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Author(s): He WW; Sciavolino PJ; Wing J; Augustus M; Hudson P; Meissner PS; Curtis RT; Shell BK; Bostwick DG; Tindall DJ; Gelmann EP; AbateShen C; Carter KC
Title: A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer
Source: GENOMICS 43 (1): 69-77
Date: 1997 JUL 1
Document Type: Journal : Article
DOI:
Language: English
Comment:
Address: HUMAN GENOME SCI INC,DEPT MOL BIOL,ROCKVILLE,MD 20850.
UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL,PISCATAWAY,NJ 08854. UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,CTR ADV BIOTECHNOL & MED,PISCATAWAY,NJ 08854. MAYO CLIN & MAYO FDN,DEPT BIOCHEM & MOL BIOL,ROCHESTER,MN 55905. MAYO CLIN & MAYO FDN,DEPT UROL,ROCHESTER,MN 55905. GEORGETOWN UNIV,MED CTR,VINCENT T LOMBARDI CANC RES CTR,DEPT MED,WASHINGTON,DC 20007. Reprint:
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Abstract: We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to the Drosophila NK homeobox gene family, Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testis, but is expressed little or not at all in several other tissues. In an androgen-dependent prostate carcinoma line, LNCaP, NKX3.1 mRNA is expressed at a basal level that was increased markedly upon androgen stimulation; the NKX3.1 mRNA was undetectable in several other human tumor cell lines including two androgen-independent prostate carcinoma lints. The NKX3.1 gene maps to chromosome band 8p21, a region frequently reported to undergo a loss of heterozygosity associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer. Based on these data we propose that NKX3.1 is a candidate gene for playing a role in the opposing processes of androgen-driven differentiation of prostatic tissue and loss of that differentiation during the progression of prostate cancer. (C) 1997 Academic Press.
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