TP, 1998, CELL, V93, P361 YEAGLEY D, 1998, J BIOL CHEM, V273, P18743 YUN Y, 1990, MOL ENDOCRINOL, V4, P931 |